SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5ao5'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C4D_D_DVAD8_0
(GRAMICIDIN A)		 5ao5 C-TYPE MANNOSE
RECEPTOR 2
(Homo
sapiens) 		3 / 3 TRP A 297
VAL A 358
TRP A 259
 None
 1.34A 1c4dC-5ao5A:
undetectable
1c4dD-5ao5A:
undetectable		 1c4dC-5ao5A:
3.25
1c4dD-5ao5A:
3.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C4D_D_DVAD8_0
(GRAMICIDIN A)		 5ao5 C-TYPE MANNOSE
RECEPTOR 2
(Homo
sapiens) 		3 / 3 TRP A 441
VAL A 418
TRP A 403
 None
 1.31A 1c4dC-5ao5A:
undetectable
1c4dD-5ao5A:
undetectable		 1c4dC-5ao5A:
3.25
1c4dD-5ao5A:
3.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTI_A_CCSA47_0
(GLUTATHIONE
S-TRANSFERASE)		 5ao5 C-TYPE MANNOSE
RECEPTOR 2
(Homo
sapiens) 		4 / 7 TRP A 158
LEU A 134
GLY A  53
LEU A  55
 None
 0.90A 1gtiA-5ao5A:
undetectable		 1gtiA-5ao5A:
19.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MRJ_A_ADNA300_1
(ALPHA-TRICHOSANTHIN)		 5ao5 C-TYPE MANNOSE
RECEPTOR 2
(Homo
sapiens) 		4 / 8 ILE A 338
TYR A 249
ILE A 285
GLU A 281
 None
 0.82A 1mrjA-5ao5A:
undetectable		 1mrjA-5ao5A:
18.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XCT_X_CPFX1020_1
(DNA GYRASE SUBUNIT
B, DNA GYRASE
SUBUNIT A)		 5ao5 C-TYPE MANNOSE
RECEPTOR 2
(Homo
sapiens) 		4 / 4 ARG A 490
GLY A 486
GLU A 488
SER A 494
 None
 1.43A 2xctS-5ao5A:
undetectable
2xctU-5ao5A:
undetectable		 2xctS-5ao5A:
21.07
2xctU-5ao5A:
21.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XDC_A_DVAA8_0
(GRAMICIDIN A)		 5ao5 C-TYPE MANNOSE
RECEPTOR 2
(Homo
sapiens) 		3 / 3 VAL A 358
TRP A 259
TRP A 297
 None
 1.20A 2xdcA-5ao5A:
undetectable
2xdcB-5ao5A:
undetectable		 2xdcA-5ao5A:
3.25
2xdcB-5ao5A:
3.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XDC_B_DVAB8_0
(GRAMICIDIN A)		 5ao5 C-TYPE MANNOSE
RECEPTOR 2
(Homo
sapiens) 		3 / 3 TRP A 297
VAL A 358
TRP A 259
 None
 1.22A 2xdcA-5ao5A:
undetectable
2xdcB-5ao5A:
undetectable		 2xdcA-5ao5A:
3.25
2xdcB-5ao5A:
3.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XDC_C_DVAC8_0
(GRAMICIDIN A)		 5ao5 C-TYPE MANNOSE
RECEPTOR 2
(Homo
sapiens) 		3 / 3 VAL A 358
TRP A 259
TRP A 297
 None
 1.27A 2xdcC-5ao5A:
undetectable
2xdcD-5ao5A:
undetectable		 2xdcC-5ao5A:
3.25
2xdcD-5ao5A:
3.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XDC_D_DVAD8_0
(GRAMICIDIN A)		 5ao5 C-TYPE MANNOSE
RECEPTOR 2
(Homo
sapiens) 		3 / 3 TRP A 297
VAL A 358
TRP A 259
 None
 1.08A 2xdcC-5ao5A:
undetectable
2xdcD-5ao5A:
undetectable		 2xdcC-5ao5A:
3.25
2xdcD-5ao5A:
3.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XDC_F_DVAF8_0
(GRAMICIDIN A)		 5ao5 C-TYPE MANNOSE
RECEPTOR 2
(Homo
sapiens) 		3 / 3 TRP A 297
VAL A 358
TRP A 259
 None
 1.11A 2xdcE-5ao5A:
undetectable
2xdcF-5ao5A:
undetectable		 2xdcE-5ao5A:
3.25
2xdcF-5ao5A:
3.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XZ5_C_ACHC1211_0
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 5ao5 C-TYPE MANNOSE
RECEPTOR 2
(Homo
sapiens) 		4 / 8 THR A 177
