SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5aza'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E06_A_IPBA600_0
(ODORANT-BINDING
PROTEIN)		 5aza MALTOSE-BINDING
PERIPLASMIC
PROTEIN,OLIGOSACCHAR
YL TRANSFERASE STT3
SUBUNIT RELATED
PROTEIN
(Escherichia
coli;
Pyrococcus
furiosus) 		4 / 6 VAL A   8
VAL A  50
ILE A  60
ASN A 267
 None
 0.90A 1e06A-5azaA:
undetectable		 1e06A-5azaA:
10.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FKP_A_NVPA999_1
(HIV-1 RT, A-CHAIN)		 5aza MALTOSE-BINDING
PERIPLASMIC
PROTEIN,OLIGOSACCHAR
YL TRANSFERASE STT3
SUBUNIT RELATED
PROTEIN
(Escherichia
coli;
Pyrococcus
furiosus) 		5 / 11 PRO A 503
LEU A 575
VAL A 531
VAL A 520
TYR A 564
 None
 1.43A 1fkpA-5azaA:
undetectable		 1fkpA-5azaA:
21.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KGL_A_RTLA175_1
(CELLULAR
RETINOL-BINDING
PROTEIN TYPE I)		 5aza MALTOSE-BINDING
PERIPLASMIC
PROTEIN,OLIGOSACCHAR
YL TRANSFERASE STT3
SUBUNIT RELATED
PROTEIN
(Escherichia
coli;
Pyrococcus
furiosus) 		4 / 7 LEU A 816
ILE A 768
MET A 789
TRP A 458
 None
 1.13A 1kglA-5azaA:
undetectable		 1kglA-5azaA:
9.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LWC_A_NVPA999_1
(HIV-1 REVERSE
TRANSCRIPTASE)		 5aza MALTOSE-BINDING
PERIPLASMIC
PROTEIN,OLIGOSACCHAR
YL TRANSFERASE STT3
SUBUNIT RELATED
PROTEIN
(Escherichia
coli;
Pyrococcus
furiosus) 		5 / 11 PRO A 503
LEU A 575
VAL A 531
VAL A 520
TYR A 564
 None
 1.42A 1lwcA-5azaA:
undetectable		 1lwcA-5azaA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OS6_A_DXCA75_0
(PPCA)		 5aza MALTOSE-BINDING
PERIPLASMIC
PROTEIN,OLIGOSACCHAR
YL TRANSFERASE STT3
SUBUNIT RELATED
PROTEIN
(Escherichia
coli;
Pyrococcus
furiosus) 		4 / 8 ILE A 132
LEU A 198
LYS A 256
GLY A 191
 None
 0.73A 1os6A-5azaA:
undetectable		 1os6A-5azaA:
6.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WOP_A_FFOA2888_0
(AMINOMETHYLTRANSFERA
SE)		 5aza MALTOSE-BINDING
PERIPLASMIC
PROTEIN,OLIGOSACCHAR
YL TRANSFERASE STT3
SUBUNIT RELATED
PROTEIN
(Escherichia
coli;
Pyrococcus
furiosus) 		5 / 10 LEU A 192
LEU A 195
ILE A 161
GLU A 153
LEU A 151
 None
None
None
MAL  A 901 (-3.7A)
None
 1.16A 1wopA-5azaA:
undetectable		 1wopA-5azaA:
18.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BR4_A_SAMA301_1
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 5aza MALTOSE-BINDING
PERIPLASMIC
PROTEIN,OLIGOSACCHAR
YL TRANSFERASE STT3
SUBUNIT RELATED
PROTEIN
(Escherichia
coli;
Pyrococcus
furiosus) 		3 / 3 LYS A   1
ASP A 777
ASP A 782
 None
 1.07A 2br4A-5azaA:
undetectable		 2br4A-5azaA:
12.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F16_H_BO2H1400_1
(PROTEASOME COMPONENT
PUP1
PROTEASOME COMPONENT
PUP3)		 5aza MALTOSE-BINDING
PERIPLASMIC
PROTEIN,OLIGOSACCHAR
