SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5anb'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID
Hit
Macromolecule
Res.
Matches
Interface HETATM RMSD Dali
Z-score
Seq.
Identity (%)
View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1AKD_A_CAMA420_0
(CYTOCHROME P450CAM)
5anb ELONGATION FACTOR TU
GTP-BINDING
DOMAIN-CONTAINING
PROTEIN 1

(Homo
sapiens)
5 / 11 PHE K 873
LEU K 887
VAL K 890
GLY K 889
THR K 763
None
1.17A 1akdA-5anbK:
undetectable
1akdA-5anbK:
16.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1BDW_B_DVAB8_0
(GRAMICIDIN A)
5anb ELONGATION FACTOR TU
GTP-BINDING
DOMAIN-CONTAINING
PROTEIN 1

(Homo
sapiens)
3 / 3 VAL K 232
VAL K 144
TRP K 268
None
0.93A 1bdwA-5anbK:
undetectable
1bdwB-5anbK:
undetectable
1bdwA-5anbK:
1.54
1bdwB-5anbK:
1.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DZ8_B_CAMB502_0
(CYTOCHROME P450-CAM)
5anb ELONGATION FACTOR TU
GTP-BINDING
DOMAIN-CONTAINING
PROTEIN 1

(Homo
sapiens)
5 / 9 PHE K 873
LEU K 887
VAL K 890
GLY K 889
THR K 763
None
1.38A 1dz8B-5anbK:
undetectable
1dz8B-5anbK:
16.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DZ9_B_CAMB502_0
(CYTOCHROME P450-CAM)
5anb ELONGATION FACTOR TU
GTP-BINDING
DOMAIN-CONTAINING
PROTEIN 1

(Homo
sapiens)
5 / 9 PHE K 873
LEU K 887
VAL K 890
GLY K 889
THR K 763
None
1.39A 1dz9B-5anbK:
undetectable
1dz9B-5anbK:
16.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FBM_B_RTLB951_1
(PROTEIN (CARTILAGE
OLIGOMERIC MATRIX
PROTEIN))
5anb ELONGATION FACTOR TU
GTP-BINDING
DOMAIN-CONTAINING
PROTEIN 1

(Homo
sapiens)
4 / 4 THR K 992
LEU K 996
VAL K 999
LEU K1003
None
1.08A 1fbmB-5anbK:
undetectable
1fbmB-5anbK:
4.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LIN_A_TFPA155_1
(CALMODULIN)
5anb ELONGATION FACTOR TU
GTP-BINDING
DOMAIN-CONTAINING
PROTEIN 1

(Homo
sapiens)
4 / 7 GLN K 393
GLU K 391
MET K 400
ALA K 398
None
1.29A 1linA-5anbK:
undetectable
1linA-5anbK:
8.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJQ_B_SAMB200_0
(METHIONINE REPRESSOR)
5anb ELONGATION FACTOR TU
GTP-BINDING
DOMAIN-CONTAINING
PROTEIN 1

(Homo
sapiens)
5 / 11 GLU K 904
GLY K 924
LEU K 865
LEU K 748
PRO K 745
None
1.46A 1mjqA-5anbK:
undetectable
1mjqB-5anbK:
undetectable
1mjqA-5anbK:
8.47
1mjqB-5anbK:
8.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJQ_B_SAMB200_0
(METHIONINE REPRESSOR)
5anb ELONGATION FACTOR TU
GTP-BINDING
DOMAIN-CONTAINING
PROTEIN 1

(Homo
sapiens)
5 / 11 GLU K 926
GLY K 924
LEU K 865
LEU K 748
PRO K 745
None
1.29A 1mjqA-5anbK:
undetectable
1mjqB-5anbK:
undetectable
1mjqA-5anbK:
8.47
1mjqB-5anbK:
8.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OE2_A_CUA502_0
(DISSIMILATORY
COPPER-CONTAINING
NITRITE REDUCTASE)
5anb ELONGATION FACTOR TU
GTP-BINDING
DOMAIN-CONTAINING
PROTEIN 1

