SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5an9'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1BDW_B_DVAB8_0
(GRAMICIDIN A)		 5an9 60S RIBOSOMAL
PROTEIN L3
(Dictyostelium
discoideum) 		3 / 3 VAL A  87
VAL A 163
TRP A 106
 None
 0.92A 1bdwA-5an9A:
undetectable
1bdwB-5an9A:
undetectable		 1bdwA-5an9A:
5.06
1bdwB-5an9A:
5.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IEP_A_STIA201_2
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL)		 5an9 60S RIBOSOMAL
PROTEIN L3
(Dictyostelium
discoideum) 		4 / 6 VAL A 336
ILE A 218
MET A  53
ARG A  24
 None
None
C  N3384 ( 3.5A)
G  N3339 ( 2.8A)
 1.01A 1iepA-5an9A:
undetectable		 1iepA-5an9A:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NOD_B_H4BB902_1
(NITRIC OXIDE
SYNTHASE)		 5an9 60S RIBOSOMAL
PROTEIN L24
(Dictyostelium
discoideum) 		3 / 3 ARG G  56
ILE G  49
TRP G  51
 None
 1.02A 1nodB-5an9G:
undetectable		 1nodB-5an9G:
8.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QOM_A_H4BA902_1
(NITRIC OXIDE
SYNTHASE)		 5an9 60S RIBOSOMAL
PROTEIN L24
(Dictyostelium
discoideum) 		3 / 3 ARG G  56
ILE G  49
TRP G  51
 None
 1.04A 1qomA-5an9G:
undetectable		 1qomA-5an9G:
9.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NOD_B_H4BB902_1
(NITRIC OXIDE
SYNTHASE)		 5an9 60S RIBOSOMAL
PROTEIN L24
(Dictyostelium
discoideum) 		3 / 3 ARG G  56
ILE G  49
TRP G  51
 None
 1.00A 2nodB-5an9G:
undetectable		 2nodB-5an9G:
8.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QL8_B_BEZB143_0
(PUTATIVE REDOX
PROTEIN)		 5an9 60S RIBOSOMAL
PROTEIN L3
(Dictyostelium
discoideum) 		4 / 6 ARG A 287
THR A 312
ALA A 291
PRO A 315
 None
 1.44A 2ql8A-5an9A:
undetectable
2ql8B-5an9A:
undetectable		 2ql8A-5an9A:
17.27
2ql8B-5an9A:
17.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DH0_B_SAMB300_0
(SAM DEPENDENT
METHYLTRANSFERASE)		 5an9 60S RIBOSOMAL
PROTEIN L3
(Dictyostelium
discoideum) 		5 / 12 PHE A 373
ARG A 340
GLY A 318
THR A 369
LEU A 377
 C  N3422 ( 4.6A)
A  N3385 ( 3.5A)
None
None
None
 1.12A 3dh0B-5an9A:
undetectable		 3dh0B-5an9A:
20.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EM0_B_CHDB152_0
(ILEAL BILE
ACID-BINDING PROTEIN)		 5an9 60S RIBOSOMAL
PROTEIN L3
(Dictyostelium
discoideum) 		4 / 8 ILE A 350
PRO A  33
HIS A 277
VAL A 279
 U  N3472 ( 4.3A)
None
A  N3475 ( 4.2A)
C  N3473 ( 4.5A)
 0.90A 3em0B-5an9A:
undetectable		 3em0B-5an9A:
15.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FI0_P_TRPP1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 5an9 60S RIBOSOMAL
PROTEIN L3
60S RIBOSOMAL
PROTEIN L23
60S RIBOSOMAL
PROTEIN L24
(Dictyostelium
discoideum;
Dictyostelium
discoideum;
Dictyostelium
discoideum) 		4 / 7 GLY E  90
VAL A  73
HIS A  55
ILE G  13
 None
None
A  N3385 ( 3.0A)
None
 0.91A 3fi0P-5an9E:
undetectable		 3fi0P-5an9E:
18.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MS9_A_STIA1_2
(TYROSINE-PROTEIN
KINASE ABL1)		 5an9 60S RIBOSOMAL
PROTEIN L3
(Dictyostelium
discoideum) 		4 / 6 VAL A 336
ILE A 218
MET A  53
ARG A  24
 None
None
C  N3384 ( 3.5A)
G  N3339 ( 2.8A)
 0.88A 3ms9A-5an9A:
undetectable		 3ms9A-5an9A:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MSS_A_STIA1_2
(TYROSINE-PROTEIN
KINASE ABL1)		 5an9 60S RIBOSOMAL
PROTEIN L3
(Dictyostelium
discoideum) 		4 / 6 VAL A 336
ILE A 218
MET A  53
ARG A  24
 None
None
C  N3384 ( 3.5A)
G  N3339 ( 2.8A)
 0.85A 3mssA-5an9A:
undetectable		 3mssA-5an9A:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MSS_B_STIB1_2
(TYROSINE-PROTEIN
KINASE ABL1)		 5an9 60S RIBOSOMAL
PROTEIN L3
(Dictyostelium
discoideum) 		4 / 7 VAL A 336
ILE A 218
MET A  53
ARG A  24
 None
None
C  N3384 ( 3.5A)
G  N3339 ( 2.8A)
 1.04A 3mssB-5an9A:
undetectable		 3mssB-5an9A:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MSS_C_STIC1_2
(TYROSINE-PROTEIN
KINASE ABL1)		 5an9 60S RIBOSOMAL
PROTEIN L3
(Dictyostelium
discoideum) 		4 / 6 VAL A 336
ILE A 218
MET A  53
ARG A  24
 None
None
C  N3384 ( 3.5A)
G  N3339 ( 2.8A)
 0.85A 3mssC-5an9A:
undetectable		 3mssC-5an9A:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NW2_A_H4BA902_1
(NITRIC OXIDE
SYNTHASE, INDUCIBLE)		 5an9 60S RIBOSOMAL
PROTEIN L24
(Dictyostelium
discoideum) 		3 / 3 ARG G  56
ILE G  49
TRP G  51
 None
 1.10A 3nw2A-5an9G:
undetectable		 3nw2A-5an9G:
8.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NW2_B_H4BB902_1
(NITRIC OXIDE
SYNTHASE, INDUCIBLE)		 5an9 60S RIBOSOMAL
PROTEIN L24
(Dictyostelium
discoideum) 		3 / 3 ARG G  56
ILE G  49
TRP G  51
 None
 1.05A 3nw2B-5an9G:
undetectable		 3nw2B-5an9G:
8.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OEZ_A_STIA601_2
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 5an9 60S RIBOSOMAL
PROTEIN L3
(Dictyostelium
discoideum) 		4 / 5 VAL A 279
ILE A 218
MET A  53
ARG A  24
 C  N3473 ( 4.5A)
None
C  N3384 ( 3.5A)
G  N3339 ( 2.8A)
 1.31A 3oezA-5an9A:
undetectable		 3oezA-5an9A:
19.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RGL_A_GLYA301_0
(GLYCYL-TRNA
SYNTHETASE ALPHA
SUBUNIT)		 5an9 60S ACIDIC RIBOSOMAL
PROTEIN P0
(Dictyostelium
discoideum) 		4 / 8 GLY C 163
THR C 162
GLN C  83
GLU C  30
 None
 0.91A 3rglA-5an9C:
undetectable		 3rglA-5an9C:
20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W68_D_VIVD301_0
(ALPHA-TOCOPHEROL
TRANSFER PROTEIN)		 5an9 60S RIBOSOMAL
PROTEIN L9
(Dictyostelium
discoideum) 		5 / 12 VAL B  27
PHE B  38
VAL B  10
LEU B  53
VAL B  18
 None
 0.93A 3w68D-5an9B:
undetectable		 3w68D-5an9B:
22.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A97_A_ZPCA1318_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 5an9 60S RIBOSOMAL
PROTEIN L23
60S RIBOSOMAL
