SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5axk'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VCV_A_ASDA1224_1
(GLUTATHIONE
S-TRANSFERASE A3)		 5axk TRNA(HIS)-5'-GUANYLY
LTRANSFERASE (THG1)
LIKE PROTEIN
(Methanosarcina
acetivorans) 		4 / 7 ALA A  98
LEU A  95
ALA A  50
PHE A  73
 None
 1.14A 2vcvA-5axkA:
undetectable		 2vcvA-5axkA:
21.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZB7_A_NCAA901_0
(PROSTAGLANDIN
REDUCTASE 2)		 5axk TRNA(HIS)-5'-GUANYLY
LTRANSFERASE (THG1)
LIKE PROTEIN
(Methanosarcina
acetivorans) 		4 / 5 TYR A  65
ILE A 224
LEU A 239
LEU A 236
 None
 1.06A 2zb7A-5axkA:
undetectable		 2zb7A-5axkA:
22.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QPS_A_CHDA211_0
(CMER)		 5axk TRNA(HIS)-5'-GUANYLY
LTRANSFERASE (THG1)
LIKE PROTEIN
(Methanosarcina
acetivorans) 		5 / 10 LEU A 105
ALA A  98
GLY A  96
ILE A 109
PHE A  34
 None
None
None
None
GOL  A 301 ( 4.5A)
 1.33A 3qpsA-5axkA:
undetectable		 3qpsA-5axkA:
22.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UCJ_A_AZMA229_2
(CARBONIC ANHYDRASE)		 5axk TRNA(HIS)-5'-GUANYLY
LTRANSFERASE (THG1)
LIKE PROTEIN
(Methanosarcina
acetivorans) 		3 / 3 GLN A 131
PHE A 227
TYR A  65
 None
 0.89A 3ucjB-5axkA:
undetectable		 3ucjB-5axkA:
21.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UCJ_B_AZMB229_1
(CARBONIC ANHYDRASE)		 5axk TRNA(HIS)-5'-GUANYLY
LTRANSFERASE (THG1)
LIKE PROTEIN
(Methanosarcina
acetivorans) 		3 / 3 GLN A 131
PHE A 227
TYR A  65
 None
 0.89A 3ucjA-5axkA:
undetectable		 3ucjA-5axkA:
21.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ACA_C_DXCC1476_0
(TRANSLATION
ELONGATION FACTOR
SELB)		 5axk TRNA(HIS)-5'-GUANYLY
LTRANSFERASE (THG1)
LIKE PROTEIN
(Methanosarcina
acetivorans) 		4 / 5 ILE A 178
ALA A 146
HIS A 170
MET A 172
 None
 1.34A 4acaB-5axkA:
undetectable
4acaC-5axkA:
undetectable		 4acaB-5axkA:
19.21
4acaC-5axkA:
19.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AXD_A_RBVA502_2
(ADENOSYLHOMOCYSTEINA
SE)		 5axk TRNA(HIS)-5'-GUANYLY
LTRANSFERASE (THG1)
LIKE PROTEIN
(Methanosarcina
acetivorans) 		3 / 3 THR A  76
HIS A 128
LEU A 236
 None
 0.72A 5axdA-5axkA:
undetectable		 5axdA-5axkA:
19.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L6E_B_ACTB401_0
(N6-ADENOSINE-METHYLT
RANSFERASE 70 KDA
SUBUNIT
N6-ADENOSINE-METHYLT
RANSFERASE SUBUNIT
METTL14)		 5axk TRNA(HIS)-5'-GUANYLY
LTRANSFERASE (THG1)
LIKE PROTEIN
(Methanosarcina
acetivorans) 		4 / 6 GLU A 133
LEU A 132
ARG A 130
ARG A 136
 None
 1.25A 5l6eA-5axkA:
undetectable
5l6eB-5axkA:
undetectable		 5l6eA-5axkA:
23.53
5l6eB-5axkA:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5O4Y_A_CCSA14_0
(PHE-MAA-ASN-PRO-HIS-
LEU-SER-TRP-SER-TRP-
9KK-9KK-ARG-CCS-GLY-
NH2)		 5axk TRNA(HIS)-5'-GUANYLY
LTRANSFERASE (THG1)
LIKE PROTEIN
(Methanosarcina
acetivorans) 		4 / 6 PHE A 138
ASN A 137
ARG A 189
GLY A 190
 None
 1.00A 5o4yA-5axkA:
undetectable		 5o4yA-5axkA:
5.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZVG_A_SAMA401_0
(389AA LONG
HYPOTHETICAL
NUCLEOLAR PROTEIN)		 5axk TRNA(HIS)-5'-GUANYLY
LTRANSFERASE (THG1)
LIKE PROTEIN
(Methanosarcina
acetivorans) 		5 / 12 GLY A  58
SER A  89
ASP A 112
ALA A  20
ARG A 114
 None
 0.99A 5zvgA-5axkA:
undetectable		 5zvgA-5axkA:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZVG_B_SAMB401_0
(389AA LONG
HYPOTHETICAL
NUCLEOLAR PROTEIN)		 5axk TRNA(HIS)-5'-GUANYLY
LTRANSFERASE (THG1)
LIKE PROTEIN
(Methanosarcina
acetivorans) 		5 / 12 GLY A  58
SER A  89
ASP A 112
ALA A  20
ARG A 114
 None
 0.97A 5zvgB-5axkA:
undetectable		 5zvgB-5axkA:
21.45