SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5avo'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JIP_A_KTNA801_1
(CYTOCHROME P450
107A1)		 5avo HOMOSERINE
DEHYDROGENASE
(Sulfurisphaera
tokodaii) 		5 / 12 PHE A 125
GLY A 132
LEU A   5
ALA A  14
THR A 128
 None
 1.17A 1jipA-5avoA:
undetectable		 1jipA-5avoA:
22.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ACL_G_REAG501_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 5avo HOMOSERINE
DEHYDROGENASE
(Sulfurisphaera
tokodaii) 		5 / 12 ILE A 201
ALA A 198
ALA A 197
LEU A 235
ILE A 236
 None
 0.97A 2aclG-5avoA:
undetectable		 2aclG-5avoA:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXQ_A_P1ZA2002_1
(SERUM ALBUMIN)		 5avo HOMOSERINE
DEHYDROGENASE
(Sulfurisphaera
tokodaii) 		6 / 12 LEU A  27
LEU A  19
LEU A   3
ILE A  68
ILE A  98
ALA A 292
 None
 1.36A 2bxqA-5avoA:
undetectable		 2bxqA-5avoA:
19.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VCV_L_ASDL1224_1
(GLUTATHIONE
S-TRANSFERASE A3)		 5avo HOMOSERINE
DEHYDROGENASE
(Sulfurisphaera
tokodaii) 		4 / 7 PHE A 195
ALA A 106
ALA A 198
PHE A 220
 None
 1.02A 2vcvL-5avoA:
undetectable		 2vcvL-5avoA:
22.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WEK_A_DIFA1374_1
(ZINC-BINDING ALCOHOL
DEHYDROGENASE
DOMAIN-CONTAINING
PROTEIN 2)		 5avo HOMOSERINE
DEHYDROGENASE
(Sulfurisphaera
tokodaii) 		4 / 5 MET A   1
PRO A  66
ASN A  96
LEU A 299
 None
 1.16A 2wekA-5avoA:
3.1		 2wekA-5avoA:
21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WEK_B_DIFB1374_1
(ZINC-BINDING ALCOHOL
DEHYDROGENASE
DOMAIN-CONTAINING
PROTEIN 2)		 5avo HOMOSERINE
DEHYDROGENASE
(Sulfurisphaera
tokodaii) 		4 / 6 MET A   1
PRO A  66
ASN A  96
LEU A 299
 None
 1.19A 2wekB-5avoA:
5.3		 2wekB-5avoA:
21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XF3_A_J01A500_1
(ORF12)		 5avo HOMOSERINE
DEHYDROGENASE
(Sulfurisphaera
tokodaii) 		5 / 10 VAL A 147
ILE A 269
LEU A 267
GLY A 152
ALA A 237
 None
 1.24A 2xf3A-5avoA:
undetectable		 2xf3A-5avoA:
20.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XKW_A_P1BA1478_2
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 5avo HOMOSERINE
DEHYDROGENASE
(Sulfurisphaera
tokodaii) 		4 / 7 GLU A 264
ILE A 278
ALA A 239
ILE A 209
 None
 0.70A 2xkwA-5avoA:
undetectable		 2xkwA-5avoA:
21.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BUF_A_AEGA394_0
(BETA-SECRETASE 1)		 5avo HOMOSERINE
DEHYDROGENASE
(Sulfurisphaera
tokodaii) 		4 / 5 LEU A   5
ILE A  98
ILE A  32
GLY A  12
 None
 0.89A 3bufA-5avoA:
undetectable		 3bufA-5avoA:
22.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CWK_A_REAA300_1
(CELLULAR RETINOIC
ACID-BINDING PROTEIN
2)		 5avo HOMOSERINE
DEHYDROGENASE
(Sulfurisphaera
tokodaii) 		5 / 12 LEU A 154
LEU A 235
ALA A 237
ALA A 239
VAL A 213
 None
 1.14A 3cwkA-5avoA:
undetectable		 3cwkA-5avoA:
18.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F84_A_SAMA501_0
(GERANYL DIPHOSPHATE
