SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5ap9'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ME7_A_MOAA600_1
(INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE)		 5ap9 LIPASE
(Thermomyces
lanuginosus) 		4 / 8 SER A  17
ILE A 265
GLY A 266
GLY A  65
 None
 0.68A 1me7A-5ap9A:
undetectable		 1me7A-5ap9A:
20.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UKB_A_BEZA1300_0
(2-HYDROXY-6-OXO-7-ME
THYLOCTA-2,4-DIENOAT
E HYDROLASE)		 5ap9 LIPASE
(Thermomyces
lanuginosus) 		5 / 11 GLY A  82
SER A  83
LEU A  93
VAL A 203
HIS A 258
 None
 1.14A 1ukbA-5ap9A:
5.1		 1ukbA-5ap9A:
23.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WRL_F_TFPF211_1
(TROPONIN C, SLOW
SKELETAL AND CARDIAC
MUSCLES)		 5ap9 LIPASE
(Thermomyces
lanuginosus) 		4 / 7 LEU A 159
PHE A 142
PHE A  80
SER A  58
 None
 0.94A 1wrlE-5ap9A:
undetectable
1wrlF-5ap9A:
undetectable		 1wrlE-5ap9A:
15.35
1wrlF-5ap9A:
15.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JUS_A_ECLA600_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 5ap9 LIPASE
(Thermomyces
lanuginosus) 		4 / 8 LEU A 147
GLY A  65
ALA A  20
ILE A 265
 None
 0.82A 3jusA-5ap9A:
undetectable		 3jusA-5ap9A:
19.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JUS_A_ECNA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 5ap9 LIPASE
(Thermomyces
lanuginosus) 		4 / 8 LEU A 147
GLY A  65
ALA A  20
ILE A 265
 None
 0.82A 3jusA-5ap9A:
undetectable		 3jusA-5ap9A:
19.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K37_B_BCZB468_1
(NEURAMINIDASE)		 5ap9 LIPASE
(Thermomyces
lanuginosus) 		3 / 3 ARG A 205
GLU A 219
TYR A 261
 None
 0.79A 3k37B-5ap9A:
undetectable		 3k37B-5ap9A:
21.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUF_B_SUEB1201_1
(NS3 PROTEASE, NS4A
PROTEIN)		 5ap9 LIPASE
(Thermomyces
lanuginosus) 		5 / 12 VAL A 203
HIS A 258
ASP A 201
GLY A  82
SER A 146
 None
 0.83A 3sufB-5ap9A:
undetectable		 3sufB-5ap9A:
22.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUF_B_SUEB1201_2
(NS3 PROTEASE, NS4A
PROTEIN)		 5ap9 LIPASE
(Thermomyces
lanuginosus) 		3 / 3 TYR A 194
LEU A 147
ARG A 195
 None
 0.56A 3sufB-5ap9A:
undetectable		 3sufB-5ap9A:
22.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TM4_A_SAMA401_1
(TRNA (GUANINE
N2-)-METHYLTRANSFERA
SE TRM14)		 5ap9 LIPASE
(Thermomyces
lanuginosus) 		4 / 5 SER A 217
THR A 186
GLU A 219
ASP A 201
 None
 1.35A 3tm4A-5ap9A:
undetectable		 3tm4A-5ap9A:
20.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TM4_B_SAMB401_1
(TRNA (GUANINE
N2-)-METHYLTRANSFERA
SE TRM14)		 5ap9 LIPASE
(Thermomyces
lanuginosus) 		4 / 5 SER A 217
THR A 186
GLU A 219
ASP A 201
 None
 1.32A 3tm4B-5ap9A:
undetectable		 3tm4B-5ap9A:
20.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UHX_A_LZUA3008_1
(ALDEHYDE OXIDASE)		 5ap9 LIPASE
(Thermomyces
lanuginosus) 		4 / 8 HIS A 215
ASP A 242
ARG A 179
PRO A 208
 None
 1.18A 4uhxA-5ap9A:
undetectable		 4uhxA-5ap9A:
12.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UHX_A_RTZA3009_1
(ALDEHYDE OXIDASE)		 5ap9 LIPASE
(Thermomyces
lanuginosus) 		4 / 8 HIS A 215
ASP A 242
ARG A 179
PRO A 208
 None
 1.18A 4uhxA-5ap9A:
undetectable		 4uhxA-5ap9A:
12.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AJQ_A_DB8A800_2
(SERINE/THREONINE-PRO
TEIN KINASE 10)		 5ap9 LIPASE
(Thermomyces
lanuginosus) 		4 / 4 VAL A   2
ILE A 196
ASN A  11
VAL A 230
 None
 1.31A 5ajqA-5ap9A:
undetectable		 5ajqA-5ap9A:
21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ERS_A_ACTA803_0
(GEPHYRIN)		 5ap9 LIPASE
(Thermomyces
lanuginosus) 		3 / 3 THR A 199
ALA A 257
ASN A 200
 None
 0.50A 5ersA-5ap9A:
undetectable		 5ersA-5ap9A:
20.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HWK_A_BEZA301_0
(GLUTATHIONE-SPECIFIC
GAMMA-GLUTAMYLCYCLOT
RANSFERASE)		 5ap9 LIPASE
(Thermomyces
lanuginosus) 		5 / 10 GLY A 148
GLY A  82
SER A  83
LEU A 147
LEU A  93
 None
 1.27A 5hwkA-5ap9A:
undetectable		 5hwkA-5ap9A:
20.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HWK_B_BEZB301_0
(GLUTATHIONE-SPECIFIC
GAMMA-GLUTAMYLCYCLOT
RANSFERASE)		 5ap9 LIPASE
(Thermomyces
lanuginosus) 		5 / 10 GLY A 148
GLY A  82
SER A  83
LEU A 147
LEU A  93
 None
 1.27A 5hwkB-5ap9A:
undetectable		 5hwkB-5ap9A:
20.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JLC_A_1YNA602_2
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 5ap9 LIPASE
(Thermomyces
lanuginosus) 		4 / 5 GLY A 191
THR A 192
GLY A  59
LEU A  78
 None
GOL  A 401 (-3.8A)
None
None
 0.91A 5jlcA-5ap9A:
undetectable		 5jlcA-5ap9A:
17.30