YL TRANSFERASE STT3
SUBUNIT RELATED
PROTEIN
(Escherichia
coli;
Pyrococcus
furiosus) 		5 / 11 THR A  93
GLN A 325
ALA A 324
ALA A 303
ALA A 301
 None
 1.16A 2f16H-5azaA:
undetectable
2f16I-5azaA:
undetectable		 2f16H-5azaA:
13.52
2f16I-5azaA:
12.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F16_V_BO2V1401_1
(PROTEASOME COMPONENT
PUP1
PROTEASOME COMPONENT
PUP3)		 5aza MALTOSE-BINDING
PERIPLASMIC
PROTEIN,OLIGOSACCHAR
YL TRANSFERASE STT3
SUBUNIT RELATED
PROTEIN
(Escherichia
coli;
Pyrococcus
furiosus) 		5 / 11 THR A  93
GLN A 325
ALA A 324
ALA A 303
ALA A 301
 None
 1.14A 2f16V-5azaA:
undetectable
2f16W-5azaA:
undetectable		 2f16V-5azaA:
13.52
2f16W-5azaA:
12.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J2P_E_SC2E1289_1
(FICOLIN-2)		 5aza MALTOSE-BINDING
PERIPLASMIC
PROTEIN,OLIGOSACCHAR
YL TRANSFERASE STT3
SUBUNIT RELATED
PROTEIN
(Escherichia
coli;
Pyrococcus
furiosus) 		4 / 6 ASP A 197
THR A 193
LYS A 200
ASP A 358
 None
 1.26A 2j2pE-5azaA:
undetectable
2j2pF-5azaA:
undetectable		 2j2pE-5azaA:
13.96
2j2pF-5azaA:
13.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y69_C_CHDC1265_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 5aza MALTOSE-BINDING
PERIPLASMIC
PROTEIN,OLIGOSACCHAR
YL TRANSFERASE STT3
SUBUNIT RELATED
PROTEIN
(Escherichia
coli;
Pyrococcus
furiosus) 		4 / 5 PHE A 463
PHE A 608
LEU A 604
PHE A 600
 None
 1.34A 2y69C-5azaA:
undetectable
2y69J-5azaA:
undetectable		 2y69C-5azaA:
13.40
2y69J-5azaA:
6.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y69_P_CHDP1265_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 5aza MALTOSE-BINDING
PERIPLASMIC
PROTEIN,OLIGOSACCHAR
YL TRANSFERASE STT3
SUBUNIT RELATED
PROTEIN
(Escherichia
coli;
Pyrococcus
furiosus) 		4 / 5 PHE A 463
PHE A 608
LEU A 604
PHE A 600
 None
 1.35A 2y69P-5azaA:
undetectable
2y69W-5azaA:
undetectable		 2y69P-5azaA:
13.40
2y69W-5azaA:
6.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YGO_A_PCFA1213_0
(WNT INHIBITORY
FACTOR 1)		 5aza MALTOSE-BINDING
PERIPLASMIC
PROTEIN,OLIGOSACCHAR
YL TRANSFERASE STT3
SUBUNIT RELATED
PROTEIN
(Escherichia
coli;
Pyrococcus
furiosus) 		5 / 12 LEU A 667
ILE A 669
ILE A 681
ILE A 683
PHE A 711
 None
 0.89A 2ygoA-5azaA:
undetectable		 2ygoA-5azaA:
11.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ABM_C_CHDC271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 5aza MALTOSE-BINDING
PERIPLASMIC
PROTEIN,OLIGOSACCHAR
YL TRANSFERASE STT3
SUBUNIT RELATED
PROTEIN
(Escherichia
coli;
Pyrococcus
furiosus) 		4 / 5 PHE A 463
PHE A 608
LEU A 604
PHE A 600
 None
 1.36A 3abmC-5azaA:
undetectable
3abmJ-5azaA:
undetectable		 3abmC-5azaA:
13.40
3abmJ-5azaA:
5.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ABM_P_CHDP1271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 5aza MALTOSE-BINDING