(Homo
sapiens)
3 / 3 GLU K 102
HIS K  96
HIS K 666
None
0.66A 1oe2A-5anbK:
undetectable
1oe2A-5anbK:
14.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ONI_A_BEZA501_0
(14.5 KDA
TRANSLATIONAL
INHIBITOR PROTEIN)
5anb 60S RIBOSOMAL
PROTEIN L10

(Dictyostelium
discoideum)
4 / 7 ARG F  32
ALA F  29
ILE F  65
PRO F  93
U  N1222 ( 3.3A)
None
None
None
0.91A 1oniA-5anbF:
undetectable
1oniB-5anbF:
undetectable
1oniA-5anbF:
20.91
1oniB-5anbF:
20.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ONI_I_BEZI517_0
(14.5 KDA
TRANSLATIONAL
INHIBITOR PROTEIN)
5anb 60S RIBOSOMAL
PROTEIN L10

(Dictyostelium
discoideum)
4 / 7 ILE F  65
PRO F  93
ARG F  32
ALA F  29
None
None
U  N1222 ( 3.3A)
None
0.92A 1oniG-5anbF:
undetectable
1oniI-5anbF:
undetectable
1oniG-5anbF:
20.91
1oniI-5anbF:
20.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P6K_B_ACTB861_0
(NITRIC-OXIDE
SYNTHASE, BRAIN)
5anb ELONGATION FACTOR TU
GTP-BINDING
DOMAIN-CONTAINING
PROTEIN 1

(Homo
sapiens)
4 / 5 GLY K  95
GLN K 126
VAL K 130
SER K 100
None
1.38A 1p6kB-5anbK:
undetectable
1p6kB-5anbK:
16.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PBC_A_BHAA396_0
(P-HYDROXYBENZOATE
HYDROXYLASE)
5anb ELONGATION FACTOR TU
GTP-BINDING
DOMAIN-CONTAINING
PROTEIN 1

(Homo
sapiens)
5 / 10 GLY K1035
VAL K 665
LEU K1052
TYR K 985
LEU K1028
None
1.35A 1pbcA-5anbK:
undetectable
1pbcA-5anbK:
16.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RS6_B_ACTB861_0
(NITRIC-OXIDE
SYNTHASE, BRAIN)
5anb ELONGATION FACTOR TU
GTP-BINDING
DOMAIN-CONTAINING
PROTEIN 1

(Homo
sapiens)
4 / 5 GLY K  95
GLN K 126
VAL K 130
SER K 100
None
1.39A 1rs6B-5anbK:
undetectable
1rs6B-5anbK:
16.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1T46_A_STIA3_2
(HOMO SAPIENS V-KIT
HARDY-ZUCKERMAN 4
FELINE SARCOMA VIRAL
ONCOGENE HOMOLOG)
5anb 60S RIBOSOMAL
PROTEIN L10

(Dictyostelium
discoideum)
4 / 7 VAL F 129
VAL F  89
CYH F  12
ARG F  10
None
None
None
G  N3189 ( 3.9A)
1.15A 1t46A-5anbF:
undetectable
1t46A-5anbF:
19.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZLQ_A_ACTA1507_0
(NICKEL-BINDING
PERIPLASMIC PROTEIN)
5anb ELONGATION FACTOR TU
GTP-BINDING
DOMAIN-CONTAINING
PROTEIN 1

(Homo
sapiens)
3 / 3 GLN K 797
HIS K 793
ARG K 817
None
1.07A 1zlqA-5anbK:
undetectable
1zlqA-5anbK:
18.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZZQ_B_ACTB861_0
(NITRIC-OXIDE
SYNTHASE, BRAIN)
5anb ELONGATION FACTOR TU
GTP-BINDING
DOMAIN-CONTAINING
PROTEIN 1

