SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5aoc'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DX6_A_GNTA602_1
(ACETYLCHOLINESTERASE)		 5aoc ESTERASE
(Thermogutta
terrifontis) 		5 / 12 GLY A  52
GLY A  53
GLY A  54
SER A 126
HIS A 248
 LEA  A1283 ( 4.0A)
LEA  A1283 (-3.4A)
LEA  A1283 (-3.5A)
LEA  A1283 (-2.3A)
LEA  A1283 (-4.0A)
 0.24A 1dx6A-5aocA:
18.2		 1dx6A-5aocA:
20.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ICU_A_NIOA221_1
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		 5aoc ESTERASE
(Thermogutta
terrifontis) 		4 / 6 THR A 264
PHE A 251
PHE A  63
GLY A 125
 None
 1.11A 1icuA-5aocA:
undetectable
1icuB-5aocA:
undetectable		 1icuA-5aocA:
21.77
1icuB-5aocA:
21.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ICU_B_NIOB219_1
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		 5aoc ESTERASE
(Thermogutta
terrifontis) 		4 / 6 PHE A  63
GLY A 125
THR A 264
PHE A 251
 None
 1.13A 1icuA-5aocA:
undetectable
1icuB-5aocA:
undetectable		 1icuA-5aocA:
21.77
1icuB-5aocA:
21.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ICU_C_NIOC225_1
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		 5aoc ESTERASE
(Thermogutta
terrifontis) 		4 / 6 THR A 264
PHE A 251
PHE A  63
GLY A 125
 None
 1.11A 1icuC-5aocA:
undetectable
1icuD-5aocA:
undetectable		 1icuC-5aocA:
21.77
1icuD-5aocA:
21.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ICU_D_NIOD223_1
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		 5aoc ESTERASE
(Thermogutta
terrifontis) 		4 / 5 PHE A  63
GLY A 125
THR A 264
PHE A 251
 None
 1.18A 1icuC-5aocA:
undetectable
1icuD-5aocA:
undetectable		 1icuC-5aocA:
21.77
1icuD-5aocA:
21.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ICV_B_NIOB702_1
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		 5aoc ESTERASE
(Thermogutta
terrifontis) 		4 / 5 PHE A  63
GLY A 125
THR A 264
PHE A 251
 None
 1.14A 1icvA-5aocA:
undetectable
1icvB-5aocA:
undetectable		 1icvA-5aocA:
21.77
1icvB-5aocA:
21.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KQB_D_BEZD523_0
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		 5aoc ESTERASE
(Thermogutta
terrifontis) 		4 / 6 PHE A  63
GLY A 125
THR A 264
PHE A 251
 None
 1.14A 1kqbC-5aocA:
undetectable
1kqbD-5aocA:
undetectable		 1kqbC-5aocA:
21.53
1kqbD-5aocA:
21.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MX1_A_THAA1_1
(LIVER
CARBOXYLESTERASE I)		 5aoc ESTERASE
(Thermogutta
terrifontis) 		5 / 11 LEU A 159
GLY A 129
GLY A 128
VAL A  92
LEU A 164
 None
None
None
PEG  A1293 ( 4.9A)
None
 1.10A 1mx1A-5aocA:
18.7		 1mx1A-5aocA:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QTI_A_GNTA600_1
(ACETYLCHOLINESTERASE)		 5aoc ESTERASE
(Thermogutta
terrifontis) 		5 / 12 GLY A  52
GLY A  53
GLY A  54
SER A 126
HIS A 248
 LEA  A1283 ( 4.0A)
LEA  A1283 (-3.4A)
LEA  A1283 (-3.5A)
LEA  A1283 (-2.3A)
LEA  A1283 (-4.0A)
 0.24A 1qtiA-5aocA:
17.9		 1qtiA-5aocA:
20.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UPF_A_URFA999_1
(URACIL
PHOSPHORIBOSYLTRANSF
ERASE)		 5aoc ESTERASE
(Thermogutta
terrifontis) 		4 / 5 MET A  75
ALA A  71
TYR A  69
ASP A 269
 None
None
EDO  A1292 (-4.1A)
None
 0.95A 1upfA-5aocA:
