SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5ao8'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RLB_F_REAF177_1
(RETINOL BINDING
PROTEIN)		 5ao8 SOLUBLE LYTIC
TRANGLYCOSILASE B3
(Pseudomonas
aeruginosa) 		5 / 11 LEU A 260
ALA A 269
VAL A 285
LEU A 293
LEU A 316
 None
 1.09A 1rlbF-5ao8A:
undetectable		 1rlbF-5ao8A:
16.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1VQ1_B_SAMB301_0
(N5-GLUTAMINE
METHYLTRANSFERASE,
HEMK)		 5ao8 SOLUBLE LYTIC
TRANGLYCOSILASE B3
(Pseudomonas
aeruginosa) 		5 / 12 ILE A 196
GLY A 230
SER A 231
ILE A 228
PRO A 191
 None
None
CA  A 997 ( 4.8A)
None
None
 1.00A 1vq1B-5ao8A:
undetectable		 1vq1B-5ao8A:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BM9_D_SAMD301_0
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 5ao8 SOLUBLE LYTIC
TRANGLYCOSILASE B3
(Pseudomonas
aeruginosa) 		5 / 12 LEU A 236
GLY A 143
SER A 150
ALA A 140
ALA A 341
 None
 1.20A 2bm9D-5ao8A:
undetectable		 2bm9D-5ao8A:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZW9_B_SAMB801_1
(LEUCINE CARBOXYL
METHYLTRANSFERASE 2)		 5ao8 SOLUBLE LYTIC
TRANGLYCOSILASE B3
(Pseudomonas
aeruginosa) 		4 / 8 ILE A 324
ASN A 328
ARG A  95
SER A 331
 None
NAG  A 999 (-4.0A)
None
None
 1.12A 2zw9B-5ao8A:
undetectable		 2zw9B-5ao8A:
19.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D91_A_REMA350_1
(RENIN)		 5ao8 SOLUBLE LYTIC
TRANGLYCOSILASE B3
(Pseudomonas
aeruginosa) 		5 / 12 ASP A 223
GLY A 222
SER A 231
ASP A 219
SER A 238
 CA  A 997 (-2.8A)
None
CA  A 997 ( 4.8A)
CA  A 997 (-3.3A)
None
 1.18A 3d91A-5ao8A:
undetectable		 3d91A-5ao8A:
19.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D91_B_REMB350_1
(RENIN)		 5ao8 SOLUBLE LYTIC
TRANGLYCOSILASE B3
(Pseudomonas
aeruginosa) 		5 / 12 ASP A 223
GLY A 222
SER A 231
ASP A 219
SER A 238
 CA  A 997 (-2.8A)
None
CA  A 997 ( 4.8A)
CA  A 997 (-3.3A)
None
 1.26A 3d91B-5ao8A:
undetectable		 3d91B-5ao8A:
19.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GCS_A_BAXA401_2
(MITOGEN-ACTIVATED
PROTEIN KINASE 14)		 5ao8 SOLUBLE LYTIC
TRANGLYCOSILASE B3
(Pseudomonas
aeruginosa) 		4 / 6 MET A 203
VAL A 157
ILE A 184
ILE A 158
 None
 0.72A 3gcsA-5ao8A:
undetectable		 3gcsA-5ao8A:
23.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HEG_A_BAXA1_2
(MITOGEN-ACTIVATED
PROTEIN KINASE 14)		 5ao8 SOLUBLE LYTIC
TRANGLYCOSILASE B3
(Pseudomonas
aeruginosa) 		4 / 6 MET A 203
VAL A 157
ILE A 184
ILE A 158
 None
 0.79A 3hegA-5ao8A:
undetectable		 3hegA-5ao8A:
22.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ROD_D_NCAD302_0
(NICOTINAMIDE
N-METHYLTRANSFERASE)		 5ao8 SOLUBLE LYTIC
TRANGLYCOSILASE B3
(Pseudomonas
aeruginosa) 		4 / 7 LEU A 340
ASP A 136
ALA A 137
TYR A 148
 None
 1.00A 3rodD-5ao8A:
undetectable		 3rodD-5ao8A:
20.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S45_B_478B201_2
(PROTEASE)		 5ao8 SOLUBLE LYTIC
TRANGLYCOSILASE B3
(Pseudomonas
aeruginosa) 		5 / 11 GLY A 201
ALA A 202
GLY A 153
ILE A 196
ILE A 228
 None
NAG  A 999 ( 4.1A)
NAG  A 999 (-3.2A)
None
None
 0.97A 3s45B-5ao8A:
undetectable		 3s45B-5ao8A:
11.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3THR_A_C2FA1100_0
(GLYCINE
N-METHYLTRANSFERASE)		 5ao8 SOLUBLE LYTIC
TRANGLYCOSILASE B3
(Pseudomonas
aeruginosa) 		4 / 6 SER A 160
LEU A 178
HIS A 175
THR A 163
 None
 1.43A 3thrB-5ao8A:
undetectable		 3thrB-5ao8A:
22.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KF9_A_ACTA407_0
(GLUTATHIONE
S-TRANSFERASE
PROTEIN)		 5ao8 SOLUBLE LYTIC
TRANGLYCOSILASE B3
(Pseudomonas
aeruginosa) 		3 / 3 GLU A 401
ARG A 376
HIS A 378
 None
 0.69A 4kf9A-5ao8A:
undetectable		 4kf9A-5ao8A:
22.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O8J_A_ADNA401_1
(RNA 3'-TERMINAL
PHOSPHATE CYCLASE)		 5ao8 SOLUBLE LYTIC
TRANGLYCOSILASE B3
(Pseudomonas
aeruginosa) 		5 / 12 GLN A 365
LEU A 369
PRO A 410
TYR A 409
ASP A 407
 None
 1.20A 4o8jA-5ao8A:
undetectable		 4o8jA-5ao8A:
22.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O8J_B_ADNB401_1
(RNA 3'-TERMINAL
PHOSPHATE CYCLASE)		 5ao8 SOLUBLE LYTIC
TRANGLYCOSILASE B3
(Pseudomonas
aeruginosa) 		5 / 12 GLN A 365
LEU A 369
PRO A 410
TYR A 409
ASP A 407
 None
 1.23A 4o8jB-5ao8A:
undetectable		 4o8jB-5ao8A:
22.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DWN_D_AQ4D602_0
(CYTOCHROME P450 1A1)		 5ao8 SOLUBLE LYTIC
TRANGLYCOSILASE B3
(Pseudomonas
aeruginosa) 		5 / 12 ILE A 184
ASN A 156
GLY A 201
ALA A 202
ILE A 228
 None
None
None
NAG  A 999 ( 4.1A)
None
 0.93A 6dwnD-5ao8A:
undetectable		 6dwnD-5ao8A:
12.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6G9B_B_IXXB705_1
(ENVELOPE
GLYCOPROTEIN,ENVELOP
E GLYCOPROTEIN
ENVELOPE
GLYCOPROTEIN)		 5ao8 SOLUBLE LYTIC
TRANGLYCOSILASE B3
(Pseudomonas
aeruginosa) 		4 / 5 ARG A  72
ALA A  73
GLN A 186
ILE A  65
 None
 1.40A 6g9bA-5ao8A:
undetectable
6g9bB-5ao8A:
undetectable		 6g9bA-5ao8A:
13.06
6g9bB-5ao8A:
12.71