PERIPLASMIC
PROTEIN,OLIGOSACCHAR
YL TRANSFERASE STT3
SUBUNIT RELATED
PROTEIN
(Escherichia
coli;
Pyrococcus
furiosus) 		4 / 5 PHE A 463
PHE A 608
LEU A 604
PHE A 600
 None
 1.31A 3abmP-5azaA:
undetectable
3abmW-5azaA:
undetectable		 3abmP-5azaA:
13.40
3abmW-5azaA:
5.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG3_C_CHDC271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 5aza MALTOSE-BINDING
PERIPLASMIC
PROTEIN,OLIGOSACCHAR
YL TRANSFERASE STT3
SUBUNIT RELATED
PROTEIN
(Escherichia
coli;
Pyrococcus
furiosus) 		4 / 5 PHE A 463
PHE A 608
LEU A 604
PHE A 600
 None
 1.30A 3ag3C-5azaA:
undetectable
3ag3J-5azaA:
undetectable		 3ag3C-5azaA:
13.40
3ag3J-5azaA:
5.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_C_SVRC507_1
(PHOSPHOLIPASE A2)		 5aza MALTOSE-BINDING
PERIPLASMIC
PROTEIN,OLIGOSACCHAR
YL TRANSFERASE STT3
SUBUNIT RELATED
PROTEIN
(Escherichia
coli;
Pyrococcus
furiosus) 		4 / 7 VAL A 110
GLY A 300
PRO A 229
LYS A 305
 None
 0.80A 3bjwC-5azaA:
1.6		 3bjwC-5azaA:
8.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ETE_B_H3PB552_1
(GLUTAMATE
DEHYDROGENASE)		 5aza MALTOSE-BINDING
PERIPLASMIC
PROTEIN,OLIGOSACCHAR
YL TRANSFERASE STT3
SUBUNIT RELATED
PROTEIN
(Escherichia
coli;
Pyrococcus
furiosus) 		3 / 3 TYR A 853
TYR A 757
ILE A 719
 None
 0.81A 3eteA-5azaA:
undetectable
3eteB-5azaA:
undetectable		 3eteA-5azaA:
21.69
3eteB-5azaA:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GV1_A_BEZA302_0
(DISULFIDE
INTERCHANGE PROTEIN)		 5aza MALTOSE-BINDING
PERIPLASMIC
PROTEIN,OLIGOSACCHAR
YL TRANSFERASE STT3
SUBUNIT RELATED
PROTEIN
(Escherichia
coli;
Pyrococcus
furiosus) 		4 / 6 PRO A 126
LEU A 147
ALA A 223
PRO A 125
 None
 1.30A 3gv1A-5azaA:
undetectable
3gv1C-5azaA:
undetectable		 3gv1A-5azaA:
10.89
3gv1C-5azaA:
10.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GV1_B_BEZB301_0
(DISULFIDE
INTERCHANGE PROTEIN)		 5aza MALTOSE-BINDING
PERIPLASMIC
PROTEIN,OLIGOSACCHAR
YL TRANSFERASE STT3
SUBUNIT RELATED
PROTEIN
(Escherichia
coli;
Pyrococcus
furiosus) 		4 / 6 LEU A 147
ALA A 223
PRO A 125
PRO A 126
 None
 1.29A 3gv1A-5azaA:
undetectable
3gv1B-5azaA:
undetectable		 3gv1A-5azaA:
10.89
3gv1B-5azaA:
10.89
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3JYR_A_ACRA371_1
(MALTOSE-BINDING
PERIPLASMIC PROTEIN)		 5aza MALTOSE-BINDING
PERIPLASMIC
PROTEIN,OLIGOSACCHAR
YL TRANSFERASE STT3
SUBUNIT RELATED
PROTEIN
(Escherichia
coli;
Pyrococcus
furiosus) 		10 / 12 ASP A  14
LYS A  15
LYS A  42
GLU A  44
GLU A  45
ALA A  63
ASP A  65
ARG A  66
GLU A 111
TRP A 230
 MAL  A 901 (-2.9A)
MAL  A 901 (-2.8A)
None
None
None
MAL  A 901 (-3.3A)
MAL  A 901 (-2.9A)
MAL  A 901 (-3.9A)
MAL  A 901 (-3.1A)
MAL  A 901 ( 4.6A)
