SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5axh'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1AL4_A_DVAA6_0
(GRAMICIDIN D)		 5axh DEXTRANASE
(Thermoanaerobact
er
pseudethanolicus) 		4 / 5 ALA A 407
VAL A 373
TRP A 376
TRP A 535
 None
 1.10A 1al4A-5axhA:
undetectable
1al4B-5axhA:
undetectable		 1al4A-5axhA:
2.52
1al4B-5axhA:
2.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DZM_A_BZMA600_0
(ODORANT-BINDING
PROTEIN)		 5axh DEXTRANASE
(Thermoanaerobact
er
pseudethanolicus) 		4 / 8 MET A 468
ASN A 410
GLY A 446
LEU A 442
 None
None
GOL  A 707 (-3.5A)
None
 0.87A 1dzmA-5axhA:
undetectable		 1dzmA-5axhA:
14.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EPB_B_9CRB165_2
(EPIDIDYMAL RETINOIC
ACID-BINDING PROTEIN)		 5axh DEXTRANASE
(Thermoanaerobact
er
pseudethanolicus) 		4 / 8 LEU A 182
ALA A 233
VAL A 308
VAL A 350
 None
 0.88A 1epbB-5axhA:
undetectable		 1epbB-5axhA:
14.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HXB_A_ROCA100_3
(HIV-1 PROTEASE)		 5axh DEXTRANASE
(Thermoanaerobact
er
pseudethanolicus) 		5 / 12 ALA A 126
ILE A  98
ILE A  94
VAL A  47
ILE A  44
 None
 0.91A 1hxbB-5axhA:
undetectable		 1hxbB-5axhA:
9.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ILQ_C_ACAC7_1
(INTERLEUKIN-8
PRECURSOR
INTERLEUKIN-8
RECEPTOR A)		 5axh DEXTRANASE
(Thermoanaerobact
er
pseudethanolicus) 		4 / 6 HIS A  84
ASP A 115
ASP A 116
PRO A 113
 None
 1.20A 1ilqA-5axhA:
undetectable
1ilqC-5axhA:
undetectable		 1ilqA-5axhA:
7.16
1ilqC-5axhA:
2.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1K4T_D_TTCD990_1
(DNA TOPOISOMERASE I)		 5axh DEXTRANASE
(Thermoanaerobact
er
pseudethanolicus) 		4 / 5 GLU A 451
ARG A 317
LYS A 258
ASP A 266
 GLC  A 702 ( 4.5A)
None
None
None
 1.49A 1k4tA-5axhA:
undetectable		 1k4tA-5axhA:
23.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WSV_A_THHA3001_0
(AMINOMETHYLTRANSFERA
SE)		 5axh DEXTRANASE
(Thermoanaerobact
er
pseudethanolicus) 		5 / 12 ILE A  44
VAL A  47
ASN A 137
PHE A  74
TYR A 125
 None
None
GOL  A 708 (-4.7A)
None
None
 1.15A 1wsvA-5axhA:
2.8		 1wsvA-5axhA:
20.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WSV_B_THHB4001_0
(AMINOMETHYLTRANSFERA
SE)		 5axh DEXTRANASE
(Thermoanaerobact
er
pseudethanolicus) 		5 / 12 ILE A  44
VAL A  47
ASN A 137
PHE A  74
TYR A 125
 None
None
GOL  A 708 (-4.7A)
None
None
 1.12A 1wsvB-5axhA:
undetectable		 1wsvB-5axhA:
20.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XZ1_A_HLTA2001_1
(FERRITIN LIGHT CHAIN)		 5axh DEXTRANASE
(Thermoanaerobact
er
pseudethanolicus) 		4 / 4 LEU A 371
SER A 397
TYR A 396
LEU A 359
 None
 1.17A 1xz1A-5axhA:
undetectable		 1xz1A-5axhA:
16.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XZ3_A_ICFA201_1
(FERRITIN LIGHT CHAIN)		 5axh DEXTRANASE
(Thermoanaerobact
er
pseudethanolicus) 		4 / 4 LEU A 371
SER A 397
TYR A 396
LEU A 359
 None
 1.18A 1xz3A-5axhA:
undetectable		 1xz3A-5axhA:
16.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AQU_B_DR7B300_2
(HIV-1 PROTEASE)		 5axh DEXTRANASE
(Thermoanaerobact
er
pseudethanolicus) 		5 / 11 ALA A 126
ILE A  98
ILE A  94
VAL A  47
ILE A  44
 None
 0.88A 2aquB-5axhA:
undetectable		 2aquB-5axhA:
9.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IJ7_C_TPFC2471_1
(CYTOCHROME P450 121)		 5axh DEXTRANASE
(Thermoanaerobact
er
pseudethanolicus) 		4 / 8 VAL A 373
VAL A 390
ASN A 392
ALA A 363
 None
 0.95A 2ij7C-5axhA:
undetectable		 2ij7C-5axhA:
20.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QO5_A_CHDA131_0
(LIVER-BASIC FATTY
ACID BINDING PROTEIN)		 5axh DEXTRANASE
(Thermoanaerobact
er
pseudethanolicus) 		5 / 12 ILE A 572
ILE A 493
ILE A 595
LEU A 580
LEU A 600
 None
 1.19A 2qo5A-5axhA:
undetectable		 2qo5A-5axhA:
12.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WD9_C_IBPC1570_1
(ACYL-COENZYME A
SYNTHETASE ACSM2A,
MITOCHONDRIAL)		 5axh DEXTRANASE
(Thermoanaerobact
er
pseudethanolicus) 		5 / 10 THR A 476
LEU A 173
GLY A 153
GLY A 180
ARG A 151
 None
 1.23A 2wd9C-5axhA:
undetectable		 2wd9C-5axhA:
19.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WX2_B_TPFB1460_1
(LANOSTEROL
14-ALPHA-DEMETHYLASE)		 5axh DEXTRANASE
(Thermoanaerobact
er
pseudethanolicus) 		4 / 8 TYR A 235
TYR A 184
THR A 276
LEU A 279
 GLC  A 703 ( 4.7A)
GLC  A 703 ( 4.4A)
None
None
 1.01A 2wx2B-5axhA:
undetectable		 2wx2B-5axhA:
21.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X45_A_HSMA1161_1
(ALLERGEN ARG R 1)		 5axh DEXTRANASE
(Thermoanaerobact
er
pseudethanolicus) 		4 / 5 VAL A 404
TYR A 152
VAL A 350
ASP A 369
 None
 1.25A 2x45A-5axhA:
undetectable		 2x45A-5axhA:
13.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X45_C_HSMC1161_1
(ALLERGEN ARG R 1)		 5axh DEXTRANASE
(Thermoanaerobact
er
pseudethanolicus) 		4 / 5 VAL A 404
TYR A 152
VAL A 350
ASP A 369
 None
 1.24A 2x45C-5axhA:
undetectable		 2x45C-5axhA:
13.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X7H_A_PFNA1374_1
(ZINC-BINDING ALCOHOL
DEHYDROGENASE
DOMAIN-CONTAINING
PROTEIN 2)		 5axh DEXTRANASE
(Thermoanaerobact
er
pseudethanolicus) 		4 / 6 PRO A 454
SER A 455
LYS A 450
GLU A 451
 None
GLC  A 701 ( 4.6A)
GLC  A 701 ( 2.6A)
GLC  A 702 ( 4.5A)
 1.20A 2x7hA-5axhA:
undetectable		 2x7hA-5axhA:
20.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D1X_A_ROCA201_1
(HIV-1 PROTEASE)		 5axh DEXTRANASE
(Thermoanaerobact
er
pseudethanolicus) 		5 / 12 ALA A 126
ILE A  98
ILE A  94
VAL A  47
ILE A  44
 None
 0.83A 3d1xA-5axhA:
undetectable		 3d1xA-5axhA:
9.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DEU_A_SALA301_1
(TRANSCRIPTIONAL
REGULATOR SLYA)		 5axh DEXTRANASE
(Thermoanaerobact
er
pseudethanolicus) 		4 / 6 ARG A 536
ILE A 375
TRP A 535
HIS A 439
 None
 1.44A 3deuA-5axhA:
undetectable		 3deuA-5axhA:
13.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EKX_B_1UNB201_2
(PROTEASE)		 5axh DEXTRANASE
(Thermoanaerobact
er
pseudethanolicus) 		5 / 11 ALA A 126
ILE A  98
ILE A  94
VAL A  47
ILE A  44
 None
 0.87A 3ekxB-5axhA:
undetectable		 3ekxB-5axhA:
9.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IV6_B_SAMB301_0
(PUTATIVE
ZN-DEPENDENT ALCOHOL
DEHYDROGENASE)		 5axh DEXTRANASE
(Thermoanaerobact
er
pseudethanolicus) 		5 / 12 PHE A 453
GLY A 443
ASP A 444
ILE A 170
LEU A 181
 GLC  A 704 ( 4.5A)
None
None
None
None
 1.09A 3iv6B-5axhA:
undetectable		 3iv6B-5axhA:
18.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KHM_A_TPFA501_1
(STEROL 14
ALPHA-DEMETHYLASE)		 5axh DEXTRANASE
(Thermoanaerobact
er
pseudethanolicus) 		4 / 8 TYR A 235
TYR A 184
THR A 276
LEU A 279
 GLC  A 703 ( 4.7A)
GLC  A 703 ( 4.4A)
None
None
 0.98A 3khmA-5axhA:
undetectable		 3khmA-5axhA:
21.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KL3_A_DHIA403_0
(GLUCURONOXYLANASE
XYNC)		 5axh DEXTRANASE
(Thermoanaerobact
er
pseudethanolicus) 		4 / 4 GLY A 153
TYR A 154
GLY A 443
ASP A 444
 None
 1.31A 3kl3A-5axhA:
6.7		 3kl3A-5axhA:
21.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NU6_B_478B401_1
(PROTEASE)		 5axh DEXTRANASE
(Thermoanaerobact
er
pseudethanolicus) 		5 / 10 ALA A 126
ILE A  98
ILE A  94
VAL A  47
ILE A  44
 None
 1.00A 3nu6A-5axhA:
undetectable		 3nu6A-5axhA:
9.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OXC_A_ROCA401_1
(PROTEASE)		 5axh DEXTRANASE
(Thermoanaerobact
er
pseudethanolicus) 		5 / 12 ALA A 126
ILE A  98
ILE A  94
VAL A  47
ILE A  44
 None
 0.92A 3oxcA-5axhA:
undetectable		 3oxcA-5axhA:
9.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TWP_D_SALD404_1
(ANTHRANILATE
PHOSPHORIBOSYLTRANSF
ERASE)		 5axh DEXTRANASE
(Thermoanaerobact
er
pseudethanolicus) 		4 / 5 ASN A 157
ALA A 156
PRO A 454
ALA A 456
 None
 1.18A 3twpD-5axhA:
undetectable		 3twpD-5axhA:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UZZ_B_ASDB501_1
(3-OXO-5-BETA-STEROID
4-DEHYDROGENASE)		 5axh DEXTRANASE
(Thermoanaerobact
er
pseudethanolicus) 		4 / 8 TYR A 184
TYR A 235
HIS A 190
LEU A 270
 GLC  A 703 ( 4.4A)
GLC  A 703 ( 4.7A)
GLC  A 703 ( 4.0A)
None
 1.37A 3uzzB-5axhA:
7.9		 3uzzB-5axhA:
20.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_F_W9TF512_1
(HEMOLYTIC LECTIN
CEL-III)		 5axh DEXTRANASE
(Thermoanaerobact
er
pseudethanolicus) 		4 / 6 THR A 353
ASN A 352
GLY A 312
ILE A 349
 None
GLC  A 704 ( 3.8A)
GLC  A 704 ( 3.9A)
None
 0.94A 3w9tF-5axhA:
undetectable		 3w9tF-5axhA:
21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WRK_D_CAMD502_0
(CAMPHOR
5-MONOOXYGENASE)		 5axh DEXTRANASE
(Thermoanaerobact
er
pseudethanolicus) 		4 / 5 PHE A 433
LEU A 442
GLY A 153
VAL A 404
 None
 0.97A 3wrkD-5axhA:
undetectable		 3wrkD-5axhA:
21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F5Z_A_BEZA302_0
(HALOALKANE