2.5		 1upfA-5aocA:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UPF_A_URFA999_1
(URACIL
PHOSPHORIBOSYLTRANSF
ERASE)		 5aoc ESTERASE
(Thermogutta
terrifontis) 		4 / 5 MET A  75
ALA A  77
ILE A  47
ASP A 269
 None
 1.23A 1upfA-5aocA:
2.5		 1upfA-5aocA:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UPF_C_URFC999_1
(URACIL
PHOSPHORIBOSYLTRANSF
ERASE)		 5aoc ESTERASE
(Thermogutta
terrifontis) 		4 / 5 MET A  75
ALA A  71
TYR A  69
ASP A 269
 None
None
EDO  A1292 (-4.1A)
None
 0.92A 1upfC-5aocA:
2.3		 1upfC-5aocA:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1W6R_A_GNTA1536_1
(ACETYLCHOLINESTERASE)		 5aoc ESTERASE
(Thermogutta
terrifontis) 		5 / 12 GLY A  52
GLY A  53
GLY A  54
SER A 126
HIS A 248
 LEA  A1283 ( 4.0A)
LEA  A1283 (-3.4A)
LEA  A1283 (-3.5A)
LEA  A1283 (-2.3A)
LEA  A1283 (-4.0A)
 0.26A 1w6rA-5aocA:
18.3		 1w6rA-5aocA:
20.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ACE_A_ACHA998_0
(ACETYLCHOLINESTERASE)		 5aoc ESTERASE
(Thermogutta
terrifontis) 		5 / 9 GLY A  52
GLY A  53
SER A 126
ALA A 127
HIS A 248
 LEA  A1283 ( 4.0A)
LEA  A1283 (-3.4A)
LEA  A1283 (-2.3A)
LEA  A1283 (-3.6A)
LEA  A1283 (-4.0A)
 0.91A 2aceA-5aocA:
18.4		 2aceA-5aocA:
20.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ACE_A_ACHA998_0
(ACETYLCHOLINESTERASE)		 5aoc ESTERASE
(Thermogutta
terrifontis) 		5 / 9 GLY A  53
GLY A  54
SER A 126
ALA A 127
HIS A 248
 LEA  A1283 (-3.4A)
LEA  A1283 (-3.5A)
LEA  A1283 (-2.3A)
LEA  A1283 (-3.6A)
LEA  A1283 (-4.0A)
 0.39A 2aceA-5aocA:
18.4		 2aceA-5aocA:
20.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CIZ_A_ACTA1320_0
(CHLOROPEROXIDASE)		 5aoc ESTERASE
(Thermogutta
terrifontis) 		4 / 6 ALA A 268
PHE A  70
ILE A  47
PHE A 160
 None
 0.98A 2cizA-5aocA:
undetectable		 2cizA-5aocA:
23.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HA4_A_ACTA544_0
(ACETYLCHOLINESTERASE)		 5aoc ESTERASE
(Thermogutta
terrifontis) 		4 / 8 GLY A  53
GLY A  54
ALA A 127
HIS A 248
 LEA  A1283 (-3.4A)
LEA  A1283 (-3.5A)
LEA  A1283 (-3.6A)
LEA  A1283 (-4.0A)
 0.19A 2ha4A-5aocA:
5.0		 2ha4A-5aocA:
22.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HA4_B_ACTB601_0
(ACETYLCHOLINESTERASE)		 5aoc ESTERASE
(Thermogutta
terrifontis) 		4 / 7 GLY A  53
GLY A  54
ALA A 127
HIS A 248
 LEA  A1283 (-3.4A)
LEA  A1283 (-3.5A)
LEA  A1283 (-3.6A)
LEA  A1283 (-4.0A)
 0.18A 2ha4B-5aocA:
18.5		 2ha4B-5aocA:
22.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VAV_K_CSCK1385_1
(ACETYL-COA--DEACETYL
CEPHALOSPORIN C
ACETYLTRANSFERASE)		 5aoc ESTERASE
(Thermogutta
terrifontis) 		5 / 12 THR A 135
ARG A 107
PHE A  50
VAL A  48
MET A  78
 None
PG4  A1285 (-3.5A)
None
None
None
 1.23A 2vavK-5aocA:
15.5		 2vavK-5aocA:
20.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VAX_C_CSCC1383_1
(ACETYL-COA--DEACETYL
CEPHALOSPORIN C
ACETYLTRANSFERASE)		 5aoc ESTERASE
(Thermogutta
terrifontis) 		5 / 12 THR A 135
ARG A 107
PHE A  50
VAL A  48
MET A  78
 None
PG4  A1285 (-3.5A)
None
None
None
 1.19A 2vaxC-5aocA:
14.3		 2vaxC-5aocA:
20.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VAX_D_CSCD1383_1
(ACETYL-COA--DEACETYL
CEPHALOSPORIN C
ACETYLTRANSFERASE)		 5aoc ESTERASE
(Thermogutta
terrifontis) 		5 / 12 THR A 135
ARG A 107
PHE A  50
