SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5aq6'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

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	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)	View	Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1KIJ_B_NOVB444_2 (DNA GYRASE SUBUNIT B)	5aq6	METAL-BINDING PROTEIN ZINT (Escherichia coli)	3 / 3	ASP A 36 PHE A 141 VAL A 92	None	0.66A	1kijB-5aq6A: undetectable	1kijB-5aq6A: 18.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1OE2_A_CUA502_0 (DISSIMILATORY COPPER-CONTAINING NITRITE REDUCTASE)	5aq6	METAL-BINDING PROTEIN ZINT (Escherichia coli)	3 / 3	GLU A 189 HIS A 1 HIS A 193	ZN A1194 (-2.2A) ZN A1194 (-3.1A) ZN A1194 (-3.1A)	0.69A	1oe2A-5aq6A: undetectable	1oe2A-5aq6A: 20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1OE2_A_CUA502_0 (DISSIMILATORY COPPER-CONTAINING NITRITE REDUCTASE)	5aq6	METAL-BINDING PROTEIN ZINT (Escherichia coli)	3 / 3	GLU A 189 HIS A 193 HIS A 6	ZN A1194 (-2.2A) ZN A1194 (-3.1A) ZN A1194 (-3.2A)	0.63A	1oe2A-5aq6A: undetectable	1oe2A-5aq6A: 20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1Y7I_A_SALA502_1 (SALICYLIC ACID-BINDING PROTEIN 2)	5aq6	METAL-BINDING PROTEIN ZINT (Escherichia coli)	3 / 3	LEU A 46 HIS A 75 LYS A 71	None ZN A1197 ( 3.2A) None	1.11A	1y7iA-5aq6A: undetectable	1y7iA-5aq6A: 19.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3KEC_A_HAEA272_1 (COLLAGENASE 3)	5aq6	METAL-BINDING PROTEIN ZINT (Escherichia coli)	4 / 5	LEU A 181 HIS A 1 HIS A 193 HIS A 6	None ZN A1194 (-3.1A) ZN A1194 (-3.1A) ZN A1194 (-3.2A)	0.89A	3kecA-5aq6A: undetectable	3kecA-5aq6A: 20.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3QPK_A_CUA602_0 (LACCASE-1)	5aq6	METAL-BINDING PROTEIN ZINT (Escherichia coli)	3 / 3	HIS A 6 HIS A 193 HIS A 1	ZN A1194 (-3.2A) ZN A1194 (-3.1A) ZN A1194 (-3.1A)	0.49A	3qpkA-5aq6A: undetectable	3qpkA-5aq6A: 14.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3QPK_B_CUB602_0 (LACCASE-1)	5aq6	METAL-BINDING PROTEIN ZINT (Escherichia coli)	3 / 3	HIS A 6 HIS A 193 HIS A 1	ZN A1194 (-3.2A) ZN A1194 (-3.1A) ZN A1194 (-3.1A)	0.47A	3qpkB-5aq6A: undetectable	3qpkB-5aq6A: 14.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4A7B_A_HAEA1273_1 (COLLAGENASE 3)	5aq6	METAL-BINDING PROTEIN ZINT (Escherichia coli)	4 / 6	LEU A 181 HIS A 1 HIS A 193 HIS A 6	None ZN A1194 (-3.1A) ZN A1194 (-3.1A) ZN A1194 (-3.2A)	0.88A	4a7bA-5aq6A: undetectable	4a7bA-5aq6A: 21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4P6X_G_HCYG900_2 (GLUCOCORTICOID RECEPTOR)	5aq6	METAL-BINDING PROTEIN ZINT (Escherichia coli)	3 / 3	LEU A 51 MET A 191 TYR A 73	None	0.83A	4p6xG-5aq6A: undetectable	4p6xG-5aq6A: 22.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5IL1_A_SAMA601_0 (METTL3)	5aq6	METAL-BINDING PROTEIN ZINT (Escherichia coli)	5 / 12	ASP A 81 ILE A 82 PRO A 136 SER A 133 GLU A 93	None None None None ZN A1196 (-2.9A)	1.32A	5il1A-5aq6A: undetectable	5il1A-5aq6A: 19.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5MIG_A_CUA601_0 (LACCASE 2)	5aq6	METAL-BINDING PROTEIN ZINT (Escherichia coli)	3 / 3	HIS A 1 HIS A 193 HIS A 6	ZN A1194 (-3.1A) ZN A1194 (-3.1A) ZN A1194 (-3.2A)	0.59A	5migA-5aq6A: undetectable	5migA-5aq6A: 13.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5MIG_A_CUA601_0 (LACCASE 2)	5aq6	METAL-BINDING PROTEIN ZINT (Escherichia coli)	3 / 3	HIS A 6 HIS A 193 HIS A 1	ZN A1194 (-3.2A) ZN A1194 (-3.1A) ZN A1194 (-3.1A)	0.46A	5migA-5aq6A: undetectable	5migA-5aq6A: 13.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5ZRD_A_CUA607_0 (TYROSINASE)	5aq6	METAL-BINDING PROTEIN ZINT (Escherichia coli)	3 / 3	HIS A 153 HIS A 144 HIS A 155	ZN A1195 (-3.3A) ZN A1195 (-3.2A) ZN A1195 (-3.1A)	0.59A	5zrdA-5aq6A: undetectable	5zrdA-5aq6A: 14.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5ZRD_A_CUA607_0 (TYROSINASE)	5aq6	METAL-BINDING PROTEIN ZINT (Escherichia coli)	3 / 3	HIS A 155 HIS A 153 HIS A 144	ZN A1195 (-3.1A) ZN A1195 (-3.3A) ZN A1195 (-3.2A)	0.50A	5zrdA-5aq6A: undetectable	5zrdA-5aq6A: 14.00

