SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5awm'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

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	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1ERR_A_RALA600_2 (ESTROGEN RECEPTOR)	5awm	STRESS-ACTIVATED PROTEIN KINASE JNK (Drosophila melanogaster)	4 / 6	LEU A 163 LEU A 166 LEU A 150 LEU A 87	None ANP A 401 ( 4.5A) None None	0.87A	1errA-5awmA: undetectable	1errA-5awmA: 20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1UWH_A_BAXA1723_2 (B-RAF PROTO-ONCOGENE SERINE/THREONINE-PRO TEIN KINASE)	5awm	STRESS-ACTIVATED PROTEIN KINASE JNK (Drosophila melanogaster)	4 / 6	ILE A 30 VAL A 38 ILE A 83 ILE A 145	ANP A 401 (-4.9A) ANP A 401 (-4.5A) None None	0.79A	1uwhA-5awmA: 7.0	1uwhA-5awmA: 23.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1XKK_A_FMMA91_2 (EPIDERMAL GROWTH FACTOR RECEPTOR)	5awm	STRESS-ACTIVATED PROTEIN KINASE JNK (Drosophila melanogaster)	6 / 9	VAL A 38 LYS A 53 LEU A 86 LEU A 104 LEU A 108 MET A 109	ANP A 401 (-4.5A) ANP A 401 (-2.9A) None None ANP A 401 ( 4.8A) None	0.48A	1xkkA-5awmA: 19.4	1xkkA-5awmA: 25.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2AVO_B_MK1B902_1 (POL POLYPROTEIN)	5awm	STRESS-ACTIVATED PROTEIN KINASE JNK (Drosophila melanogaster)	5 / 9	LEU A 113 ILE A 83 GLY A 136 VAL A 157 ILE A 155	None	1.12A	2avoA-5awmA: undetectable	2avoA-5awmA: 13.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2B25_B_SAMB602_1 (HYPOTHETICAL PROTEIN)	5awm	STRESS-ACTIVATED PROTEIN KINASE JNK (Drosophila melanogaster)	3 / 3	GLY A 169 GLU A 71 ASP A 149	None MG A 403 (-3.4A) None	0.44A	2b25B-5awmA: undetectable	2b25B-5awmA: 21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2ITZ_A_IREA2021_2 (EPIDERMAL GROWTH FACTOR RECEPTOR)	5awm	STRESS-ACTIVATED PROTEIN KINASE JNK (Drosophila melanogaster)	3 / 3	LEU A 104 LEU A 108 MET A 109	None ANP A 401 ( 4.8A) None	0.41A	2itzA-5awmA: 20.1	2itzA-5awmA: 23.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2OTH_A_IMNA301_1 (PHOSPHOLIPASE A2 VRV-PL-VIIIA)	5awm	STRESS-ACTIVATED PROTEIN KINASE JNK (Drosophila melanogaster)	3 / 3	ASP A 338 TYR A 337 LYS A 73	None	1.04A	2othA-5awmA: undetectable	2othA-5awmA: 17.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2Y7J_A_B49A1294_1 (PHOSPHORYLASE B KINASE GAMMA CATALYTIC CHAIN, TESTIS/LIVER ISOFORM)	5awm	STRESS-ACTIVATED PROTEIN KINASE JNK (Drosophila melanogaster)	6 / 12	ILE A 30 VAL A 38 ALA A 51 ILE A 84 LEU A 108 MET A 109	ANP A 401 (-4.9A) ANP A 401 (-4.5A) ANP A 401 (-3.5A) None ANP A 401 ( 4.8A) None	0.46A	2y7jA-5awmA: 23.3	2y7jA-5awmA: 23.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2Y7J_B_B49B1294_1 (PHOSPHORYLASE B KINASE GAMMA CATALYTIC CHAIN, TESTIS/LIVER ISOFORM)	5awm	STRESS-ACTIVATED PROTEIN KINASE JNK (Drosophila melanogaster)	6 / 10	ILE A 30 VAL A 38 ALA A 51 ILE A 84 LEU A 108 MET A 109	ANP A 401 (-4.9A) ANP A 401 (-4.5A) ANP A 401 (-3.5A) None ANP A 401 ( 4.8A) None	0.46A	2y7jB-5awmA: 23.3	2y7jB-5awmA: 23.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2Y7J_C_B49C1294_1 (PHOSPHORYLASE B KINASE GAMMA CATALYTIC CHAIN, TESTIS/LIVER ISOFORM)	5awm	STRESS-ACTIVATED PROTEIN KINASE JNK (Drosophila melanogaster)	6 / 10	ILE A 30 VAL A 38 ALA A 51 ILE A 84 LEU A 108 MET A 109	ANP A 401 (-4.9A) ANP A 401 (-4.5A) ANP A 401 (-3.5A) None ANP A 401 ( 4.8A) None	0.49A	2y7jC-5awmA: 23.4	2y7jC-5awmA: 23.