(Homo
sapiens)
4 / 5 GLY K  95
GLN K 126
VAL K 130
SER K 100
None
1.41A 1zzqB-5anbK:
undetectable
1zzqB-5anbK:
16.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZZU_B_ACTB861_0
(NITRIC-OXIDE
SYNTHASE, BRAIN)
5anb ELONGATION FACTOR TU
GTP-BINDING
DOMAIN-CONTAINING
PROTEIN 1

(Homo
sapiens)
4 / 5 GLY K  95
GLN K 126
VAL K 130
SER K 100
None
1.40A 1zzuB-5anbK:
undetectable
1zzuB-5anbK:
16.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A1N_A_CAMA1422_0
(CYTOCHROME P450-CAM)
5anb ELONGATION FACTOR TU
GTP-BINDING
DOMAIN-CONTAINING
PROTEIN 1

(Homo
sapiens)
5 / 11 PHE K 873
LEU K 887
VAL K 890
GLY K 889
THR K 763
None
1.19A 2a1nA-5anbK:
undetectable
2a1nA-5anbK:
16.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A3A_A_TEPA1436_1
(CHITINASE)
5anb 60S RIBOSOMAL
PROTEIN L10

(Dictyostelium
discoideum)
3 / 3 ASP F  83
PHE F  46
ARG F  38
None
0.64A 2a3aA-5anbF:
undetectable
2a3aA-5anbF:
19.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2B9E_A_SAMA1201_0
(NOL1/NOP2/SUN DOMAIN
FAMILY, MEMBER 5
ISOFORM 2)
5anb ELONGATION FACTOR TU
GTP-BINDING
DOMAIN-CONTAINING
PROTEIN 1

(Homo
sapiens)
5 / 12 GLY K 112
ASN K  21
LEU K 136
ARG K 373
PHE K 612
None
1.44A 2b9eA-5anbK:
2.5
2b9eA-5anbK:
14.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OAX_D_SNLD4001_2
(MINERALOCORTICOID
RECEPTOR)
5anb EUKARYOTIC
TRANSLATION
INITIATION FACTOR 6

(Dictyostelium
discoideum)
4 / 5 LEU I 104
LEU I  70
CYH I  76
THR I  75
None
1.17A 2oaxD-5anbI:
undetectable
2oaxD-5anbI:
24.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QD4_B_CHDB928_0
(FERROCHELATASE)
5anb ELONGATION FACTOR TU
GTP-BINDING
DOMAIN-CONTAINING
PROTEIN 1

(Homo
sapiens)
5 / 12 PHE K 678
ARG K  60
HIS K 666
LEU K 667
VAL K 620
None
1.27A 2qd4B-5anbK:
2.6
2qd4B-5anbK:
16.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RHM_B_BEZB194_0
(PUTATIVE KINASE)
5anb ELONGATION FACTOR TU
GTP-BINDING
DOMAIN-CONTAINING
PROTEIN 1

(Homo
sapiens)
4 / 5 PRO K 579
ILE K  19
ARG K 510
ASP K 111
None
1.41A 2rhmB-5anbK:
undetectable
2rhmB-5anbK:
10.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RHM_D_BEZD194_0
(PUTATIVE KINASE)
5anb ELONGATION FACTOR TU
GTP-BINDING
DOMAIN-CONTAINING
PROTEIN 1

(Homo
sapiens)
4 / 5 PRO K 579
ILE K  19
ARG K 510
ASP K 111
None
1.38A 2rhmD-5anbK:
2.0
2rhmD-5anbK:
10.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VDB_A_NPSA1591_1
(SERUM ALBUMIN)
5anb 60S RIBOSOMAL
PROTEIN L10

(Dictyostelium
discoideum)
4 / 8 PHE F 159
PHE F 136
ARG F 154
GLY F  68
None
None
A  N3171 ( 3.0A)
None
0.93A 2vdbA-5anbF:
undetectable
2vdbA-5anbF:
15.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XCT_H_CPFH1020_1
(DNA GYRASE SUBUNIT
B, DNA GYRASE
SUBUNIT A)
5anb ELONGATION FACTOR TU
GTP-BINDING
DOMAIN-CONTAINING
PROTEIN 1

