SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5apa'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1R15_C_NCAC339_0
(ADP-RIBOSYL CYCLASE)		 5apa ASPARTYL/ASPARAGINYL
BETA-HYDROXYLASE
(Homo
sapiens) 		3 / 3 GLU A 617
ASN A 618
TRP A 625
 LMR  A1760 ( 4.7A)
NI  A1759 ( 4.7A)
LMR  A1760 (-4.2A)
 1.25A 1r15C-5apaA:
undetectable		 1r15C-5apaA:
22.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1R15_D_NCAD349_0
(ADP-RIBOSYL CYCLASE)		 5apa ASPARTYL/ASPARAGINYL
BETA-HYDROXYLASE
(Homo
sapiens) 		3 / 3 GLU A 617
ASN A 618
TRP A 625
 LMR  A1760 ( 4.7A)
NI  A1759 ( 4.7A)
LMR  A1760 (-4.2A)
 1.23A 1r15D-5apaA:
undetectable		 1r15D-5apaA:
22.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1R15_E_NCAE359_0
(ADP-RIBOSYL CYCLASE)		 5apa ASPARTYL/ASPARAGINYL
BETA-HYDROXYLASE
(Homo
sapiens) 		3 / 3 GLU A 617
ASN A 618
TRP A 625
 LMR  A1760 ( 4.7A)
NI  A1759 ( 4.7A)
LMR  A1760 (-4.2A)
 1.25A 1r15E-5apaA:
undetectable		 1r15E-5apaA:
22.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1R15_F_NCAF369_0
(ADP-RIBOSYL CYCLASE)		 5apa ASPARTYL/ASPARAGINYL
BETA-HYDROXYLASE
(Homo
sapiens) 		3 / 3 GLU A 617
ASN A 618
TRP A 625
 LMR  A1760 ( 4.7A)
NI  A1759 ( 4.7A)
LMR  A1760 (-4.2A)
 1.22A 1r15F-5apaA:
undetectable		 1r15F-5apaA:
22.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UOF_A_PNNA1312_0
(DEACETOXYCEPHALOSPOR
IN C SYNTHETASE)		 5apa ASPARTYL/ASPARAGINYL
BETA-HYDROXYLASE
(Homo
sapiens) 		5 / 11 HIS A 679
HIS A 725
VAL A 727
ARG A 735
SER A 668
 NI  A1759 ( 3.2A)
NI  A1759 ( 3.3A)
LMR  A1760 ( 4.9A)
LMR  A1760 (-2.9A)
LMR  A1760 (-2.7A)
 1.23A 1uofA-5apaA:
7.2		 1uofA-5apaA:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1X8V_A_ESLA471_1
(CYTOCHROME P450 51)		 5apa ASPARTYL/ASPARAGINYL
BETA-HYDROXYLASE
(Homo
sapiens) 		4 / 8 TYR A 667
PHE A 612
ALA A 640
MET A 605
 None
 1.04A 1x8vA-5apaA:
undetectable		 1x8vA-5apaA:
18.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
209D_C_DVAC2_0
(N8-ACTINOMYCIN D)		 5apa ASPARTYL/ASPARAGINYL
BETA-HYDROXYLASE
(Homo
sapiens) 		3 / 3 THR A 647
PRO A 645
THR A 649
 None
 0.74A 209dC-5apaA:
undetectable		 209dC-5apaA:
6.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZWE_B_DAHB98_1
(TYROSINASE
MELC)		 5apa ASPARTYL/ASPARAGINYL
BETA-HYDROXYLASE
(Homo
sapiens) 		5 / 11 HIS A 690
ILE A 739
HIS A 679
ASN A 618
ASP A 616
 LMR  A1760 (-3.8A)
LMR  A1760 (-4.0A)
NI  A1759 ( 3.2A)
NI  A1759 ( 4.7A)
None
 1.16A 2zweA-5apaA:
undetectable
2zweB-5apaA:
undetectable		 2zweA-5apaA:
21.88
2zweB-5apaA:
17.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DH0_A_SAMA220_1
(SAM DEPENDENT
METHYLTRANSFERASE)		 5apa ASPARTYL/ASPARAGINYL
BETA-HYDROXYLASE
(Homo
sapiens) 		4 / 8 ARG A 735
ASP A 741
GLN A 664
GLU A 617
 LMR  A1760 (-2.9A)
None
None
LMR  A1760 ( 4.7A)
 1.22A 3dh0A-5apaA:
undetectable		 3dh0A-5apaA:
18.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ONN_A_ACTA271_0
(PROTEIN SSM1)		 5apa ASPARTYL/ASPARAGINYL
BETA-HYDROXYLASE
(Homo
sapiens) 		4 / 5 GLY A 623
LYS A 622
GLU A 621
GLY A 673
 None
 1.00A 3onnA-5apaA:
undetectable		 3onnA-5apaA:
24.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4B9Z_A_ACRA1818_1
(ALPHA-GLUCOSIDASE,
PUTATIVE, ADG31B)		 5apa ASPARTYL/ASPARAGINYL
BETA-HYDROXYLASE
(Homo
sapiens) 		5 / 12 ASP A 741
GLU A 617
ARG A 686
ASP A 721
PHE A 719
 None
LMR  A1760 ( 4.7A)
None
None
None
 1.35A 4b9zA-5apaA:
undetectable		 4b9zA-5apaA:
13.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K7A_A_MXDA1002_1
(ANDROGEN RECEPTOR)		 5apa ASPARTYL/ASPARAGINYL
BETA-HYDROXYLASE
(Homo
sapiens) 		3 / 3 GLU A 713
TRP A 594
LYS A 697
 None
 1.38A 4k7aA-5apaA:
undetectable		 4k7aA-5apaA:
19.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z0F_B_DAHB98_0
(MELC
TYROSINASE)		 5apa ASPARTYL/ASPARAGINYL
BETA-HYDROXYLASE
(Homo
sapiens) 		5 / 11 HIS A 690
ILE A 739
HIS A 679
ASN A 618
ASP A 616
 LMR  A1760 (-3.8A)
LMR  A1760 (-4.0A)
NI  A1759 ( 3.2A)
NI  A1759 ( 4.7A)
None
 1.11A 5z0fA-5apaA:
undetectable
5z0fB-5apaA:
undetectable		 5z0fA-5apaA:
16.51
5z0fB-5apaA:
14.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z0G_B_DAHB98_0
(MELC
TYROSINASE)		 5apa ASPARTYL/ASPARAGINYL
BETA-HYDROXYLASE
(Homo
sapiens) 		5 / 11 HIS A 690
ILE A 739
HIS A 679
ASN A 618
ASP A 616
 LMR  A1760 (-3.8A)
LMR  A1760 (-4.0A)
NI  A1759 ( 3.2A)
NI  A1759 ( 4.7A)
None
 1.11A 5z0gA-5apaA:
undetectable
5z0gB-5apaA:
undetectable		 5z0gA-5apaA:
16.51
5z0gB-5apaA:
14.62