SER A 182
TYR A 219
TRP A 212
 None
None
SO4  A1513 (-4.2A)
SO4  A1513 ( 3.8A)
 1.38A 2xz5A-5ao5A:
undetectable
2xz5C-5ao5A:
undetectable		 2xz5A-5ao5A:
16.43
2xz5C-5ao5A:
16.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y5M_A_DVAA8_0
(VAL-GRAMICIDIN A)		 5ao5 C-TYPE MANNOSE
RECEPTOR 2
(Homo
sapiens) 		3 / 3 VAL A 358
TRP A 259
TRP A 297
 None
 1.19A 2y5mA-5ao5A:
undetectable
2y5mB-5ao5A:
undetectable		 2y5mA-5ao5A:
3.25
2y5mB-5ao5A:
3.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y5M_F_DVAF8_0
(VAL-GRAMICIDIN A)		 5ao5 C-TYPE MANNOSE
RECEPTOR 2
(Homo
sapiens) 		3 / 3 TRP A 297
VAL A 358
TRP A 259
 None
 1.09A 2y5mE-5ao5A:
undetectable
2y5mF-5ao5A:
undetectable		 2y5mE-5ao5A:
3.25
2y5mF-5ao5A:
3.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y6N_A_DVAA8_0
(VAL-GRAMICIDIN A)		 5ao5 C-TYPE MANNOSE
RECEPTOR 2
(Homo
sapiens) 		3 / 3 VAL A 358
TRP A 259
TRP A 297
 None
 1.18A 2y6nA-5ao5A:
undetectable
2y6nB-5ao5A:
undetectable		 2y6nA-5ao5A:
3.25
2y6nB-5ao5A:
3.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y6N_B_DVAB8_0
(VAL-GRAMICIDIN A)		 5ao5 C-TYPE MANNOSE
RECEPTOR 2
(Homo
sapiens) 		3 / 3 TRP A 297
VAL A 358
TRP A 259
 None
 1.20A 2y6nA-5ao5A:
undetectable
2y6nB-5ao5A:
undetectable		 2y6nA-5ao5A:
3.25
2y6nB-5ao5A:
3.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y6N_D_DVAD8_0
(VAL-GRAMICIDIN A)		 5ao5 C-TYPE MANNOSE
RECEPTOR 2
(Homo
sapiens) 		3 / 3 TRP A 297
VAL A 358
TRP A 259
 None
 1.07A 2y6nC-5ao5A:
undetectable
2y6nD-5ao5A:
undetectable		 2y6nC-5ao5A:
3.25
2y6nD-5ao5A:
3.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y6N_F_DVAF8_0
(VAL-GRAMICIDIN A)		 5ao5 C-TYPE MANNOSE
RECEPTOR 2
(Homo
sapiens) 		3 / 3 TRP A 297
VAL A 358
TRP A 259
 None
 1.07A 2y6nE-5ao5A:
undetectable
2y6nF-5ao5A:
undetectable		 2y6nE-5ao5A:
3.25
2y6nF-5ao5A:
3.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EEY_C_SAMC300_1
(PUTATIVE RRNA
METHYLASE)		 5ao5 C-TYPE MANNOSE
RECEPTOR 2
(Homo
sapiens) 		3 / 3 ASN A 497
ASP A 480
GLN A 450
 None
 0.79A 3eeyC-5ao5A:
undetectable		 3eeyC-5ao5A:
16.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EEY_D_SAMD300_1
(PUTATIVE RRNA
METHYLASE)		 5ao5 C-TYPE MANNOSE
RECEPTOR 2
(Homo
sapiens) 		3 / 3 ASN A 497
ASP A 480
GLN A 450
 None
 0.80A 3eeyD-5ao5A:
undetectable		 3eeyD-5ao5A:
16.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EEY_E_SAME300_1
(PUTATIVE RRNA
METHYLASE)		 5ao5 C-TYPE MANNOSE
RECEPTOR 2
(Homo
sapiens) 		3 / 3 ASN A 497
ASP A 480
GLN A 450
 None
 0.77A 3eeyE-5ao5A:
undetectable		 3eeyE-5ao5A:
16.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G1U_A_ADNA438_1
(ADENOSYLHOMOCYSTEINA
SE)		 5ao5 C-TYPE MANNOSE
RECEPTOR 2
(Homo
sapiens) 		5 / 12 LEU A 126
ASN A 118
LEU A 133
LEU A 107
GLY A 108
 None
 1.32A 3g1uA-5ao5A:
undetectable		 3g1uA-5ao5A:
21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ZQ8_A_DVAA8_0
(VAL-GRAMICIDIN A)		 5ao5 C-TYPE MANNOSE
RECEPTOR 2
(Homo
