SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5aov'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DF7_A_MTXA501_1
(DIHYDROFOLATE
REDUCTASE)		 5aov GLYOXYLATE REDUCTASE
(Pyrococcus
furiosus) 		5 / 12 ALA A 240
LEU A 198
VAL A 201
LEU A 202
ILE A 222
 NAP  A1335 (-4.8A)
None
None
None
None
 0.94A 1df7A-5aovA:
undetectable		 1df7A-5aovA:
18.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EQB_A_FFOA1293_2
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 5aov GLYOXYLATE REDUCTASE
(Pyrococcus
furiosus) 		3 / 3 SER A 279
GLU A 275
GLU A 276
 None
 0.71A 1eqbD-5aovA:
2.8		 1eqbD-5aovA:
23.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1M2Z_D_DEXD401_1
(GLUCOCORTICOID
RECEPTOR)		 5aov GLYOXYLATE REDUCTASE
(Pyrococcus
furiosus) 		5 / 12 ASN A  80
GLY A  77
ARG A 160
ILE A  57
LEU A  53
 None
GLV  A1336 (-3.3A)
NAP  A1335 (-3.3A)
None
GLV  A1356 ( 3.7A)
 1.46A 1m2zD-5aovA:
undetectable		 1m2zD-5aovA:
22.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2C6N_B_LPRB705_2
(ANGIOTENSIN-CONVERTI
NG ENZYME, SOMATIC
ISOFORM)		 5aov GLYOXYLATE REDUCTASE
(Pyrococcus
furiosus) 		3 / 3 ALA A 164
THR A 101
PHE A 158
 1PE  A1346 ( 4.7A)
1PE  A1346 ( 4.7A)
None
 0.76A 2c6nB-5aovA:
undetectable		 2c6nB-5aovA:
20.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIM_J_CHDJ60_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART)		 5aov GLYOXYLATE REDUCTASE
(Pyrococcus
furiosus) 		4 / 5 TYR A 220
MET A 219
THR A 218
LEU A 214
 EDO  A1351 (-3.4A)
1PE  A1349 (-4.2A)
NAP  A1335 (-4.2A)
1PE  A1345 (-4.5A)
 1.32A 2eimJ-5aovA:
undetectable		 2eimJ-5aovA:
13.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIM_W_CHDW1060_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART)		 5aov GLYOXYLATE REDUCTASE
(Pyrococcus
furiosus) 		4 / 5 TYR A 220
MET A 219
THR A 218
LEU A 214
 EDO  A1351 (-3.4A)
1PE  A1349 (-4.2A)
NAP  A1335 (-4.2A)
1PE  A1345 (-4.5A)
 1.32A 2eimW-5aovA:
undetectable		 2eimW-5aovA:
13.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V7B_A_BEZA1529_0
(BENZOATE-COENZYME A
LIGASE)		 5aov GLYOXYLATE REDUCTASE
(Pyrococcus
furiosus) 		5 / 9 ALA A 166
ALA A 211
GLY A 157
GLY A 159
ILE A 161
 None
None
NAP  A1335 (-3.3A)
NAP  A1335 (-3.0A)
NAP  A1335 (-3.5A)
 1.23A 2v7bA-5aovA:
6.2		 2v7bA-5aovA:
21.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V7B_B_BEZB1529_0
(BENZOATE-COENZYME A
LIGASE)		 5aov GLYOXYLATE REDUCTASE
(Pyrococcus
furiosus) 		5 / 9 ALA A 166
ALA A 211
GLY A 157
GLY A 159
ILE A 161
 None
None
NAP  A1335 (-3.3A)
NAP  A1335 (-3.0A)
NAP  A1335 (-3.5A)
 1.21A 2v7bB-5aovA:
6.1		 2v7bB-5aovA:
21.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG1_J_CHDJ60_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1)		 5aov GLYOXYLATE REDUCTASE
(Pyrococcus
furiosus) 		4 / 5 TYR A 220
MET A 219
THR A 218
LEU A 214
 EDO  A1351 (-3.4A)
1PE  A1349 (-4.2A)
NAP  A1335 (-4.2A)
1PE  A1345 (-4.5A)
 1.37A 3ag1J-5aovA:
undetectable		 3ag1J-5aovA:
13.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG2_J_CHDJ60_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1)		 5aov GLYOXYLATE REDUCTASE
(Pyrococcus
furiosus) 		4 / 5 TYR A 220
MET A 219
THR A 218
LEU A 214
 EDO  A1351 (-3.4A)
1PE  A1349 (-4.2A)
NAP  A1335 (-4.2A)
1PE  A1345 (-4.5A)
 1.33A 3ag2J-5aovA:
undetectable		 3ag2J-5aovA:
13.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG4_J_CHDJ60_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1)		 5aov GLYOXYLATE REDUCTASE
(Pyrococcus
furiosus) 		4 / 5 TYR A 220
MET A 219
THR A 218
LEU A 214
 EDO  A1351 (-3.4A)
1PE  A1349 (-4.2A)
NAP  A1335 (-4.2A)
1PE  A1345 (-4.5A)
 1.34A 3ag4J-5aovA:
undetectable		 3ag4J-5aovA:
13.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LB3_A_4CHA191_0
(DEHALOPEROXIDASE A)		 5aov GLYOXYLATE REDUCTASE
(Pyrococcus
furiosus) 		4 / 6 PHE A 278
PHE A 267
TYR A 272
VAL A 283
 None
None
1PE  A1355 (-4.4A)
None
 1.28A 3lb3A-5aovA:
undetectable		 3lb3A-5aovA:
17.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LB3_B_4CHB192_0
(DEHALOPEROXIDASE A)		 5aov GLYOXYLATE REDUCTASE
(Pyrococcus
furiosus) 		4 / 6 PHE A 278