(Homo
sapiens)
3 / 3 ARG K 619
GLU K 653
SER K 101
None
0.86A 2xctD-5anbK:
2.8
2xctD-5anbK:
21.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XDC_D_DVAD8_0
(GRAMICIDIN A)
5anb ELONGATION FACTOR TU
GTP-BINDING
DOMAIN-CONTAINING
PROTEIN 1

(Homo
sapiens)
3 / 3 TRP K 848
VAL K 820
TRP K 801
None
1.34A 2xdcC-5anbK:
undetectable
2xdcD-5anbK:
undetectable
2xdcC-5anbK:
1.54
2xdcD-5anbK:
1.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YA7_C_ZMRC1776_2
(NEURAMINIDASE A)
5anb ELONGATION FACTOR TU
GTP-BINDING
DOMAIN-CONTAINING
PROTEIN 1

(Homo
sapiens)
4 / 6 ARG K 373
ASP K 111
ILE K  19
GLN K  13
None
1.38A 2ya7C-5anbK:
undetectable
2ya7C-5anbK:
18.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A65_A_ACAA601_1
(6-AMINOHEXANOATE-DIM
ER HYDROLASE)
5anb EUKARYOTIC
TRANSLATION
INITIATION FACTOR 6

(Dictyostelium
discoideum)
5 / 12 ALA I  64
VAL I 135
ASN I  66
GLY I 105
ILE I 108
None
1.43A 3a65A-5anbI:
undetectable
3a65A-5anbI:
21.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_F_SVRF502_3
(PHOSPHOLIPASE A2)
5anb ELONGATION FACTOR TU
GTP-BINDING
DOMAIN-CONTAINING
PROTEIN 1

(Homo
sapiens)
5 / 12 VAL K 582
LEU K 583
GLY K 584
ILE K 585
PHE K 413
None
1.26A 3bjwF-5anbK:
undetectable
3bjwF-5anbK:
7.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DL9_A_V2HA602_0
(CYTOCHROME P450 2R1)
5anb EUKARYOTIC
TRANSLATION
INITIATION FACTOR 6

(Dictyostelium
discoideum)
5 / 12 THR I 210
VAL I 199
ALA I 204
ILE I 221
THR I 155
None
1.24A 3dl9A-5anbI:
undetectable
3dl9A-5anbI:
17.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DL9_B_V2HB602_0
(CYTOCHROME P450 2R1)
5anb EUKARYOTIC
TRANSLATION
INITIATION FACTOR 6

(Dictyostelium
discoideum)
5 / 12 THR I 210
VAL I 199
ALA I 204
ILE I 221
THR I 155
None
1.26A 3dl9B-5anbI:
undetectable
3dl9B-5anbI:
17.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EIG_A_MTXA200_2
(DIHYDROFOLATE
REDUCTASE)
5anb ELONGATION FACTOR TU
GTP-BINDING
DOMAIN-CONTAINING
PROTEIN 1

(Homo
sapiens)
4 / 5 ASP K  58
ILE K  68
VAL K  97
THR K 105
None
1.15A 3eigA-5anbK:
undetectable
3eigA-5anbK:
10.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HLW_B_CE3B304_1
(CTX-M-9
EXTENDED-SPECTRUM
BETA-LACTAMASE)
5anb ELONGATION FACTOR TU
GTP-BINDING
DOMAIN-CONTAINING
PROTEIN 1

(Homo
sapiens)
4 / 5 THR K 780
SER K 782
SER K 382
ARG K 536
None
1.32A 3hlwB-5anbK:
undetectable
3hlwB-5anbK:
13.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IJX_H_HCZH800_1
(GLUTAMATE RECEPTOR 2)
5anb ELONGATION FACTOR TU
GTP-BINDING
DOMAIN-CONTAINING
PROTEIN 1

