SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5avi'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID
Hit
Macromolecule
Res.
Matches
Interface HETATM RMSD Dali
Z-score
Seq.
Identity (%)
View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CBS_A_REAA200_1
(CELLULAR RETINOIC
ACID BINDING PROTEIN
TYPE II)
5avi OXYSTEROLS RECEPTOR
LXR-ALPHA

(Homo
sapiens)
5 / 12 PHE A 271
LEU A 275
ILE A 362
ALA A 361
ALA A 357
None
1.11A 1cbsA-5aviA:
undetectable
1cbsA-5aviA:
18.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UKB_A_BEZA1301_0
(2-HYDROXY-6-OXO-7-ME
THYLOCTA-2,4-DIENOAT
E HYDROLASE)
5avi OXYSTEROLS RECEPTOR
LXR-ALPHA

(Homo
sapiens)
4 / 6 LEU A 359
PHE A 356
ALA A 357
LEU A 389
None
0.99A 1ukbA-5aviA:
undetectable
1ukbA-5aviA:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IGZ_A_SPRA404_2
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E II)
5avi OXYSTEROLS RECEPTOR
LXR-ALPHA

(Homo
sapiens)
5 / 9 LEU A 414
ILE A 339
GLU A 341
PHE A 342
GLU A 301
None
4KM  A 501 ( 4.0A)
None
None
None
1.49A 5igzA-5aviA:
undetectable
5igzA-5aviA:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6E43_A_BEZA502_0
(INDOLEAMINE
2,3-DIOXYGENASE 1)
5avi OXYSTEROLS RECEPTOR
LXR-ALPHA

(Homo
sapiens)
4 / 6 PHE A 335
LEU A 414
LEU A 417
HIS A 421
4KM  A 501 (-4.6A)
None
None
4KM  A 501 ( 4.8A)
0.82A 6e43A-5aviA:
undetectable
6e43A-5aviA:
22.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6E43_B_BEZB502_0
(INDOLEAMINE
2,3-DIOXYGENASE 1)
5avi OXYSTEROLS RECEPTOR
LXR-ALPHA

(Homo
sapiens)
4 / 6 PHE A 335
LEU A 414
LEU A 417
HIS A 421
4KM  A 501 (-4.6A)
None
None
4KM  A 501 ( 4.8A)
0.83A 6e43B-5aviA:
undetectable
6e43B-5aviA:
22.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6E43_C_BEZC502_0
(INDOLEAMINE
2,3-DIOXYGENASE 1)
5avi OXYSTEROLS RECEPTOR
LXR-ALPHA

(Homo
sapiens)
4 / 6 PHE A 335
LEU A 414
LEU A 417
HIS A 421
4KM  A 501 (-4.6A)
None
None
4KM  A 501 ( 4.8A)
0.85A 6e43C-5aviA:
undetectable
6e43C-5aviA:
22.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6E43_D_BEZD502_0
(INDOLEAMINE
2,3-DIOXYGENASE 1)
5avi OXYSTEROLS RECEPTOR
LXR-ALPHA

(Homo
sapiens)
4 / 6 PHE A 335
LEU A 414
LEU A 417
HIS A 421
4KM  A 501 (-4.6A)
None
None
4KM  A 501 ( 4.8A)
0.82A 6e43D-5aviA:
undetectable
6e43D-5aviA:
22.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6J20_A_GBQA1201_1
(SUBSTANCE-P
RECEPTOR,ENDOLYSIN)
5avi OXYSTEROLS RECEPTOR
LXR-ALPHA

(Homo
sapiens)
4 / 7 ILE A 360
GLN A 221
GLU A 267
VAL A 297
None
1.17A 6j20A-5aviA:
undetectable
6j20A-5aviA:
18.59