VAL A  48
MET A  78
 None
PG4  A1285 (-3.5A)
None
None
None
 1.19A 2vaxD-5aocA:
14.3		 2vaxD-5aocA:
20.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VAX_G_CSCG1383_1
(ACETYL-COA--DEACETYL
CEPHALOSPORIN C
ACETYLTRANSFERASE)		 5aoc ESTERASE
(Thermogutta
terrifontis) 		5 / 12 THR A 135
ARG A 107
PHE A  50
VAL A  48
MET A  78
 None
PG4  A1285 (-3.5A)
None
None
None
 1.19A 2vaxG-5aocA:
14.3		 2vaxG-5aocA:
20.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VAX_L_CSCL1383_1
(ACETYL-COA--DEACETYL
CEPHALOSPORIN C
ACETYLTRANSFERASE)		 5aoc ESTERASE
(Thermogutta
terrifontis) 		5 / 12 THR A 135
ARG A 107
PHE A  50
VAL A  48
MET A  78
 None
PG4  A1285 (-3.5A)
None
None
None
 1.23A 2vaxL-5aocA:
14.3		 2vaxL-5aocA:
20.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3O9M_A_BEZA999_0
(CHOLINESTERASE)		 5aoc ESTERASE
(Thermogutta
terrifontis) 		4 / 7 GLY A  53
GLY A  54
SER A 126
HIS A 248
 LEA  A1283 (-3.4A)
LEA  A1283 (-3.5A)
LEA  A1283 (-2.3A)
LEA  A1283 (-4.0A)
 0.39A 3o9mA-5aocA:
18.1		 3o9mA-5aocA:
20.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3O9M_B_BEZB999_0
(CHOLINESTERASE)		 5aoc ESTERASE
(Thermogutta
terrifontis) 		4 / 6 GLY A  53
GLY A  54
SER A 126
HIS A 248
 LEA  A1283 (-3.4A)
LEA  A1283 (-3.5A)
LEA  A1283 (-2.3A)
LEA  A1283 (-4.0A)
 0.50A 3o9mB-5aocA:
4.8		 3o9mB-5aocA:
20.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EY6_A_GNTA604_1
(ACETYLCHOLINESTERASE)		 5aoc ESTERASE
(Thermogutta
terrifontis) 		6 / 12 GLY A  52
GLY A  53
GLY A  54
SER A  57
SER A 126
HIS A 248
 LEA  A1283 ( 4.0A)
LEA  A1283 (-3.4A)
LEA  A1283 (-3.5A)
None
LEA  A1283 (-2.3A)
LEA  A1283 (-4.0A)
 0.37A 4ey6A-5aocA:
18.5		 4ey6A-5aocA:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EY6_B_GNTB605_1
(ACETYLCHOLINESTERASE)		 5aoc ESTERASE
(Thermogutta
terrifontis) 		5 / 12 GLY A  52
GLY A  53
GLY A  54
SER A 126
HIS A 248
 LEA  A1283 ( 4.0A)
LEA  A1283 (-3.4A)
LEA  A1283 (-3.5A)
LEA  A1283 (-2.3A)
LEA  A1283 (-4.0A)
 0.25A 4ey6B-5aocA:
18.1		 4ey6B-5aocA:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QD3_A_5AEA201_1
(PEPTIDYL-TRNA
HYDROLASE)		 5aoc ESTERASE
(Thermogutta
terrifontis) 		5 / 9 LEU A 141
GLY A 189
VAL A 195
VAL A  96
LEU A 131
 None
 1.11A 4qd3A-5aocA:
3.0		 4qd3A-5aocA:
22.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M0O_A_EPAA502_1
(TERMINAL
OLEFIN-FORMING FATTY
ACID DECARBOXYLASE)		 5aoc ESTERASE
(Thermogutta
terrifontis) 		5 / 10 PRO A  60
ILE A 158
PHE A  49
ALA A 268
PHE A  70
 None
 1.24A 5m0oA-5aocA:
undetectable		 5m0oA-5aocA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X66_A_MTXA402_1
(THYMIDYLATE SYNTHASE)		 5aoc ESTERASE
(Thermogutta
terrifontis) 		5 / 12 PHE A 250
GLY A 254
ASN A 258
ALA A  61
ASP A 216
 None
None
None
None
CL  A1296 ( 4.5A)
 1.01A 5x66A-5aocA:
undetectable
5x66B-5aocA:
undetectable		 5x66A-5aocA:
18.59
5x66B-5aocA:
18.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DJZ_B_GMJB301_0
(SIGMA NON-OPIOID
INTRACELLULAR
RECEPTOR 1)		 5aoc ESTERASE
(Thermogutta
terrifontis) 		5 / 12 LEU A 240
SER A 126
PHE A 251
HIS A 248
THR A 223
 None
LEA  A1283 (-2.3A)
None
LEA  A1283 (-4.0A)
EDO  A1286 ( 4.9A)
 1.29A 6djzB-5aocA:
undetectable		 6djzB-5aocA:
21.59