 0.72A 3jyrA-5azaA:
58.0		 3jyrA-5azaA:
42.46
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3JYR_A_ACRA371_1
(MALTOSE-BINDING
PERIPLASMIC PROTEIN)		 5aza MALTOSE-BINDING
PERIPLASMIC
PROTEIN,OLIGOSACCHAR
YL TRANSFERASE STT3
SUBUNIT RELATED
PROTEIN
(Escherichia
coli;
Pyrococcus
furiosus) 		10 / 12 ASP A  14
LYS A  15
LYS A  42
GLU A  44
GLU A  45
ALA A  63
ASP A  65
GLU A 111
PRO A 154
TRP A 230
 MAL  A 901 (-2.9A)
MAL  A 901 (-2.8A)
None
None
None
MAL  A 901 (-3.3A)
MAL  A 901 (-2.9A)
MAL  A 901 (-3.1A)
MAL  A 901 (-3.5A)
MAL  A 901 ( 4.6A)
 0.46A 3jyrA-5azaA:
58.0		 3jyrA-5azaA:
42.46
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3JYR_A_ACRA371_2
(MALTOSE-BINDING
PERIPLASMIC PROTEIN)		 5aza MALTOSE-BINDING
PERIPLASMIC
PROTEIN,OLIGOSACCHAR
YL TRANSFERASE STT3
SUBUNIT RELATED
PROTEIN
(Escherichia
coli;
Pyrococcus
furiosus) 		6 / 7 ASN A  12
TRP A  62
GLU A 153
TYR A 155
MET A 330
TRP A 340
 MAL  A 901 ( 4.9A)
MAL  A 901 (-4.4A)
MAL  A 901 (-3.7A)
MAL  A 901 (-3.8A)
MAL  A 901 ( 4.4A)
MAL  A 901 (-3.6A)
 0.44A 3jyrA-5azaA:
58.0		 3jyrA-5azaA:
42.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_H_TFPH202_1
(PROTEIN S100-A4)		 5aza MALTOSE-BINDING
PERIPLASMIC
PROTEIN,OLIGOSACCHAR
YL TRANSFERASE STT3
SUBUNIT RELATED
PROTEIN
(Escherichia
coli;
Pyrococcus
furiosus) 		5 / 12 ASP A 661
LEU A 713
ILE A 655
PHE A 622
ASP A 454
 None
 0.93A 3ko0G-5azaA:
undetectable
3ko0H-5azaA:
undetectable
3ko0I-5azaA:
undetectable
3ko0J-5azaA:
undetectable		 3ko0G-5azaA:
8.49
3ko0H-5azaA:
8.49
3ko0I-5azaA:
8.49
3ko0J-5azaA:
8.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R6W_A_NFZA214_1
(FMN-DEPENDENT
NADH-AZOREDUCTASE 1)		 5aza MALTOSE-BINDING
PERIPLASMIC
PROTEIN,OLIGOSACCHAR
YL TRANSFERASE STT3
SUBUNIT RELATED
PROTEIN
(Escherichia
coli;
Pyrococcus
furiosus) 		5 / 10 PHE A 473
VAL A 465
PHE A 463
PHE A 608
PHE A 658
 None
 1.21A 3r6wA-5azaA:
undetectable
3r6wB-5azaA:
undetectable		 3r6wA-5azaA:
13.36
3r6wB-5azaA:
13.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SEL_X_DXCX75_0
(CYTOCHROME C7)		 5aza MALTOSE-BINDING
PERIPLASMIC
PROTEIN,OLIGOSACCHAR
YL TRANSFERASE STT3
SUBUNIT RELATED
PROTEIN
(Escherichia
coli;
Pyrococcus
furiosus) 		4 / 8 ILE A 132
LEU A 198
LYS A 256
GLY A 191
 None
 0.67A 3selX-5azaA:
undetectable		 3selX-5azaA:
6.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SI7_A_ACTA5_0
(CYSTIC FIBROSIS
TRANSMEMBRANE
CONDUCTANCE
REGULATOR)		 5aza MALTOSE-BINDING
PERIPLASMIC
PROTEIN,OLIGOSACCHAR
YL TRANSFERASE STT3
SUBUNIT RELATED
PROTEIN
(Escherichia
coli;
Pyrococcus
furiosus) 		3 / 3 LYS A 378
SER A  73
GLN A  72
 None
 1.25A 3si7A-5azaA:
undetectable		 3si7A-5azaA:
15.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TBG_B_RTZB1_1