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2Y7J_D_B49D1294_1 (PHOSPHORYLASE B KINASE GAMMA CATALYTIC CHAIN, TESTIS/LIVER ISOFORM)	5awm	STRESS-ACTIVATED PROTEIN KINASE JNK (Drosophila melanogaster)	6 / 10	ILE A 30 VAL A 38 ALA A 51 ILE A 84 LEU A 108 MET A 109	ANP A 401 (-4.9A) ANP A 401 (-4.5A) ANP A 401 (-3.5A) None ANP A 401 ( 4.8A) None	0.42A	2y7jD-5awmA: 23.7	2y7jD-5awmA: 23.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3BWM_A_SAMA301_0 (CATECHOL O-METHYLTRANSFERASE)	5awm	STRESS-ACTIVATED PROTEIN KINASE JNK (Drosophila melanogaster)	5 / 12	MET A 109 VAL A 50 GLY A 85 ILE A 83 ASN A 82	None	1.47A	3bwmA-5awmA: undetectable	3bwmA-5awmA: 20.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3D1Y_A_ROCA201_2 (HIV-1 PROTEASE)	5awm	STRESS-ACTIVATED PROTEIN KINASE JNK (Drosophila melanogaster)	5 / 9	LEU A 113 ILE A 83 GLY A 136 VAL A 157 ILE A 155	None	1.17A	3d1yB-5awmA: undetectable	3d1yB-5awmA: 14.32
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	3HEC_A_STIA1_1 (MITOGEN-ACTIVATED PROTEIN KINASE 14)	5awm	STRESS-ACTIVATED PROTEIN KINASE JNK (Drosophila melanogaster)	5 / 12	ALA A 51 ILE A 84 LEU A 108 LEU A 166 ASP A 167	ANP A 401 (-3.5A) None ANP A 401 ( 4.8A) ANP A 401 ( 4.5A) None	1.00A	3hecA-5awmA: 35.7	3hecA-5awmA: 44.33
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	3HEC_A_STIA1_1 (MITOGEN-ACTIVATED PROTEIN KINASE 14)	5awm	STRESS-ACTIVATED PROTEIN KINASE JNK (Drosophila melanogaster)	5 / 12	ALA A 51 LYS A 53 ILE A 84 LEU A 108 ASP A 167	ANP A 401 (-3.5A) ANP A 401 (-2.9A) None ANP A 401 ( 4.8A) None	0.63A	3hecA-5awmA: 35.7	3hecA-5awmA: 44.33
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	3LFA_A_1N1A361_1 (MITOGEN-ACTIVATED PROTEIN KINASE 14)	5awm	STRESS-ACTIVATED PROTEIN KINASE JNK (Drosophila melanogaster)	5 / 8	ALA A 51 LYS A 53 LEU A 104 LEU A 108 MET A 109	ANP A 401 (-3.5A) ANP A 401 (-2.9A) None ANP A 401 ( 4.8A) None	0.32A	3lfaA-5awmA: 35.4	3lfaA-5awmA: 46.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3Q5S_A_ACHA1289_0 (MULTIDRUG-EFFLUX TRANSPORTER 1 REGULATOR)	5awm	STRESS-ACTIVATED PROTEIN KINASE JNK (Drosophila melanogaster)	4 / 6	ASN A 112 TYR A 189 GLU A 215 ILE A 117	ANP A 401 (-3.9A) None None None	1.02A	3q5sA-5awmA: undetectable	3q5sA-5awmA: 22.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3UG2_A_IREA1_1 (EPIDERMAL GROWTH FACTOR RECEPTOR)	5awm	STRESS-ACTIVATED PROTEIN KINASE JNK (Drosophila melanogaster)	7 / 12	VAL A 38 ALA A 51 LYS A 53 LEU A 104 MET A 106 LEU A 108 MET A 109	ANP A 401 (-4.5A) ANP A 401 (-3.5A) ANP A 401 (-2.9A) None ANP A 401 (-3.8A) ANP A 401 ( 4.8A) None	0.53A	3ug2A-5awmA: 19.6	3ug2A-5awmA: 24.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3ZOS_A_0LIA1000_2 (EPITHELIAL DISCOIDIN DOMAIN-CONTAINING RECEPTOR 1)	5awm	STRESS-ACTIVATED PROTEIN KINASE JNK (Drosophila melanogaster)	5 / 9	MET A 75 ILE A 83 ILE A 84 MET A 109 ILE A 165	None	0.67A	3zosA-5awmA: 18.9	3zosA-5awmA: 24.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4C8B_A_0LIA1000_2 (RECEPTOR-INTERACTING SERINE/THREONINE-PRO TEIN KINASE 2)	5awm	STRESS-ACTIVATED PROTEIN KINASE JNK (Drosophila melanogaster)	4 / 5	VAL A 38 ILE A 83 MET A 109 ILE A 165	ANP A 401 (-4.5A) None None None	0.43A	4c8bA-5awmA: 20.2	4c8bA-5awmA: 24.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4EXS_B_X8ZB301_1 (BETA-LACTAMASE NDM-1)	5awm	STRESS-ACTIVATED PROTEIN KINASE JNK (Drosophila melanogaster)	4 / 8	VAL A 311 HIS A 147 ASP A 205 HIS A 141	None	0.89A	4exsB-5awmA: undetectable	4exsB-5awmA: 20.