SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5ax0'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

Filter list by:

	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1U18_A_HSMA401_1 (NITROPHORIN 1)	5ax0	RHODOPSIN I (Acetabularia acetabulum)	4 / 4	ASP A 119 LEU A 99 LEU A 96 LEU A 98	None OLB A 304 ( 4.4A) OLB A 304 (-4.6A) None	1.29A	1u18A-5ax0A: undetectable	1u18A-5ax0A: 18.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1YA4_B_CTXB2_2 (CES1 PROTEIN)	5ax0	RHODOPSIN I (Acetabularia acetabulum)	4 / 4	LEU A 98 PRO A 189 ILE A 182 LEU A 181	None RET A 301 (-4.1A) None None	0.92A	1ya4B-5ax0A: undetectable	1ya4B-5ax0A: 18.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1YA4_C_CTXC3_2 (CES1 PROTEIN)	5ax0	RHODOPSIN I (Acetabularia acetabulum)	4 / 4	LEU A 98 PRO A 189 ILE A 182 LEU A 181	None RET A 301 (-4.1A) None None	1.06A	1ya4C-5ax0A: undetectable	1ya4C-5ax0A: 18.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2AOF_C_FRDC305_1 (POL POLYPROTEIN PEPTIDE INHIBITOR)	5ax0	RHODOPSIN I (Acetabularia acetabulum)	4 / 5	ASP A 204 GLY A 67 ALA A 15 ILE A 207	None	0.92A	2aofA-5ax0A: undetectable	2aofA-5ax0A: 21.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2QK8_A_MTXA200_1 (DIHYDROFOLATE REDUCTASE)	5ax0	RHODOPSIN I (Acetabularia acetabulum)	5 / 12	ALA A 173 VAL A 232 ARG A 37 LEU A 41 PRO A 38	None	1.22A	2qk8A-5ax0A: undetectable	2qk8A-5ax0A: 20.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2WX2_A_TPFA1460_1 (LANOSTEROL 14-ALPHA-DEMETHYLASE)	5ax0	RHODOPSIN I (Acetabularia acetabulum)	4 / 7	MET A 122 ALA A 149 ALA A 152 LEU A 181	RET A 301 (-3.7A) R16 A 308 ( 3.8A) None None	0.95A	2wx2A-5ax0A: undetectable	2wx2A-5ax0A: 20.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3JAY_A_SAMA1102_0 (STRUCTURAL PROTEIN VP3)	5ax0	RHODOPSIN I (Acetabularia acetabulum)	5 / 12	TYR A 87 GLY A 195 GLY A 197 ALA A 130 PRO A 4	None	1.11A	3jayA-5ax0A: undetectable	3jayA-5ax0A: 12.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4E7C_A_ACTA504_0 (UDP-N-ACETYLGLUCOSAM INE 1-CARBOXYVINYLTRANSF ERASE)	5ax0	RHODOPSIN I (Acetabularia acetabulum)	3 / 3	ARG A 80 TRP A 192 GLY A 193	None RET A 301 ( 4.1A) D12 A 306 ( 3.9A)	0.82A	4e7cA-5ax0A: undetectable	4e7cA-5ax0A: 22.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5KPC_B_SAMB401_0 (PAVINE N-METHYLTRANSFERASE)	5ax0	RHODOPSIN I (Acetabularia acetabulum)	5 / 12	LYS A 137 PHE A 141 GLY A 126 ASP A 89 ALA A 196	None R16 A 308 (-4.8A) RET A 301 ( 3.8A) RET A 301 ( 4.9A) None	1.11A	5kpcB-5ax0A: undetectable	5kpcB-5ax0A: 20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6AYC_A_1YNA502_1 (PROTEIN CYP51)	5ax0	RHODOPSIN I (Acetabularia acetabulum)	5 / 12	ALA A 50 MET A 122 ALA A 149 ALA A 152 LEU A 181	D10 A 309 ( 3.8A) RET A 301 (-3.7A) R16 A 308 ( 3.8A) None None	1.35A	6aycA-5ax0A: undetectable	6aycA-5ax0A: 13.62