PROTEIN L24
(Dictyostelium
discoideum) 		4 / 7 GLU G  37
PHE G  40
TYR E  94
VAL E 136
 G  N3388 ( 3.8A)
None
None
None
 1.10A 4a97A-5an9G:
undetectable		 4a97A-5an9G:
8.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A97_E_ZPCE1318_2
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 5an9 60S RIBOSOMAL
PROTEIN L23
60S RIBOSOMAL
PROTEIN L24
(Dictyostelium
discoideum) 		4 / 6 GLU G  37
PHE G  40
TYR E  94
VAL E 136
 G  N3388 ( 3.8A)
None
None
None
 1.16A 4a97E-5an9G:
undetectable		 4a97E-5an9G:
8.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CP3_B_RBTB1129_1
(B-CELL LYMPHOMA 6
PROTEIN)		 5an9 60S RIBOSOMAL
PROTEIN L9
(Dictyostelium
discoideum) 		4 / 7 ASN B  46
LEU B  53
GLY B  22
SER B  24
 None
 0.90A 4cp3A-5an9B:
undetectable
4cp3B-5an9B:
undetectable		 4cp3A-5an9B:
21.98
4cp3B-5an9B:
21.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EB6_C_VLBC503_1
(TUBULIN BETA CHAIN
TUBULIN ALPHA CHAIN)		 5an9 60S ACIDIC RIBOSOMAL
PROTEIN P0
(Dictyostelium
discoideum) 		5 / 12 ASP C  66
THR C  79
TYR C 192
VAL C  63
ILE C  60
 None
None
None
None
A  N1456 ( 4.1A)
 1.29A 4eb6B-5an9C:
undetectable
4eb6C-5an9C:
undetectable		 4eb6B-5an9C:
20.23
4eb6C-5an9C:
18.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FOX_D_D16D301_1
(THYMIDYLATE SYNTHASE)		 5an9 60S RIBOSOMAL
PROTEIN L3
(Dictyostelium
discoideum) 		5 / 12 ILE A 147
LEU A  89
GLY A  88
VAL A 199
ALA A 200
 None
 1.23A 4foxD-5an9A:
undetectable		 4foxD-5an9A:
19.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FP9_C_SAMC401_1
(METHYLTRANSFERASE
NSUN4)		 5an9 60S ACIDIC RIBOSOMAL
PROTEIN P0
(Dictyostelium
discoideum) 		3 / 3 ASP C  69
ARG C  65
ASP C 193
 None
 0.78A 4fp9C-5an9C:
undetectable		 4fp9C-5an9C:
18.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FP9_F_SAMF401_1
(METHYLTRANSFERASE
NSUN4)		 5an9 60S ACIDIC RIBOSOMAL
PROTEIN P0
(Dictyostelium
discoideum) 		3 / 3 ASP C  69
ARG C  65
ASP C 193
 None
 0.76A 4fp9F-5an9C:
undetectable		 4fp9F-5an9C:
18.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IMA_D_ADND604_1
(PYRUVATE KINASE)		 5an9 60S RIBOSOMAL
PROTEIN L9
(Dictyostelium
discoideum) 		3 / 3 ARG B  31
GLU B 186
ASN B 188
 None
 0.84A 4imaD-5an9B:
undetectable		 4imaD-5an9B:
19.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IP7_D_ADND604_1
(PYRUVATE KINASE
ISOZYMES L)		 5an9 60S RIBOSOMAL
PROTEIN L9
(Dictyostelium
discoideum) 		3 / 3 ARG B  31
GLU B 186
ASN B 188
 None
 0.87A 4ip7D-5an9B:
undetectable		 4ip7D-5an9B:
19.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZZB_C_ACTC401_0
(PROTON-GATED ION
CHANNEL)		 5an9 60S RIBOSOMAL
PROTEIN L3
(Dictyostelium
discoideum) 		4 / 7 ILE A  78
PHE A 329
ARG A 287
ILE A 367
 None
 0.97A 4zzbC-5an9A:
undetectable
4zzbD-5an9A:
undetectable		 4zzbC-5an9A:
21.04
4zzbD-5an9A:
21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZZC_A_ACTA401_0
(PROTON-GATED ION
CHANNEL)		 5an9 60S RIBOSOMAL
PROTEIN L3
(Dictyostelium
discoideum) 		4 / 6 ILE A  78
PHE A 329
ARG A 287
ILE A 367
 None
 0.91A 4zzcA-5an9A:
undetectable
4zzcB-5an9A:
undetectable		 4zzcA-5an9A:
20.65
4zzcB-5an9A:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZZC_B_ACTB401_0
(PROTON-GATED ION
CHANNEL)		 5an9 60S RIBOSOMAL
PROTEIN L3
(Dictyostelium
discoideum) 		4 / 6 ILE A  78
PHE A 329
ARG A 287
ILE A 367
 None
 0.89A 4zzcB-5an9A:
undetectable
4zzcC-5an9A:
undetectable		 4zzcB-5an9A:
20.65
4zzcC-5an9A:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DSG_B_0HKB1201_2
(MUSCARINIC
ACETYLCHOLINE
RECEPTOR
M4,ENDOLYSIN,ENDOLYS
IN,MUSCARINIC
ACETYLCHOLINE
RECEPTOR M4)		 5an9 60S RIBOSOMAL
PROTEIN L23
(Dictyostelium
discoideum) 		3 / 3 ASP E  27
ASN E  24
PHE E  95
 None
 0.79A 5dsgB-5an9E:
undetectable		 5dsgB-5an9E:
15.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E4D_A_BEZA201_0
(HYDROXYNITRILE LYASE)		 5an9 60S RIBOSOMAL
PROTEIN L3
(Dictyostelium
discoideum) 		5 / 9 VAL A 161
VAL A 186
ILE A  86
PHE A 202
LEU A  89
 None
 1.38A 5e4dA-5an9A:
undetectable		 5e4dA-5an9A:
19.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E4D_B_BEZB201_0
(HYDROXYNITRILE LYASE)		 5an9 60S RIBOSOMAL
PROTEIN L9
(Dictyostelium
discoideum) 		5 / 11 VAL B  20
VAL B  25
ILE B  68
ILE B  71
LEU B  53
 None
 0.98A 5e4dB-5an9B:
2.8		 5e4dB-5an9B:
22.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XDH_C_DAHC60_1
(PUTATIVE CYTOCHROME
C)		 5an9 60S RIBOSOMAL
PROTEIN L23
(Dictyostelium
discoideum) 		4 / 6 GLN E  81
MET E  57
VAL E  54
LEU E  77
 None
 1.05A 5xdhA-5an9E:
undetectable
5xdhC-5an9E:
undetectable		 5xdhA-5an9E:
22.79
5xdhC-5an9E:
22.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AK3_B_P2EB1201_1
(PROSTAGLANDIN E2
RECEPTOR EP3
SUBTYPE,SOLUBLE
CYTOCHROME B562)		 5an9 60S RIBOSOMAL
PROTEIN L23
60S RIBOSOMAL
PROTEIN L24
(Dictyostelium
discoideum;
Dictyostelium
discoideum) 		4 / 5 PRO E 116
VAL G  22
GLY E  16
VAL E  54
 None
 1.09A 6ak3B-5an9E:
undetectable		 6ak3B-5an9E:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6J20_A_GBQA1201_0
(SUBSTANCE-P
RECEPTOR,ENDOLYSIN)		 5an9 60S RIBOSOMAL
PROTEIN L9
(Dictyostelium
discoideum) 		5 / 12 ASN B  77
VAL B  55
ILE B  68
PHE B  38
HIS B  40
 G  N3448 ( 3.1A)
None
None
None
A  N3459 ( 4.2A)
 1.50A 6j20A-5an9B:
undetectable		 6j20A-5an9B:
19.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MVX_A_K4DA1304_0
(ION TRANSPORT
PROTEIN)		 5an9 60S RIBOSOMAL
PROTEIN L3
(Dictyostelium
discoideum) 		4 / 6 THR A 345
LEU A 346
THR A 167
LEU A  43
 None
 1.10A 6mvxA-5an9A:
undetectable
6mvxB-5an9A:
undetectable
6mvxC-5an9A:
undetectable		 6mvxA-5an9A:
21.45
6mvxB-5an9A:
21.45
6mvxC-5an9A:
21.45