SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5awp'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1BX4_A_ADNA350_1
(PROTEIN (ADENOSINE
KINASE))		 5awp ISOMALTODEXTRANASE
(Arthrobacter
globiformis) 		5 / 12 LEU A 582
GLY A 303
ASN A 302
ALA A 515
LEU A 584
 None
 0.85A 1bx4A-5awpA:
undetectable		 1bx4A-5awpA:
22.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ONI_G_BEZG513_0
(14.5 KDA
TRANSLATIONAL
INHIBITOR PROTEIN)		 5awp ISOMALTODEXTRANASE
(Arthrobacter
globiformis) 		4 / 5 ARG A 195
ILE A 308
PRO A  34
GLU A 238
 None
 1.45A 1oniG-5awpA:
undetectable
1oniH-5awpA:
0.9		 1oniG-5awpA:
13.14
1oniH-5awpA:
13.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UPF_A_URFA999_1
(URACIL
PHOSPHORIBOSYLTRANSF
ERASE)		 5awp ISOMALTODEXTRANASE
(Arthrobacter
globiformis) 		4 / 5 MET A 314
ALA A 342
TYR A  36
ILE A 341
 None
 1.02A 1upfA-5awpA:
undetectable		 1upfA-5awpA:
15.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UPF_C_URFC999_1
(URACIL
PHOSPHORIBOSYLTRANSF
ERASE)		 5awp ISOMALTODEXTRANASE
(Arthrobacter
globiformis) 		4 / 5 MET A 314
ALA A 342
TYR A  36
ILE A 341
 None
 0.99A 1upfC-5awpA:
undetectable		 1upfC-5awpA:
15.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UPF_D_URFD999_1
(URACIL
PHOSPHORIBOSYLTRANSF
ERASE)		 5awp ISOMALTODEXTRANASE
(Arthrobacter
globiformis) 		4 / 4 MET A 314
ALA A 342
TYR A  36
ILE A 341
 None
 1.01A 1upfD-5awpA:
undetectable		 1upfD-5awpA:
15.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QHF_A_ACTA509_0
(CHORISMATE SYNTHASE)		 5awp ISOMALTODEXTRANASE
(Arthrobacter
globiformis) 		3 / 3 ARG A 304
GLN A 517
PRO A 397
 None
 0.66A 2qhfA-5awpA:
undetectable		 2qhfA-5awpA:
21.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QWX_B_ML1B233_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 5awp ISOMALTODEXTRANASE
(Arthrobacter
globiformis) 		4 / 7 TRP A 479
GLY A 494
GLY A 394
PHE A 485
 None
 0.88A 2qwxA-5awpA:
undetectable
2qwxB-5awpA:
undetectable		 2qwxA-5awpA:
16.92
2qwxB-5awpA:
16.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RCT_A_RTLA140_1
(RETINOL-BINDING
PROTEIN II, CELLULAR)		 5awp ISOMALTODEXTRANASE
(Arthrobacter
globiformis) 		3 / 3 GLN A 395
THR A 469
TRP A 601
 None
 1.15A 2rctA-5awpA:
undetectable		 2rctA-5awpA:
12.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LCV_B_SAMB301_0
(SISOMICIN-GENTAMICIN
RESISTANCE METHYLASE
SGM)		 5awp ISOMALTODEXTRANASE
(Arthrobacter
globiformis) 		5 / 12 ARG A 521
THR A 541
ALA A 544
ASP A 579
LEU A 578
 None
 1.39A 3lcvB-5awpA:
undetectable		 3lcvB-5awpA:
18.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3M7R_A_VDXA425_1
(VITAMIN D3 RECEPTOR)		 5awp ISOMALTODEXTRANASE
(Arthrobacter
globiformis) 		5 / 12 SER A  98
SER A  43
GLN A 164
LEU A 165
HIS A 127
 None
 1.31A 3m7rA-5awpA:
undetectable		 3m7rA-5awpA:
16.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A6E_A_SAMA1349_0