(CYTOCHROME P450 2D6)		 5aza MALTOSE-BINDING
PERIPLASMIC
PROTEIN,OLIGOSACCHAR
YL TRANSFERASE STT3
SUBUNIT RELATED
PROTEIN
(Escherichia
coli;
Pyrococcus
furiosus) 		5 / 12 PHE A 156
GLY A 300
LEU A 299
GLU A 111
ALA A 231
 None
None
None
MAL  A 901 (-3.1A)
None
 0.87A 3tbgB-5azaA:
undetectable		 3tbgB-5azaA:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TBG_D_RTZD1_1
(CYTOCHROME P450 2D6)		 5aza MALTOSE-BINDING
PERIPLASMIC
PROTEIN,OLIGOSACCHAR
YL TRANSFERASE STT3
SUBUNIT RELATED
PROTEIN
(Escherichia
coli;
Pyrococcus
furiosus) 		5 / 12 PHE A 156
GLY A 300
LEU A 299
GLU A 111
ALA A 231
 None
None
None
MAL  A 901 (-3.1A)
None
 0.86A 3tbgD-5azaA:
undetectable		 3tbgD-5azaA:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TMZ_A_06XA504_1
(CYTOCHROME P450 2B4)		 5aza MALTOSE-BINDING
PERIPLASMIC
PROTEIN,OLIGOSACCHAR
YL TRANSFERASE STT3
SUBUNIT RELATED
PROTEIN
(Escherichia
coli;
Pyrococcus
furiosus) 		5 / 9 LEU A 854
ILE A 677
ILE A 678
PHE A 711
GLU A 852
 None
 1.49A 3tmzA-5azaA:
undetectable		 3tmzA-5azaA:
19.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VYW_A_SAMA501_1
(MNMC2)		 5aza MALTOSE-BINDING
PERIPLASMIC
PROTEIN,OLIGOSACCHAR
YL TRANSFERASE STT3
SUBUNIT RELATED
PROTEIN
(Escherichia
coli;
Pyrococcus
furiosus) 		4 / 6 GLU A 308
ASP A 314
ASP A 287
ASN A 294
 None
 1.31A 3vywA-5azaA:
undetectable		 3vywA-5azaA:
17.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VYW_D_SAMD401_1
(MNMC2)		 5aza MALTOSE-BINDING
PERIPLASMIC
PROTEIN,OLIGOSACCHAR
YL TRANSFERASE STT3
SUBUNIT RELATED
PROTEIN
(Escherichia
coli;
Pyrococcus
furiosus) 		4 / 5 GLU A 308
ASP A 314
ASP A 287
ASN A 294
 None
 1.29A 3vywD-5azaA:
undetectable		 3vywD-5azaA:
17.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C9W_A_VGHA1158_1
(7,8-DIHYDRO-8-OXOGUA
NINE TRIPHOSPHATASE)		 5aza MALTOSE-BINDING
PERIPLASMIC
PROTEIN,OLIGOSACCHAR
YL TRANSFERASE STT3
SUBUNIT RELATED
PROTEIN
(Escherichia
coli;
Pyrococcus
furiosus) 		5 / 12 LEU A 442
PHE A 455
PHE A 608
VAL A 453
PHE A 463
 None
 1.48A 4c9wA-5azaA:
undetectable		 4c9wA-5azaA:
10.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JX1_E_CAME502_0
(CAMPHOR
5-MONOOXYGENASE)		 5aza MALTOSE-BINDING
PERIPLASMIC
PROTEIN,OLIGOSACCHAR
YL TRANSFERASE STT3
SUBUNIT RELATED
PROTEIN
(Escherichia
coli;
Pyrococcus
furiosus) 		4 / 5 PHE A 625
TYR A 853
THR A 666
ILE A 662
 None
 1.00A 4jx1E-5azaA:
undetectable		 4jx1E-5azaA:
18.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M2X_G_TMQG202_1
(DIHYDROFOLATE
REDUCTASE)		 5aza MALTOSE-BINDING
PERIPLASMIC
PROTEIN,OLIGOSACCHAR
YL TRANSFERASE STT3
SUBUNIT RELATED
PROTEIN
(Escherichia
coli;
Pyrococcus
furiosus) 		5 / 12 ILE A 266
ALA A 105
LEU A  20
VAL A  23
ILE A  59
 None
 1.09A 4m2xG-5azaA:
undetectable		 4m2xG-5azaA:
10.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4N48_A_SAMA601_1
(CAP-SPECIFIC MRNA
(NUCLEOSIDE-2'-O-)-M
ETHYLTRANSFERASE 1)		 5aza MALTOSE-BINDING
PERIPLASMIC
PROTEIN,OLIGOSACCHAR
YL TRANSFERASE STT3
SUBUNIT RELATED
PROTEIN
(Escherichia
coli;
Pyrococcus
furiosus) 		4 / 5 ASN A 267
ALA A  51
GLY A  56
ASP A  14
 None
None
None
MAL  A 901 (-2.9A)
 0.98A 4n48A-5azaA:
undetectable		 4n48A-5azaA:
19.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OJB_A_198A1001_2
(ANDROGEN RECEPTOR)		 5aza MALTOSE-BINDING
PERIPLASMIC
PROTEIN,OLIGOSACCHAR
YL TRANSFERASE STT3
SUBUNIT RELATED
PROTEIN
(Escherichia
coli;
Pyrococcus
furiosus) 		4 / 7 LEU A 856
ILE A 681
ILE A 683
VAL A 701
 None
 0.85A 4ojbA-5azaA:
undetectable		 4ojbA-5azaA:
14.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OR0_B_NPSB602_1
(SERUM ALBUMIN)		 5aza MALTOSE-BINDING
PERIPLASMIC
PROTEIN,OLIGOSACCHAR
YL TRANSFERASE STT3
SUBUNIT RELATED
PROTEIN
(Escherichia
coli;
Pyrococcus
furiosus) 		5 / 9 ALA A 264
ALA A 105
LEU A 103
LEU A 262
VAL A 261
 None
 1.14A 4or0B-5azaA:
2.4		 4or0B-5azaA:
22.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PB1_A_RBVA501_1
(NUPC FAMILY PROTEIN)		 5aza MALTOSE-BINDING
PERIPLASMIC
PROTEIN,OLIGOSACCHAR
YL TRANSFERASE STT3
SUBUNIT RELATED
PROTEIN
(Escherichia
coli;
Pyrococcus
furiosus) 		5 / 12 GLY A  19
GLU A  22
ALA A 292
TYR A 307
SER A 233
 None
 1.29A 4pb1A-5azaA:
undetectable		 4pb1A-5azaA:
19.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PUO_A_NVPA901_1
(HIV-1 REVERSE
TRANSCRIPTASE, P66
SUBUNIT)		 5aza MALTOSE-BINDING
PERIPLASMIC
PROTEIN,OLIGOSACCHAR
YL TRANSFERASE STT3
SUBUNIT RELATED
PROTEIN
(Escherichia
coli;
Pyrococcus
furiosus) 		5 / 9 PRO A 503
LEU A 575
VAL A 531
VAL A 520
TYR A 564
 None
 1.48A 4puoA-5azaA:
undetectable		 4puoA-5azaA:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5F1A_B_SALB601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 5aza MALTOSE-BINDING
PERIPLASMIC
PROTEIN,OLIGOSACCHAR
YL TRANSFERASE STT3
SUBUNIT RELATED
PROTEIN
(Escherichia
coli;
Pyrococcus
furiosus) 		4 / 7 LEU A  76
GLY A 265
ALA A 264
SER A 263
 None
 0.91A 5f1aB-5azaA:
undetectable		 5f1aB-5azaA:
20.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HBM_A_NVPA601_1
(REVERSE
TRANSCRIPTASE/RIBONU
CLEASE H)		 5aza MALTOSE-BINDING
PERIPLASMIC
PROTEIN,OLIGOSACCHAR
YL TRANSFERASE STT3
SUBUNIT RELATED
PROTEIN
(Escherichia
coli;
Pyrococcus
furiosus) 		5 / 11 PRO A 503
LEU A 575
VAL A 531
VAL A 520
TYR A 564
 None
 1.47A 5hbmA-5azaA:
undetectable		 5hbmA-5azaA:
21.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IGV_A_ZITA404_2
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E II)		 5aza MALTOSE-BINDING