PHE A 267
TYR A 272
VAL A 283
 None
None
1PE  A1355 (-4.4A)
None
 1.16A 3lb3B-5aovA:
undetectable		 3lb3B-5aovA:
17.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DX7_A_DM2A1106_1
(ACRIFLAVINE
RESISTANCE PROTEIN B)		 5aov GLYOXYLATE REDUCTASE
(Pyrococcus
furiosus) 		5 / 11 PHE A 172
PHE A 109
LEU A 112
ALA A 211
ARG A 167
 None
None
None
None
1PE  A1346 (-4.3A)
 1.32A 4dx7A-5aovA:
0.0		 4dx7A-5aovA:
15.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E1G_B_LNLB701_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		 5aov GLYOXYLATE REDUCTASE
(Pyrococcus
furiosus) 		4 / 7 VAL A 266
ASN A  73
MET A 219
VAL A 244
 None
None
1PE  A1349 (-4.2A)
None
 1.04A 4e1gB-5aovA:
undetectable		 4e1gB-5aovA:
19.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JLG_B_SAMB401_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD7)		 5aov GLYOXYLATE REDUCTASE
(Pyrococcus
furiosus) 		5 / 11 ALA A 249
GLU A 256
GLY A 261
ASN A 282
GLU A 268
 None
None
1PE  A1343 ( 3.7A)
None
EDO  A1351 (-4.8A)
 1.46A 4jlgB-5aovA:
undetectable		 4jlgB-5aovA:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RVG_A_SAMA503_0
(D-MYCAROSE
3-C-METHYLTRANSFERAS
E)		 5aov GLYOXYLATE REDUCTASE
(Pyrococcus
furiosus) 		5 / 12 THR A  96
ILE A  57
ASN A  95
VAL A  71
ILE A  91
 None
 1.14A 4rvgA-5aovA:
6.6		 4rvgA-5aovA:
22.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HS1_A_VORA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 5aov GLYOXYLATE REDUCTASE
(Pyrococcus
furiosus) 		4 / 8 ILE A 209
GLY A 263
LEU A 250
LEU A 227
 None
 0.83A 5hs1A-5aovA:
undetectable		 5hs1A-5aovA:
20.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5W97_J_CHDJ101_1
(CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 5aov GLYOXYLATE REDUCTASE
(Pyrococcus
furiosus) 		4 / 5 TYR A 220
MET A 219
THR A 218
LEU A 214
 EDO  A1351 (-3.4A)
1PE  A1349 (-4.2A)
NAP  A1335 (-4.2A)
1PE  A1345 (-4.5A)
 1.36A 5w97J-5aovA:
undetectable		 5w97J-5aovA:
13.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WAU_J_CHDJ101_1
(CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 5aov GLYOXYLATE REDUCTASE
(Pyrococcus
furiosus) 		4 / 5 TYR A 220
MET A 219
THR A 218
LEU A 214
 EDO  A1351 (-3.4A)
1PE  A1349 (-4.2A)
NAP  A1335 (-4.2A)
1PE  A1345 (-4.5A)
 1.31A 5wauJ-5aovA:
undetectable		 5wauJ-5aovA:
13.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X19_J_CHDJ101_0
(CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 5aov GLYOXYLATE REDUCTASE
(Pyrococcus
furiosus) 		4 / 5 TYR A 220
MET A 219
THR A 218
LEU A 214
 EDO  A1351 (-3.4A)
1PE  A1349 (-4.2A)
NAP  A1335 (-4.2A)
1PE  A1345 (-4.5A)
 1.33A 5x19J-5aovA:
undetectable		 5x19J-5aovA:
13.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X1B_W_CHDW101_0
(CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 5aov GLYOXYLATE REDUCTASE
(Pyrococcus
furiosus) 		4 / 5 TYR A 220
MET A 219
THR A 218
LEU A 214
 EDO  A1351 (-3.4A)
1PE  A1349 (-4.2A)
NAP  A1335 (-4.2A)
1PE  A1345 (-4.5A)
 1.30A 5x1bW-5aovA:
undetectable		 5x1bW-5aovA:
13.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X1F_W_CHDW101_0
(CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 5aov GLYOXYLATE REDUCTASE
(Pyrococcus
furiosus) 		4 / 5 TYR A 220
MET A 219
THR A 218
LEU A 214
 EDO  A1351 (-3.4A)
1PE  A1349 (-4.2A)
NAP  A1335 (-4.2A)
1PE  A1345 (-4.5A)
 1.31A 5x1fW-5aovA:
undetectable		 5x1fW-5aovA:
13.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z86_J_CHDJ101_0
(CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 5aov GLYOXYLATE REDUCTASE
(Pyrococcus
furiosus) 		4 / 5 TYR A 220
MET A 219
THR A 218
LEU A 214
 EDO  A1351 (-3.4A)
1PE  A1349 (-4.2A)
NAP  A1335 (-4.2A)
1PE  A1345 (-4.5A)
 1.35A 5z86J-5aovA:
undetectable		 5z86J-5aovA:
13.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NKN_J_CHDJ102_0
(CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 5aov GLYOXYLATE REDUCTASE
(Pyrococcus
furiosus) 		4 / 5 TYR A 220
MET A 219
THR A 218
LEU A 214
 EDO  A1351 (-3.4A)
1PE  A1349 (-4.2A)
NAP  A1335 (-4.2A)
1PE  A1345 (-4.5A)
 1.38A 6nknJ-5aovA:
undetectable		 6nknJ-5aovA:
13.44