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["1KIJ_B_NOVB444_2","DNA GYRASE SUBUNIT B","5aq6","METAL-BINDING PROTEIN ZINT","Escherichia coli",3,"ASP A  36;PHE A 141;VAL A  92","None","0.66A","1kijB-5aq6A:undetectable","1kijB-5aq6A:18.68"],["1OE2_A_CUA502_0","DISSIMILATORY COPPER-CONTAINING NITRITE REDUCTASE","5aq6","METAL-BINDING PROTEIN ZINT","Escherichia coli",3,"GLU A 189;HIS A   1;HIS A 193"," ZN A1194 (-2.2A); ZN A1194 (-3.1A); ZN A1194 (-3.1A)","0.69A","1oe2A-5aq6A:undetectable","1oe2A-5aq6A:20.63"],["1OE2_A_CUA502_0","DISSIMILATORY COPPER-CONTAINING NITRITE REDUCTASE","5aq6","METAL-BINDING PROTEIN ZINT","Escherichia coli",3,"GLU A 189;HIS A 193;HIS A   6"," ZN A1194 (-2.2A); ZN A1194 (-3.1A); ZN A1194 (-3.2A)","0.63A","1oe2A-5aq6A:undetectable","1oe2A-5aq6A:20.63"],["1Y7I_A_SALA502_1","SALICYLIC ACID-BINDING PROTEIN 2","5aq6","METAL-BINDING PROTEIN ZINT","Escherichia coli",3,"LEU A  46;HIS A  75;LYS A  71","None; ZN A1197 ( 3.2A);None","1.11A","1y7iA-5aq6A:undetectable","1y7iA-5aq6A:19.43"],["3KEC_A_HAEA272_1","COLLAGENASE 3","5aq6","METAL-BINDING PROTEIN ZINT","Escherichia coli",4,"LEU A 181;HIS A   1;HIS A 193;HIS A   6","None; ZN A1194 (-3.1A); ZN A1194 (-3.1A); ZN A1194 (-3.2A)","0.89A","3kecA-5aq6A:undetectable","3kecA-5aq6A:20.38"],["3QPK_A_CUA602_0","LACCASE-1","5aq6","METAL-BINDING PROTEIN ZINT","Escherichia coli",3,"HIS A   6;HIS A 193;HIS A   1"," ZN A1194 (-3.2A); ZN A1194 (-3.1A); ZN A1194 (-3.1A)","0.49A","3qpkA-5aq6A:undetectable","3qpkA-5aq6A:14.59"],["3QPK_B_CUB602_0","LACCASE-1","5aq6","METAL-BINDING PROTEIN ZINT","Escherichia coli",3,"HIS A   6;HIS A 193;HIS A   1"," ZN A1194 (-3.2A); ZN A1194 (-3.1A); ZN A1194 (-3.1A)","0.47A","3qpkB-5aq6A:undetectable","3qpkB-5aq6A:14.59"],["4A7B_A_HAEA1273_1","COLLAGENASE 3","5aq6","METAL-BINDING PROTEIN ZINT","Escherichia coli",4,"LEU A 181;HIS A   1;HIS A 193;HIS A   6","None; ZN A1194 (-3.1A); ZN A1194 (-3.1A); ZN A1194 (-3.2A)","0.88A","4a7bA-5aq6A:undetectable","4a7bA-5aq6A:21.67"],["4P6X_G_HCYG900_2","GLUCOCORTICOID RECEPTOR","5aq6","METAL-BINDING PROTEIN ZINT","Escherichia coli",3,"LEU A  51;MET A 191;TYR A  73","None","0.83A","4p6xG-5aq6A:undetectable","4p6xG-5aq6A:22.14"],["5IL1_A_SAMA601_0","METTL3","5aq6","METAL-BINDING PROTEIN ZINT","Escherichia coli",5,"ASP A  81;ILE A  82;PRO A 136;SER A 133;GLU A  93","None;None;None;None; ZN A1196 (-2.9A)","1.32A","5il1A-5aq6A:undetectable","5il1A-5aq6A:19.37"],["5MIG_A_CUA601_0","LACCASE 2","5aq6","METAL-BINDING PROTEIN ZINT","Escherichia coli",3,"HIS A   1;HIS A 193;HIS A   6"," ZN A1194 (-3.1A); ZN A1194 (-3.1A); ZN A1194 (-3.2A)","0.59A","5migA-5aq6A:undetectable","5migA-5aq6A:13.64"],["5MIG_A_CUA601_0","LACCASE 2","5aq6","METAL-BINDING PROTEIN ZINT","Escherichia coli",3,"HIS A   6;HIS A 193;HIS A   1"," ZN A1194 (-3.2A); ZN A1194 (-3.1A); ZN A1194 (-3.1A)","0.46A","5migA-5aq6A:undetectable","5migA-5aq6A:13.64"],["5ZRD_A_CUA607_0","TYROSINASE","5aq6","METAL-BINDING PROTEIN ZINT","Escherichia coli",3,"HIS A 153;HIS A 144;HIS A 155"," ZN A1195 (-3.3A); ZN A1195 (-3.2A); ZN A1195 (-3.1A)","0.59A","5zrdA-5aq6A:undetectable","5zrdA-5aq6A:14.00"],["5ZRD_A_CUA607_0","TYROSINASE","5aq6","METAL-BINDING PROTEIN ZINT","Escherichia coli",3,"HIS A 155;HIS A 153;HIS A 144"," ZN A1195 (-3.1A); ZN A1195 (-3.3A); ZN A1195 (-3.2A)","0.50A","5zrdA-5aq6A:undetectable","5zrdA-5aq6A:14.00"]]