(Homo
sapiens)
4 / 5 LYS K 493
PRO K 494
SER K 489
LEU K 496
None
1.20A 3ijxH-5anbK:
undetectable
3ijxH-5anbK:
13.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ILU_H_HFZH800_1
(GLUTAMATE RECEPTOR 2)
5anb ELONGATION FACTOR TU
GTP-BINDING
DOMAIN-CONTAINING
PROTEIN 1

(Homo
sapiens)
4 / 5 LYS K 493
PRO K 494
SER K 489
LEU K 496
None
1.28A 3iluH-5anbK:
undetectable
3iluH-5anbK:
13.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LXI_A_CAMA423_0
(CYTOCHROME P450)
5anb EUKARYOTIC
TRANSLATION
INITIATION FACTOR 6

(Dictyostelium
discoideum)
5 / 10 LEU I  70
LEU I  71
GLY I  65
THR I 110
VAL I 135
None
1.32A 3lxiA-5anbI:
undetectable
3lxiA-5anbI:
20.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LXI_B_CAMB423_0
(CYTOCHROME P450)
5anb EUKARYOTIC
TRANSLATION
INITIATION FACTOR 6

(Dictyostelium
discoideum)
5 / 11 LEU I  70
LEU I  71
GLY I  65
THR I 110
VAL I 135
None
1.29A 3lxiB-5anbI:
undetectable
3lxiB-5anbI:
20.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3Q5S_A_ACHA1289_0
(MULTIDRUG-EFFLUX
TRANSPORTER 1
REGULATOR)
5anb ELONGATION FACTOR TU
GTP-BINDING
DOMAIN-CONTAINING
PROTEIN 1

(Homo
sapiens)
4 / 6 ASN K 342
TYR K 305
GLU K 154
ILE K 238
None
1.03A 3q5sA-5anbK:
undetectable
3q5sA-5anbK:
13.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QJ7_A_SPMA264_1
(THYMIDYLATE SYNTHASE)
5anb ELONGATION FACTOR TU
GTP-BINDING
DOMAIN-CONTAINING
PROTEIN 1

(Homo
sapiens)
4 / 8 ALA K 119
LEU K 151
ASP K 149
SER K 236
None
1.01A 3qj7A-5anbK:
undetectable
3qj7D-5anbK:
undetectable
3qj7A-5anbK:
12.20
3qj7D-5anbK:
12.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T7S_B_SAMB300_0
(PUTATIVE
METHYLTRANSFERASE)
5anb 60S RIBOSOMAL
PROTEIN L10

(Dictyostelium
discoideum)
5 / 12 ARG F  38
GLY F 194
GLU F  45
ALA F 195
ASN F 196
None
C  N1226 ( 3.8A)
None
G  N1225 ( 3.8A)
U  N1257 ( 3.4A)
1.32A 3t7sB-5anbF:
undetectable
3t7sB-5anbF:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T7S_D_SAMD300_0
(PUTATIVE
METHYLTRANSFERASE)
5anb 60S RIBOSOMAL
PROTEIN L10

(Dictyostelium
discoideum)
5 / 12 ARG F  38
GLY F 194
GLU F  45
ALA F 195
ASN F 196
None
C  N1226 ( 3.8A)
None
G  N1225 ( 3.8A)
U  N1257 ( 3.4A)
1.33A 3t7sD-5anbF:
undetectable
3t7sD-5anbF:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ZQ8_D_DVAD8_0
(VAL-GRAMICIDIN A)
5anb ELONGATION FACTOR TU
GTP-BINDING
DOMAIN-CONTAINING
PROTEIN 1

(Homo
sapiens)
3 / 3 TRP K 848
VAL K 820
TRP K 801
None
0.88A 3zq8C-5anbK:
undetectable
3zq8D-5anbK:
undetectable
3zq8C-5anbK:
1.54
3zq8D-5anbK:
1.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AGA_A_ACTA1131_0
(LYSOZYME C)
5anb EUKARYOTIC
TRANSLATION
INITIATION FACTOR 6

