SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5az3'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HS1_A_017A201_2
(HIV-1 PROTEASE)		 5az3 ABC-TYPE
TRANSPORTER,
PERIPLASMIC
COMPONENT
(Corynebacterium
glutamicum) 		5 / 12 LEU A  99
GLY A 163
ILE A 180
VAL A 156
ILE A 158
 None
 0.90A 2hs1B-5az3A:
undetectable		 2hs1B-5az3A:
17.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q64_B_1UNB1001_2
(PROTEASE RETROPEPSIN)		 5az3 ABC-TYPE
TRANSPORTER,
PERIPLASMIC
COMPONENT
(Corynebacterium
glutamicum) 		3 / 3 ARG A  95
THR A 133
VAL A 119
 None
 0.71A 2q64A-5az3A:
undetectable		 2q64A-5az3A:
15.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A50_E_VD3E2001_1
(VITAMIN D
HYDROXYLASE)		 5az3 ABC-TYPE
TRANSPORTER,
PERIPLASMIC
COMPONENT
(Corynebacterium
glutamicum) 		5 / 12 THR A 138
ILE A 162
LEU A 143
ILE A 148
THR A 178
 None
 1.27A 3a50E-5az3A:
undetectable		 3a50E-5az3A:
27.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A51_A_VDYA6178_1
(VITAMIN D
HYDROXYLASE)		 5az3 ABC-TYPE
TRANSPORTER,
PERIPLASMIC
COMPONENT
(Corynebacterium
glutamicum) 		5 / 11 THR A 138
ILE A 162
LEU A 143
ILE A 148
THR A 178
 None
 1.25A 3a51A-5az3A:
undetectable		 3a51A-5az3A:
27.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R24_A_SAMA302_1
(2'-O-METHYL
TRANSFERASE)		 5az3 ABC-TYPE
TRANSPORTER,
PERIPLASMIC
COMPONENT
(Corynebacterium
glutamicum) 		3 / 3 TYR A 105
ASP A  84
ASP A 159
 None
 0.81A 3r24A-5az3A:
2.4		 3r24A-5az3A:
21.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V3O_C_T1CC401_1
(TETX2 PROTEIN)		 5az3 ABC-TYPE
TRANSPORTER,
PERIPLASMIC
COMPONENT
(Corynebacterium
glutamicum) 		5 / 11 ASP A 100
ARG A 185
GLY A 191
SER A 214
GLY A 103
 None
 1.28A 3v3oC-5az3A:
undetectable		 3v3oC-5az3A:
19.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C9K_A_CAMA424_0
(CYTOCHROME P450)		 5az3 ABC-TYPE
TRANSPORTER,
PERIPLASMIC
COMPONENT
(Corynebacterium
glutamicum) 		5 / 9 THR A  69
THR A 108
LEU A 210
GLY A 207
VAL A 201
 None
 1.32A 4c9kA-5az3A:
undetectable		 4c9kA-5az3A:
23.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C9N_B_CAMB1420_0
(CYTOCHROME P450)		 5az3 ABC-TYPE
TRANSPORTER,
PERIPLASMIC
COMPONENT
(Corynebacterium
glutamicum) 		5 / 10 THR A  69
THR A 108
LEU A 210
GLY A 207
VAL A 201
 None
 1.34A 4c9nB-5az3A:
undetectable		 4c9nB-5az3A:
23.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C9P_A_CAMA423_0
(CYTOCHROME P450)		 5az3 ABC-TYPE
TRANSPORTER,
PERIPLASMIC
COMPONENT
(Corynebacterium
glutamicum) 		5 / 9 THR A  69
THR A 108
LEU A 210
GLY A 207
VAL A 201
 None
 1.32A 4c9pA-5az3A:
undetectable		 4c9pA-5az3A:
23.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C9P_B_CAMB423_0
(CYTOCHROME P450)		 5az3 ABC-TYPE
TRANSPORTER,
PERIPLASMIC
COMPONENT
(Corynebacterium
glutamicum) 		5 / 10 THR A  69
THR A 108
LEU A 210
GLY A 207
VAL A 201
 None
 1.35A 4c9pB-5az3A:
undetectable		 4c9pB-5az3A:
23.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HDL_A_DXCA75_0
(PPCA)		 5az3 ABC-TYPE
TRANSPORTER,
PERIPLASMIC
COMPONENT
(Corynebacterium
glutamicum) 		4 / 8 ILE A 316
ILE A 250
MET A 297
GLY A 300
 None
None
