SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5aor'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C4D_A_DVAA6_0
(GRAMICIDIN A)		 5aor DOSAGE COMPENSATION
REGULATOR
(Drosophila
melanogaster) 		3 / 3 ALA A 434
VAL A 501
TRP A 328
 None
 0.63A 1c4dA-5aorA:
undetectable
1c4dB-5aorA:
undetectable		 1c4dA-5aorA:
1.12
1c4dB-5aorA:
1.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C4D_B_DVAB6_0
(GRAMICIDIN A)		 5aor DOSAGE COMPENSATION
REGULATOR
(Drosophila
melanogaster) 		3 / 3 TRP A 328
ALA A 434
VAL A 501
 None
 0.87A 1c4dA-5aorA:
undetectable
1c4dB-5aorA:
undetectable		 1c4dA-5aorA:
1.12
1c4dB-5aorA:
1.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CD2_A_FOLA307_1
(DIHYDROFOLATE
REDUCTASE)		 5aor DOSAGE COMPENSATION
REGULATOR
(Drosophila
melanogaster) 		3 / 3 GLU A1054
ILE A1056
ARG A 739
 None
None
U  C   5 ( 3.0A)
 0.84A 1cd2A-5aorA:
undetectable		 1cd2A-5aorA:
10.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EII_A_RTLA135_1
(CELLULAR
RETINOL-BINDING
PROTEIN II)		 5aor DOSAGE COMPENSATION
REGULATOR
(Drosophila
melanogaster) 		4 / 7 TYR A 752
GLN A 693
SER A 692
GLN A1065
 U  C   5 ( 4.1A)
U  C   5 ( 3.0A)
U  C   7 ( 2.5A)
None
 1.28A 1eiiA-5aorA:
undetectable		 1eiiA-5aorA:
6.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ETB_2_T442129_1
(TRANSTHYRETIN)		 5aor DOSAGE COMPENSATION
REGULATOR
(Drosophila
melanogaster) 		4 / 6 GLU A 804
THR A 808
ALA A 860
LEU A 858
 GOL  A2163 (-3.5A)
None
None
None
 0.96A 1etb2-5aorA:
undetectable		 1etb2-5aorA:
8.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GSE_B_EAAB224_1
(GLUTATHIONE
TRANSFERASE)		 5aor DOSAGE COMPENSATION
REGULATOR
(Drosophila
melanogaster) 		5 / 12 GLY A1109
LEU A1146
VAL A1143
LEU A1115
ALA A1114
 None
 1.09A 1gseB-5aorA:
undetectable		 1gseB-5aorA:
9.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KGL_A_RTLA175_1
(CELLULAR
RETINOL-BINDING
PROTEIN TYPE I)		 5aor DOSAGE COMPENSATION
REGULATOR
(Drosophila
melanogaster) 		4 / 7 LEU A 665
ILE A 719
THR A 717
GLN A 699
 None
U  C   7 ( 3.9A)
U  C   7 ( 2.9A)
None
 1.04A 1kglA-5aorA:
undetectable		 1kglA-5aorA:
7.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIJ_A_NOVA400_1
(DNA GYRASE SUBUNIT B)		 5aor DOSAGE COMPENSATION
REGULATOR
(Drosophila
melanogaster) 		5 / 12 GLU A 558
ARG A 406
ILE A 405
ASP A 507
ILE A 393
 None
None
None
MG  A2160 (-3.6A)
None
 1.37A 1kijA-5aorA:
undetectable		 1kijA-5aorA:
16.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NBI_C_SAMC2293_0
(GLYCINE
N-METHYLTRANSFERASE)		 5aor DOSAGE COMPENSATION
REGULATOR
(Drosophila
melanogaster) 		5 / 12 GLY A1007
ALA A1002
MET A 871
GLY A1053
HIS A 922
 None
 1.11A 1nbiC-5aorA:
undetectable		 1nbiC-5aorA:
12.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NBI_D_SAMD3293_0