DEHALOGENASE)		 5axh DEXTRANASE
(Thermoanaerobact
er
pseudethanolicus) 		4 / 8 ASN A 573
ASP A 574
PHE A  29
VAL A  36
 None
GOL  A 708 (-3.4A)
None
None
 1.21A 4f5zA-5axhA:
2.2		 4f5zA-5axhA:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MM4_B_8PRB603_1
(TRANSPORTER)		 5axh DEXTRANASE
(Thermoanaerobact
er
pseudethanolicus) 		5 / 12 VAL A 127
ALA A 126
TYR A  79
TYR A 125
VAL A 124
 None
 1.28A 4mm4B-5axhA:
undetectable		 4mm4B-5axhA:
21.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P7N_A_GCSA702_1
(POLY-BETA-1,6-N-ACET
YL-D-GLUCOSAMINE
N-DEACETYLASE)		 5axh DEXTRANASE
(Thermoanaerobact
er
pseudethanolicus) 		3 / 3 ASP A 571
TYR A 602
TRP A 603
 None
 1.43A 4p7nA-5axhA:
16.9		 4p7nA-5axhA:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YO9_B_ACTB401_0
(3C-LIKE PROTEINASE)		 5axh DEXTRANASE
(Thermoanaerobact
er
pseudethanolicus) 		3 / 3 ARG A 211
ASP A 207
TYR A 184
 None
None
GLC  A 703 ( 4.4A)
 0.78A 4yo9B-5axhA:
1.9		 4yo9B-5axhA:
19.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N5D_A_SAMA306_1
(METHYLTRANSFERASE)		 5axh DEXTRANASE
(Thermoanaerobact
er
pseudethanolicus) 		4 / 7 LEU A 458
PHE A 420
SER A 461
ASN A 541
 None
None
PO4  A 705 ( 2.6A)
None
 1.05A 5n5dA-5axhA:
undetectable		 5n5dA-5axhA:
15.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VLM_A_CVIA301_1
(REGULATORY PROTEIN
TETR)		 5axh DEXTRANASE
(Thermoanaerobact
er
pseudethanolicus) 		4 / 8 GLY A 437
TRP A 510
ASP A 391
TYR A 394
 None
 1.08A 5vlmA-5axhA:
undetectable		 5vlmA-5axhA:
14.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WBV_A_SAMA402_1
(HISTONE-LYSINE
N-METHYLTRANSFERASE
KMT5B)		 5axh DEXTRANASE
(Thermoanaerobact
er
pseudethanolicus) 		3 / 3 HIS A 190
GLU A 297
ASN A 234
 GLC  A 703 ( 4.0A)
None
None
 1.02A 5wbvA-5axhA:
undetectable		 5wbvA-5axhA:
18.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AJI_A_AY6A1001_0
(DRUG EXPORTERS OF
THE RND
SUPERFAMILY-LIKE
PROTEIN,ENDOLYSIN)		 5axh DEXTRANASE
(Thermoanaerobact
er
pseudethanolicus) 		5 / 12 ILE A 548
VAL A 509
LEU A 527
LEU A 427
ALA A 430
 None
 1.06A 6ajiA-5axhA:
2.0		 6ajiA-5axhA:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HU9_I_PCFI101_0
(CYTOCHROME B-C1
COMPLEX SUBUNIT 1,
MITOCHONDRIAL
CYTOCHROME B-C1
COMPLEX SUBUNIT 9
CYTOCHROME B-C1
COMPLEX SUBUNIT
RIESKE,
MITOCHONDRIAL)		 5axh DEXTRANASE
(Thermoanaerobact
er
pseudethanolicus) 		5 / 11 ASP A 571
SER A 569
MET A 605
TYR A 471
GLY A 437
 None
 1.46A 6hu9A-5axhA:
undetectable
6hu9E-5axhA:
undetectable
6hu9I-5axhA:
undetectable		 6hu9A-5axhA:
20.55
6hu9E-5axhA:
18.15
6hu9I-5axhA:
8.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MN4_B_AM2B301_0
(AMINOGLYCOSIDE
N(3)-ACETYLTRANSFERA
SE, AAC(3)-IVA)		 5axh DEXTRANASE
(Thermoanaerobact
er
pseudethanolicus) 		4 / 8 ASP A 438
ARG A 151
GLU A 479
ASP A 141
 None
 1.16A 6mn4B-5axhA:
undetectable		 6mn4B-5axhA:
18.44