SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5awe'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FKP_A_NVPA999_1
(HIV-1 RT, A-CHAIN)		 5awe PUTATIVE ACETOIN
UTILIZATION PROTEIN,
ACETOIN
DEHYDROGENASE
(Thermus
thermophilus) 		5 / 11 PRO A  11
LEU A 117
VAL A  85
VAL A  37
GLY A  45
 None
 1.25A 1fkpA-5aweA:
3.0		 1fkpA-5aweA:
16.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LWC_A_NVPA999_1
(HIV-1 REVERSE
TRANSCRIPTASE)		 5awe PUTATIVE ACETOIN
UTILIZATION PROTEIN,
ACETOIN
DEHYDROGENASE
(Thermus
thermophilus) 		5 / 11 PRO A  11
LEU A 117
VAL A  85
VAL A  37
GLY A  45
 None
 1.27A 1lwcA-5aweA:
3.4		 1lwcA-5aweA:
15.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QEI_A_CXXA802_1
(TRANSPORTER)		 5awe PUTATIVE ACETOIN
UTILIZATION PROTEIN,
ACETOIN
DEHYDROGENASE
(Thermus
thermophilus) 		4 / 6 ARG A  33
ARG A  34
PHE A  32
ILE A 120
 None
 1.25A 2qeiA-5aweA:
undetectable		 2qeiA-5aweA:
18.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QO4_A_CHDA130_0
(LIVER-BASIC FATTY
ACID BINDING PROTEIN)		 5awe PUTATIVE ACETOIN
UTILIZATION PROTEIN,
ACETOIN
DEHYDROGENASE
(Thermus
thermophilus) 		5 / 12 ALA A  97
VAL A  88
THR A   8
MET A   7
ASP A 125
 None
 1.15A 2qo4A-5aweA:
undetectable		 2qo4A-5aweA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QO4_A_CHDA130_0
(LIVER-BASIC FATTY
ACID BINDING PROTEIN)		 5awe PUTATIVE ACETOIN
UTILIZATION PROTEIN,
ACETOIN
DEHYDROGENASE
(Thermus
thermophilus) 		5 / 12 VAL A  88
THR A   8
MET A   7
ASP A 125
PHE A  32
 None
 1.03A 2qo4A-5aweA:
undetectable		 2qo4A-5aweA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KPB_A_SAMA1000_0
(UNCHARACTERIZED
PROTEIN MJ0100)		 5awe PUTATIVE ACETOIN
UTILIZATION PROTEIN,
ACETOIN
DEHYDROGENASE
(Thermus
thermophilus) 		5 / 12 ILE A 120
THR A 122
ASP A 125
THR A   8
PRO A  36
 None
 0.66A 3kpbA-5aweA:
12.1		 3kpbA-5aweA:
24.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KPB_A_SAMA1000_0
(UNCHARACTERIZED
PROTEIN MJ0100)		 5awe PUTATIVE ACETOIN
UTILIZATION PROTEIN,
ACETOIN
DEHYDROGENASE
(Thermus
thermophilus) 		5 / 12 THR A  48
ASP A  51
VAL A  85
ILE A 106
PRO A 110
 None
 0.60A 3kpbA-5aweA:
12.1		 3kpbA-5aweA:
24.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KPB_C_SAMC1000_0
(UNCHARACTERIZED
PROTEIN MJ0100)		 5awe PUTATIVE ACETOIN
UTILIZATION PROTEIN,
ACETOIN
DEHYDROGENASE
(Thermus
thermophilus) 		5 / 12 ILE A 120
THR A 122
ASP A 125
THR A   8
PRO A  36
 None
 0.63A 3kpbC-5aweA:
12.2		 3kpbC-5aweA:
24.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KPB_C_SAMC1000_0
(UNCHARACTERIZED
PROTEIN MJ0100)		 5awe PUTATIVE ACETOIN
UTILIZATION PROTEIN,
ACETOIN
DEHYDROGENASE
(Thermus
thermophilus) 		5 / 12 THR A  48
ASP A  51
VAL A  85
ILE A 106
PRO A 110
 None
 0.67A 3kpbC-5aweA:
12.2		 3kpbC-5aweA:
24.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KPC_A_SAMA1000_0
(UNCHARACTERIZED
PROTEIN MJ0100)		 5awe PUTATIVE ACETOIN