(GLYCINE
N-METHYLTRANSFERASE)		 5aor DOSAGE COMPENSATION
REGULATOR
(Drosophila
melanogaster) 		5 / 12 GLY A1007
ALA A1002
MET A 871
GLY A1053
HIS A 922
 None
 1.12A 1nbiD-5aorA:
undetectable		 1nbiD-5aorA:
12.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_I_FUAI707_2
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 5aor DOSAGE COMPENSATION
REGULATOR
(Drosophila
melanogaster) 		5 / 11 PHE A1077
PHE A 878
PHE A 976
VAL A1121
VAL A 877
 None
 1.24A 1q23I-5aorA:
undetectable		 1q23I-5aorA:
9.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SN5_C_T3C601_2
(TRANSTHYRETIN)		 5aor DOSAGE COMPENSATION
REGULATOR
(Drosophila
melanogaster) 		4 / 8 GLU A 804
THR A 808
ALA A 860
LEU A 858
 GOL  A2163 (-3.5A)
None
None
None
 0.94A 1sn5C-5aorA:
undetectable		 1sn5C-5aorA:
8.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A8T_A_ADNA252_1
(U8 SNORNA-BINDING
PROTEIN X29)		 5aor DOSAGE COMPENSATION
REGULATOR
(Drosophila
melanogaster) 		5 / 9 GLY A 410
THR A 414
ILE A 724
SER A 445
GLN A 440
 ADP  A2159 ( 3.3A)
MG  A2160 ( 2.9A)
None
None
MG  A2160 ( 4.9A)
 1.49A 2a8tA-5aorA:
0.0		 2a8tA-5aorA:
9.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FT9_A_CHDA130_0
(FATTY ACID-BINDING
PROTEIN 2, LIVER)		 5aor DOSAGE COMPENSATION
REGULATOR
(Drosophila
melanogaster) 		5 / 12 PHE A1077
VAL A1143
ILE A1129
CYH A 980
LEU A1003
 None
 1.18A 2ft9A-5aorA:
undetectable		 2ft9A-5aorA:
7.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HC4_A_VDXA525_1
(VITAMIN D RECEPTOR)		 5aor DOSAGE COMPENSATION
REGULATOR
(Drosophila
melanogaster) 		5 / 12 LEU A 537
VAL A 506
CYH A 554
LEU A 498
LEU A 491
 None
 1.39A 2hc4A-5aorA:
undetectable		 2hc4A-5aorA:
12.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J2P_B_SC2B1290_1
(FICOLIN-2)		 5aor DOSAGE COMPENSATION
REGULATOR
(Drosophila
melanogaster) 		4 / 8 LEU A 348
SER A 352
LEU A 356
ASP A 355
 None
 1.05A 2j2pA-5aorA:
undetectable
2j2pB-5aorA:
undetectable		 2j2pA-5aorA:
10.27
2j2pB-5aorA:
10.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J2P_E_SC2E1289_1
(FICOLIN-2)		 5aor DOSAGE COMPENSATION
REGULATOR
(Drosophila
melanogaster) 		4 / 6 ARG A 457
ASP A 463
THR A 464
ASP A 423
 None
 1.02A 2j2pE-5aorA:
undetectable
2j2pF-5aorA:
undetectable		 2j2pE-5aorA:
10.27
2j2pF-5aorA:
10.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XAT_A_CLMA301_0
(XENOBIOTIC
ACETYLTRANSFERASE)		 5aor DOSAGE COMPENSATION
REGULATOR
(Drosophila
melanogaster) 		3 / 3 GLY A 431
TYR A 360
SER A 357
 None
 0.73A 2xatA-5aorA:
undetectable		 2xatA-5aorA:
9.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZLC_A_VDXA500_1
(VITAMIN D3 RECEPTOR)		 5aor DOSAGE COMPENSATION
REGULATOR
(Drosophila
melanogaster) 		5 / 12 LEU A 537
VAL A 506
CYH A 554
LEU A 498
LEU A 491
 None
 1.34A 2zlcA-5aorA:
undetectable		 2zlcA-5aorA:
13.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZZM_A_SAMA401_0
(UNCHARACTERIZED
PROTEIN MJ0883)		 5aor DOSAGE COMPENSATION
REGULATOR
(Drosophila
melanogaster) 		5 / 12 LEU A 859
GLY A1007
VAL A 999
LEU A 874
PHE A 878
 None
 1.09A 2zzmA-5aorA:
3.7		 2zzmA-5aorA:
14.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BXO_B_SAMB238_1
(N,N-DIMETHYLTRANSFER
ASE)		 5aor DOSAGE COMPENSATION
REGULATOR
(Drosophila
melanogaster) 		3 / 3 TYR A1009
GLU A1025
ASP A 257
 None
 0.81A 3bxoB-5aorA:
4.3		 3bxoB-5aorA:
11.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DZY_A_9CRA463_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 5aor DOSAGE COMPENSATION
REGULATOR
(Drosophila
melanogaster) 		5 / 12 ILE A 574
ASN A 612
SER A 636
LEU A 643
ALA A 642
 None
 1.09A 3dzyA-5aorA:
undetectable		 3dzyA-5aorA:
17.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EIG_A_MTXA200_2
(DIHYDROFOLATE
REDUCTASE)		 5aor DOSAGE COMPENSATION
REGULATOR
(Drosophila
melanogaster) 		4 / 5 ASP A 507
ILE A 417
VAL A 403
THR A 544
 MG  A2160 (-3.6A)
None
None
None
 0.71A 3eigA-5aorA:
undetectable		 3eigA-5aorA:
8.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FI0_P_TRPP1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 5aor DOSAGE COMPENSATION
REGULATOR
(Drosophila
melanogaster) 		4 / 7 GLN A 686
VAL A 706
ASP A 728
ILE A 729
 None
 0.92A 3fi0P-5aorA:
undetectable		 3fi0P-5aorA:
15.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HJO_B_EAAB211_1
(GLUTATHIONE
S-TRANSFERASE P)		 5aor DOSAGE COMPENSATION
REGULATOR
(Drosophila
melanogaster) 		4 / 8 VAL A1069
ILE A1082
VAL A1092
GLY A1078
 None
 0.73A 3hjoB-5aorA:
undetectable		 3hjoB-5aorA:
10.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LOQ_A_ACTA277_0
(UNIVERSAL STRESS
PROTEIN)		 5aor DOSAGE COMPENSATION
REGULATOR
(Drosophila
melanogaster) 		3 / 3 ASP A 882
SER A 983
ARG A 933
 None
 0.67A 3loqA-5aorA:
2.1		 3loqA-5aorA:
12.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U52_A_CUA515_0
(PHENOL HYDROXYLASE
COMPONENT PHL
PHENOL HYDROXYLASE
COMPONENT PHN)		 5aor DOSAGE COMPENSATION
REGULATOR
(Drosophila
melanogaster) 		3 / 3 HIS A 534
HIS A 503
ILE A 397
 None
 0.80A 3u52A-5aorA:
undetectable
3u52C-5aorA:
undetectable		 3u52A-5aorA:
16.33
3u52C-5aorA:
14.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A7T_A_5FWA1001_1
(SUPEROXIDE DISMUTASE
[CU-ZN])		 5aor DOSAGE COMPENSATION
REGULATOR
(Drosophila
melanogaster) 		3 / 3 ASP A 603
LYS A 604
ASP A 605
 None
 0.74A 4a7tA-5aorA:
undetectable		 4a7tA-5aorA:
7.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CEV_C_GAIC409_0
(PROTEIN (ARGINASE))		 5aor DOSAGE COMPENSATION
REGULATOR
(Drosophila
melanogaster) 		4 / 6 MET A 843
ARG A 867
GLU A1116
LEU A 855
 None
 1.22A 4cevA-5aorA:
3.2
4cevC-5aorA:
undetectable		 4cevA-5aorA:
11.87
4cevC-5aorA:
11.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CEV_D_GAID410_0
(PROTEIN (ARGINASE))		 5aor DOSAGE COMPENSATION
REGULATOR
(Drosophila
melanogaster) 		4 / 6 ARG A 867
GLU A1116
LEU A 855
MET A 843
 None
 1.22A 4cevD-5aorA:
3.7
4cevE-5aorA:
3.4		 4cevD-5aorA:
11.87
4cevE-5aorA:
11.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CEV_F_GAIF411_0
(PROTEIN (ARGINASE))		 5aor DOSAGE COMPENSATION
REGULATOR
(Drosophila
melanogaster) 		4 / 6 ARG A 867
GLU A1116
LEU A 855
MET A 843
 None
 1.24A 4cevE-5aorA:
3.3
4cevF-5aorA:
3.5		 4cevE-5aorA:
11.87
4cevF-5aorA:
11.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KT0_A_PQNA2001_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1
PHOTOSYSTEM I
REACTION CENTER
SUBUNIT IX)		 5aor DOSAGE COMPENSATION
REGULATOR
(Drosophila
melanogaster) 		5 / 11 PHE A 475
GLY A 462
ALA A 481
ILE A 326
LEU A 812
 None
 1.08A 4kt0A-5aorA:
undetectable
4kt0J-5aorA:
undetectable		 4kt0A-5aorA:
19.22
4kt0J-5aorA:
3.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MK4_A_CHDA503_0
(FERROCHELATASE,
MITOCHONDRIAL)		 5aor DOSAGE COMPENSATION
REGULATOR
(Drosophila
melanogaster) 		5 / 10 LEU A 643
LEU A 639
LEU A 630
ILE A 733
TRP A 756
 None
 1.41A 4mk4A-5aorA:
2.6		 4mk4A-5aorA:
14.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QC6_B_KANB201_2
(BIFUNCTIONAL AAC/APH)		 5aor DOSAGE COMPENSATION
REGULATOR
(Drosophila
melanogaster) 		3 / 3 LEU A 356
ASP A 359
TYR A 360
 None
 0.54A 4qc6B-5aorA:
undetectable		 4qc6B-5aorA:
9.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z2D_F_LFXF102_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
SYMMETRIZED E-SITE
DNA)		 5aor DOSAGE COMPENSATION
REGULATOR
(Drosophila
melanogaster) 		3 / 4 ARG A 124
GLY A 120
GLU A 121
 None
 0.64A 4z2dB-5aorA:
undetectable
4z2dC-5aorA:
3.1		 4z2dB-5aorA:
17.49
4z2dC-5aorA:
11.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LJB_A_RTLA201_1
(RETINOL-BINDING
PROTEIN 1)		 5aor DOSAGE COMPENSATION
REGULATOR
(Drosophila
melanogaster) 		4 / 8 LEU A 665
ILE A 719
THR A 717
GLN A 699
 None
U  C   7 ( 3.9A)
U  C   7 ( 2.9A)
None
 0.89A 5ljbA-5aorA:
undetectable		 5ljbA-5aorA:
7.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QH8_A_ACTA302_0
(PEROXISOMAL COENZYME
A DIPHOSPHATASE
NUDT7)		 5aor DOSAGE COMPENSATION
REGULATOR
(Drosophila
melanogaster) 		3 / 3 CYH A 947
MET A 957
ASN A 958
 None
 1.21A 5qh8A-5aorA:
undetectable		 5qh8A-5aorA:
11.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TIX_B_OQRB302_0
(SULFOTRANSFERASE)		 5aor DOSAGE COMPENSATION
REGULATOR
(Drosophila
melanogaster) 		5 / 10 ILE A 886
LEU A1001
VAL A 986
ASP A 882
SER A1000
 None
 1.47A 5tixB-5aorA:
undetectable		 5tixB-5aorA:
11.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XXI_A_LSNA501_2
(CYTOCHROME P450 2C9)		 5aor DOSAGE COMPENSATION
REGULATOR
(Drosophila
melanogaster) 		4 / 4 PHE A 672
LEU A 780
LEU A 644
VAL A 635
 None
 1.32A 5xxiA-5aorA:
undetectable		 5xxiA-5aorA:
16.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CHG_C_SAMC1101_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-4 SPECIFIC)		 5aor DOSAGE COMPENSATION
REGULATOR
(Drosophila
melanogaster) 		5 / 12 ILE A 886
SER A 915
HIS A 922
LEU A 883
LEU A1001
 None
 1.37A 6chgC-5aorA:
undetectable		 6chgC-5aorA:
9.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DLZ_A_CYZA1302_0
(GLUTAMATE RECEPTOR
2,VOLTAGE-DEPENDENT
CALCIUM CHANNEL
GAMMA-2 SUBUNIT)		 5aor DOSAGE COMPENSATION
REGULATOR
(Drosophila
melanogaster) 		5 / 10 SER A 920
SER A1000
ASP A 998
LYS A1149
ILE A 886
 None
 1.49A 6dlzA-5aorA:
undetectable
6dlzD-5aorA:
3.4		 6dlzA-5aorA:
5.36
6dlzD-5aorA:
5.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DLZ_C_CYZC1302_0
(GLUTAMATE RECEPTOR
2,VOLTAGE-DEPENDENT
CALCIUM CHANNEL
GAMMA-2 SUBUNIT)		 5aor DOSAGE COMPENSATION
REGULATOR
(Drosophila
melanogaster) 		5 / 10 ILE A 886
SER A 920
SER A1000
ASP A 998
LYS A1149
 None
 1.49A 6dlzB-5aorA:
3.2
6dlzC-5aorA:
undetectable		 6dlzB-5aorA:
5.36
6dlzC-5aorA:
5.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DM0_A_CYZA1302_0
(GLUTAMATE RECEPTOR
2,VOLTAGE-DEPENDENT
CALCIUM CHANNEL
GAMMA-2 SUBUNIT)		 5aor DOSAGE COMPENSATION
REGULATOR
(Drosophila
melanogaster) 		5 / 9 SER A 920
SER A1000
ASP A 998
LYS A1149
ILE A 886
 None
 1.48A 6dm0A-5aorA:
2.1
6dm0D-5aorA:
undetectable		 6dm0A-5aorA:
5.36
6dm0D-5aorA:
5.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DM0_C_CYZC1302_0
(GLUTAMATE RECEPTOR
2,VOLTAGE-DEPENDENT
CALCIUM CHANNEL
GAMMA-2 SUBUNIT)		 5aor DOSAGE COMPENSATION
REGULATOR
(Drosophila
melanogaster) 		5 / 9 ILE A 886
SER A 920
SER A1000
ASP A 998
LYS A1149
 None
 1.48A 6dm0B-5aorA:
3.2
6dm0C-5aorA:
undetectable		 6dm0B-5aorA:
5.36
6dm0C-5aorA:
5.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DM1_A_CYZA1302_0
(GLUTAMATE RECEPTOR
2,VOLTAGE-DEPENDENT
CALCIUM CHANNEL
GAMMA-2 SUBUNIT)		 5aor DOSAGE COMPENSATION
REGULATOR
(Drosophila
melanogaster) 		5 / 10 SER A 920
SER A1000
ASP A 998
LYS A1149
ILE A 886
 None
 1.49A 6dm1A-5aorA:
undetectable
6dm1D-5aorA:
3.4		 6dm1A-5aorA:
5.36
6dm1D-5aorA:
5.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DM1_C_CYZC1302_0
(GLUTAMATE RECEPTOR
2,VOLTAGE-DEPENDENT
CALCIUM CHANNEL
GAMMA-2 SUBUNIT)		 5aor DOSAGE COMPENSATION
REGULATOR
(Drosophila
melanogaster) 		5 / 10 ILE A 886
SER A 920
SER A1000
ASP A 998
LYS A1149
 None
 1.48A 6dm1B-5aorA:
3.4
6dm1C-5aorA:
undetectable		 6dm1B-5aorA:
5.36
6dm1C-5aorA:
5.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EXI_A_ADNA503_1
