SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5ayn'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HK3_A_T44A3002_1
(SERUM ALBUMIN)		 5ayn SOLUTE CARRIER
FAMILY 39
(IRON-REGULATED
TRANSPORTER)
(Bdellovibrio
bacteriovorus) 		4 / 8 LEU A  13
ARG A  17
LEU A 216
SER A 136
 None
 1.07A 1hk3A-5aynA:
undetectable		 1hk3A-5aynA:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XOT_B_VDNB102_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4B)		 5ayn SOLUTE CARRIER
FAMILY 39
(IRON-REGULATED
TRANSPORTER)
(Bdellovibrio
bacteriovorus) 		5 / 12 LEU A  13
ILE A 161
SER A 355
SER A 156
PHE A 154
 None
 1.43A 1xotB-5aynA:
undetectable		 1xotB-5aynA:
21.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EFJ_A_37TA502_1
(3,7-DIMETHYLXANTHINE
METHYLTRANSFERASE)		 5ayn SOLUTE CARRIER
FAMILY 39
(IRON-REGULATED
TRANSPORTER)
(Bdellovibrio
bacteriovorus) 		5 / 12 LEU A 253
TRP A 423
ILE A 247
ILE A 243
TYR A 250
 None
 1.34A 2efjA-5aynA:
undetectable		 2efjA-5aynA:
20.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IJX_H_HCZH800_1
(GLUTAMATE RECEPTOR 2)		 5ayn SOLUTE CARRIER
FAMILY 39
(IRON-REGULATED
TRANSPORTER)
(Bdellovibrio
bacteriovorus) 		4 / 5 PRO A 299
SER A 294
LEU A 307
SER A 311
 None
 1.05A 3ijxH-5aynA:
undetectable		 3ijxH-5aynA:
19.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NK7_A_SAMA770_0
(23S RRNA
METHYLTRANSFERASE)		 5ayn SOLUTE CARRIER
FAMILY 39
(IRON-REGULATED
TRANSPORTER)
(Bdellovibrio
bacteriovorus) 		5 / 12 LEU A 374
GLY A 372
GLY A  65
ILE A 247
SER A 379
 None
 1.10A 3nk7A-5aynA:
undetectable		 3nk7A-5aynA:
21.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O0U_A_ADNA501_1
(AURORA KINASE A)		 5ayn SOLUTE CARRIER
FAMILY 39
(IRON-REGULATED
TRANSPORTER)
(Bdellovibrio
bacteriovorus) 		4 / 6 VAL A 146
ALA A 142
LEU A 158
LEU A  14
 None
 0.77A 4o0uA-5aynA:
undetectable		 4o0uA-5aynA:
22.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OLM_A_198A1001_2
(ANDROGEN RECEPTOR)		 5ayn SOLUTE CARRIER
FAMILY 39
(IRON-REGULATED
TRANSPORTER)
(Bdellovibrio
bacteriovorus) 		4 / 6 ASN A 375
ILE A 132
ILE A  68
VAL A  76
 None
 0.99A 4olmA-5aynA:
undetectable		 4olmA-5aynA:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XK8_A_PQNA844_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1)		 5ayn SOLUTE CARRIER
FAMILY 39
(IRON-REGULATED
TRANSPORTER)
(Bdellovibrio
bacteriovorus) 		4 / 7 PHE A 420
SER A 249
ARG A 362
LEU A 361
 None
 1.11A 4xk8A-5aynA:
undetectable		 4xk8A-5aynA:
23.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CZY_A_SAMA603_0
(LEGIONELLA EFFECTOR
LEGAS4)		 5ayn SOLUTE CARRIER
FAMILY 39
(IRON-REGULATED
TRANSPORTER)
(Bdellovibrio
bacteriovorus) 		5 / 12 GLY A 138
ARG A  17
ASN A 155
GLU A 358
LEU A 151
 None
 1.17A 5czyA-5aynA:
undetectable		 5czyA-5aynA:
21.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JNC_D_ACTD305_0
(CARBONIC ANHYDRASE 4)		 5ayn SOLUTE CARRIER
FAMILY 39
(IRON-REGULATED
TRANSPORTER)
(Bdellovibrio
bacteriovorus) 		4 / 5 ALA A  26
ALA A 173
ILE A 192
LEU A 189
 None
 0.82A 5jncD-5aynA:
undetectable		 5jncD-5aynA:
22.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_A_PCFA1801_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 5ayn SOLUTE CARRIER