UTILIZATION PROTEIN,
ACETOIN
DEHYDROGENASE
(Thermus
thermophilus) 		5 / 11 ILE A 120
THR A 122
ASP A 125
THR A   8
PRO A  36
 None
 0.66A 3kpcA-5aweA:
12.5		 3kpcA-5aweA:
24.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KPC_A_SAMA1000_0
(UNCHARACTERIZED
PROTEIN MJ0100)		 5awe PUTATIVE ACETOIN
UTILIZATION PROTEIN,
ACETOIN
DEHYDROGENASE
(Thermus
thermophilus) 		5 / 11 THR A  48
ASP A  51
VAL A  85
ILE A 106
PRO A 110
 None
 0.58A 3kpcA-5aweA:
12.5		 3kpcA-5aweA:
24.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KPD_B_SAMB1000_0
(UNCHARACTERIZED
PROTEIN MJ0100)		 5awe PUTATIVE ACETOIN
UTILIZATION PROTEIN,
ACETOIN
DEHYDROGENASE
(Thermus
thermophilus) 		5 / 12 ILE A 120
THR A 122
ASP A 125
THR A   8
PRO A  36
 None
 0.68A 3kpdB-5aweA:
11.9		 3kpdB-5aweA:
24.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KPD_B_SAMB1000_0
(UNCHARACTERIZED
PROTEIN MJ0100)		 5awe PUTATIVE ACETOIN
UTILIZATION PROTEIN,
ACETOIN
DEHYDROGENASE
(Thermus
thermophilus) 		5 / 12 THR A  48
ASP A  51
VAL A  85
ILE A 106
PRO A 110
 None
 0.58A 3kpdB-5aweA:
11.9		 3kpdB-5aweA:
24.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KPD_C_SAMC1000_1
(UNCHARACTERIZED
PROTEIN MJ0100)		 5awe PUTATIVE ACETOIN
UTILIZATION PROTEIN,
ACETOIN
DEHYDROGENASE
(Thermus
thermophilus) 		5 / 12 ILE A 120
THR A 122
ASP A 125
THR A   8
PRO A  36
 None
 0.66A 3kpdC-5aweA:
12.1		 3kpdC-5aweA:
24.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KPD_C_SAMC1000_1
(UNCHARACTERIZED
PROTEIN MJ0100)		 5awe PUTATIVE ACETOIN
UTILIZATION PROTEIN,
ACETOIN
DEHYDROGENASE
(Thermus
thermophilus) 		5 / 12 THR A  48
ASP A  51
VAL A  85
ILE A 106
PRO A 110
 None
 0.60A 3kpdC-5aweA:
12.1		 3kpdC-5aweA:
24.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PCU_A_SAMA603_0
(CYSTATHIONINE
BETA-SYNTHASE)		 5awe PUTATIVE ACETOIN
UTILIZATION PROTEIN,
ACETOIN
DEHYDROGENASE
(Thermus
thermophilus) 		4 / 7 PHE A  32
PRO A  36
THR A 122
ASP A 125
 None
 0.75A 4pcuA-5aweA:
9.9		 4pcuA-5aweA:
18.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QW0_K_BO2K301_1
(PROTEASOME SUBUNIT
BETA TYPE-5)		 5awe PUTATIVE ACETOIN
UTILIZATION PROTEIN,
ACETOIN
DEHYDROGENASE
(Thermus
thermophilus) 		4 / 7 ALA A 172
THR A 171
ALA A 170
THR A 144
 None
 0.90A 4qw0K-5aweA:
undetectable		 4qw0K-5aweA:
22.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QW0_Y_BO2Y301_1
(PROTEASOME SUBUNIT
BETA TYPE-5)		 5awe PUTATIVE ACETOIN
UTILIZATION PROTEIN,
ACETOIN
DEHYDROGENASE
(Thermus
thermophilus) 		4 / 7 ALA A 172
THR A 171
ALA A 170
THR A 144
 None
 0.89A 4qw0Y-5aweA:
undetectable		 4qw0Y-5aweA:
22.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HBM_A_NVPA601_1
(REVERSE
TRANSCRIPTASE/RIBONU
CLEASE H)		 5awe PUTATIVE ACETOIN
UTILIZATION PROTEIN,
ACETOIN
DEHYDROGENASE
(Thermus
thermophilus) 		5 / 11 PRO A  11
LEU A 117
VAL A  85
VAL A  37
GLY A  45
 None
 1.24A 5hbmA-5aweA:
2.3		 5hbmA-5aweA:
16.55