(Dictyostelium
discoideum)
3 / 3 ASN I 156
ASP I 112
ASN I  21
None
0.77A 4agaA-5anbI:
undetectable
4agaA-5anbI:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C9K_B_CAMB424_0
(CYTOCHROME P450)
5anb EUKARYOTIC
TRANSLATION
INITIATION FACTOR 6

(Dictyostelium
discoideum)
5 / 9 LEU I  70
LEU I  71
GLY I  65
THR I 110
VAL I 135
None
1.35A 4c9kB-5anbI:
undetectable
4c9kB-5anbI:
20.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DC3_A_ADNA401_2
(ADENOSINE KINASE)
5anb ELONGATION FACTOR TU
GTP-BINDING
DOMAIN-CONTAINING
PROTEIN 1

(Homo
sapiens)
4 / 4 LEU K 766
ILE K 792
GLY K 832
PHE K 826
None
1.10A 4dc3A-5anbK:
undetectable
4dc3A-5anbK:
16.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K50_B_ACTB701_0
(RNA (33-MER)
RNA POLYMERASE
3D-POL)
5anb ELONGATION FACTOR TU
GTP-BINDING
DOMAIN-CONTAINING
PROTEIN 1

(Homo
sapiens)
3 / 3 HIS K 353
GLY K 244
ILE K 351
None
0.60A 4k50A-5anbK:
undetectable
4k50A-5anbK:
17.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K50_J_ACTJ701_0
(RNA (33-MER)
RNA POLYMERASE
3D-POL)
5anb ELONGATION FACTOR TU
GTP-BINDING
DOMAIN-CONTAINING
PROTEIN 1

(Homo
sapiens)
3 / 3 HIS K 353
GLY K 244
ILE K 351
None
0.63A 4k50I-5anbK:
undetectable
4k50I-5anbK:
17.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OBW_C_SAMC601_0
(2-METHOXY-6-POLYPREN
YL-1,4-BENZOQUINOL
METHYLASE,
MITOCHONDRIAL)
5anb ELONGATION FACTOR TU
GTP-BINDING
DOMAIN-CONTAINING
PROTEIN 1

(Homo
sapiens)
5 / 12 TYR K 862
GLY K 866
ASP K 864
ILE K 823
SER K 846
None
1.28A 4obwC-5anbK:
undetectable
4obwC-5anbK:
13.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R21_B_STRB601_1
(CYTOCHROME P450
FAMILY 17
POLYPEPTIDE 2)
5anb EUKARYOTIC
TRANSLATION
INITIATION FACTOR 6

(Dictyostelium
discoideum)
5 / 9 VAL I  92
GLY I  65
ALA I  64
ILE I  97
VAL I  94
None
1.09A 4r21B-5anbI:
undetectable
4r21B-5anbI:
21.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X1Y_B_LOCB502_1
(TUBULIN BETA CHAIN)
5anb ELONGATION FACTOR TU
GTP-BINDING
DOMAIN-CONTAINING
PROTEIN 1

(Homo
sapiens)
5 / 12 LEU K 131
LEU K 143
THR K 235
VAL K 123
ILE K 145
None
1.13A 4x1yB-5anbK:
undetectable
4x1yB-5anbK:
16.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X3M_B_ADNB301_1
(RNA 2'-O RIBOSE
METHYLTRANSFERASE)
5anb EUKARYOTIC
TRANSLATION
INITIATION FACTOR 6

(Dictyostelium
discoideum)
5 / 9 LEU I  81
ILE I  97
SER I  63
LEU I  71
VAL I  94
None
1.26A 4x3mB-5anbI:
undetectable
4x3mB-5anbI:
25.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XQE_A_AG2A505_1
(HOMOSPERMIDINE
SYNTHASE)
5anb ELONGATION FACTOR TU
GTP-BINDING
DOMAIN-CONTAINING
PROTEIN 1

