SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5awn'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1H8S_A_AICA1000_1
(MUTANT AL2 6E7P9G)		 5awn HEAVY CHAIN OF
3BC176 FAB
LIGHT CHAIN OF
3BC176 FAB
(Homo
sapiens) 		6 / 12 TYR L  36
LEU L  96
PHE L  98
VAL H  37
ALA H  93
TRP H 103
 None
 0.77A 1h8sA-5awnL:
17.6		 1h8sA-5awnL:
34.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KF6_B_ACTB704_0
(FUMARATE REDUCTASE
FLAVOPROTEIN
FUMARATE REDUCTASE
IRON-SULFUR PROTEIN)		 5awn HEAVY CHAIN OF
3BC176 FAB
(Homo
sapiens) 		3 / 3 ARG H  66
GLY H  85
ASP H  86
 None
 0.57A 1kf6A-5awnH:
undetectable
1kf6B-5awnH:
undetectable		 1kf6A-5awnH:
16.36
1kf6B-5awnH:
22.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XDC_D_DVAD8_0
(GRAMICIDIN A)		 5awn HEAVY CHAIN OF
3BC176 FAB
(Homo
sapiens) 		3 / 3 TRP H  47
VAL H 100
TRP H  50
 None
 0.71A 2xdcC-5awnH:
undetectable
2xdcD-5awnH:
undetectable		 2xdcC-5awnH:
8.47
2xdcD-5awnH:
8.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XDC_F_DVAF8_0
(GRAMICIDIN A)		 5awn HEAVY CHAIN OF
3BC176 FAB
(Homo
sapiens) 		3 / 3 TRP H  47
VAL H 100
TRP H  50
 None
 0.74A 2xdcE-5awnH:
undetectable
2xdcF-5awnH:
undetectable		 2xdcE-5awnH:
8.47
2xdcF-5awnH:
8.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y5M_F_DVAF8_0
(VAL-GRAMICIDIN A)		 5awn HEAVY CHAIN OF
3BC176 FAB
(Homo
sapiens) 		3 / 3 TRP H  47
VAL H 100
TRP H  50
 None
 0.71A 2y5mE-5awnH:
undetectable
2y5mF-5awnH:
undetectable		 2y5mE-5awnH:
8.47
2y5mF-5awnH:
8.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y6N_D_DVAD8_0
(VAL-GRAMICIDIN A)		 5awn HEAVY CHAIN OF
3BC176 FAB
(Homo
sapiens) 		3 / 3 TRP H  47
VAL H 100
TRP H  50
 None
 0.71A 2y6nC-5awnH:
undetectable
2y6nD-5awnH:
undetectable		 2y6nC-5awnH:
8.47
2y6nD-5awnH:
8.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y6N_F_DVAF8_0
(VAL-GRAMICIDIN A)		 5awn HEAVY CHAIN OF
3BC176 FAB
(Homo
sapiens) 		3 / 3 TRP H  47
VAL H 100
TRP H  50
 None
 0.70A 2y6nE-5awnH:
undetectable
2y6nF-5awnH:
undetectable		 2y6nE-5awnH:
8.47
2y6nF-5awnH:
8.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YA7_A_ZMRA1776_2
(NEURAMINIDASE A)		 5awn HEAVY CHAIN OF
3BC176 FAB
(Homo
sapiens) 		4 / 6 ASP H  52
ILE H  51
LEU H  78
TYR H  27
 None
 1.07A 2ya7A-5awnH:
undetectable		 2ya7A-5awnH:
18.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YA7_B_ZMRB1776_2
(NEURAMINIDASE A)		 5awn HEAVY CHAIN OF
3BC176 FAB
(Homo
sapiens) 		4 / 6 ASP H  52
ILE H  51
LEU H  78
TYR H  27
 None
 1.05A 2ya7B-5awnH:
undetectable		 2ya7B-5awnH:
18.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YA7_D_ZMRD1776_2
(NEURAMINIDASE A)		 5awn HEAVY CHAIN OF
3BC176 FAB
(Homo
sapiens) 		4 / 6 ASP H  52
ILE H  51
LEU H  78
TYR H  27
 None
 1.05A 2ya7D-5awnH:
undetectable		 2ya7D-5awnH:
18.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EEY_C_SAMC300_1
(PUTATIVE RRNA
METHYLASE)		 5awn HEAVY CHAIN OF
3BC176 FAB
LIGHT CHAIN OF
3BC176 FAB
(Homo
sapiens;
Homo
sapiens) 		3 / 3 ASN L 128
ASP H 144
GLN H 171
 None
 0.81A 3eeyC-5awnL:
undetectable		 3eeyC-5awnL:
19.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EEY_D_SAMD300_1
(PUTATIVE RRNA
METHYLASE)		 5awn HEAVY CHAIN OF
3BC176 FAB
LIGHT CHAIN OF
3BC176 FAB
(Homo
sapiens;
Homo
sapiens) 		3 / 3 ASN L 128
ASP H 144
GLN H 171
 None
 0.82A 3eeyD-5awnL:
undetectable		 3eeyD-5awnL:
19.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EEY_E_SAME300_1
(PUTATIVE RRNA
METHYLASE)		 5awn HEAVY CHAIN OF
3BC176 FAB
LIGHT CHAIN OF
3BC176 FAB
(Homo
sapiens;
Homo
sapiens) 		3 / 3 ASN L 128
ASP H 144
GLN H 171
 None
 0.81A 3eeyE-5awnL:
undetectable		 3eeyE-5awnL:
19.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HGX_A_SALA102_1
(SALICYLATE
