SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5aum'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3QXT_A_MTXA2000_1
(ANTI-METHOTREXATE
CDR1-3 GRAFT VHH)		 5aum HEAVY CHAIN OF FAB
FRAGMENT
(Rattus) 		5 / 12 ALA H  24
MET H  34
ARG H  71
VAL H  78
ALA H  94
 None
 0.64A 3qxtA-5aumH:
19.7		 3qxtA-5aumH:
38.65
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3QXT_A_MTXA2000_1
(ANTI-METHOTREXATE
CDR1-3 GRAFT VHH)		 5aum HEAVY CHAIN OF FAB
FRAGMENT
(Rattus) 		5 / 12 VAL H   2
MET H  34
ARG H  71
VAL H  78
ALA H  94
 None
 0.54A 3qxtA-5aumH:
19.7		 3qxtA-5aumH:
38.65
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3QXT_B_MTXB2000_1
(ANTI-METHOTREXATE
CDR1-3 GRAFT VHH)		 5aum HEAVY CHAIN OF FAB
FRAGMENT
(Rattus) 		6 / 12 LEU H   4
ALA H  24
MET H  34
ARG H  71
VAL H  78
ALA H  94
 None
 0.63A 3qxtB-5aumH:
20.1		 3qxtB-5aumH:
38.65
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3QXT_B_MTXB2000_1
(ANTI-METHOTREXATE
CDR1-3 GRAFT VHH)		 5aum HEAVY CHAIN OF FAB
FRAGMENT
(Rattus) 		6 / 12 VAL H   2
LEU H   4
MET H  34
ARG H  71
VAL H  78
ALA H  94
 None
 0.60A 3qxtB-5aumH:
20.1		 3qxtB-5aumH:
38.65
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3QXV_A_MTXA2000_1
(ANTI-METHOTREXATE
CDR1-4 GRAFT VHH)		 5aum HEAVY CHAIN OF FAB
FRAGMENT
(Rattus) 		6 / 12 VAL H   2
ALA H  24
MET H  34
ARG H  71
VAL H  78
ALA H  94
 None
 0.63A 3qxvA-5aumH:
19.7		 3qxvA-5aumH:
38.16
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3QXV_B_MTXB2000_1
(ANTI-METHOTREXATE
CDR1-4 GRAFT VHH)		 5aum HEAVY CHAIN OF FAB
FRAGMENT
(Rattus) 		6 / 12 VAL H   2
ALA H  24
MET H  34
ARG H  71
VAL H  78
ALA H  94
 None
 0.70A 3qxvB-5aumH:
19.7		 3qxvB-5aumH:
38.16
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3QXV_C_MTXC2000_1
(ANTI-METHOTREXATE
CDR1-4 GRAFT VHH)		 5aum HEAVY CHAIN OF FAB
FRAGMENT
(Rattus) 		6 / 11 VAL H   2
ALA H  24
MET H  34
ARG H  71
VAL H  78
ALA H  94
 None
 0.70A 3qxvC-5aumH:
20.0		 3qxvC-5aumH:
38.16
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3QXV_D_MTXD2000_1
(ANTI-METHOTREXATE
CDR1-4 GRAFT VHH)		 5aum HEAVY CHAIN OF FAB
FRAGMENT
(Rattus) 		5 / 12 ALA H  24
MET H  34
ARG H  71
VAL H  78
ALA H  94
 None
 0.67A 3qxvD-5aumH:
19.7		 3qxvD-5aumH:
38.16
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3QXV_D_MTXD2000_1
(ANTI-METHOTREXATE
CDR1-4 GRAFT VHH)		 5aum HEAVY CHAIN OF FAB
FRAGMENT
(Rattus) 		5 / 12 VAL H   2
MET H  34
ARG H  71
VAL H  78
ALA H  94
 None
 0.58A 3qxvD-5aumH:
19.7		 3qxvD-5aumH:
38.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUE_D_SUED1201_2
(NS3 PROTEASE, NS4A
PROTEIN)		 5aum HEAVY CHAIN OF FAB
FRAGMENT
(Rattus) 		3 / 3 TYR H  35
LEU H  18
LYS H  19
 None
 0.78A 3sueD-5aumH:
undetectable		 3sueD-5aumH:
23.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IKL_A_SUZA201_1
(TRANSTHYRETIN)		 5aum HEAVY CHAIN OF FAB
FRAGMENT
(Rattus) 		4 / 7 LYS H   1
SER H  76
THR H  28
SER H  30
 None
 1.13A 4iklA-5aumH:
3.3
4iklB-5aumH:
undetectable		 4iklA-5aumH:
20.34
4iklB-5aumH:
20.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P6X_G_HCYG900_2
(GLUCOCORTICOID
RECEPTOR)		 5aum HEAVY CHAIN OF FAB
FRAGMENT
(Rattus) 		3 / 3 LEU H   4
MET H  77
TYR H  35
 None
 0.95A 4p6xG-5aumH:
undetectable		 4p6xG-5aumH:
19.41
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5MTH_A_ACTA302_0
(ANTIBODY FAB HEAVY
CHAIN)		 5aum HEAVY CHAIN OF FAB
FRAGMENT
(Rattus) 		4 / 5 SER H 112
ALA H 114
PHE H 146
LEU H 170
 None
 0.33A 5mthA-5aumH:
18.4		 5mthA-5aumH:
57.02