FAMILY 39
(IRON-REGULATED
TRANSPORTER)
(Bdellovibrio
bacteriovorus) 		4 / 6 ILE A 135
ILE A 161
LEU A 158
PHE A 359
 None
 1.10A 5vkqA-5aynA:
2.7
5vkqB-5aynA:
2.6		 5vkqA-5aynA:
14.13
5vkqB-5aynA:
14.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_D_PCFD1807_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 5ayn SOLUTE CARRIER
FAMILY 39
(IRON-REGULATED
TRANSPORTER)
(Bdellovibrio
bacteriovorus) 		4 / 6 ILE A 135
ILE A 161
LEU A 158
PHE A 359
 None
 1.08A 5vkqA-5aynA:
2.7
5vkqD-5aynA:
2.6		 5vkqA-5aynA:
14.13
5vkqD-5aynA:
14.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B5V_A_ECLA1001_1
(TRANSIENT RECEPTOR
POTENTIAL CATION
CHANNEL SUBFAMILY V
MEMBER 5)		 5ayn SOLUTE CARRIER
FAMILY 39
(IRON-REGULATED
TRANSPORTER)
(Bdellovibrio
bacteriovorus) 		4 / 7 ILE A 243
PHE A 420
LEU A 246
ILE A 135
 None
 0.72A 6b5vA-5aynA:
undetectable
6b5vC-5aynA:
undetectable		 6b5vA-5aynA:
10.57
6b5vC-5aynA:
10.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B5V_C_ECLC1001_1
(TRANSIENT RECEPTOR
POTENTIAL CATION
CHANNEL SUBFAMILY V
MEMBER 5)		 5ayn SOLUTE CARRIER
FAMILY 39
(IRON-REGULATED
TRANSPORTER)
(Bdellovibrio
bacteriovorus) 		4 / 7 ILE A 243
PHE A 420
LEU A 246
ILE A 135
 None
 0.72A 6b5vC-5aynA:
undetectable
6b5vD-5aynA:
0.0		 6b5vC-5aynA:
10.57
6b5vD-5aynA:
10.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B5V_D_ECLD1001_1
(TRANSIENT RECEPTOR
POTENTIAL CATION
CHANNEL SUBFAMILY V
MEMBER 5)		 5ayn SOLUTE CARRIER
FAMILY 39
(IRON-REGULATED
TRANSPORTER)
(Bdellovibrio
bacteriovorus) 		4 / 7 ILE A 243
PHE A 420
LEU A 246
ILE A 135
 None
 0.73A 6b5vB-5aynA:
2.1
6b5vD-5aynA:
0.0		 6b5vB-5aynA:
10.57
6b5vD-5aynA:
10.57
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6BTX_A_EDTA503_0
(SOLUTE CARRIER
FAMILY 39
(IRON-REGULATED
TRANSPORTER))		 5ayn SOLUTE CARRIER
FAMILY 39
(IRON-REGULATED
TRANSPORTER)
(Bdellovibrio
bacteriovorus) 		6 / 7 SER A 256
SER A 259
HIS A 261
GLY A 262
ARG A 348
LEU A 351
 None
 0.93A 6btxA-5aynA:
32.1		 6btxA-5aynA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6BTX_A_EDTA503_0
(SOLUTE CARRIER
FAMILY 39
(IRON-REGULATED
TRANSPORTER))		 5ayn SOLUTE CARRIER
FAMILY 39
(IRON-REGULATED
TRANSPORTER)
(Bdellovibrio
bacteriovorus) 		5 / 7 TRP A 254
SER A 259
HIS A 261
ARG A 348
LEU A 351
 None
 1.04A 6btxA-5aynA:
32.1		 6btxA-5aynA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CLX_A_SAMA401_0
(O-METHYLTRANSFERASE)		 5ayn SOLUTE CARRIER
FAMILY 39
(IRON-REGULATED
TRANSPORTER)
(Bdellovibrio
bacteriovorus) 		5 / 12 ARG A  17
GLY A 129
GLY A  80
SER A 122
ASP A  24
 None
None
None
None
K  A 501 (-3.3A)
 1.22A 6clxA-5aynA:
undetectable		 6clxA-5aynA:
24.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DLZ_A_CYZA1302_0
(GLUTAMATE RECEPTOR
2,VOLTAGE-DEPENDENT
CALCIUM CHANNEL
GAMMA-2 SUBUNIT)		 5ayn SOLUTE CARRIER
FAMILY 39
(IRON-REGULATED
TRANSPORTER)
(Bdellovibrio
bacteriovorus) 		5 / 10 PRO A 299
SER A 294
LEU A 307
SER A 311
SER A 355
 None
 1.47A 6dlzA-5aynA:
undetectable
6dlzD-5aynA:
3.1		 6dlzA-5aynA:
13.99
6dlzD-5aynA:
13.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DLZ_C_CYZC1302_0
(GLUTAMATE RECEPTOR
2,VOLTAGE-DEPENDENT
CALCIUM CHANNEL