2-C-METHYLTRANSFERAS
E)		 5avo HOMOSERINE
DEHYDROGENASE
(Sulfurisphaera
tokodaii) 		5 / 12 GLY A 282
GLY A 280
VAL A 263
ASN A 155
SER A 131
 None
 1.21A 4f84A-5avoA:
undetectable		 4f84A-5avoA:
19.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IV0_B_SAMB302_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE,
PUTATIVE)		 5avo HOMOSERINE
DEHYDROGENASE
(Sulfurisphaera
tokodaii) 		5 / 12 GLY A 291
GLY A 132
ILE A 136
ARG A  23
SER A 294
 None
 1.09A 4iv0B-5avoA:
undetectable		 4iv0B-5avoA:
22.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J03_A_FVSA603_1
(BIFUNCTIONAL EPOXIDE
HYDROLASE 2)		 5avo HOMOSERINE
DEHYDROGENASE
(Sulfurisphaera
tokodaii) 		5 / 12 ASP A  45
ILE A  68
TYR A   8
LEU A  19
HIS A  20
 None
 1.21A 4j03A-5avoA:
2.6		 4j03A-5avoA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J26_B_ESTB600_1
(ESTROGEN RECEPTOR
BETA)		 5avo HOMOSERINE
DEHYDROGENASE
(Sulfurisphaera
tokodaii) 		5 / 12 LEU A  18
LEU A  27
ILE A  98
ILE A  68
LEU A   5
 None
 1.22A 4j26B-5avoA:
undetectable		 4j26B-5avoA:
21.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KOS_A_4KOA201_1
(UNCHARACTERIZED
PROTEIN)		 5avo HOMOSERINE
DEHYDROGENASE
(Sulfurisphaera
tokodaii) 		5 / 12 ARG A 140
GLY A 124
ILE A  97
PHE A 109
TYR A  87
 None
 1.38A 4kosA-5avoA:
undetectable		 4kosA-5avoA:
19.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KOT_A_CE3A205_1
(UNCHARACTERIZED
PROTEIN)		 5avo HOMOSERINE
DEHYDROGENASE
(Sulfurisphaera
tokodaii) 		5 / 12 ARG A 140
GLY A 124
ILE A  97
PHE A 109
TYR A  87
 None
 1.42A 4kotA-5avoA:
undetectable		 4kotA-5avoA:
19.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KOV_A_KOVA204_1
(UNCHARACTERIZED
PROTEIN)		 5avo HOMOSERINE
DEHYDROGENASE
(Sulfurisphaera
tokodaii) 		5 / 12 ARG A 140
GLY A 124
ILE A  97
PHE A 109
TYR A  87
 None
 1.41A 4kovA-5avoA:
undetectable		 4kovA-5avoA:
19.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MWZ_A_SAMA301_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE,
PUTATIVE)		 5avo HOMOSERINE
DEHYDROGENASE
(Sulfurisphaera
tokodaii) 		5 / 12 GLY A 291
GLY A 132
ILE A 136
ARG A  23
SER A 294
 None
 1.10A 4mwzA-5avoA:
2.5		 4mwzA-5avoA:
22.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OLT_A_GCSA303_1
(CHITOSANASE)		 5avo HOMOSERINE
DEHYDROGENASE
(Sulfurisphaera
tokodaii) 		4 / 6 ILE A  32
ASP A  45
ARG A  16
GLY A  12
 None
 1.00A 4oltA-5avoA:
undetectable		 4oltA-5avoA:
24.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OLT_B_GCSB303_1
(CHITOSANASE)		 5avo HOMOSERINE
DEHYDROGENASE
(Sulfurisphaera
tokodaii) 		4 / 6 ILE A  32
ASP A  45
ARG A  16
GLY A  12
 None
 1.03A 4oltB-5avoA:
undetectable		 4oltB-5avoA:
24.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TOA_A_ESTA601_1
(ESTROGEN RECEPTOR
BETA)		 5avo HOMOSERINE
DEHYDROGENASE
(Sulfurisphaera
tokodaii) 		5 / 12 ALA A 289
LEU A  18
ILE A  68
LEU A  27
LEU A   5
 None
 1.01A 5toaA-5avoA:
undetectable		 5toaA-5avoA:
21.85