sapiens) 		3 / 3 VAL A 358
TRP A 259
TRP A 297
 None
 1.20A 3zq8A-5ao5A:
undetectable
3zq8B-5ao5A:
undetectable		 3zq8A-5ao5A:
3.25
3zq8B-5ao5A:
3.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ZQ8_D_DVAD8_0
(VAL-GRAMICIDIN A)		 5ao5 C-TYPE MANNOSE
RECEPTOR 2
(Homo
sapiens) 		3 / 3 TRP A 441
VAL A 418
TRP A 403
 None
 0.93A 3zq8C-5ao5A:
undetectable
3zq8D-5ao5A:
undetectable		 3zq8C-5ao5A:
3.25
3zq8D-5ao5A:
3.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FGZ_B_CQAB301_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE)		 5ao5 C-TYPE MANNOSE
RECEPTOR 2
(Homo
sapiens) 		4 / 8 GLY A 100
GLY A  97
TYR A 110
LEU A 117
 None
 0.88A 4fgzB-5ao5A:
undetectable		 4fgzB-5ao5A:
19.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R1Z_B_AERB601_1
(CYP17A1 PROTEIN)		 5ao5 C-TYPE MANNOSE
RECEPTOR 2
(Homo
sapiens) 		4 / 7 GLY A 270
ALA A 271
GLU A 267
SER A 312
 None
 0.86A 4r1zB-5ao5A:
undetectable		 4r1zB-5ao5A:
20.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CXV_A_0HKA501_2
(MUSCARINIC
ACETYLCHOLINE
RECEPTOR
M1,ENDOLYSIN,MUSCARI
NIC ACETYLCHOLINE
RECEPTOR M1)		 5ao5 C-TYPE MANNOSE
RECEPTOR 2
(Homo
sapiens) 		3 / 3 THR A 216
THR A 188
PHE A 198
 SO4  A1512 (-4.1A)
SO4  A1512 ( 4.0A)
None
 0.64A 5cxvA-5ao5A:
undetectable		 5cxvA-5ao5A:
22.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IMS_B_ACTB713_0
(ACETOLACTATE
SYNTHASE CATALYTIC
SUBUNIT,
MITOCHONDRIAL)		 5ao5 C-TYPE MANNOSE
RECEPTOR 2
(Homo
sapiens) 		3 / 3 GLY A 413
GLN A 397
LYS A 506
 None
 0.73A 5imsB-5ao5A:
undetectable		 5imsB-5ao5A:
19.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ODI_D_ACTD202_0
(METHYL-VIOLOGEN
REDUCING
HYDROGENASE, SUBUNIT
D)		 5ao5 C-TYPE MANNOSE
RECEPTOR 2
(Homo
sapiens) 		3 / 3 HIS A 467
GLU A 470
TRP A 485
 None
NA  A 902 (-2.6A)
None
 1.20A 5odiD-5ao5A:
undetectable		 5odiD-5ao5A:
12.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ODR_D_ACTD202_0
(METHYL-VIOLOGEN
REDUCING
HYDROGENASE, SUBUNIT
D)		 5ao5 C-TYPE MANNOSE
RECEPTOR 2
(Homo
sapiens) 		3 / 3 HIS A 467
GLU A 470
TRP A 485
 None
NA  A 902 (-2.6A)
None
 1.21A 5odrD-5ao5A:
undetectable		 5odrD-5ao5A:
12.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XIP_A_HFGA1003_0
(PROLYL-TRNA
SYNTHETASE, PUTATIVE)		 5ao5 C-TYPE MANNOSE
RECEPTOR 2
(Homo
sapiens) 		5 / 12 LEU A 444
PHE A 463
VAL A 461
THR A 305
GLY A 307
 None
 1.11A 5xipA-5ao5A:
undetectable		 5xipA-5ao5A:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XIQ_A_HFGA1002_0
(PROLYL-TRNA
SYNTHETASE (PRORS))		 5ao5 C-TYPE MANNOSE
RECEPTOR 2
(Homo
sapiens) 		5 / 12 LEU A 444
PHE A 463
VAL A 461
THR A 305
GLY A 307
 None
 1.08A 5xiqA-5ao5A:
undetectable		 5xiqA-5ao5A:
19.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XIQ_D_HFGD1002_0
(PROLYL-TRNA
SYNTHETASE (PRORS))		 5ao5 C-TYPE MANNOSE
RECEPTOR 2
(Homo
sapiens) 		5 / 12 LEU A 444
PHE A 463
VAL A 461
THR A 305
GLY A 307
 None
 1.10A 5xiqD-5ao5A:
undetectable		 5xiqD-5ao5A:
19.36