SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5ap8'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LWF_A_NVPA999_1
(HIV-1 REVERSE
TRANSCRIPTASE)		 5ap8 TSR3
(Sulfolobus
solfataricus) 		5 / 9 LEU A  38
VAL A  54
VAL A   3
GLY A  58
LEU A  46
 None
 1.19A 1lwfA-5ap8A:
undetectable		 1lwfA-5ap8A:
17.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AI9_X_SAMX501_0
(UPF0217 PROTEIN
MJ1640)		 5ap8 TSR3
(Sulfolobus
solfataricus) 		5 / 9 ILE A  59
GLY A  58
SER A  47
LEU A  46
GLU A  80
 None
 1.12A 3ai9X-5ap8A:
3.7		 3ai9X-5ap8A:
22.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BEX_C_PAUC248_0
(TYPE III
PANTOTHENATE KINASE)		 5ap8 TSR3
(Sulfolobus
solfataricus) 		5 / 11 VAL A  54
GLY A  58
ILE A  61
THR A 110
LEU A 107
 None
 1.30A 3bexC-5ap8A:
undetectable
3bexD-5ap8A:
undetectable		 3bexC-5ap8A:
22.50
3bexD-5ap8A:
22.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BF1_A_PAUA248_0
(TYPE III
PANTOTHENATE KINASE)		 5ap8 TSR3
(Sulfolobus
solfataricus) 		5 / 11 VAL A  54
GLY A  58
ILE A  61
THR A 110
LEU A 107
 None
 1.32A 3bf1A-5ap8A:
undetectable
3bf1B-5ap8A:
undetectable		 3bf1A-5ap8A:
22.50
3bf1B-5ap8A:
22.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BF1_C_PAUC248_0
(TYPE III
PANTOTHENATE KINASE)		 5ap8 TSR3
(Sulfolobus
solfataricus) 		5 / 11 VAL A  54
GLY A  58
ILE A  61
THR A 110
LEU A 107
 None
 1.27A 3bf1C-5ap8A:
undetectable
3bf1D-5ap8A:
undetectable		 3bf1C-5ap8A:
22.50
3bf1D-5ap8A:
22.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BF1_F_PAUF248_0
(TYPE III
PANTOTHENATE KINASE)		 5ap8 TSR3
(Sulfolobus
solfataricus) 		5 / 11 THR A 110
LEU A 107
VAL A  54
GLY A  58
ILE A  61
 None
 1.32A 3bf1E-5ap8A:
undetectable
3bf1F-5ap8A:
undetectable		 3bf1E-5ap8A:
22.50
3bf1F-5ap8A:
22.50