(HYDROXYINDOLE
O-METHYLTRANSFERASE)		 5awp ISOMALTODEXTRANASE
(Arthrobacter
globiformis) 		5 / 12 LEU A 584
GLY A 303
GLY A 305
ILE A 308
ALA A 477
 None
 1.14A 4a6eA-5awpA:
undetectable		 4a6eA-5awpA:
20.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A6E_A_SAMA1349_1
(HYDROXYINDOLE
O-METHYLTRANSFERASE)		 5awp ISOMALTODEXTRANASE
(Arthrobacter
globiformis) 		3 / 3 TYR A  36
ASP A 310
ASP A 258
 None
 0.65A 4a6eA-5awpA:
undetectable		 4a6eA-5awpA:
20.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M5M_A_DX4A401_0
(2-AMINO-4-HYDROXY-6-
HYDROXYMETHYLDIHYDRO
PTERIDINE
PYROPHOSPHOKINASE)		 5awp ISOMALTODEXTRANASE
(Arthrobacter
globiformis) 		4 / 8 GLY A 303
LEU A 368
ASN A 302
ARG A 304
 None
 1.17A 4m5mA-5awpA:
undetectable		 4m5mA-5awpA:
15.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MM5_A_SREA603_1
(TRANSPORTER)		 5awp ISOMALTODEXTRANASE
(Arthrobacter
globiformis) 		5 / 9 VAL A 403
ALA A 393
GLY A 430
PHE A 420
SER A 400
 None
 1.32A 4mm5A-5awpA:
undetectable		 4mm5A-5awpA:
22.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4N09_C_ADNC401_1
(ADENOSINE KINASE)		 5awp ISOMALTODEXTRANASE
(Arthrobacter
globiformis) 		5 / 12 LEU A 582
GLY A 303
ASN A 302
ALA A 515
LEU A 584
 None
 0.93A 4n09C-5awpA:
undetectable		 4n09C-5awpA:
20.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PCL_A_SAMA301_0
(O-METHYLTRANSFERASE
FAMILY PROTEIN)		 5awp ISOMALTODEXTRANASE
(Arthrobacter
globiformis) 		5 / 12 ALA A 503
GLN A 502
LEU A 501
GLY A 481
ALA A 508
 None
BGC  A 703 (-2.6A)
None
None
None
 1.17A 4pclA-5awpA:
undetectable		 4pclA-5awpA:
16.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QTU_B_SAMB301_1
(PUTATIVE
METHYLTRANSFERASE
BUD23)		 5awp ISOMALTODEXTRANASE
(Arthrobacter
globiformis) 		4 / 5 TYR A  36
SER A 337
ASP A 312
ASP A 267
 None
None
BGC  A 701 ( 4.0A)
None
 1.49A 4qtuB-5awpA:
undetectable		 4qtuB-5awpA:
16.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R38_A_RBFA201_1
(BLUE-LIGHT-ACTIVATED
HISTIDINE KINASE 2)		 5awp ISOMALTODEXTRANASE
(Arthrobacter
globiformis) 		5 / 12 ALA A 572
ALA A 596
ILE A 597
LEU A 563
GLY A 570
 None
GLC  A 704 (-3.5A)
None
None
None
 1.20A 4r38A-5awpA:
undetectable		 4r38A-5awpA:
12.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R38_D_RBFD201_1
(BLUE-LIGHT-ACTIVATED
HISTIDINE KINASE 2)		 5awp ISOMALTODEXTRANASE
(Arthrobacter
globiformis) 		5 / 12 ALA A 572
ALA A 596
ILE A 597
LEU A 563
GLY A 570
 None
GLC  A 704 (-3.5A)
None
None
None
 1.21A 4r38D-5awpA:
undetectable		 4r38D-5awpA:
12.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RP8_C_ASCC501_1
(ASCORBATE-SPECIFIC
PERMEASE IIC
COMPONENT ULAA)		 5awp ISOMALTODEXTRANASE
(Arthrobacter
globiformis) 		3 / 3 SER A 240
TYR A 193
ASP A 312
 None
None
BGC  A 701 ( 4.0A)
 0.65A 4rp8C-5awpA:
undetectable		 4rp8C-5awpA:
21.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5D4N_C_ACTC201_0
