SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5ayd'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HDN_B_TACB1888_1
(ELONGATION FACTOR
EF-TU)		 5ayd BETA-1,4-MANNOOLIGOS
ACCHARIDE
PHOSPHORYLASE
(Ruminococcus
albus) 		4 / 5 THR A 301
SER A  10
ASP A 298
PRO A  12
 None
 1.42A 2hdnA-5aydA:
undetectable
2hdnB-5aydA:
undetectable
2hdnD-5aydA:
undetectable		 2hdnA-5aydA:
8.20
2hdnB-5aydA:
22.75
2hdnD-5aydA:
22.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ARR_A_PNXA606_1
(CHITINASE A)		 5ayd BETA-1,4-MANNOOLIGOS
ACCHARIDE
PHOSPHORYLASE
(Ruminococcus
albus) 		4 / 7 TRP A 263
GLY A 173
LYS A 174
ASP A 260
 None
 1.29A 3arrA-5aydA:
undetectable		 3arrA-5aydA:
19.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KIC_A_SAMA401_0
(METHYLTRANSFERASE
MPPJ)		 5ayd BETA-1,4-MANNOOLIGOS
ACCHARIDE
PHOSPHORYLASE
(Ruminococcus
albus) 		5 / 12 CYH A 293
GLY A 309
ARG A  73
PHE A  66
ASP A  69
 None
 1.16A 4kicA-5aydA:
undetectable		 4kicA-5aydA:
18.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HW8_G_FK5G201_1
(FK506-BINDING
PROTEIN 1)		 5ayd BETA-1,4-MANNOOLIGOS
ACCHARIDE
PHOSPHORYLASE
(Ruminococcus
albus) 		3 / 3 ILE A  36
PRO A  37
ILE A  47
 None
 0.36A 5hw8F-5aydA:
undetectable		 5hw8F-5aydA:
18.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KVA_A_SAMA301_1
(CAFFEOYL-COA
O-METHYLTRANSFERASE)		 5ayd BETA-1,4-MANNOOLIGOS
ACCHARIDE
PHOSPHORYLASE
(Ruminococcus
albus) 		3 / 3 THR A 187
SER A 182
ASP A 115
 PO4  A 401 ( 4.8A)
None
None
 0.85A 5kvaA-5aydA:
undetectable		 5kvaA-5aydA:
20.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KVA_B_SAMB301_1
(CAFFEOYL-COA
O-METHYLTRANSFERASE)		 5ayd BETA-1,4-MANNOOLIGOS
ACCHARIDE
PHOSPHORYLASE
(Ruminococcus
albus) 		3 / 3 THR A 187
SER A 182
ASP A 115
 PO4  A 401 ( 4.8A)
None
None
 0.86A 5kvaB-5aydA:
undetectable		 5kvaB-5aydA:
20.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FGD_A_ACTA824_0
(GEPHYRIN)		 5ayd BETA-1,4-MANNOOLIGOS
ACCHARIDE
PHOSPHORYLASE
(Ruminococcus
albus) 		4 / 4 LEU A  77
ASP A 115
PRO A 116
ARG A  67
 None
 1.22A 6fgdA-5aydA:
undetectable		 6fgdA-5aydA:
20.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6H7L_A_Y00A406_1
(BETA-1 ADRENERGIC
RECEPTOR)		 5ayd BETA-1,4-MANNOOLIGOS
ACCHARIDE
PHOSPHORYLASE
(Ruminococcus
albus) 		4 / 6 GLY A 113
VAL A 118
PHE A  66
PHE A 147
 None
 0.91A 6h7lA-5aydA:
undetectable		 6h7lA-5aydA:
12.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6H7L_B_Y00B405_1
(BETA-1 ADRENERGIC
RECEPTOR)		 5ayd BETA-1,4-MANNOOLIGOS
ACCHARIDE
PHOSPHORYLASE
(Ruminococcus
albus) 		4 / 6 GLY A 113
VAL A 118
PHE A  66
PHE A 147
 None
 0.91A 6h7lB-5aydA:
undetectable		 6h7lB-5aydA:
12.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HD4_A_STIA604_1
(TYROSINE-PROTEIN
KINASE ABL1)		 5ayd BETA-1,4-MANNOOLIGOS
ACCHARIDE
PHOSPHORYLASE
(Ruminococcus
albus) 		4 / 5 VAL A 127
PHE A 193
MET A 192
GLY A 190
 None
 1.01A 6hd4A-5aydA:
undetectable		 6hd4A-5aydA:
11.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HD4_B_STIB602_1
(TYROSINE-PROTEIN
KINASE ABL1)		 5ayd BETA-1,4-MANNOOLIGOS
ACCHARIDE
PHOSPHORYLASE
(Ruminococcus
albus) 		4 / 6 VAL A 127
PHE A 193
MET A 192
GLY A 190
 None
 0.98A 6hd4B-5aydA:
undetectable		 6hd4B-5aydA:
11.28