SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5avp'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OE2_A_CUA502_0
(DISSIMILATORY
COPPER-CONTAINING
NITRITE REDUCTASE)		 5avp L-RIBOSE ISOMERASE
(Geodermatophilus
obscurus) 		3 / 3 GLU A 117
HIS A 192
HIS A 112
 MN  A 401 (-2.3A)
MN  A 401 (-3.5A)
MN  A 401 (-3.5A)
 0.66A 1oe2A-5avpA:
1.2		 1oe2A-5avpA:
23.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1T9W_A_NFNA6001_1
(ACRIFLAVINE
RESISTANCE PROTEIN B)		 5avp L-RIBOSE ISOMERASE
(Geodermatophilus
obscurus) 		3 / 3 SER A 245
GLY A 246
ARG A 164
 None
 0.54A 1t9wA-5avpA:
undetectable		 1t9wA-5avpA:
13.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TUV_A_VK3A4558_1
(PROTEIN YGIN)		 5avp L-RIBOSE ISOMERASE
(Geodermatophilus
obscurus) 		4 / 7 GLU A 208
HIS A 112
MET A  67
ILE A  69
 None
MN  A 401 (-3.5A)
None
None
 0.92A 1tuvA-5avpA:
undetectable		 1tuvA-5avpA:
17.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Y93_A_HAEA301_1
(MACROPHAGE
METALLOELASTASE)		 5avp L-RIBOSE ISOMERASE
(Geodermatophilus
obscurus) 		4 / 6 ILE A  69
HIS A 110
HIS A 192
HIS A 112
 None
MN  A 401 (-3.4A)
MN  A 401 (-3.5A)
MN  A 401 (-3.5A)
 0.98A 1y93A-5avpA:
undetectable		 1y93A-5avpA:
18.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2B82_A_ADNA1001_1
(CLASS B ACID
PHOSPHATASE)		 5avp L-RIBOSE ISOMERASE
(Geodermatophilus
obscurus) 		5 / 10 PHE A 129
GLU A  65
TYR A 168
LEU A 160
GLY A 157
 None
 1.40A 2b82A-5avpA:
undetectable		 2b82A-5avpA:
21.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2R2V_C_ACTC36_0
(GCN4 LEUCINE ZIPPER)		 5avp L-RIBOSE ISOMERASE
(Geodermatophilus
obscurus) 		5 / 10 ALA A 241
ASN A 244
ALA A 243
ALA A 240
SER A 167
 None
 1.31A 2r2vC-5avpA:
undetectable
2r2vF-5avpA:
undetectable
2r2vG-5avpA:
undetectable		 2r2vC-5avpA:
7.92
2r2vF-5avpA:
7.92
2r2vG-5avpA:
7.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G89_A_SAMA303_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE G)		 5avp L-RIBOSE ISOMERASE
(Geodermatophilus
obscurus) 		5 / 12 GLY A 246
ALA A 242
ARG A 164
GLU A  65
ALA A 251
 None
 1.04A 3g89A-5avpA:
undetectable		 3g89A-5avpA:
23.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LJG_A_HAEA301_1
(MACROPHAGE
METALLOELASTASE)		 5avp L-RIBOSE ISOMERASE
(Geodermatophilus
obscurus) 		4 / 5 ILE A  69
HIS A 110
HIS A 192
HIS A 112
 None
MN  A 401 (-3.4A)
MN  A 401 (-3.5A)
MN  A 401 (-3.5A)
 0.98A 3ljgA-5avpA:
undetectable		 3ljgA-5avpA:
18.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4B17_A_SAMA1358_0
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE M)		 5avp L-RIBOSE ISOMERASE
(Geodermatophilus
obscurus) 		5 / 12 CYH A 196
PRO A 103
GLY A 104
MET A  67
VAL A  68
 None
 1.12A 4b17A-5avpA:
undetectable		 4b17A-5avpA:
20.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F3T_A_IPHA902_0
(PROTEIN ARGONAUTE-2)		 5avp L-RIBOSE ISOMERASE
(Geodermatophilus
obscurus) 		4 / 6 LEU A  94
TYR A 212
LEU A  73
GLU A  71
 None
