SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5aul'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QXV_D_MTXD2000_2
(ANTI-METHOTREXATE
CDR1-4 GRAFT VHH)		 5aul PHOSPHATIDYLINOSITOL
3-KINASE REGULATORY
SUBUNIT ALPHA
(Homo
sapiens) 		3 / 3 LEU A 710
ARG A 649
ASN A 673
 None
 0.78A 3qxvD-5aulA:
undetectable		 3qxvD-5aulA:
22.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V4T_D_ACTD502_0
(UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE)		 5aul PHOSPHATIDYLINOSITOL
3-KINASE REGULATORY
SUBUNIT ALPHA
(Homo
sapiens) 		3 / 3 GLY A 678
THR A 677
ASN A 686
 None
GOL  A 801 (-3.2A)
GOL  A 801 (-4.3A)
 0.69A 3v4tD-5aulA:
undetectable		 3v4tD-5aulA:
13.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C49_A_HCYA1384_1
(CORTICOSTEROID-BINDI
NG GLOBULIN)		 5aul PHOSPHATIDYLINOSITOL
3-KINASE REGULATORY
SUBUNIT ALPHA
(Homo
sapiens) 		5 / 12 SER A 660
VAL A 661
GLN A 705
THR A 701
HIS A 697
 None
 1.21A 4c49A-5aulA:
undetectable		 4c49A-5aulA:
17.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K50_A_ACTA505_0
(RNA POLYMERASE
3D-POL)		 5aul PHOSPHATIDYLINOSITOL
3-KINASE REGULATORY
SUBUNIT ALPHA
(Homo
sapiens) 		3 / 3 CYH A 670
ASN A 707
LYS A 668
 None
 1.39A 4k50A-5aulA:
undetectable		 4k50A-5aulA:
13.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LAK_I_BEZI1_0
(3CL PROTEASE
BEZ-TYR-TYR-ASN-ECC
PEPTIDE INHIBITOR)		 5aul PHOSPHATIDYLINOSITOL
3-KINASE REGULATORY
SUBUNIT ALPHA
(Homo
sapiens) 		3 / 3 SER A 690
TYR A 688
TYR A 679
 None
 0.69A 5lakA-5aulA:
undetectable
5lakI-5aulA:
undetectable		 5lakA-5aulA:
16.61
5lakI-5aulA:
9.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LAK_J_BEZJ1_0
(3CL PROTEASE
BEZ-TYR-TYR-ASN-ECC
PEPTIDE INHIBITOR)		 5aul PHOSPHATIDYLINOSITOL
3-KINASE REGULATORY
SUBUNIT ALPHA
(Homo
sapiens) 		3 / 3 SER A 690
TYR A 688
TYR A 679
 None
 0.76A 5lakC-5aulA:
undetectable
5lakJ-5aulA:
undetectable		 5lakC-5aulA:
16.61
5lakJ-5aulA:
9.09