SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5awf'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EKJ_A_ACTA3001_0
(BETA-CARBONIC
ANHYDRASE)		 5awf FES CLUSTER ASSEMBLY
PROTEIN SUFB
(Escherichia
coli) 		4 / 8 ASP A 260
GLY A 295
GLY A 296
TYR A 262
 None
 0.85A 1ekjA-5awfA:
undetectable
1ekjB-5awfA:
undetectable		 1ekjA-5awfA:
19.48
1ekjB-5awfA:
19.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GSF_A_EAAA223_1
(GLUTATHIONE
TRANSFERASE A1-1)		 5awf PROBABLE
ATP-DEPENDENT
TRANSPORTER SUFC
(Escherichia
coli) 		4 / 8 PHE C 146
GLY C 149
LEU C 176
VAL C 183
 None
 1.20A 1gsfA-5awfC:
undetectable		 1gsfA-5awfC:
24.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GSF_B_EAAB223_1
(GLUTATHIONE
TRANSFERASE A1-1)		 5awf PROBABLE
ATP-DEPENDENT
TRANSPORTER SUFC
(Escherichia
coli) 		4 / 8 PHE C 146
GLY C 149
LEU C 176
VAL C 183
 None
 1.20A 1gsfB-5awfC:
undetectable		 1gsfB-5awfC:
24.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GSF_D_EAAD223_1
(GLUTATHIONE
TRANSFERASE A1-1)		 5awf PROBABLE
ATP-DEPENDENT
TRANSPORTER SUFC
(Escherichia
coli) 		4 / 8 PHE C 146
GLY C 149
LEU C 176
VAL C 183
 None
 1.20A 1gsfD-5awfC:
undetectable		 1gsfD-5awfC:
24.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MX1_D_THAD4_2
(LIVER
CARBOXYLESTERASE I)		 5awf PROBABLE
ATP-DEPENDENT
TRANSPORTER SUFC
(Escherichia
coli) 		3 / 3 PHE C 120
LEU C 138
MET C 133
 None
 0.91A 1mx1D-5awfC:
undetectable		 1mx1D-5awfC:
18.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FK8_A_SAMA302_0
(METHOXY MYCOLIC ACID
SYNTHASE 4)		 5awf FES CLUSTER ASSEMBLY
PROTEIN SUFB
PROBABLE
ATP-DEPENDENT
TRANSPORTER SUFC
(Escherichia
coli;
Escherichia
coli) 		5 / 12 ILE A 453
GLY A 452
GLY C  77
LEU C 162
ALA C 105
 None
 0.91A 2fk8A-5awfA:
undetectable		 2fk8A-5awfA:
19.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OKC_A_SAMA500_1
(TYPE I RESTRICTION
ENZYME STYSJI M
PROTEIN)		 5awf FES CLUSTER ASSEMBLY
PROTEIN SUFB
(Escherichia
coli) 		4 / 6 THR A 326
THR A 349
ASN A 292
ASP A 291
 None
 1.30A 2okcA-5awfA:
undetectable		 2okcA-5awfA:
21.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZW9_B_SAMB801_0
(LEUCINE CARBOXYL
METHYLTRANSFERASE 2)		 5awf FES CLUSTER ASSEMBLY
PROTEIN SUFB
(Escherichia
coli) 		5 / 12 THR A 357
GLY A 376
ASP A 406
LEU A 486
ASN A 286
 None
 1.24A 2zw9B-5awfA:
undetectable		 2zw9B-5awfA:
22.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AIA_B_SAMB206_0
(UPF0217 PROTEIN
MJ1640)		 5awf PROBABLE
ATP-DEPENDENT
TRANSPORTER SUFC
(Escherichia
coli) 		4 / 5 SER C  10
LEU C  68
GLY C  58
GLU C  54
 None
 1.15A 3aiaA-5awfC:
undetectable
3aiaB-5awfC:
undetectable		 3aiaA-5awfC:
21.96
3aiaB-5awfC:
21.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_B_SVRB512_1
