SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5ay6'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HRE_B_CHDB701_0
(FERROCHELATASE)		 5ay6 FLAGELLAR HOOK
PROTEIN FLGE
(Caulobacter
vibrioides) 		3 / 3 LYS A 236
GLY A 356
PRO A 357
 None
 0.75A 2hreB-5ay6A:
undetectable		 2hreB-5ay6A:
21.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3F78_A_ICFA1_1
(INTEGRIN ALPHA-L)		 5ay6 FLAGELLAR HOOK
PROTEIN FLGE
(Caulobacter
vibrioides) 		5 / 9 ILE A 261
ILE A 235
LEU A 290
LEU A 287
TYR A 249
 None
 1.32A 3f78A-5ay6A:
undetectable		 3f78A-5ay6A:
19.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P50_D_PFLD320_1
(GLR4197 PROTEIN)		 5ay6 FLAGELLAR HOOK
PROTEIN FLGE
(Caulobacter
vibrioides) 		4 / 7 PRO A 311
ILE A 221
TYR A 361
ILE A 383
 None
 0.90A 3p50D-5ay6A:
undetectable		 3p50D-5ay6A:
22.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4COX_A_IMNA701_1
(CYCLOOXYGENASE-2)		 5ay6 FLAGELLAR HOOK
PROTEIN FLGE
(Caulobacter
vibrioides) 		5 / 12 LEU A 308
TRP A 314
VAL A 304
GLY A 306
ALA A 305
 None
 1.16A 4coxA-5ay6A:
undetectable		 4coxA-5ay6A:
18.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4COX_B_IMNB701_1
(CYCLOOXYGENASE-2)		 5ay6 FLAGELLAR HOOK
PROTEIN FLGE
(Caulobacter
vibrioides) 		5 / 12 LEU A 308
TRP A 314
VAL A 304
GLY A 306
ALA A 305
 None
 1.16A 4coxB-5ay6A:
undetectable		 4coxB-5ay6A:
18.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4COX_D_IMND701_1
(CYCLOOXYGENASE-2)		 5ay6 FLAGELLAR HOOK
PROTEIN FLGE
(Caulobacter
vibrioides) 		5 / 12 LEU A 308
TRP A 314
VAL A 304
GLY A 306
ALA A 305
 None
 1.15A 4coxD-5ay6A:
undetectable		 4coxD-5ay6A:
18.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PGH_A_SAMA401_0
(CAFFEIC ACID
O-METHYLTRANSFERASE)		 5ay6 FLAGELLAR HOOK
PROTEIN FLGE
(Caulobacter
vibrioides) 		5 / 11 GLY A 343
GLY A 342
ASP A 339
LEU A 436
ASP A 370
 None
 1.08A 4pghA-5ay6A:
undetectable		 4pghA-5ay6A:
20.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XUE_A_SAMA303_1
(CATECHOL
O-METHYLTRANSFERASE)		 5ay6 FLAGELLAR HOOK
PROTEIN FLGE
(Caulobacter
vibrioides) 		4 / 5 GLY A 291
TYR A 212
GLU A 302
ASP A 289
 None
 1.35A 4xueA-5ay6A:
undetectable		 4xueA-5ay6A:
22.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JWA_A_ACTA609_0
(NADH DEHYDROGENASE,
PUTATIVE)		 5ay6 FLAGELLAR HOOK
PROTEIN FLGE
(Caulobacter
vibrioides) 		3 / 3 VAL A 327
SER A 315
TRP A 314
 None
 1.07A 5jwaA-5ay6A:
undetectable		 5jwaA-5ay6A:
20.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UC1_A_486A801_1
(GLUCOCORTICOID
RECEPTOR)		 5ay6 FLAGELLAR HOOK
PROTEIN FLGE
(Caulobacter
vibrioides) 		5 / 12 LEU A 392
GLY A 453
GLY A 452
LEU A 349
MET A 351
 None
 0.94A 5uc1A-5ay6A:
undetectable		 5uc1A-5ay6A:
15.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UC1_B_486B801_2
(GLUCOCORTICOID
RECEPTOR)		 5ay6 FLAGELLAR HOOK
PROTEIN FLGE
(Caulobacter
vibrioides) 		5 / 12 LEU A 392
GLY A 453
GLY A 452
LEU A 349
MET A 351
 None
 0.95A 5uc1B-5ay6A:
undetectable		 5uc1B-5ay6A:
15.60