SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5avm'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID
Hit
Macromolecule
Res.
Matches
Interface HETATM RMSD Dali
Z-score
Seq.
Identity (%)
View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KT6_A_RTLA184_0
(PLASMA
RETINOL-BINDING
PROTEIN)
5avm PHOSPHORIBOSYLFORMYL
GLYCINAMIDINE
CYCLO-LIGASE

(Thermus
thermophilus)
5 / 11 LEU A 156
LEU A  83
ALA A 106
VAL A  84
LEU A 133
None
1.44A 1kt6A-5avmA:
undetectable
1kt6A-5avmA:
19.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1T69_A_SHHA379_1
(HISTONE DEACETYLASE
8)
5avm PHOSPHORIBOSYLFORMYL
GLYCINAMIDINE
CYCLO-LIGASE

(Thermus
thermophilus)
5 / 12 HIS A 243
GLY A 246
ASP A  90
HIS A  86
ASP A  61
None
1.38A 1t69A-5avmA:
undetectable
1t69A-5avmA:
21.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZUC_B_T98B202_1
(PROGESTERONE
RECEPTOR)
5avm PHOSPHORIBOSYLFORMYL
GLYCINAMIDINE
CYCLO-LIGASE

(Thermus
thermophilus)
5 / 12 LEU A 119
LEU A 118
LEU A  79
LEU A  71
LEU A 110
None
1.17A 1zucB-5avmA:
undetectable
1zucB-5avmA:
18.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D90_B_NOGB2001_1
(PROGESTERONE
RECEPTOR)
5avm PHOSPHORIBOSYLFORMYL
GLYCINAMIDINE
CYCLO-LIGASE

(Thermus
thermophilus)
5 / 12 LEU A 119
LEU A 118
LEU A  79
LEU A  71
LEU A 110
None
1.20A 3d90B-5avmA:
undetectable
3d90B-5avmA:
18.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KP2_A_PNNA5001_0
(TRANSCRIPTIONAL
REGULATOR TCAR)
5avm PHOSPHORIBOSYLFORMYL
GLYCINAMIDINE
CYCLO-LIGASE

(Thermus
thermophilus)
5 / 8 THR A  59
LEU A  91
GLN A  94
HIS A 243
ASN A 188
None
1.49A 3kp2A-5avmA:
undetectable
3kp2B-5avmA:
undetectable
3kp2A-5avmA:
20.00
3kp2B-5avmA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KP4_A_MIIA2001_1
(TRANSCRIPTIONAL
REGULATOR TCAR)
5avm PHOSPHORIBOSYLFORMYL
GLYCINAMIDINE
CYCLO-LIGASE

(Thermus
thermophilus)
5 / 9 THR A  59
LEU A  91
GLN A  94
HIS A 243
ASN A 188
None
1.42A 3kp4A-5avmA:
undetectable
3kp4B-5avmA:
undetectable
3kp4A-5avmA:
20.00
3kp4B-5avmA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P2K_C_SAMC6735_0
(16S RRNA METHYLASE)
5avm PHOSPHORIBOSYLFORMYL
GLYCINAMIDINE
CYCLO-LIGASE

(Thermus
thermophilus)
5 / 12 GLY A 299
ALA A  93
PHE A 319
LEU A 302
TRP A 270
None
1.09A 3p2kC-5avmA:
undetectable
3p2kC-5avmA:
21.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MA3_L_ACTL301_0
(C2095 HEAVY CHAIN
C2095 LIGHT CHAIN)
5avm PHOSPHORIBOSYLFORMYL
GLYCINAMIDINE
CYCLO-LIGASE

(Thermus
thermophilus)
3 / 3 PRO A 273
ASN A 295
HIS A 186
None
0.87A 4ma3H-5avmA:
undetectable
4ma3L-5avmA:
undetectable
4ma3H-5avmA:
21.36
4ma3L-5avmA:
19.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEI_A_SHHA2004_1
(HDAC6 PROTEIN)
5avm PHOSPHORIBOSYLFORMYL
GLYCINAMIDINE
CYCLO-LIGASE

(Thermus
thermophilus)
5 / 12 HIS A 243
GLY A 246
ASP A  90
HIS A  86
ASP A  61
None
1.41A 5eeiA-5avmA:
undetectable
5eeiA-5avmA:
21.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEI_B_SHHB801_1
(HDAC6 PROTEIN)
5avm PHOSPHORIBOSYLFORMYL
GLYCINAMIDINE
CYCLO-LIGASE

(Thermus
thermophilus)
5 / 12 HIS A 243
GLY A 246
ASP A  90
HIS A  86
ASP A  61
None
1.42A 5eeiB-5avmA:
undetectable
5eeiB-5avmA:
21.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N4T_B_BEZB306_0
(BETA-LACTAMASE VIM-2)
5avm PHOSPHORIBOSYLFORMYL
GLYCINAMIDINE
CYCLO-LIGASE

(Thermus
thermophilus)
3 / 3 HIS A  86
ASN A  89
ALA A  93
None
0.44A 5n4tB-5avmA:
undetectable
5n4tB-5avmA:
23.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A7P_A_9SCA601_1
(SERUM ALBUMIN)
5avm PHOSPHORIBOSYLFORMYL
GLYCINAMIDINE
CYCLO-LIGASE

(Thermus
thermophilus)
4 / 5 ASN A 295
TYR A 190
VAL A  63
LEU A  79
None
1.21A 6a7pA-5avmA:
undetectable
6a7pA-5avmA:
20.10