GAMMA-2 SUBUNIT)		 5ayn SOLUTE CARRIER
FAMILY 39
(IRON-REGULATED
TRANSPORTER)
(Bdellovibrio
bacteriovorus) 		5 / 10 SER A 355
PRO A 299
SER A 294
LEU A 307
SER A 311
 None
 1.46A 6dlzB-5aynA:
3.2
6dlzC-5aynA:
undetectable		 6dlzB-5aynA:
13.99
6dlzC-5aynA:
13.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DM0_A_CYZA1302_0
(GLUTAMATE RECEPTOR
2,VOLTAGE-DEPENDENT
CALCIUM CHANNEL
GAMMA-2 SUBUNIT)		 5ayn SOLUTE CARRIER
FAMILY 39
(IRON-REGULATED
TRANSPORTER)
(Bdellovibrio
bacteriovorus) 		5 / 9 PRO A 299
SER A 294
LEU A 307
SER A 311
SER A 355
 None
 1.48A 6dm0A-5aynA:
2.9
6dm0D-5aynA:
3.1		 6dm0A-5aynA:
13.99
6dm0D-5aynA:
13.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DM0_C_CYZC1302_0
(GLUTAMATE RECEPTOR
2,VOLTAGE-DEPENDENT
CALCIUM CHANNEL
GAMMA-2 SUBUNIT)		 5ayn SOLUTE CARRIER
FAMILY 39
(IRON-REGULATED
TRANSPORTER)
(Bdellovibrio
bacteriovorus) 		5 / 9 SER A 355
PRO A 299
SER A 294
LEU A 307
SER A 311
 None
 1.48A 6dm0B-5aynA:
3.2
6dm0C-5aynA:
2.9		 6dm0B-5aynA:
13.99
6dm0C-5aynA:
13.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DM1_A_CYZA1302_0
(GLUTAMATE RECEPTOR
2,VOLTAGE-DEPENDENT
CALCIUM CHANNEL
GAMMA-2 SUBUNIT)		 5ayn SOLUTE CARRIER
FAMILY 39
(IRON-REGULATED
TRANSPORTER)
(Bdellovibrio
bacteriovorus) 		5 / 10 PRO A 299
SER A 294
LEU A 307
SER A 311
SER A 355
 None
 1.47A 6dm1A-5aynA:
undetectable
6dm1D-5aynA:
3.1		 6dm1A-5aynA:
13.99
6dm1D-5aynA:
13.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DM1_C_CYZC1302_0
(GLUTAMATE RECEPTOR
2,VOLTAGE-DEPENDENT
CALCIUM CHANNEL
GAMMA-2 SUBUNIT)		 5ayn SOLUTE CARRIER
FAMILY 39
(IRON-REGULATED
TRANSPORTER)
(Bdellovibrio
bacteriovorus) 		5 / 10 SER A 355
PRO A 299
SER A 294
LEU A 307
SER A 311
 None
 1.46A 6dm1B-5aynA:
3.1
6dm1C-5aynA:
undetectable		 6dm1B-5aynA:
13.99
6dm1C-5aynA:
13.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DM2_A_CYZA1302_0
(GLUTAMATE RECEPTOR
2,VOLTAGE-DEPENDENT
CALCIUM CHANNEL
GAMMA-2 SUBUNIT)		 5ayn SOLUTE CARRIER
FAMILY 39
(IRON-REGULATED
TRANSPORTER)
(Bdellovibrio
bacteriovorus) 		5 / 9 PRO A 299
SER A 294
LEU A 307
SER A 311
SER A 355
 None
 1.47A 6dm2A-5aynA:
3.0
6dm2D-5aynA:
3.2		 6dm2A-5aynA:
13.99
6dm2D-5aynA:
13.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DM2_C_CYZC1302_0
(GLUTAMATE RECEPTOR
2,VOLTAGE-DEPENDENT
CALCIUM CHANNEL
GAMMA-2 SUBUNIT)		 5ayn SOLUTE CARRIER
FAMILY 39
(IRON-REGULATED
TRANSPORTER)
(Bdellovibrio
bacteriovorus) 		5 / 9 SER A 355
PRO A 299
SER A 294
LEU A 307
SER A 311
 None
 1.46A 6dm2B-5aynA:
3.2
6dm2C-5aynA:
3.0		 6dm2B-5aynA:
13.99
6dm2C-5aynA:
13.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DWN_B_AQ4B602_1
(CYTOCHROME P450 1A1)		 5ayn SOLUTE CARRIER
FAMILY 39
(IRON-REGULATED
TRANSPORTER)
(Bdellovibrio
bacteriovorus) 		4 / 7 SER A 109
PHE A  39
GLY A 105
ALA A 104
 None
OLC  A 503 (-4.2A)
None
OLC  A 509 (-3.6A)
 0.74A 6dwnB-5aynA:
undetectable		 6dwnB-5aynA:
11.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HD4_A_STIA604_1
(TYROSINE-PROTEIN
KINASE ABL1)		 5ayn SOLUTE CARRIER
FAMILY 39
(IRON-REGULATED
TRANSPORTER)
(Bdellovibrio
bacteriovorus) 		4 / 5 TYR A 268
VAL A 413
MET A 331
GLY A 332
 None
 1.37A 6hd4A-5aynA:
undetectable		 6hd4A-5aynA:
9.13