SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5apm'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ETB_2_T442129_1
(TRANSTHYRETIN)		 5apm VP1
VP3
(Parechovirus
A) 		4 / 6 LEU A 119
GLU A 155
THR B  37
ALA B  41
 None
 1.21A 1etb2-5apmA:
undetectable		 1etb2-5apmA:
24.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GAH_A_ACRA497_1
(GLUCOAMYLASE-471)		 5apm VP0
(Parechovirus
A) 		5 / 12 ASP C 194
GLY C 241
TYR C 187
GLU C 188
TYR C 246
 None
 1.47A 1gahA-5apmC:
undetectable		 1gahA-5apmC:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A3C_A_PNXA1435_1
(CHITINASE)		 5apm VP1
VP3
(Parechovirus
A) 		4 / 6 TYR B  61
GLY A  73
PHE A  72
SER A 200
 None
 1.32A 2a3cA-5apmB:
undetectable		 2a3cA-5apmB:
19.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DG4_A_RAPA501_1
(FK506-BINDING
PROTEIN 1A)		 5apm VP1
VP3
(Parechovirus
A) 		5 / 11 PHE A 208
VAL A  68
ILE A  71
PHE A  72
TYR B 135
 None
 1.26A 2dg4A-5apmA:
undetectable		 2dg4A-5apmA:
19.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W1B_A_DXCA2034_0
(ACRIFLAVIN
RESISTANCE PROTEIN B)		 5apm VP0
(Parechovirus
A) 		3 / 3 PHE C 169
SER C 144
LEU C 141
 None
 0.51A 2w1bA-5apmC:
undetectable		 2w1bA-5apmC:
13.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WX2_A_TPFA1460_1
(LANOSTEROL
14-ALPHA-DEMETHYLASE)		 5apm VP1
VP3
(Parechovirus
A) 		4 / 7 PHE A 206
ALA A 108
THR A 216
LEU B 130
 None
 0.95A 2wx2A-5apmA:
undetectable		 2wx2A-5apmA:
17.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KHM_A_TPFA501_1
(STEROL 14
ALPHA-DEMETHYLASE)		 5apm VP1
VP3
(Parechovirus
A) 		4 / 8 PHE A 206
ALA A 108
THR A 216
LEU B 130
 None
 0.96A 3khmA-5apmA:
undetectable		 3khmA-5apmA:
17.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3L4D_D_TPFD490_1
(STEROL 14-ALPHA
DEMETHYLASE)		 5apm VP1
VP3
(Parechovirus
A) 		4 / 8 PHE A 206
ALA A 108
THR A 216
LEU B 130
 None
 1.06A 3l4dD-5apmA:
undetectable		 3l4dD-5apmA:
18.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G19_D_ACTD302_0
(GLUTATHIONE
TRANSFERASE GTE1)		 5apm VP3
(Parechovirus
A) 		3 / 3 TYR B 196
PHE B 246
ARG B 139
 None
 1.15A 4g19D-5apmB:
undetectable		 4g19D-5apmB:
19.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QKN_A_JMSA602_1
(ALPHA-KETOGLUTARATE-
DEPENDENT
DIOXYGENASE FTO)		 5apm VP0
VP3
(Parechovirus
A) 		4 / 8 ARG C 132
LEU C 184
VAL B  84
SER B  83
 None
 1.13A 4qknA-5apmC:
undetectable		 4qknA-5apmC:
19.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QOG_B_ML1B302_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 5apm VP1
VP3
(Parechovirus
A) 		4 / 6 GLY A  40
GLN A  37
ILE A  26
PHE B  82
 None
 1.08A 4qogA-5apmA:
undetectable
4qogB-5apmA:
undetectable		 4qogA-5apmA:
21.79
4qogB-5apmA:
21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4H_A_IPHA904_0
(PROTEIN ARGONAUTE-2)		 5apm VP0
(Parechovirus
A) 		4 / 5 ARG C 150
PRO C 152
ILE C 119
ASP C 148
 None
 1.43A 4z4hA-5apmC:
undetectable		 4z4hA-5apmC:
15.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HUA_A_FK5A201_1
(FK506-BINDING
PROTEIN 1)		 5apm VP1
VP3
(Parechovirus
A) 		5 / 11 PHE A 208
VAL A  68
ILE A  71
TYR B 135
PHE B 245
 None
 1.35A 5huaA-5apmA:
undetectable		 5huaA-5apmA:
18.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QGK_A_ACTA301_0
(PEROXISOMAL COENZYME
A DIPHOSPHATASE
NUDT7)		 5apm VP0
(Parechovirus
A) 		3 / 3 VAL C 247
TYR C 134
GLN C 133
 None
 0.73A 5qgkA-5apmC:
undetectable		 5qgkA-5apmC:
22.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QGT_A_ACTA301_0
(PEROXISOMAL COENZYME
A DIPHOSPHATASE
NUDT7)		 5apm VP0
(Parechovirus
A) 		3 / 3 VAL C 247
TYR C 134
GLN C 133
 None
 0.75A 5qgtA-5apmC:
undetectable		 5qgtA-5apmC:
22.31