SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5ayh'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JFA_A_RALA600_1
(ESTROGEN RECEPTOR)		 5ayh CYTOPLASMIC DYNEIN 1
HEAVY CHAIN 1
(Mus
musculus) 		5 / 12 ALA A3394
LEU A3398
LEU A3325
LEU A3326
ILE A3336
 None
 0.99A 2jfaA-5ayhA:
undetectable		 2jfaA-5ayhA:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K8M_B_ACRB820_1
(ALPHA-AMYLASE, SUSG)		 5ayh CYTOPLASMIC DYNEIN 1
HEAVY CHAIN 1
(Mus
musculus) 		4 / 7 GLU A3355
LEU A3398
LYS A3366
ASN A3399
 None
 1.42A 3k8mB-5ayhA:
undetectable		 3k8mB-5ayhA:
16.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MNO_A_DEXA784_1
(GLUCOCORTICOID
RECEPTOR)		 5ayh CYTOPLASMIC DYNEIN 1
HEAVY CHAIN 1
(Mus
musculus) 		5 / 12 MET A3365
LEU A3324
CYH A3323
ILE A3349
PHE A3345
 None
 1.33A 3mnoA-5ayhA:
undetectable		 3mnoA-5ayhA:
19.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MNP_A_DEXA784_1
(GLUCOCORTICOID
RECEPTOR)		 5ayh CYTOPLASMIC DYNEIN 1
HEAVY CHAIN 1
(Mus
musculus) 		5 / 12 MET A3365
LEU A3324
CYH A3323
ILE A3349
PHE A3345
 None
 1.37A 3mnpA-5ayhA:
undetectable		 3mnpA-5ayhA:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MWZ_B_CQAB303_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE,
PUTATIVE)		 5ayh CYTOPLASMIC DYNEIN 1
HEAVY CHAIN 1
(Mus
musculus) 		4 / 8 GLU A3413
LEU A3414
LEU A3417
GLU A3418
 None
 0.65A 4mwzB-5ayhA:
undetectable		 4mwzB-5ayhA:
23.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QN9_B_DXCB610_0
(N-ACYL-PHOSPHATIDYLE
THANOLAMINE-HYDROLYZ
ING PHOSPHOLIPASE D)		 5ayh CYTOPLASMIC DYNEIN 1
HEAVY CHAIN 1
(Mus
musculus) 		3 / 3 GLY A3388
PRO A3389
ALA A3290
 None
 0.54A 4qn9B-5ayhA:
undetectable		 4qn9B-5ayhA:
21.52