SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5apg'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1S9P_A_DESA459_1
(ESTROGEN-RELATED
RECEPTOR GAMMA)		 5apg TSR3
(Vulcanisaeta
distributa) 		5 / 12 ALA A 118
LEU A  93
TYR A 153
LEU A 164
ILE A 145
 None
EEM  A1185 (-3.9A)
None
None
None
 1.01A 1s9pA-5apgA:
undetectable		 1s9pA-5apgA:
21.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1S9P_D_DESD600_1
(ESTROGEN-RELATED
RECEPTOR GAMMA)		 5apg TSR3
(Vulcanisaeta
distributa) 		5 / 12 ALA A 118
LEU A  93
TYR A 153
LEU A 164
ILE A 145
 None
EEM  A1185 (-3.9A)
None
None
None
 1.10A 1s9pD-5apgA:
undetectable		 1s9pD-5apgA:
21.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EGV_A_SAMA1300_0
(UPF0088 PROTEIN
AQ_165)		 5apg TSR3
(Vulcanisaeta
distributa) 		5 / 12 LEU A  45
LEU A  93
LEU A 110
THR A 112
ALA A 115
 EEM  A1185 (-3.9A)
EEM  A1185 (-3.9A)
EEM  A1185 (-4.1A)
EEM  A1185 (-3.9A)
EEM  A1185 (-3.4A)
 0.46A 2egvA-5apgA:
5.6		 2egvA-5apgA:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EGV_B_SAMB1400_0
(UPF0088 PROTEIN
AQ_165)		 5apg TSR3
(Vulcanisaeta
distributa) 		5 / 12 LEU A  45
LEU A  93
LEU A 110
THR A 112
ALA A 115
 EEM  A1185 (-3.9A)
EEM  A1185 (-3.9A)
EEM  A1185 (-4.1A)
EEM  A1185 (-3.9A)
EEM  A1185 (-3.4A)
 0.42A 2egvB-5apgA:
4.6		 2egvB-5apgA:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NYR_B_SVRB401_3
(NAD-DEPENDENT
DEACETYLASE
SIRTUIN-5)		 5apg TSR3
(Vulcanisaeta
distributa) 		5 / 12 ARG A  58
ILE A  43
PHE A 125
LEU A  96
TYR A 121
 None
 1.39A 2nyrB-5apgA:
undetectable		 2nyrB-5apgA:
20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FGJ_A_1PQA304_0
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 5apg TSR3
(Vulcanisaeta
distributa) 		4 / 8 ILE A 109
TRP A 138
GLY A 105
ASN A 146
 None
 1.01A 4fgjA-5apgA:
undetectable
4fgjB-5apgA:
undetectable		 4fgjA-5apgA:
22.51
4fgjB-5apgA:
22.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X3U_B_SVRB102_1
(CHROMOBOX PROTEIN
HOMOLOG 7)		 5apg TSR3
(Vulcanisaeta
distributa) 		3 / 3 LYS A  50
ARG A 162
VAL A 167
 None
None
MES  A1186 (-4.1A)
 0.91A 4x3uA-5apgA:
undetectable
4x3uB-5apgA:
undetectable		 4x3uA-5apgA:
14.29
4x3uB-5apgA:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5H5F_A_SAMA301_0
(PROTEIN ARGININE
N-METHYLTRANSFERASE
SFM1)		 5apg TSR3
(Vulcanisaeta
distributa) 		5 / 12 LEU A  45
PRO A  47
ARG A  92
LEU A  93
ALA A 115
 EEM  A1185 (-3.9A)
EEM  A1185 (-3.9A)
None
EEM  A1185 (-3.9A)
EEM  A1185 (-3.4A)
 0.78A 5h5fA-5apgA:
7.3		 5h5fA-5apgA:
22.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JH7_D_6K9D502_0
(TUBULIN BETA-2B
CHAIN)		 5apg TSR3
(Vulcanisaeta
distributa) 		5 / 11 ASN A  18
VAL A 116
THR A  19
PRO A   3
LEU A  66
 EEM  A1185 (-3.8A)
None
EEM  A1185 (-2.7A)
None
None
 1.46A 5jh7D-5apgA:
undetectable		 5jh7D-5apgA:
18.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5O96_B_SAMB501_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE E)		 5apg TSR3
(Vulcanisaeta
distributa) 		5 / 9 LEU A  45
PRO A  47
LEU A  93
LEU A 110
ALA A 115
 EEM  A1185 (-3.9A)
EEM  A1185 (-3.9A)
EEM  A1185 (-3.9A)
EEM  A1185 (-4.1A)
EEM  A1185 (-3.4A)
 0.71A 5o96A-5apgA:
5.4
5o96B-5apgA:
5.2		 5o96A-5apgA:
21.51
5o96B-5apgA:
21.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5O96_H_SAMH501_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE E)		 5apg TSR3
(Vulcanisaeta
distributa) 		5 / 10 LEU A  45
PRO A  47
LEU A  93
LEU A 110
ALA A 115
 EEM  A1185 (-3.9A)
EEM  A1185 (-3.9A)
EEM  A1185 (-3.9A)
EEM  A1185 (-4.1A)
EEM  A1185 (-3.4A)
 0.72A 5o96G-5apgA:
4.8
5o96H-5apgA:
5.3		 5o96G-5apgA:
21.51
5o96H-5apgA:
21.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5O96_H_SAMH501_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE E)		 5apg TSR3
(Vulcanisaeta
distributa) 		5 / 10 LEU A  45
PRO A  47
LEU A 110
THR A 112
ALA A 115
 EEM  A1185 (-3.9A)
EEM  A1185 (-3.9A)
EEM  A1185 (-4.1A)
EEM  A1185 (-3.9A)
EEM  A1185 (-3.4A)
 0.72A 5o96G-5apgA:
4.8
5o96H-5apgA:
5.3		 5o96G-5apgA:
21.51
5o96H-5apgA:
21.51