(ADENOSYLHOMOCYSTEINA
SE)		 5aor DOSAGE COMPENSATION
REGULATOR
(Drosophila
melanogaster) 		3 / 3 LEU A 907
GLN A 911
LYS A1064
 None
None
U  C   4 ( 4.5A)
 0.83A 6exiB-5aorA:
undetectable		 6exiB-5aorA:
5.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EXI_B_ADNB503_0
(ADENOSYLHOMOCYSTEINA
SE)		 5aor DOSAGE COMPENSATION
REGULATOR
(Drosophila
melanogaster) 		3 / 3 LEU A 907
GLN A 911
LYS A1064
 None
None
U  C   4 ( 4.5A)
 0.77A 6exiA-5aorA:
3.0		 6exiA-5aorA:
5.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HIS_A_TKTA508_0
(5-HYDROXYTRYPTAMINE
RECEPTOR 3A)		 5aor DOSAGE COMPENSATION
REGULATOR
(Drosophila
melanogaster) 		4 / 8 ILE A 444
ARG A 443
ARG A 696
ASN A 718
 None
U  C   9 ( 4.1A)
None
U  C   6 ( 2.8A)
 1.05A 6hisA-5aorA:
2.3
6hisB-5aorA:
2.3		 6hisA-5aorA:
5.75
6hisB-5aorA:
5.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HIS_B_TKTB508_0
(5-HYDROXYTRYPTAMINE
RECEPTOR 3A)		 5aor DOSAGE COMPENSATION
REGULATOR
(Drosophila
melanogaster) 		4 / 8 ILE A 444
ARG A 443
ARG A 696
ASN A 718
 None
U  C   9 ( 4.1A)
None
U  C   6 ( 2.8A)
 1.06A 6hisB-5aorA:
2.3
6hisC-5aorA:
2.3		 6hisB-5aorA:
5.75
6hisC-5aorA:
5.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HIS_C_TKTC508_0
(5-HYDROXYTRYPTAMINE
RECEPTOR 3A)		 5aor DOSAGE COMPENSATION
REGULATOR
(Drosophila
melanogaster) 		4 / 8 ILE A 444
ARG A 443
ARG A 696
ASN A 718
 None
U  C   9 ( 4.1A)
None
U  C   6 ( 2.8A)
 1.06A 6hisC-5aorA:
2.2
6hisD-5aorA:
2.3		 6hisC-5aorA:
5.75
6hisD-5aorA:
5.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HIS_D_TKTD501_0
(5-HYDROXYTRYPTAMINE
RECEPTOR 3A)		 5aor DOSAGE COMPENSATION
REGULATOR
(Drosophila
melanogaster) 		4 / 8 ILE A 444
ARG A 443
ARG A 696
ASN A 718
 None
U  C   9 ( 4.1A)
None
U  C   6 ( 2.8A)
 1.06A 6hisD-5aorA:
2.3
6hisE-5aorA:
2.3		 6hisD-5aorA:
5.75
6hisE-5aorA:
5.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HIS_E_TKTE501_0
(5-HYDROXYTRYPTAMINE
RECEPTOR 3A)		 5aor DOSAGE COMPENSATION
REGULATOR
(Drosophila
melanogaster) 		4 / 8 ASN A 718
ILE A 444
ARG A 443
ARG A 696
 U  C   6 ( 2.8A)
None
U  C   9 ( 4.1A)
None
 1.07A 6hisA-5aorA:
2.3
6hisE-5aorA:
2.3		 6hisA-5aorA:
5.75
6hisE-5aorA:
5.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6N91_A_DCFA401_0
(ADENOSINE DEAMINASE)		 5aor DOSAGE COMPENSATION
REGULATOR
(Drosophila
melanogaster) 		5 / 12 LEU A1004
LEU A1008
ILE A 864
SER A 892
ALA A 888
 None
None
None
GOL  A2163 ( 4.7A)
None
 1.16A 6n91A-5aorA:
undetectable		 6n91A-5aorA:
5.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6N91_B_DCFB401_0
(ADENOSINE DEAMINASE)		 5aor DOSAGE COMPENSATION
REGULATOR
(Drosophila
melanogaster) 		5 / 12 LEU A1004
LEU A1008
ILE A 864
SER A 892
ALA A 888
 None
None
None
GOL  A2163 ( 4.7A)
None
 1.20A 6n91B-5aorA:
undetectable		 6n91B-5aorA:
5.37