BIOSYNTHESIS PROTEIN
PCHB)		 5awn HEAVY CHAIN OF
3BC176 FAB
(Homo
sapiens) 		4 / 7 ARG H  94
VAL H   2
TYR H  27
GLN H   1
 None
 0.85A 3hgxA-5awnH:
undetectable		 3hgxA-5awnH:
17.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NBR_A_ASDA129_1
(STEROID
DELTA-ISOMERASE)		 5awn HEAVY CHAIN OF
3BC176 FAB
LIGHT CHAIN OF
3BC176 FAB
(Homo
sapiens) 		5 / 12 PHE H 166
VAL L 195
VAL L 144
PRO L 113
PHE L 139
 None
 1.42A 3nbrA-5awnH:
undetectable		 3nbrA-5awnH:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3REM_A_SALA301_1
(SALICYLATE
BIOSYNTHESIS PROTEIN
PCHB)		 5awn HEAVY CHAIN OF
3BC176 FAB
(Homo
sapiens) 		4 / 8 ARG H  94
VAL H   2
TYR H  27
GLN H   1
 None
 0.88A 3remA-5awnH:
undetectable		 3remA-5awnH:
17.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3REM_B_SALB301_1
(SALICYLATE
BIOSYNTHESIS PROTEIN
PCHB)		 5awn HEAVY CHAIN OF
3BC176 FAB
(Homo
sapiens) 		4 / 8 ARG H  94
VAL H   2
TYR H  27
GLN H   1
 None
 0.91A 3remB-5awnH:
undetectable		 3remB-5awnH:
17.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JX1_B_CAMB502_0
(CAMPHOR
5-MONOOXYGENASE)		 5awn HEAVY CHAIN OF
3BC176 FAB
(Homo
sapiens) 		5 / 10 PHE H 122
GLY H 118
THR H 205
VAL H 198
VAL H 207
 None
 1.18A 4jx1B-5awnH:
undetectable		 4jx1B-5awnH:
17.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O0U_A_ADNA501_1
(AURORA KINASE A)		 5awn LIGHT CHAIN OF
3BC176 FAB
(Homo
sapiens) 		5 / 6 VAL L 155
ALA L 150
LEU L 132
THR L 181
LEU L 180
 None
 1.39A 4o0uA-5awnL:
undetectable		 4o0uA-5awnL:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P7N_A_GCSA702_1
(POLY-BETA-1,6-N-ACET
YL-D-GLUCOSAMINE
N-DEACETYLASE)		 5awn HEAVY CHAIN OF
3BC176 FAB
LIGHT CHAIN OF
3BC176 FAB
(Homo
sapiens) 		3 / 3 ASP L  95
TYR L  94
TRP H  50
 None
 1.29A 4p7nA-5awnL:
undetectable		 4p7nA-5awnL:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XUD_A_SAMA303_0
(CATECHOL
O-METHYLTRANSFERASE)		 5awn LIGHT CHAIN OF
3BC176 FAB
(Homo
sapiens) 		5 / 12 VAL L  21
GLY L  99
TYR L  86
ILE L  97
SER L   2
 None
 1.47A 4xudA-5awnL:
undetectable		 4xudA-5awnL:
21.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZE2_A_1YNA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 5awn HEAVY CHAIN OF
3BC176 FAB
(Homo
sapiens) 		5 / 12 GLY H  85
LEU H  80
ILE H  34
GLY H 104
THR H  87
 None
 0.98A 4ze2A-5awnH:
undetectable		 4ze2A-5awnH:
18.01
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ACL_A_SASA1111_1
(MCG)		 5awn LIGHT CHAIN OF
3BC176 FAB
(Homo
sapiens) 		5 / 7 SER L  34
TYR L  36
TYR L  49
GLU L  50
PRO L  55
 None
 0.62A 5aclA-5awnL:
23.3		 5aclA-5awnL:
68.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EQB_A_1YNA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 5awn HEAVY CHAIN OF
3BC176 FAB
(Homo
sapiens) 		5 / 12 GLY H  85
ILE H  34
GLY H 104
PHE H  63
THR H  87
 None
 1.12A 5eqbA-5awnH:
undetectable		 5eqbA-5awnH:
18.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ESK_A_1YNA701_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 5awn HEAVY CHAIN OF
3BC176 FAB
(Homo
sapiens) 		5 / 12 GLY H  85
LEU H  80
ILE H  34
PHE H  63
THR H  87
 None
 1.10A 5eskA-5awnH:
undetectable		 5eskA-5awnH:
18.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JLC_A_1YNA602_2
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 5awn HEAVY CHAIN OF
3BC176 FAB
LIGHT CHAIN OF
3BC176 FAB
(Homo
sapiens) 		4 / 5 TYR L  87
GLY L 101
THR L 102
GLY H 174
 None
 0.80A 5jlcA-5awnL:
undetectable		 5jlcA-5awnL:
17.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5T8S_B_SAMB402_1
(S-ADENOSYLMETHIONINE
SYNTHASE)		 5awn LIGHT CHAIN OF
3BC176 FAB
(Homo
sapiens) 		4 / 8 PRO L  40
ASP L  85
SER L   9
THR L 145
 None
 1.23A 5t8sB-5awnL:
undetectable		 5t8sB-5awnL:
19.90