SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5ax7'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CQP_A_803A311_1
(ANTIGEN CD11A (P180))		 5ax7 PYRUVYL TRANSFERASE
1
(Schizosaccharomy
ces
pombe) 		5 / 10 LEU A 267
ILE A 263
TYR A 292
LEU A 392
LEU A 389
 None
 0.97A 1cqpA-5ax7A:
2.9
1cqpB-5ax7A:
undetectable		 1cqpA-5ax7A:
18.80
1cqpB-5ax7A:
18.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DY4_A_SNPA437_2
(EXOGLUCANASE 1)		 5ax7 PYRUVYL TRANSFERASE
1
(Schizosaccharomy
ces
pombe) 		4 / 5 HIS A 351
TRP A 297
TYR A 320
ALA A 108
 None
 1.11A 1dy4A-5ax7A:
undetectable		 1dy4A-5ax7A:
22.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DYR_A_TOPA407_1
(DIHYDROFOLATE
REDUCTASE)		 5ax7 PYRUVYL TRANSFERASE
1
(Schizosaccharomy
ces
pombe) 		5 / 11 ILE A 241
ILE A 185
PHE A 187
ILE A 122
THR A 238
 None
 1.00A 1dyrA-5ax7A:
2.2		 1dyrA-5ax7A:
21.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EKJ_A_ACTA3001_0
(BETA-CARBONIC
ANHYDRASE)		 5ax7 PYRUVYL TRANSFERASE
1
(Schizosaccharomy
ces
pombe) 		4 / 8 ASP A 240
HIS A 339
GLY A 158
GLY A 159
 None
 0.86A 1ekjA-5ax7A:
undetectable
1ekjB-5ax7A:
undetectable		 1ekjA-5ax7A:
21.57
1ekjB-5ax7A:
21.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EKJ_E_ACTE3005_0
(BETA-CARBONIC
ANHYDRASE)		 5ax7 PYRUVYL TRANSFERASE
1
(Schizosaccharomy
ces
pombe) 		4 / 7 ASP A 240
HIS A 339
GLY A 158
GLY A 159
 None
 0.83A 1ekjE-5ax7A:
undetectable
1ekjF-5ax7A:
undetectable		 1ekjE-5ax7A:
21.57
1ekjF-5ax7A:
21.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EKJ_G_ACTG3002_0
(BETA-CARBONIC
ANHYDRASE)		 5ax7 PYRUVYL TRANSFERASE
1
(Schizosaccharomy
ces
pombe) 		4 / 8 ASP A 240
HIS A 339
GLY A 158
GLY A 159
 None
 0.85A 1ekjG-5ax7A:
undetectable
1ekjH-5ax7A:
undetectable		 1ekjG-5ax7A:
21.57
1ekjH-5ax7A:
21.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXK_A_IMNA2001_1
(SERUM ALBUMIN)		 5ax7 PYRUVYL TRANSFERASE
1
(Schizosaccharomy
ces
pombe) 		4 / 8 SER A 144
PHE A 151
ALA A  94
LEU A 153
 None
 1.13A 2bxkA-5ax7A:
undetectable		 2bxkA-5ax7A:
18.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HDN_J_TACJ5888_1
(ELONGATION FACTOR
EF-TU)		 5ax7 PYRUVYL TRANSFERASE
1
(Schizosaccharomy
ces
pombe) 		4 / 6 SER A 311
ASP A 313
SER A 310
VAL A 304
 None
 1.30A 2hdnI-5ax7A:
undetectable
2hdnJ-5ax7A:
2.6
2hdnL-5ax7A:
2.7		 2hdnI-5ax7A:
9.35
2hdnJ-5ax7A:
20.97
2hdnL-5ax7A:
20.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HDN_L_TACL6888_1
(ELONGATION FACTOR
EF-TU)		 5ax7 PYRUVYL TRANSFERASE
1
(Schizosaccharomy
ces
pombe) 		4 / 6 SER A 310
VAL A 304
SER A 311
ASP A 313
 None
 1.30A 2hdnJ-5ax7A:
2.6
2hdnK-5ax7A:
undetectable
2hdnL-5ax7A:
2.7		 2hdnJ-5ax7A:
20.97
2hdnK-5ax7A:
9.35
2hdnL-5ax7A:
20.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZIA_B_CL9B401_2
(DEOXYCYTIDINE KINASE)		 5ax7 PYRUVYL TRANSFERASE
1
(Schizosaccharomy
ces
pombe) 		4 / 4 ARG A 217
ASP A 218
LEU A 370
ARG A 337
 None
 1.33A 2ziaB-5ax7A:
undetectable		 2ziaB-5ax7A:
22.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SFU_B_RBVB601_1
(RNA POLYMERASE)		 5ax7 PYRUVYL TRANSFERASE
1
(Schizosaccharomy
ces
pombe) 		5 / 9 ASN A 160
GLY A 158
ASP A 106
LEU A 338
ARG A 337
 None
 1.42A 3sfuB-5ax7A:
undetectable		 3sfuB-5ax7A:
21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U52_A_CUA515_0
(PHENOL HYDROXYLASE
COMPONENT PHL
PHENOL HYDROXYLASE
COMPONENT PHN)		 5ax7 PYRUVYL TRANSFERASE
1
(Schizosaccharomy
ces
pombe) 		3 / 3 HIS A 366
HIS A 341
ILE A 362
 None
 0.77A 3u52A-5ax7A:
undetectable
3u52C-5ax7A:
undetectable		 3u52A-5ax7A:
22.22
3u52C-5ax7A:
21.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M7T_A_SAMA503_0
(BTRN)		 5ax7 PYRUVYL TRANSFERASE
1
(Schizosaccharomy
ces
pombe) 		5 / 11 HIS A 366
TYR A 365
GLU A 355
THR A 335
LEU A 343
 None
 1.34A 4m7tA-5ax7A:
undetectable		 4m7tA-5ax7A:
20.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IEP_A_VDYA201_2
(CDL2.3B)		 5ax7 PYRUVYL TRANSFERASE
1
(Schizosaccharomy
ces
pombe) 		5 / 9 ILE A  90
VAL A 176
ILE A 212
TYR A  83
LEU A 117
 None
 1.32A 5iepA-5ax7A:
undetectable		 5iepA-5ax7A:
19.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N4I_A_SAMA501_1
(PEPTIDE
N-METHYLTRANSFERASE)		 5ax7 PYRUVYL TRANSFERASE
1
(Schizosaccharomy
ces
pombe) 		4 / 5 TYR A 206
ALA A 225
GLN A 189
THR A 216
 None
 1.20A 5n4iA-5ax7A:
undetectable		 5n4iA-5ax7A:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6H7U_A_FVTA501_0
(PEPTIDE ABC
TRANSPORTER PERMEASE)		 5ax7 PYRUVYL TRANSFERASE
1
(Schizosaccharomy
ces
pombe) 		4 / 6 ASN A 233
ASN A 209
PRO A 210
ILE A 212
 None
 1.00A 6h7uA-5ax7A:
undetectable		 6h7uA-5ax7A:
22.51