SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5any'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CIZ_A_ACTA1321_0
(CHLOROPEROXIDASE)		 5any E1
(Chikungunya
virus) 		4 / 5 LEU A  33
ASN A   9
VAL A 163
ALA A 131
 None
 1.07A 2cizA-5anyA:
undetectable		 2cizA-5anyA:
21.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2KAW_A_SUZA91_1
(SEGMENT POLARITY
PROTEIN DISHEVELLED
HOMOLOG DVL-1)		 5any E1
(Chikungunya
virus) 		5 / 11 ILE A 280
SER A 279
ILE A 278
LEU A 133
VAL A 144
 None
 0.82A 2kawA-5anyA:
undetectable		 2kawA-5anyA:
14.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PO5_A_CHDA502_0
(FERROCHELATASE,
MITOCHONDRIAL)		 5any E1
(Chikungunya
virus) 		4 / 8 LEU A  38
LEU A  33
VAL A 163
GLY A 164
 None
 0.93A 2po5A-5anyA:
undetectable		 2po5A-5anyA:
21.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2I_C_QPSC1060_1
(ALPHA-1,4-GLUCAN
LYASE ISOZYME 1)		 5any E1
(Chikungunya
virus) 		5 / 12 THR A 217
VAL A 108
SER A 111
SER A 113
GLY A 239
 None
 1.20A 2x2iC-5anyA:
undetectable		 2x2iC-5anyA:
17.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2I_D_QPSD1060_1
(ALPHA-1,4-GLUCAN
LYASE ISOZYME 1)		 5any E1
(Chikungunya
virus) 		5 / 10 THR A 217
VAL A 108
SER A 111
SER A 113
GLY A 239
 None
 1.18A 2x2iD-5anyA:
undetectable		 2x2iD-5anyA:
17.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MZE_A_CFXA364_2
(D-ALANYL-D-ALANINE
CARBOXYPEPTIDASE
DACA)		 5any E1
(Chikungunya
virus) 		3 / 3 SER A 309
SER A 310
HIS A 386
 None
 0.78A 3mzeA-5anyA:
undetectable		 3mzeA-5anyA:
21.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TBG_D_RTZD2_1
(CYTOCHROME P450 2D6)		 5any E1
(Chikungunya
virus) 		5 / 9 LEU A  29
THR A  17
VAL A  19
ILE A 282
PHE A 161
 None
 1.12A 3tbgD-5anyA:
undetectable		 3tbgD-5anyA:
20.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZDY_A_1YNA602_2
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 5any E1
(Chikungunya
virus) 		3 / 3 ALA A 121
TYR A 122
PRO A 208
 None
 0.66A 4zdyA-5anyA:
undetectable		 4zdyA-5anyA:
22.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XIW_D_LOCD503_1
(TUBULIN ALPHA-1B
CHAIN
TUBULIN BETA CHAIN)		 5any FAB CHK265
(Mus
musculus) 		3 / 3 SER I 203
ALA I 198
VAL I 197
 None
 0.54A 5xiwC-5anyI:
undetectable		 5xiwC-5anyI:
18.35