 1.15A 4f3tA-5avpA:
undetectable		 4f3tA-5avpA:
15.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JVL_A_ESTA702_1
(ESTROGEN
SULFOTRANSFERASE)		 5avp L-RIBOSE ISOMERASE
(Geodermatophilus
obscurus) 		4 / 9 LYS A 115
PHE A 194
ILE A  44
MET A  67
 MN  A 401 ( 3.9A)
None
None
None
 1.36A 4jvlA-5avpA:
undetectable		 4jvlA-5avpA:
22.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M5M_A_DX4A401_0
(2-AMINO-4-HYDROXY-6-
HYDROXYMETHYLDIHYDRO
PTERIDINE
PYROPHOSPHOKINASE)		 5avp L-RIBOSE ISOMERASE
(Geodermatophilus
obscurus) 		4 / 8 GLY A  26
LEU A  19
TRP A  18
PHE A  70
 None
 1.21A 4m5mA-5avpA:
undetectable		 4m5mA-5avpA:
22.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XMF_A_HSMA202_1
(NITROPHORIN-7)		 5avp L-RIBOSE ISOMERASE
(Geodermatophilus
obscurus) 		3 / 3 ASP A 201
LEU A 123
GLY A 124
 None
 0.45A 4xmfA-5avpA:
undetectable		 4xmfA-5avpA:
18.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5D0Y_A_FOLA201_0
(CONSERVED
HYPOTHETICAL
MEMBRANE PROTEIN)		 5avp L-RIBOSE ISOMERASE
(Geodermatophilus
obscurus) 		5 / 12 LEU A 204
ASP A  96
SER A  72
TYR A 119
HIS A 192
 None
None
None
None
MN  A 401 (-3.5A)
 1.35A 5d0yA-5avpA:
undetectable		 5d0yA-5avpA:
23.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L6E_A_SAMA601_0
(N6-ADENOSINE-METHYLT
RANSFERASE 70 KDA
SUBUNIT)		 5avp L-RIBOSE ISOMERASE
(Geodermatophilus
obscurus) 		5 / 12 ILE A  44
PRO A 108
PHE A  46
GLY A  47
GLY A 246
 None
 1.09A 5l6eA-5avpA:
undetectable		 5l6eA-5avpA:
22.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N5K_A_HAEA306_1
(MACROPHAGE
METALLOELASTASE)		 5avp L-RIBOSE ISOMERASE
(Geodermatophilus
obscurus) 		4 / 5 ILE A  69
HIS A 110
HIS A 192
HIS A 112
 None
MN  A 401 (-3.4A)
MN  A 401 (-3.5A)
MN  A 401 (-3.5A)
 0.99A 5n5kA-5avpA:
undetectable		 5n5kA-5avpA:
18.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5PAH_A_LDPA600_1
(PHENYLALANINE
4-MONOOXYGENASE)		 5avp L-RIBOSE ISOMERASE
(Geodermatophilus
obscurus) 		4 / 4 HIS A 110
HIS A 192
TYR A 119
GLU A 117
 MN  A 401 (-3.4A)
MN  A 401 (-3.5A)
None
MN  A 401 (-2.3A)
 1.25A 5pahA-5avpA:
undetectable		 5pahA-5avpA:
22.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5PAH_A_LDPA600_1
(PHENYLALANINE
4-MONOOXYGENASE)		 5avp L-RIBOSE ISOMERASE
(Geodermatophilus
obscurus) 		4 / 4 HIS A 112
HIS A 192
TYR A 119
GLU A 117
 MN  A 401 (-3.5A)
MN  A 401 (-3.5A)
None
MN  A 401 (-2.3A)
 1.16A 5pahA-5avpA:
undetectable		 5pahA-5avpA:
22.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZRD_A_CUA607_0
(TYROSINASE)		 5avp L-RIBOSE ISOMERASE
(Geodermatophilus
obscurus) 		3 / 3 HIS A 110
HIS A 192
HIS A 112
 MN  A 401 (-3.4A)
MN  A 401 (-3.5A)
MN  A 401 (-3.5A)
 0.42A 5zrdA-5avpA:
undetectable		 5zrdA-5avpA:
17.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GTQ_A_ACTA204_0
(N-ACETYLTRANSFERASE)		 5avp L-RIBOSE ISOMERASE
(Geodermatophilus
obscurus) 		4 / 5 LEU A  73
CYH A  95
THR A 211
GLY A  93
 None
 1.26A 6gtqA-5avpA:
undetectable		 6gtqA-5avpA:
18.59