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["1U18_A_HSMA401_1","NITROPHORIN 1","5ax0","RHODOPSIN I","Acetabularia acetabulum",4,"ASP A 119;LEU A  99;LEU A  96;LEU A  98","None;OLB A 304 ( 4.4A);OLB A 304 (-4.6A);None","1.29A","1u18A-5ax0A:undetectable","1u18A-5ax0A:18.33"],["1YA4_B_CTXB2_2","CES1 PROTEIN","5ax0","RHODOPSIN I","Acetabularia acetabulum",4,"LEU A  98;PRO A 189;ILE A 182;LEU A 181","None;RET A 301 (-4.1A);None;None","0.92A","1ya4B-5ax0A:undetectable","1ya4B-5ax0A:18.23"],["1YA4_C_CTXC3_2","CES1 PROTEIN","5ax0","RHODOPSIN I","Acetabularia acetabulum",4,"LEU A  98;PRO A 189;ILE A 182;LEU A 181","None;RET A 301 (-4.1A);None;None","1.06A","1ya4C-5ax0A:undetectable","1ya4C-5ax0A:18.23"],["2AOF_C_FRDC305_1","POL POLYPROTEIN;PEPTIDE INHIBITOR","5ax0","RHODOPSIN I","Acetabularia acetabulum",4,"ASP A 204;GLY A  67;ALA A  15;ILE A 207","None","0.92A","2aofA-5ax0A:undetectable","2aofA-5ax0A:21.83"],["2QK8_A_MTXA200_1","DIHYDROFOLATE REDUCTASE","5ax0","RHODOPSIN I","Acetabularia acetabulum",5,"ALA A 173;VAL A 232;ARG A  37;LEU A  41;PRO A  38","None","1.22A","2qk8A-5ax0A:undetectable","2qk8A-5ax0A:20.40"],["2WX2_A_TPFA1460_1","LANOSTEROL 14-ALPHA-DEMETHYLASE","5ax0","RHODOPSIN I","Acetabularia acetabulum",4,"MET A 122;ALA A 149;ALA A 152;LEU A 181","RET A 301 (-3.7A);R16 A 308 ( 3.8A);None;None","0.95A","2wx2A-5ax0A:undetectable","2wx2A-5ax0A:20.17"],["3JAY_A_SAMA1102_0","STRUCTURAL PROTEIN VP3","5ax0","RHODOPSIN I","Acetabularia acetabulum",5,"TYR A  87;GLY A 195;GLY A 197;ALA A 130;PRO A   4","None","1.11A","3jayA-5ax0A:undetectable","3jayA-5ax0A:12.12"],["4E7C_A_ACTA504_0","UDP-N-ACETYLGLUCOSAMINE 1-CARBOXYVINYLTRANSFERASE","5ax0","RHODOPSIN I","Acetabularia acetabulum",3,"ARG A  80;TRP A 192;GLY A 193","None;RET A 301 ( 4.1A);D12 A 306 ( 3.9A)","0.82A","4e7cA-5ax0A:undetectable","4e7cA-5ax0A:22.49"],["5KPC_B_SAMB401_0","PAVINE N-METHYLTRANSFERASE","5ax0","RHODOPSIN I","Acetabularia acetabulum",5,"LYS A 137;PHE A 141;GLY A 126;ASP A  89;ALA A 196","None;R16 A 308 (-4.8A);RET A 301 ( 3.8A);RET A 301 ( 4.9A);None","1.11A","5kpcB-5ax0A:undetectable","5kpcB-5ax0A:20.00"],["6AYC_A_1YNA502_1","PROTEIN CYP51","5ax0","RHODOPSIN I","Acetabularia acetabulum",5,"ALA A  50;MET A 122;ALA A 149;ALA A 152;LEU A 181","D10 A 309 ( 3.8A);RET A 301 (-3.7A);R16 A 308 ( 3.8A);None;None","1.35A","6aycA-5ax0A:undetectable","6aycA-5ax0A:13.62"]]