SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5anc'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA3_A_STRA1001_2
(MINERALOCORTICOID
RECEPTOR)		 5anc RIBOSOME MATURATION
PROTEIN SBDS
(Homo
sapiens) 		4 / 4 LEU J 174
LEU J 234
SER J 233
LEU J 178
 None
 0.99A 1ya3A-5ancJ:
undetectable		 1ya3A-5ancJ:
22.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HA6_A_SCKA902_1
(ACETYLCHOLINESTERASE)		 5anc RIBOSOME MATURATION
PROTEIN SBDS
(Homo
sapiens) 		5 / 10 GLU J 219
ASP J 213
THR J 228
LEU J 193
LEU J 190
 A  N2522 ( 3.7A)
None
None
None
None
 1.44A 2ha6A-5ancJ:
undetectable		 2ha6A-5ancJ:
16.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HA6_B_SCKB952_1
(ACETYLCHOLINESTERASE)		 5anc RIBOSOME MATURATION
PROTEIN SBDS
(Homo
sapiens) 		5 / 10 GLU J 219
ASP J 213
THR J 228
LEU J 193
LEU J 190
 A  N2522 ( 3.7A)
None
None
None
None
 1.43A 2ha6B-5ancJ:
undetectable		 2ha6B-5ancJ:
16.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W3B_B_FOLB401_1
(DIHYDROFOLATE
REDUCTASE)		 5anc RIBOSOME MATURATION
PROTEIN SBDS
(Homo
sapiens) 		3 / 3 GLU J  99
GLN J 106
ARG J 109
 None
 0.94A 2w3bB-5ancJ:
undetectable		 2w3bB-5ancJ:
23.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KP3_B_AICB2002_1
(TRANSCRIPTIONAL
REGULATOR TCAR)		 5anc RIBOSOME MATURATION
PROTEIN SBDS
(Homo
sapiens) 		3 / 3 ALA J  23
ARG J  22
LYS J  90
 None
 0.81A 3kp3B-5ancJ:
undetectable		 3kp3B-5ancJ:
22.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M11_B_MXMB606_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 5anc RIBOSOME MATURATION
PROTEIN SBDS
(Homo
sapiens) 		5 / 12 VAL J 120
ILE J 158
VAL J 157
LEU J 161
ALA J 112
 None
 1.04A 4m11B-5ancJ:
undetectable		 4m11B-5ancJ:
19.23