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4K50_I_ACTI507_0 (RNA POLYMERASE 3D-POL)	5awm	STRESS-ACTIVATED PROTEIN KINASE JNK (Drosophila melanogaster)	3 / 3	LYS A 151 PRO A 152 SER A 153	None None MG A 402 (-4.5A)	0.30A	4k50I-5awmA: undetectable	4k50I-5awmA: 20.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4OKB_A_198A1002_2 (ANDROGEN RECEPTOR)	5awm	STRESS-ACTIVATED PROTEIN KINASE JNK (Drosophila melanogaster)	5 / 6	LEU A 163 ASN A 82 MET A 216 LEU A 130 VAL A 311	None	1.38A	4okbA-5awmA: undetectable	4okbA-5awmA: 20.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4OKX_A_198A1002_2 (ANDROGEN RECEPTOR)	5awm	STRESS-ACTIVATED PROTEIN KINASE JNK (Drosophila melanogaster)	4 / 6	LEU A 163 ASN A 82 MET A 216 LEU A 130	None	1.16A	4okxA-5awmA: undetectable	4okxA-5awmA: 20.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4RKU_A_PQNA5001_1 (PHOTOSYSTEM I P700 CHLOROPHYLL A APOPROTEIN A1 PHOTOSYSTEM I REACTION CENTER SUBUNIT IX)	5awm	STRESS-ACTIVATED PROTEIN KINASE JNK (Drosophila melanogaster)	4 / 8	ARG A 28 ALA A 40 LEU A 27 PHE A 99	None	0.97A	4rkuA-5awmA: undetectable 4rkuJ-5awmA: undetectable	4rkuA-5awmA: 19.18 4rkuJ-5awmA: 17.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4RZ7_A_1E8A901_1 (CGMP-DEPENDENT PROTEIN KINASE, PUTATIVE)	5awm	STRESS-ACTIVATED PROTEIN KINASE JNK (Drosophila melanogaster)	5 / 10	ILE A 30 ALA A 51 LYS A 53 ILE A 84 LEU A 108	ANP A 401 (-4.9A) ANP A 401 (-3.5A) ANP A 401 (-2.9A) None ANP A 401 ( 4.8A)	0.43A	4rz7A-5awmA: 22.3	4rz7A-5awmA: 17.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4WBO_C_ANWC601_0 (RHODOPSIN KINASE)	5awm	STRESS-ACTIVATED PROTEIN KINASE JNK (Drosophila melanogaster)	4 / 6	ARG A 28 ALA A 51 MET A 106 MET A 109	None ANP A 401 (-3.5A) ANP A 401 (-3.8A) None	0.81A	4wboC-5awmA: 22.1	4wboC-5awmA: 22.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4XP6_A_B40A601_1 (TRANSPORTER)	5awm	STRESS-ACTIVATED PROTEIN KINASE JNK (Drosophila melanogaster)	4 / 5	ASP A 270 ASP A 281 PHE A 278 GLY A 276	None	1.14A	4xp6A-5awmA: undetectable	4xp6A-5awmA: 19.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4XUE_B_SAMB303_0 (CATECHOL O-METHYLTRANSFERASE)	5awm	STRESS-ACTIVATED PROTEIN KINASE JNK (Drosophila melanogaster)	5 / 12	MET A 109 VAL A 50 GLY A 85 ILE A 83 ASN A 82	None	1.41A	4xueB-5awmA: undetectable	4xueB-5awmA: 19.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5A5Z_A_WJZA304_0 (BETA-LACTAMASE NDM-1)	5awm	STRESS-ACTIVATED PROTEIN KINASE JNK (Drosophila melanogaster)	4 / 8	VAL A 311 HIS A 147 ASP A 205 HIS A 141	None	0.86A	5a5zA-5awmA: undetectable	5a5zA-5awmA: 20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5C6P_A_4YHA601_1 (PROTEIN C)	5awm	STRESS-ACTIVATED PROTEIN KINASE JNK (Drosophila melanogaster)	4 / 6	ALA A 290 SER A 291 GLN A 284 ASP A 281	None	1.22A	5c6pA-5awmA: undetectable	5c6pA-5awmA: 21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5ESG_A_1YNA701_2 (LANOSTEROL 14-ALPHA DEMETHYLASE)	5awm	STRESS-ACTIVATED PROTEIN KINASE JNK (Drosophila melanogaster)	4 / 4	LEU A 250 TYR A 200 PRO A 192 ILE A 303	None	1.30A	5esgA-5awmA: undetectable	5esgA-5awmA: 19.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5I8F_A_ML1A211_1 (PHENOLIC OXIDATIVE COUPLING PROTEIN)	5awm	STRESS-ACTIVATED PROTEIN KINASE JNK (Drosophila melanogaster)	4 / 6	VAL A 157 ALA A 111 GLN A 115 VAL A 116	None	0.97A	5i8fA-5awmA: undetectable	5i8fA-5awmA: 17.80