(NITROGEN REGULATORY
PROTEIN P-II)		 5awp ISOMALTODEXTRANASE
(Arthrobacter
globiformis) 		4 / 5 VAL A 432
VAL A 403
GLY A 402
PHE A 420
 None
 0.96A 5d4nA-5awpA:
undetectable
5d4nC-5awpA:
undetectable		 5d4nA-5awpA:
10.87
5d4nC-5awpA:
10.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E26_A_PAUA602_0
(PANTOTHENATE KINASE
2, MITOCHONDRIAL)		 5awp ISOMALTODEXTRANASE
(Arthrobacter
globiformis) 		4 / 7 GLY A 535
GLY A 595
TYR A 530
ALA A 533
 None
 0.98A 5e26A-5awpA:
undetectable
5e26B-5awpA:
undetectable		 5e26A-5awpA:
21.04
5e26B-5awpA:
21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KB5_A_ADNA401_1
(ADENOSINE KINASE)		 5awp ISOMALTODEXTRANASE
(Arthrobacter
globiformis) 		5 / 12 LEU A 582
GLY A 303
ASN A 302
ALA A 515
LEU A 584
 None
 0.82A 5kb5A-5awpA:
undetectable		 5kb5A-5awpA:
22.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N4T_B_BEZB306_0
(BETA-LACTAMASE VIM-2)		 5awp ISOMALTODEXTRANASE
(Arthrobacter
globiformis) 		3 / 3 HIS A 217
ASN A 221
ALA A 225
 None
 0.81A 5n4tB-5awpA:
undetectable		 5n4tB-5awpA:
20.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NY7_A_NCAA303_0
(AMIDASE)		 5awp ISOMALTODEXTRANASE
(Arthrobacter
globiformis) 		4 / 6 GLY A 554
PRO A 555
THR A 551
GLU A 545
 None
 1.13A 5ny7A-5awpA:
1.6		 5ny7A-5awpA:
19.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5SYF_B_TA1B502_1
(TUBULIN BETA CHAIN)		 5awp ISOMALTODEXTRANASE
(Arthrobacter
globiformis) 		5 / 12 VAL A 369
ASP A 258
ARG A 549
PRO A 397
LEU A 582
 None
 1.43A 5syfB-5awpA:
undetectable		 5syfB-5awpA:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WWS_A_SAMA501_0
(PUTATIVE
METHYLTRANSFERASE
NSUN6)		 5awp ISOMALTODEXTRANASE
(Arthrobacter
globiformis) 		5 / 12 PRO A  49
GLY A  82
GLY A 118
LEU A 110
LEU A 117
 None
 1.12A 5wwsA-5awpA:
undetectable		 5wwsA-5awpA:
20.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X7P_A_ACRA1431_1
(GLYCOSIDE HYDROLASE
FAMILY 31
ALPHA-GLUCOSIDASE)		 5awp ISOMALTODEXTRANASE
(Arthrobacter
globiformis) 		5 / 7 ASN A 488
HIS A 489
ASP A 499
TRP A 566
ASN A 598
 GLC  A 704 ( 4.4A)
GLC  A 704 (-3.9A)
None
GLC  A 704 (-3.6A)
GLC  A 704 (-3.0A)
 0.17A 5x7pA-5awpA:
7.4		 5x7pA-5awpA:
19.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DWN_C_AQ4C602_0
(CYTOCHROME P450 1A1)		 5awp ISOMALTODEXTRANASE
(Arthrobacter
globiformis) 		5 / 12 ASN A 214
PHE A 156
ASP A 197
ILE A  80
LEU A 165
 None
GLC  A 702 ( 4.9A)
BGC  A 701 (-3.0A)
GLC  A 702 (-4.1A)
None
 0.93A 6dwnC-5awpA:
undetectable		 6dwnC-5awpA:
8.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DWN_D_AQ4D602_0
(CYTOCHROME P450 1A1)		 5awp ISOMALTODEXTRANASE
(Arthrobacter
globiformis) 		5 / 12 ASN A 214
PHE A 156
ASP A 197
ILE A  80
LEU A 165
 None
GLC  A 702 ( 4.9A)
BGC  A 701 (-3.0A)
GLC  A 702 (-4.1A)
None
 0.92A 6dwnD-5awpA:
undetectable		 6dwnD-5awpA:
8.70