(PHOSPHOLIPASE A2)		 5awf FES CLUSTER ASSEMBLY
PROTEIN SUFB
(Escherichia
coli) 		4 / 5 VAL A 269
VAL A 268
THR A 283
ARG A 237
 None
 1.15A 3bjwA-5awfA:
undetectable		 3bjwA-5awfA:
13.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_F_SVRF509_1
(PHOSPHOLIPASE A2)		 5awf FES CLUSTER ASSEMBLY
PROTEIN SUFB
(Escherichia
coli) 		4 / 5 VAL A 269
VAL A 268
THR A 283
ARG A 237
 None
 1.20A 3bjwC-5awfA:
undetectable		 3bjwC-5awfA:
13.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G2O_A_SAMA500_0
(PCZA361.24)		 5awf FES CLUSTER ASSEMBLY
PROTEIN SUFB
(Escherichia
coli) 		5 / 12 GLY A 322
LEU A 486
SER A 493
GLY A 351
SER A 350
 None
 0.83A 3g2oA-5awfA:
undetectable		 3g2oA-5awfA:
21.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G2O_B_SAMB600_0
(PCZA361.24)		 5awf FES CLUSTER ASSEMBLY
PROTEIN SUFB
(Escherichia
coli) 		5 / 12 GLY A 322
LEU A 486
SER A 493
GLY A 351
SER A 350
 None
 0.91A 3g2oB-5awfA:
undetectable		 3g2oB-5awfA:
21.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N62_B_ACTB860_0
(NITRIC OXIDE
SYNTHASE)		 5awf FES CLUSTER ASSEMBLY
PROTEIN SUFB
(Escherichia
coli) 		3 / 3 GLY A 322
TRP A 287
VAL A 258
 None
 0.64A 3n62B-5awfA:
undetectable		 3n62B-5awfA:
23.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N65_B_ACTB860_0
(NITRIC OXIDE
SYNTHASE)		 5awf FES CLUSTER ASSEMBLY
PROTEIN SUFB
(Escherichia
coli) 		3 / 3 GLY A 322
TRP A 287
VAL A 258
 None
 0.66A 3n65B-5awfA:
undetectable		 3n65B-5awfA:
22.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N66_B_ACTB860_0
(NITRIC OXIDE
SYNTHASE)		 5awf FES CLUSTER ASSEMBLY
PROTEIN SUFB
(Escherichia
coli) 		3 / 3 GLY A 322
TRP A 287
VAL A 258
 None
 0.64A 3n66B-5awfA:
undetectable		 3n66B-5awfA:
22.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T7S_C_SAMC300_0
(PUTATIVE
METHYLTRANSFERASE)		 5awf FES CLUSTER ASSEMBLY
PROTEIN SUFB
(Escherichia
coli) 		5 / 12 GLY A 358
GLN A 318
SER A 407
ALA A 347
ASN A 384
 None
 1.44A 3t7sC-5awfA:
undetectable		 3t7sC-5awfA:
21.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3THR_A_C2FA1100_0
(GLYCINE
N-METHYLTRANSFERASE)		 5awf FES CLUSTER ASSEMBLY
PROTEIN SUFB
(Escherichia
coli) 		4 / 6 SER A 323
LEU A 298
HIS A  79
THR A 326
 None
 1.38A 3thrB-5awfA:
undetectable		 3thrB-5awfA:
20.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UJ6_A_SAMA300_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE)		 5awf PROBABLE
ATP-DEPENDENT
TRANSPORTER SUFC
(Escherichia
coli) 		5 / 12 LEU C  22
ILE C 199
ILE C 200
ASP C 229
HIS C 217
 None
 0.96A 3uj6A-5awfC:
2.6		 3uj6A-5awfC:
22.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ZS3_A_ACTA1224_0
(THAUMATIN-LIKE
PROTEIN)		 5awf PROBABLE
ATP-DEPENDENT
TRANSPORTER SUFC
(Escherichia
coli) 		4 / 5 SER C 174
GLU C 171
TYR C  86
ASP C 170
 None