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	5LW1_B_ADNB401_1 (MITOGEN-ACTIVATED PROTEIN KINASE 8)	5awm	STRESS-ACTIVATED PROTEIN KINASE JNK (Drosophila melanogaster)	7 / 9	ILE A 30 GLY A 31 ALA A 51 ILE A 84 MET A 106 MET A 109 LEU A 166	ANP A 401 (-4.9A) ANP A 401 (-3.3A) ANP A 401 (-3.5A) None ANP A 401 (-3.8A) None ANP A 401 ( 4.5A)	0.69A	5lw1B-5awmA: 43.8	5lw1B-5awmA: 64.44
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	5LW1_B_ADNB401_1 (MITOGEN-ACTIVATED PROTEIN KINASE 8)	5awm	STRESS-ACTIVATED PROTEIN KINASE JNK (Drosophila melanogaster)	8 / 9	ILE A 30 VAL A 38 ALA A 51 ILE A 84 MET A 106 MET A 109 ASN A 112 LEU A 166	ANP A 401 (-4.9A) ANP A 401 (-4.5A) ANP A 401 (-3.5A) None ANP A 401 (-3.8A) None ANP A 401 (-3.9A) ANP A 401 ( 4.5A)	0.56A	5lw1B-5awmA: 43.8	5lw1B-5awmA: 64.44
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	5LW1_E_ADNE401_1 (MITOGEN-ACTIVATED PROTEIN KINASE 8)	5awm	STRESS-ACTIVATED PROTEIN KINASE JNK (Drosophila melanogaster)	9 / 10	GLY A 31 VAL A 38 ALA A 51 ILE A 84 MET A 106 LEU A 108 MET A 109 VAL A 156 LEU A 166	ANP A 401 (-3.3A) ANP A 401 (-4.5A) ANP A 401 (-3.5A) None ANP A 401 (-3.8A) ANP A 401 ( 4.8A) None None ANP A 401 ( 4.5A)	0.82A	5lw1E-5awmA: 43.6	5lw1E-5awmA: 64.44
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	5LW1_E_ADNE401_1 (MITOGEN-ACTIVATED PROTEIN KINASE 8)	5awm	STRESS-ACTIVATED PROTEIN KINASE JNK (Drosophila melanogaster)	9 / 10	VAL A 38 ALA A 51 ILE A 84 MET A 106 LEU A 108 MET A 109 ASN A 112 VAL A 156 LEU A 166	ANP A 401 (-4.5A) ANP A 401 (-3.5A) None ANP A 401 (-3.8A) ANP A 401 ( 4.8A) None ANP A 401 (-3.9A) None ANP A 401 ( 4.5A)	0.61A	5lw1E-5awmA: 43.6	5lw1E-5awmA: 64.44
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	5LW1_H_ADNH401_1 (MITOGEN-ACTIVATED PROTEIN KINASE 8)	5awm	STRESS-ACTIVATED PROTEIN KINASE JNK (Drosophila melanogaster)	7 / 9	GLY A 31 ALA A 51 MET A 106 LEU A 108 MET A 109 VAL A 156 LEU A 166	ANP A 401 (-3.3A) ANP A 401 (-3.5A) ANP A 401 (-3.8A) ANP A 401 ( 4.8A) None None ANP A 401 ( 4.5A)	0.71A	5lw1H-5awmA: 44.0	5lw1H-5awmA: 64.44
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	5LW1_H_ADNH401_1 (MITOGEN-ACTIVATED PROTEIN KINASE 8)	5awm	STRESS-ACTIVATED PROTEIN KINASE JNK (Drosophila melanogaster)	8 / 9	VAL A 38 ALA A 51 MET A 106 LEU A 108 MET A 109 ASN A 112 VAL A 156 LEU A 166	ANP A 401 (-4.5A) ANP A 401 (-3.5A) ANP A 401 (-3.8A) ANP A 401 ( 4.8A) None ANP A 401 (-3.9A) None ANP A 401 ( 4.5A)	0.45A	5lw1H-5awmA: 44.0	5lw1H-5awmA: 64.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5NZY_A_CE3A1103_1 (DNA CROSS-LINK REPAIR 1A PROTEIN)	5awm	STRESS-ACTIVATED PROTEIN KINASE JNK (Drosophila melanogaster)	4 / 8	PRO A 152 TYR A 189 VAL A 221 GLY A 220	None	1.03A	5nzyA-5awmA: undetectable	5nzyA-5awmA: 21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6CDU_A_EY4A501_0 (CHIMERIC ALPHA1GABAA RECEPTOR)	5awm	STRESS-ACTIVATED PROTEIN KINASE JNK (Drosophila melanogaster)	4 / 5	GLN A 350 VAL A 348 TRP A 351 THR A 63	None	1.24A	6cduA-5awmA: undetectable 6cduB-5awmA: undetectable	6cduA-5awmA: 21.31 6cduB-5awmA: 21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6CDU_I_EY4I500_0 (CHIMERIC ALPHA1GABAA RECEPTOR)	5awm	STRESS-ACTIVATED PROTEIN KINASE JNK (Drosophila melanogaster)	4 / 5	GLN A 350 VAL A 348 TRP A 351 THR A 63	None	1.33A	6cduI-5awmA: undetectable 6cduJ-5awmA: undetectable	6cduI-5awmA: 21.31 6cduJ-5awmA: 21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6FGC_A_ACTA811_0 (GEPHYRIN)	5awm	STRESS-ACTIVATED PROTEIN KINASE JNK (Drosophila melanogaster)	3 / 3	LEU A 129 LEU A 121 ARG A 125	None	0.45A	6fgcA-5awmA: undetectable	6fgcA-5awmA: 23.