(Homo
sapiens)
5 / 12 ALA K 859
ASN K 845
GLU K 947
SER K 948
THR K 849
None
1.32A 4xqeA-5anbK:
1.4
4xqeA-5anbK:
18.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XQE_B_AG2B504_1
(HOMOSPERMIDINE
SYNTHASE)
5anb ELONGATION FACTOR TU
GTP-BINDING
DOMAIN-CONTAINING
PROTEIN 1

(Homo
sapiens)
5 / 12 ALA K 859
ASN K 845
GLU K 947
SER K 948
THR K 849
None
1.32A 4xqeB-5anbK:
1.8
4xqeB-5anbK:
18.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XRG_B_AG2B502_1
(HOMOSPERMIDINE
SYNTHASE)
5anb ELONGATION FACTOR TU
GTP-BINDING
DOMAIN-CONTAINING
PROTEIN 1

(Homo
sapiens)
5 / 12 ALA K 859
ASN K 845
GLU K 947
SER K 948
THR K 849
None
1.31A 4xrgB-5anbK:
1.2
4xrgB-5anbK:
18.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YIA_B_IMNB401_2
(THYROXINE-BINDING
GLOBULIN)
5anb ELONGATION FACTOR TU
GTP-BINDING
DOMAIN-CONTAINING
PROTEIN 1

(Homo
sapiens)
3 / 3 LEU K 878
ARG K 970
ARG K1095
None
0.85A 4yiaB-5anbK:
undetectable
4yiaB-5anbK:
2.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZE2_A_1YNA602_2
(LANOSTEROL 14-ALPHA
DEMETHYLASE)
5anb ELONGATION FACTOR TU
GTP-BINDING
DOMAIN-CONTAINING
PROTEIN 1

(Homo
sapiens)
4 / 5 ALA K1037
HIS K1056
PRO K1029
PHE K1054
None
1.36A 4ze2A-5anbK:
undetectable
4ze2A-5anbK:
19.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DB5_A_CYSA503_0
(CYSTEINE DESULFURASE)
5anb EUKARYOTIC
TRANSLATION
INITIATION FACTOR 6
ELONGATION FACTOR TU
GTP-BINDING
DOMAIN-CONTAINING
PROTEIN 1

(Dictyostelium
discoideum;
Homo
sapiens)
4 / 8 ALA I 183
LYS K 493
HIS I 162
THR I 165
None
1.32A 5db5A-5anbI:
undetectable
5db5B-5anbI:
undetectable
5db5A-5anbI:
19.61
5db5B-5anbI:
19.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DV4_A_NMYA601_2
(CCR4-NOT
TRANSCRIPTION
COMPLEX SUBUNIT
6-LIKE)
5anb ELONGATION FACTOR TU
GTP-BINDING
DOMAIN-CONTAINING
PROTEIN 1

(Homo
sapiens)
3 / 3 GLU K 802
TRP K 801
ASN K 818
None
1.06A 5dv4A-5anbK:
undetectable
5dv4A-5anbK:
16.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ESG_A_1YNA701_2
(LANOSTEROL 14-ALPHA
DEMETHYLASE)
5anb ELONGATION FACTOR TU
GTP-BINDING
DOMAIN-CONTAINING
PROTEIN 1

(Homo
sapiens)
4 / 4 LEU K 667
TYR K1090
PRO K 616
ILE K 617
None
1.27A 5esgA-5anbK:
undetectable
5esgA-5anbK:
19.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5J6H_A_NCAA402_0
(H-2 CLASS I
HISTOCOMPATIBILITY
ANTIGEN, Q10 ALPHA
CHAIN)
5anb ELONGATION FACTOR TU
GTP-BINDING
DOMAIN-CONTAINING
PROTEIN 1