 1.20A 3zs3A-5awfC:
undetectable		 3zs3A-5awfC:
20.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A97_H_ZPCH1318_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 5awf FES CLUSTER ASSEMBLY
PROTEIN SUFB
(Escherichia
coli) 		4 / 8 PHE A 471
VAL A 346
MET A 408
ILE A 377
 None
 1.06A 4a97G-5awfA:
undetectable		 4a97G-5awfA:
19.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KN2_C_LYAC304_2
(FOLATE RECEPTOR BETA)		 5awf FES CLUSTER ASSEMBLY
PROTEIN SUFB
(Escherichia
coli) 		3 / 3 TYR A 386
GLN A 318
TRP A 327
 None
 1.07A 4kn2C-5awfA:
undetectable		 4kn2C-5awfA:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OLT_B_GCSB304_1
(CHITOSANASE)		 5awf FES CLUSTER ASSEMBLY
PROTEIN SUFB
(Escherichia
coli) 		4 / 5 TYR A 386
ILE A 372
THR A 359
HIS A 363
 None
 1.25A 4oltB-5awfA:
undetectable		 4oltB-5awfA:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QWP_A_GCSA303_1
(CHITOSANASE)		 5awf FES CLUSTER ASSEMBLY
PROTEIN SUFB
(Escherichia
coli) 		4 / 6 TYR A 386
ILE A 372
THR A 359
HIS A 363
 None
 1.23A 4qwpA-5awfA:
undetectable		 4qwpA-5awfA:
21.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z90_F_4LEF401_1
(GAMMA-AMINOBUTYRIC-A
CID RECEPTOR SUBUNIT
BETA-1)		 5awf PROBABLE
ATP-DEPENDENT
TRANSPORTER SUFC
(Escherichia
coli) 		4 / 8 LEU C  20
THR C  46
LEU C  47
LEU C  43
 None
 0.63A 4z90F-5awfC:
undetectable
4z90G-5awfC:
undetectable
4z90H-5awfC:
undetectable
4z90I-5awfC:
undetectable
4z90J-5awfC:
undetectable		 4z90F-5awfC:
22.19
4z90G-5awfC:
22.19
4z90H-5awfC:
22.19
4z90I-5awfC:
22.19
4z90J-5awfC:
22.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5K7U_A_SAMA601_1
(N6-ADENOSINE-METHYLT
RANSFERASE 70 KDA
SUBUNIT)		 5awf PROBABLE
ATP-DEPENDENT
TRANSPORTER SUFC
(Escherichia
coli) 		3 / 3 ASP C 119
ASN C 104
GLN C 100
 None
 0.77A 5k7uA-5awfC:
1.5		 5k7uA-5awfC:
21.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VUO_B_ACTB804_0
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5awf FES CLUSTER ASSEMBLY
PROTEIN SUFB
(Escherichia
coli) 		3 / 3 GLY A 322
TRP A 287
VAL A 258
 None
 0.66A 5vuoB-5awfA:
undetectable		 5vuoB-5awfA:
23.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MN5_D_LLLD301_0
(AMINOGLYCOSIDE
N(3)-ACETYLTRANSFERA
SE, AAC(3)-IVA)		 5awf FES CLUSTER ASSEMBLY
PROTEIN SUFB
PROBABLE
ATP-DEPENDENT
TRANSPORTER SUFC
(Escherichia
coli;
Escherichia
coli) 		4 / 6 ASP A 443
GLU C  51
ASP C  52
GLU C  12
 None
 1.22A 6mn5D-5awfA:
undetectable		 6mn5D-5awfA:
11.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6QGB_E_BEZE701_0
(MONO(2-HYDROXYETHYL)
TEREPHTHALATE
HYDROLASE)		 5awf FES CLUSTER ASSEMBLY
PROTEIN SUFB
(Escherichia
coli) 		5 / 11 GLY A 185
ALA A 203
ARG A  60
PHE A  59
PHE A 169
 None
 1.35A 6qgbE-5awfA:
undetectable		 6qgbE-5awfA:
22.05