SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5axi'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JG3_A_ADNA500_1
(PROTEIN-L-ISOASPARTA
TE
O-METHYLTRANSFERASE)		 5axi E3 UBIQUITIN-PROTEIN
LIGASE CBL-B
(Mus
musculus) 		5 / 11 GLY A 281
ILE A 306
LEU A 273
ASP A 303
GLY A 302
 None
 1.07A 1jg3A-5axiA:
undetectable		 1jg3A-5axiA:
20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JG3_B_ADNB550_1
(PROTEIN-L-ISOASPARTA
TE
O-METHYLTRANSFERASE)		 5axi E3 UBIQUITIN-PROTEIN
LIGASE CBL-B
(Mus
musculus) 		5 / 11 GLY A 281
ILE A 306
LEU A 273
ASP A 303
GLY A 302
 None
 1.06A 1jg3B-5axiA:
2.1		 1jg3B-5axiA:
20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TW4_A_CHDA130_1
(FATTY ACID-BINDING
PROTEIN)		 5axi E3 UBIQUITIN-PROTEIN
LIGASE CBL-B
(Mus
musculus) 		3 / 3 TYR A 110
ARG A  86
GLN A  83
 None
 1.00A 1tw4A-5axiA:
undetectable		 1tw4A-5axiA:
18.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BDM_A_TMIA502_1
(CYTOCHROME P450 2B4)		 5axi E3 UBIQUITIN-PROTEIN
LIGASE CBL-B
(Mus
musculus) 		5 / 12 LEU A  78
LEU A 143
THR A 144
LEU A 146
PHE A 150
 None
 0.72A 2bdmA-5axiA:
undetectable		 2bdmA-5axiA:
22.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BDM_A_TMIA502_1
(CYTOCHROME P450 2B4)		 5axi E3 UBIQUITIN-PROTEIN
LIGASE CBL-B
(Mus
musculus) 		5 / 12 LEU A  78
THR A 144
LEU A 146
SER A 147
PHE A 150
 None
 0.77A 2bdmA-5axiA:
undetectable		 2bdmA-5axiA:
22.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PH9_A_GNTA301_1
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 5axi E3 UBIQUITIN-PROTEIN
LIGASE CBL-B
(Mus
musculus) 		4 / 7 GLN A  83
TYR A  82
TYR A 110
ILE A 111
 None
 1.08A 2ph9A-5axiA:
undetectable
2ph9B-5axiA:
undetectable		 2ph9A-5axiA:
24.21
2ph9B-5axiA:
24.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TVX_B_PNXB902_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4A)		 5axi E3 UBIQUITIN-PROTEIN
LIGASE CBL-B
(Mus
musculus) 		4 / 7 TYR A 283
ASN A 338
PHE A 285
PHE A 252
 None
 1.28A 3tvxB-5axiA:
undetectable		 3tvxB-5axiA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EVR_A_BEZA401_0
(PUTATIVE ABC
TRANSPORTER SUBUNIT,
SUBSTRATE-BINDING
COMPONENT)		 5axi E3 UBIQUITIN-PROTEIN
LIGASE CBL-B
(Mus
musculus) 		5 / 11 LEU A 222
TYR A 260
ALA A 254
PHE A 240
PHE A 236
 None
 0.97A 4evrA-5axiA:
undetectable		 4evrA-5axiA:
22.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LJ0_A_ACTA505_0
(NAB2)		 5axi E3 UBIQUITIN-PROTEIN
LIGASE CBL-B
(Mus
musculus) 		3 / 3 LEU A 148
LYS A 145
THR A 144
 None
 0.56A 4lj0A-5axiA:
undetectable		 4lj0A-5axiA:
12.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V32_A_EF2A151_1
(CEREBLON ISOFORM 4)		 5axi E3 UBIQUITIN-PROTEIN
LIGASE CBL-B
(Mus
musculus) 		4 / 7 ASN A 251
PHE A 252
TRP A 250
PHE A 236
 None
 1.21A 4v32A-5axiA:
undetectable		 4v32A-5axiA:
21.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UUN_A_ACTA310_0
(GLUTATHIONE
S-TRANSFERASE-LIKE
PROTEIN)		 5axi E3 UBIQUITIN-PROTEIN
LIGASE CBL-B
(Mus
musculus) 		3 / 3 GLU A 203
HIS A 202
ARG A 198
 None
 0.97A 5uunA-5axiA:
undetectable		 5uunA-5axiA:
22.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VCE_A_RITA602_2
(CYTOCHROME P450 3A4)		 5axi E3 UBIQUITIN-PROTEIN
LIGASE CBL-B
(Mus
musculus) 		4 / 6 ARG A 248
PHE A 240
ILE A 220
THR A 219
 None
 0.89A 5vceA-5axiA:
undetectable		 5vceA-5axiA:
19.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EFN_A_SAMA501_0
(SPORULATION KILLING
FACTOR MATURATION
PROTEIN SKFB)		 5axi E3 UBIQUITIN-PROTEIN
LIGASE CBL-B
(Mus
musculus) 		5 / 11 TYR A 110
PHE A 150
SER A 118
THR A  49
ALA A  41
 None
 1.37A 6efnA-5axiA:
undetectable		 6efnA-5axiA:
21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FGD_A_D8ZA831_0
(GEPHYRIN)		 5axi E3 UBIQUITIN-PROTEIN
LIGASE CBL-B
(Mus
musculus) 		5 / 11 MET A  53
ILE A 122
LEU A 114
ARG A 120
ILE A 149
 None
 1.30A 6fgdA-5axiA:
undetectable		 6fgdA-5axiA:
13.77