(Homo
sapiens)
3 / 3 PRO K 691
ARG K 693
GLU K 885
None
0.85A 5j6hA-5anbK:
undetectable
5j6hA-5anbK:
14.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JKW_A_TESA601_1
(AROMATASE)
5anb EUKARYOTIC
TRANSLATION
INITIATION FACTOR 6

(Dictyostelium
discoideum)
5 / 11 ILE I  97
ASP I 131
VAL I 137
VAL I 117
LEU I 133
None
1.32A 5jkwA-5anbI:
undetectable
5jkwA-5anbI:
17.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KR0_A_478A101_2
(PROTEASE E35D-APV)
5anb ELONGATION FACTOR TU
GTP-BINDING
DOMAIN-CONTAINING
PROTEIN 1

(Homo
sapiens)
5 / 9 LEU K 583
GLY K 586
VAL K 414
ILE K 522
VAL K 511
None
1.05A 5kr0B-5anbK:
undetectable
5kr0B-5anbK:
6.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LF3_H_BO2H306_1
(PROTEASOME SUBUNIT
BETA TYPE-7
PROTEASOME SUBUNIT
BETA TYPE-3)
5anb EUKARYOTIC
TRANSLATION
INITIATION FACTOR 6

(Dictyostelium
discoideum)
5 / 10 GLU I 219
CYH I 197
ALA I 159
GLY I 158
THR I 155
None
1.12A 5lf3H-5anbI:
undetectable
5lf3I-5anbI:
undetectable
5lf3H-5anbI:
21.14
5lf3I-5anbI:
22.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LF7_H_6V8H305_0
(PROTEASOME SUBUNIT
BETA TYPE-3
PROTEASOME SUBUNIT
BETA TYPE-7)
5anb EUKARYOTIC
TRANSLATION
INITIATION FACTOR 6

(Dictyostelium
discoideum)
5 / 11 GLU I 219
CYH I 197
ALA I 159
GLY I 158
THR I 155
None
1.07A 5lf7H-5anbI:
undetectable
5lf7I-5anbI:
undetectable
5lf7H-5anbI:
21.14
5lf7I-5anbI:
22.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LF7_V_6V8V303_0
(PROTEASOME SUBUNIT
BETA TYPE-3
PROTEASOME SUBUNIT
BETA TYPE-7)
5anb EUKARYOTIC
TRANSLATION
INITIATION FACTOR 6

(Dictyostelium
discoideum)
5 / 11 GLU I 219
CYH I 197
ALA I 159
GLY I 158
THR I 155
None
1.09A 5lf7V-5anbI:
undetectable
5lf7W-5anbI:
undetectable
5lf7V-5anbI:
21.14
5lf7W-5anbI:
22.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6C06_D_FI8D1404_1
(DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA')
5anb ELONGATION FACTOR TU
GTP-BINDING
DOMAIN-CONTAINING
PROTEIN 1

(Homo
sapiens)
3 / 3 ARG K 250
LYS K 260
ARG K 192
None
1.08A 6c06D-5anbK:
undetectable
6c06D-5anbK:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CDU_B_EY4B500_0
(CHIMERIC ALPHA1GABAA
RECEPTOR)
5anb ELONGATION FACTOR TU
GTP-BINDING
DOMAIN-CONTAINING
PROTEIN 1

(Homo
sapiens)
4 / 6 VAL K 577
PRO K 366
ALA K 516
THR K 407
None
0.93A 6cduB-5anbK:
undetectable
6cduC-5anbK:
undetectable
6cduB-5anbK:
15.68
6cduC-5anbK:
15.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6G1P_B_ACTB403_0
(ADP-RIBOSYLHYDROLASE
LIKE 2)
5anb ELONGATION FACTOR TU
GTP-BINDING
DOMAIN-CONTAINING
PROTEIN 1

(Homo
sapiens)
3 / 3 PHE K1065
ARG K1088
GLN K 978
None
0.86A 6g1pB-5anbK:
undetectable
6g1pB-5anbK:
17.27