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6FGD_A_ACTA810_0 (GEPHYRIN)	5awm	STRESS-ACTIVATED PROTEIN KINASE JNK (Drosophila melanogaster)	3 / 3	LEU A 129 LEU A 121 ARG A 125	None	0.46A	6fgdA-5awmA: undetectable	6fgdA-5awmA: 23.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6GNE_B_ACRB602_2 (-)	5awm	STRESS-ACTIVATED PROTEIN KINASE JNK (Drosophila melanogaster)	4 / 8	VAL A 311 HIS A 139 ASN A 82 GLU A 328	None	1.30A	6gneB-5awmA: undetectable	6gneB-5awmA: 22.93

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["1ERR_A_RALA600_2","ESTROGEN RECEPTOR","5awm","STRESS-ACTIVATED PROTEIN KINASE JNK","Drosophila melanogaster",4,"LEU A 163;LEU A 166;LEU A 150;LEU A  87","None;ANP A 401 ( 4.5A);None;None","0.87A","1errA-5awmA:undetectable","1errA-5awmA:20.65"],["1UWH_A_BAXA1723_2","B-RAF PROTO-ONCOGENE SERINE\/THREONINE-PROTEIN KINASE","5awm","STRESS-ACTIVATED PROTEIN KINASE JNK","Drosophila melanogaster",4,"ILE A  30;VAL A  38;ILE A  83;ILE A 145","ANP A 401 (-4.9A);ANP A 401 (-4.5A);None;None","0.79A","1uwhA-5awmA:7.0","1uwhA-5awmA:23.91"],["1XKK_A_FMMA91_2","EPIDERMAL GROWTH FACTOR RECEPTOR","5awm","STRESS-ACTIVATED PROTEIN KINASE JNK","Drosophila melanogaster",6,"VAL A  38;LYS A  53;LEU A  86;LEU A 104;LEU A 108;MET A 109","ANP A 401 (-4.5A);ANP A 401 (-2.9A);None;None;ANP A 401 ( 4.8A);None","0.48A","1xkkA-5awmA:19.4","1xkkA-5awmA:25.72"],["2AVO_B_MK1B902_1","POL POLYPROTEIN;POL POLYPROTEIN","5awm","STRESS-ACTIVATED PROTEIN KINASE JNK","Drosophila melanogaster",5,"LEU A 113;ILE A  83;GLY A 136;VAL A 157;ILE A 155","None","1.12A","2avoA-5awmA:undetectable","2avoA-5awmA:13.00"],["2B25_B_SAMB602_1","HYPOTHETICAL PROTEIN","5awm","STRESS-ACTIVATED PROTEIN KINASE JNK","Drosophila melanogaster",3,"GLY A 169;GLU A  71;ASP A 149","None; MG A 403 (-3.4A);None","0.44A","2b25B-5awmA:undetectable","2b25B-5awmA:21.88"],["2ITZ_A_IREA2021_2","EPIDERMAL GROWTH FACTOR RECEPTOR","5awm","STRESS-ACTIVATED PROTEIN KINASE JNK","Drosophila melanogaster",3,"LEU A 104;LEU A 108;MET A 109","None;ANP A 401 ( 4.8A);None","0.41A","2itzA-5awmA:20.1","2itzA-5awmA:23.72"],["2OTH_A_IMNA301_1","PHOSPHOLIPASE A2 VRV-PL-VIIIA","5awm","STRESS-ACTIVATED PROTEIN KINASE JNK","Drosophila melanogaster",3,"ASP A 338;TYR A 337;LYS A  73","None","1.04A","2othA-5awmA:undetectable","2othA-5awmA:17.07"],["2Y7J_A_B49A1294_1","PHOSPHORYLASE B KINASE GAMMA CATALYTIC CHAIN, TESTIS\/LIVER ISOFORM","5awm","STRESS-ACTIVATED PROTEIN KINASE JNK","Drosophila melanogaster",6,"ILE A  30;VAL A  38;ALA A  51;ILE A  84;LEU A 108;MET A 109","ANP A 401 (-4.9A);ANP A 401 (-4.5A);ANP A 401 (-3.5A);None;ANP A 401 ( 4.8A);None","0.46A","2y7jA-5awmA:23.3","2y7jA-5awmA:23.23"],["2Y7J_B_B49B1294_1","PHOSPHORYLASE B KINASE GAMMA CATALYTIC CHAIN, TESTIS\/LIVER ISOFORM","5awm","STRESS-ACTIVATED PROTEIN KINASE JNK","Drosophila melanogaster",6,"ILE A  30;VAL A  38;ALA A  51;ILE A  84;LEU A 108;MET A 109","ANP A 401 (-4.9A);ANP A 401 (-4.5A);ANP A 401 (-3.5A);None;ANP A 401 ( 4.8A);None","0.46A","2y7jB-5awmA:23.3","2y7jB-5awmA:23.23"],["2Y7J_C_B49C1294_1","PHOSPHORYLASE B KINASE GAMMA CATALYTIC CHAIN, TESTIS\/LIVER ISOFORM","5awm","STRESS-ACTIVATED PROTEIN KINASE JNK","Drosophila melanogaster",6,"ILE A  30;VAL A  38;ALA A  51;ILE A  84;LEU A 108;MET A 109","ANP A 401 (-4.9A);ANP A 401 (-4.5A);ANP A 401 (-3.5A);None;ANP A 401 ( 4.8A);None","0.49A","2y7jC-5awmA:23.4","2y7jC-5awmA:23.23"],["2Y7J_D_B49D1294_1","PHOSPHORYLASE B KINASE GAMMA CATALYTIC CHAIN, TESTIS\/LIVER ISOFORM","5awm","STRESS-ACTIVATED PROTEIN KINASE JNK","Drosophila melanogaster",6,"ILE A  30;VAL A  38;ALA A  51;ILE A  84;LEU A 108;MET A 109","ANP A 401 (-4.9A);ANP A 401 (-4.5A);ANP A 401 (-3.5A);None;ANP A 401 ( 4.8A);None","0.42A","2y7jD-5awmA:23.7","2y7jD-5awmA:23.23"],["3BWM_A_SAMA301_0","CATECHOL O-METHYLTRANSFERASE","5awm","STRESS-ACTIVATED PROTEIN KINASE JNK","Drosophila melanogaster",5,"MET A 109;VAL A  50;GLY A  85;ILE A  83;ASN A  82","None","1.47A","3bwmA-5awmA:undetectable","3bwmA-5awmA:20.21"],["3D1Y_A_ROCA201_2","HIV-1 PROTEASE;HIV-1 PROTEASE","5awm","STRESS-ACTIVATED PROTEIN KINASE JNK","Drosophila melanogaster",5,"LEU A 113;ILE A  83;GLY A 136;VAL A 157;ILE A 155","None","1.17A","3d1yB-5awmA:undetectable","3d1yB-5awmA:14.32"],["3HEC_A_STIA1_1","MITOGEN-ACTIVATED PROTEIN KINASE 14","5awm","STRESS-ACTIVATED PROTEIN KINASE JNK","Drosophila melanogaster",5,"ALA A  51;ILE A  84;LEU A 108;LEU A 166;ASP A 167","ANP A 401 (-3.5A);None;ANP A 401 ( 4.8A);ANP A 401 ( 4.5A);None","1.00A","3hecA-5awmA:35.7","3hecA-5awmA:44.33"],["3HEC_A_STIA1_1","MITOGEN-ACTIVATED PROTEIN KINASE 14","5awm","STRESS-ACTIVATED PROTEIN KINASE JNK","Drosophila melanogaster",5,"ALA A  51;LYS A  53;ILE A  84;LEU A 108;ASP A 167","ANP A 401 (-3.5A);ANP A 401 (-2.9A);None;ANP A 401 ( 4.8A);None","0.63A","3hecA-5awmA:35.7","3hecA-5awmA:44.33"],["3LFA_A_1N1A361_1","MITOGEN-ACTIVATED PROTEIN KINASE 14","5awm","STRESS-ACTIVATED PROTEIN KINASE JNK","Drosophila melanogaster",5,"ALA A  51;LYS A  53;LEU A 104;LEU A 108;MET A 109","ANP A 401 (-3.5A);ANP A 401 (-2.9A);None;ANP A 401 ( 4.8A);None","0.32A","3lfaA-5awmA:35.4","3lfaA-5awmA:46.86"],["3Q5S_A_ACHA1289_0","MULTIDRUG-EFFLUX TRANSPORTER 1 REGULATOR","5awm","STRESS-ACTIVATED PROTEIN KINASE JNK","Drosophila melanogaster",4,"ASN A 112;TYR A 189;GLU A 215;ILE A 117","ANP A 401 (-3.9A);None;None;None","1.02A","3q5sA-5awmA:undetectable","3q5sA-5awmA:22.14"],["3UG2_A_IREA1_1","EPIDERMAL GROWTH FACTOR RECEPTOR","5awm","STRESS-ACTIVATED PROTEIN KINASE JNK","Drosophila melanogaster",7,"VAL A  38;ALA A  51;LYS A  53;LEU A 104;MET A 106;LEU A 108;MET A 109","ANP A 401 (-4.5A);ANP A 401 (-3.5A);ANP A 401 (-2.9A);None;ANP A 401 (-3.8A);ANP A 401 ( 4.8A);None","0.53A","3ug2A-5awmA:19.6","3ug2A-5awmA:24.63"],["3ZOS_A_0LIA1000_2","EPITHELIAL DISCOIDIN DOMAIN-CONTAINING RECEPTOR 1","5awm","STRESS-ACTIVATED PROTEIN KINASE JNK","Drosophila melanogaster",5,"MET A  75;ILE A  83;ILE A  84;MET A 109;ILE A 165","None","0.67A","3zosA-5awmA:18.9","3zosA-5awmA:24.26"],["4C8B_A_0LIA1000_2","RECEPTOR-INTERACTING SERINE\/THREONINE-PROTEIN KINASE 2","5awm","STRESS-ACTIVATED PROTEIN KINASE JNK","Drosophila melanogaster",4,"VAL A  38;ILE A  83;MET A 109;ILE A 165","ANP A 401 (-4.5A);None;None;None","0.43A","4c8bA-5awmA:20.2","4c8bA-5awmA:24.52"],["4EXS_B_X8ZB301_1","BETA-LACTAMASE NDM-1","5awm","STRESS-ACTIVATED