HEM  A 401 (-4.0A)
None
 0.88A 4hdlA-5az3A:
undetectable		 4hdlA-5az3A:
9.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LNX_A_T44A501_1
(THYROID HORMONE
RECEPTOR ALPHA)		 5az3 ABC-TYPE
TRANSPORTER,
PERIPLASMIC
COMPONENT
(Corynebacterium
glutamicum) 		4 / 6 GLU A 299
VAL A 135
THR A 122
ARG A 121
 HEM  A 401 (-3.5A)
None
None
None
 1.30A 4lnxA-5az3A:
undetectable		 4lnxA-5az3A:
23.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4POO_B_SAMB301_0
(PUTATIVE RNA
METHYLASE)		 5az3 ABC-TYPE
TRANSPORTER,
PERIPLASMIC
COMPONENT
(Corynebacterium
glutamicum) 		5 / 12 THR A 104
GLY A 339
ASP A 193
GLN A 334
SER A 125
 None
 1.38A 4pooB-5az3A:
undetectable		 4pooB-5az3A:
20.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R38_C_RBFC201_2
(BLUE-LIGHT-ACTIVATED
HISTIDINE KINASE 2)		 5az3 ABC-TYPE
TRANSPORTER,
PERIPLASMIC
COMPONENT
(Corynebacterium
glutamicum) 		5 / 9 ILE A 316
LEU A 278
LEU A 289
ILE A 275
PHE A 294
 None
 1.28A 4r38C-5az3A:
undetectable		 4r38C-5az3A:
18.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5D4U_C_SAMC301_0
(UNCHARACTERIZED
PROTEIN MJ0489)		 5az3 ABC-TYPE
TRANSPORTER,
PERIPLASMIC
COMPONENT
(Corynebacterium
glutamicum) 		5 / 12 MET A 269
LEU A 239
THR A 319
GLY A 322
ILE A 316
 None
 0.88A 5d4uC-5az3A:
undetectable		 5d4uC-5az3A:
20.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5D4U_D_SAMD301_0
(UNCHARACTERIZED
PROTEIN MJ0489)		 5az3 ABC-TYPE
TRANSPORTER,
PERIPLASMIC
COMPONENT
(Corynebacterium
glutamicum) 		5 / 12 MET A 269
LEU A 239
THR A 319
GLY A 322
ILE A 316
 None
 0.91A 5d4uD-5az3A:
undetectable		 5d4uD-5az3A:
20.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5H5F_A_SAMA301_0
(PROTEIN ARGININE
N-METHYLTRANSFERASE
SFM1)		 5az3 ABC-TYPE
TRANSPORTER,
PERIPLASMIC
COMPONENT
(Corynebacterium
glutamicum) 		5 / 12 PHE A 248
GLY A 252
ASP A 253
LEU A 286
ALA A 281
 None
 1.17A 5h5fA-5az3A:
undetectable		 5h5fA-5az3A:
20.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I1O_F_DVAF9_0
(D-VILLIN HEADPIECE
SUBDOMAIN
VILLIN-1)		 5az3 ABC-TYPE
TRANSPORTER,
PERIPLASMIC
COMPONENT
(Corynebacterium
glutamicum) 		3 / 3 ALA A 147
ASN A 150
LEU A 151
 None
 0.36A 5i1oC-5az3A:
undetectable		 5i1oC-5az3A:
8.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I1P_F_DVAF9_0
(D-VILLIN HEADPIECE
SUBDOMAIN
VILLIN-1)		 5az3 ABC-TYPE
TRANSPORTER,
PERIPLASMIC
COMPONENT
(Corynebacterium
glutamicum) 		3 / 3 ALA A 147
ASN A 150
LEU A 151
 None
 0.30A 5i1pA-5az3A:
undetectable		 5i1pA-5az3A:
8.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I3C_B_AC2B301_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE
DEOD-TYPE)		 5az3 ABC-TYPE
TRANSPORTER,
PERIPLASMIC
COMPONENT
(Corynebacterium
glutamicum) 		5 / 10 GLY A  55
ALA A 329
VAL A 327
GLU A 352
ILE A 307
 None
 1.08A 5i3cB-5az3A:
undetectable		 5i3cB-5az3A:
22.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5W4Z_A_RBFA502_1
(RIBOFLAVIN LYASE)		 5az3 ABC-TYPE
TRANSPORTER,
PERIPLASMIC
COMPONENT
(Corynebacterium
glutamicum) 		5 / 12 ALA A 281
ALA A 279
GLY A 252
PHE A 294
ALA A 321
 None
 0.96A 5w4zA-5az3A:
undetectable		 5w4zA-5az3A:
14.56