PROTEIN KINASE JNK","Drosophila melanogaster",4,"VAL A 311;HIS A 147;ASP A 205;HIS A 141","None","0.89A","4exsB-5awmA:undetectable","4exsB-5awmA:20.67"],["4K50_I_ACTI507_0","RNA POLYMERASE 3D-POL","5awm","STRESS-ACTIVATED PROTEIN KINASE JNK","Drosophila melanogaster",3,"LYS A 151;PRO A 152;SER A 153","None;None; MG A 402 (-4.5A)","0.30A","4k50I-5awmA:undetectable","4k50I-5awmA:20.93"],["4OKB_A_198A1002_2","ANDROGEN RECEPTOR","5awm","STRESS-ACTIVATED PROTEIN KINASE JNK","Drosophila melanogaster",5,"LEU A 163;ASN A  82;MET A 216;LEU A 130;VAL A 311","None","1.38A","4okbA-5awmA:undetectable","4okbA-5awmA:20.38"],["4OKX_A_198A1002_2","ANDROGEN RECEPTOR","5awm","STRESS-ACTIVATED PROTEIN KINASE JNK","Drosophila melanogaster",4,"LEU A 163;ASN A  82;MET A 216;LEU A 130","None","1.16A","4okxA-5awmA:undetectable","4okxA-5awmA:20.38"],["4RKU_A_PQNA5001_1","PHOTOSYSTEM I P700 CHLOROPHYLL A APOPROTEIN A1;PHOTOSYSTEM I REACTION CENTER SUBUNIT IX","5awm","STRESS-ACTIVATED PROTEIN KINASE JNK","Drosophila melanogaster",4,"ARG A  28;ALA A  40;LEU A  27;PHE A  99","None","0.97A","4rkuA-5awmA:undetectable;4rkuJ-5awmA:undetectable","4rkuA-5awmA:19.18;4rkuJ-5awmA:17.91"],["4RZ7_A_1E8A901_1","CGMP-DEPENDENT PROTEIN KINASE, PUTATIVE","5awm","STRESS-ACTIVATED PROTEIN KINASE JNK","Drosophila melanogaster",5,"ILE A  30;ALA A  51;LYS A  53;ILE A  84;LEU A 108","ANP A 401 (-4.9A);ANP A 401 (-3.5A);ANP A 401 (-2.9A);None;ANP A 401 ( 4.8A)","0.43A","4rz7A-5awmA:22.3","4rz7A-5awmA:17.69"],["4WBO_C_ANWC601_0","RHODOPSIN KINASE","5awm","STRESS-ACTIVATED PROTEIN KINASE JNK","Drosophila melanogaster",4,"ARG A  28;ALA A  51;MET A 106;MET A 109","None;ANP A 401 (-3.5A);ANP A 401 (-3.8A);None","0.81A","4wboC-5awmA:22.1","4wboC-5awmA:22.98"],["4XP6_A_B40A601_1","TRANSPORTER","5awm","STRESS-ACTIVATED PROTEIN KINASE JNK","Drosophila melanogaster",4,"ASP A 270;ASP A 281;PHE A 278;GLY A 276","None","1.14A","4xp6A-5awmA:undetectable","4xp6A-5awmA:19.64"],["4XUE_B_SAMB303_0","CATECHOL O-METHYLTRANSFERASE","5awm","STRESS-ACTIVATED PROTEIN KINASE JNK","Drosophila melanogaster",5,"MET A 109;VAL A  50;GLY A  85;ILE A  83;ASN A  82","None","1.41A","4xueB-5awmA:undetectable","4xueB-5awmA:19.07"],["5A5Z_A_WJZA304_0","BETA-LACTAMASE NDM-1","5awm","STRESS-ACTIVATED PROTEIN KINASE JNK","Drosophila melanogaster",4,"VAL A 311;HIS A 147;ASP A 205;HIS A 141","None","0.86A","5a5zA-5awmA:undetectable","5a5zA-5awmA:20.75"],["5C6P_A_4YHA601_1","PROTEIN C","5awm","STRESS-ACTIVATED PROTEIN KINASE JNK","Drosophila melanogaster",4,"ALA A 290;SER A 291;GLN A 284;ASP A 281","None","1.22A","5c6pA-5awmA:undetectable","5c6pA-5awmA:21.37"],["5ESG_A_1YNA701_2","LANOSTEROL 14-ALPHA DEMETHYLASE","5awm","STRESS-ACTIVATED PROTEIN KINASE JNK","Drosophila melanogaster",4,"LEU A 250;TYR A 200;PRO A 192;ILE A 303","None","1.30A","5esgA-5awmA:undetectable","5esgA-5awmA:19.29"],["5I8F_A_ML1A211_1","PHENOLIC OXIDATIVE COUPLING PROTEIN","5awm","STRESS-ACTIVATED PROTEIN KINASE JNK","Drosophila melanogaster",4,"VAL A 157;ALA A 111;GLN A 115;VAL A 116","None","0.97A","5i8fA-5awmA:undetectable","5i8fA-5awmA:17.80"],["5LW1_B_ADNB401_1","MITOGEN-ACTIVATED PROTEIN KINASE 8","5awm","STRESS-ACTIVATED PROTEIN KINASE JNK","Drosophila melanogaster",7,"ILE A  30;GLY A  31;ALA A  51;ILE A  84;MET A 106;MET A 109;LEU A 166","ANP A 401 (-4.9A);ANP A 401 (-3.3A);ANP A 401 (-3.5A);None;ANP A 401 (-3.8A);None;ANP A 401 ( 4.5A)","0.69A","5lw1B-5awmA:43.8","5lw1B-5awmA:64.44"],["5LW1_B_ADNB401_1","MITOGEN-ACTIVATED PROTEIN KINASE 8","5awm","STRESS-ACTIVATED PROTEIN KINASE JNK","Drosophila melanogaster",8,"ILE A  30;VAL A  38;ALA A  51;ILE A  84;MET A 106;MET A 109;ASN A 112;LEU A 166","ANP A 401 (-4.9A);ANP A 401 (-4.5A);ANP A 401 (-3.5A);None;ANP A 401 (-3.8A);None;ANP A 401 (-3.9A);ANP A 401 ( 4.5A)","0.56A","5lw1B-5awmA:43.8","5lw1B-5awmA:64.44"],["5LW1_E_ADNE401_1","MITOGEN-ACTIVATED PROTEIN KINASE 8","5awm","STRESS-ACTIVATED PROTEIN KINASE JNK","Drosophila melanogaster",9,"GLY A  31;VAL A  38;ALA A  51;ILE A  84;MET A 106;LEU A 108;MET A 109;VAL A 156;LEU A 166","ANP A 401 (-3.3A);ANP A 401 (-4.5A);ANP A 401 (-3.5A);None;ANP A 401 (-3.8A);ANP A 401 ( 4.8A);None;None;ANP A 401 ( 4.5A)","0.82A","5lw1E-5awmA:43.6","5lw1E-5awmA:64.44"],["5LW1_E_ADNE401_1","MITOGEN-ACTIVATED PROTEIN KINASE 8","5awm","STRESS-ACTIVATED PROTEIN KINASE JNK","Drosophila melanogaster",9,"VAL A  38;ALA A  51;ILE A  84;MET A 106;LEU A 108;MET A 109;ASN A 112;VAL A 156;LEU A 166","ANP A 401 (-4.5A);ANP A 401 (-3.5A);None;ANP A 401 (-3.8A);ANP A 401 ( 4.8A);None;ANP A 401 (-3.9A);None;ANP A 401 ( 4.5A)","0.61A","5lw1E-5awmA:43.6","5lw1E-5awmA:64.44"],["5LW1_H_ADNH401_1","MITOGEN-ACTIVATED PROTEIN KINASE 8","5awm","STRESS-ACTIVATED PROTEIN KINASE JNK","Drosophila melanogaster",7,"GLY A  31;ALA A  51;MET A 106;LEU A 108;MET A 109;VAL A 156;LEU A 166","ANP A 401 (-3.3A);ANP A 401 (-3.5A);ANP A 401 (-3.8A);ANP A 401 ( 4.8A);None;None;ANP A 401 ( 4.5A)","0.71A","5lw1H-5awmA:44.0","5lw1H-5awmA:64.44"],["5LW1_H_ADNH401_1","MITOGEN-ACTIVATED PROTEIN KINASE 8","5awm","STRESS-ACTIVATED PROTEIN KINASE JNK","Drosophila melanogaster",8,"VAL A  38;ALA A  51;MET A 106;LEU A 108;MET A 109;ASN A 112;VAL A 156;LEU A 166","ANP A 401 (-4.5A);ANP A 401 (-3.5A);ANP A 401 (-3.8A);ANP A 401 ( 4.8A);None;ANP A 401 (-3.9A);None;ANP A 401 ( 4.5A)","0.45A","5lw1H-5awmA:44.0","5lw1H-5awmA:64.44"],["5NZY_A_CE3A1103_1","DNA CROSS-LINK REPAIR 1A PROTEIN","5awm","STRESS-ACTIVATED PROTEIN KINASE JNK","Drosophila melanogaster",4,"PRO A 152;TYR A 189;VAL A 221;GLY A 220","None","1.03A","5nzyA-5awmA:undetectable","5nzyA-5awmA:21.04"],["6CDU_A_EY4A501_0","CHIMERIC ALPHA1GABAA RECEPTOR","5awm","STRESS-ACTIVATED PROTEIN KINASE JNK","Drosophila melanogaster",4,"GLN A 350;VAL A 348;TRP A 351;THR A  63","None","1.24A","6cduA-5awmA:undetectable;6cduB-5awmA:undetectable","6cduA-5awmA:21.31;6cduB-5awmA:21.31"],["6CDU_I_EY4I500_0","CHIMERIC ALPHA1GABAA RECEPTOR","5awm","STRESS-ACTIVATED PROTEIN KINASE JNK","Drosophila melanogaster",4,"GLN A 350;VAL A 348;TRP A 351;THR A  63","None","1.33A","6cduI-5awmA:undetectable;6cduJ-5awmA:undetectable","6cduI-5awmA:21.31;6cduJ-5awmA:21.31"],["6FGC_A_ACTA811_0","GEPHYRIN","5awm","STRESS-ACTIVATED PROTEIN KINASE JNK","Drosophila melanogaster",3,"LEU A 129;LEU A 121;ARG A 125","None","0.45A","6fgcA-5awmA:undetectable","6fgcA-5awmA:23.21"],["6FGD_A_ACTA810_0","GEPHYRIN","5awm","STRESS-ACTIVATED PROTEIN KINASE JNK","Drosophila melanogaster",3,"LEU A 129;LEU A 121;ARG A 125","None","0.46A","6fgdA-5awmA:undetectable","6fgdA-5awmA:23.21"],["6GNE_B_ACRB602_2","-","5awm","STRESS-ACTIVATED PROTEIN KINASE JNK","Drosophila melanogaster",4,"VAL A 311;HIS A 139;ASN A  82;GLU A 328","None","1.30A","6gneB-5awmA:undetectable","6gneB-5awmA:22.93"]]