PERIPLASMIC
PROTEIN,OLIGOSACCHAR
YL TRANSFERASE STT3
SUBUNIT RELATED
PROTEIN
(Escherichia
coli;
Pyrococcus
furiosus) 		4 / 4 ASN A 693
ILE A 627
TYR A 628
PHE A 608
 None
 1.47A 5igvA-5azaA:
undetectable		 5igvA-5azaA:
18.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LJE_A_RTLA201_1
(RETINOL-BINDING
PROTEIN 1)		 5aza MALTOSE-BINDING
PERIPLASMIC
PROTEIN,OLIGOSACCHAR
YL TRANSFERASE STT3
SUBUNIT RELATED
PROTEIN
(Escherichia
coli;
Pyrococcus
furiosus) 		4 / 6 LEU A 763
ILE A 768
MET A 789
TRP A 458
 None
 1.35A 5ljeA-5azaA:
undetectable		 5ljeA-5azaA:
10.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OAJ_E_TKTE601_1
()		 5aza MALTOSE-BINDING
PERIPLASMIC
PROTEIN,OLIGOSACCHAR
YL TRANSFERASE STT3
SUBUNIT RELATED
PROTEIN
(Escherichia
coli;
Pyrococcus
furiosus) 		4 / 8 GLU A 850
PHE A 625
TYR A 853
ARG A 660
 None
 1.38A 5oajD-5azaA:
undetectable
5oajE-5azaA:
undetectable		 5oajD-5azaA:
14.68
5oajE-5azaA:
14.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UIG_A_EDTA501_0
(ADENOSINE RECEPTOR
A2A,SOLUBLE
CYTOCHROME
B562,ADENOSINE
RECEPTOR A2A)		 5aza MALTOSE-BINDING
PERIPLASMIC
PROTEIN,OLIGOSACCHAR
YL TRANSFERASE STT3
SUBUNIT RELATED
PROTEIN
(Escherichia
coli;
Pyrococcus
furiosus) 		4 / 6 THR A 736
ASN A 737
ILE A 841
GLU A   3
 None
 1.22A 5uigA-5azaA:
2.4		 5uigA-5azaA:
19.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WAU_C_CHDC306_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 5aza MALTOSE-BINDING
PERIPLASMIC
PROTEIN,OLIGOSACCHAR
YL TRANSFERASE STT3
SUBUNIT RELATED
PROTEIN
(Escherichia
coli;
Pyrococcus
furiosus) 		4 / 5 PHE A 463
PHE A 608
LEU A 604
PHE A 600
 None
 1.28A 5wauC-5azaA:
undetectable
5wauJ-5azaA:
undetectable		 5wauC-5azaA:
13.40
5wauJ-5azaA:
5.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WAU_C_CHDC308_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 5aza MALTOSE-BINDING
PERIPLASMIC
PROTEIN,OLIGOSACCHAR
YL TRANSFERASE STT3
SUBUNIT RELATED
PROTEIN
(Escherichia
coli;
Pyrococcus
furiosus) 		4 / 5 PHE A 463
PHE A 608
LEU A 604
PHE A 600
 None
 1.27A 5wauc-5azaA:
undetectable
5wauj-5azaA:
undetectable		 5wauc-5azaA:
13.40
5wauj-5azaA:
5.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XDQ_C_CHDC308_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 5aza MALTOSE-BINDING
PERIPLASMIC
PROTEIN,OLIGOSACCHAR
YL TRANSFERASE STT3
SUBUNIT RELATED
PROTEIN
(Escherichia
coli;
Pyrococcus
furiosus) 		4 / 5 PHE A 463
PHE A 608
LEU A 604
PHE A 600
 None
 1.26A 5xdqC-5azaA:
undetectable
5xdqJ-5azaA:
undetectable		 5xdqC-5azaA:
13.40
5xdqJ-5azaA:
5.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XDQ_P_CHDP306_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 5aza MALTOSE-BINDING
PERIPLASMIC
PROTEIN,OLIGOSACCHAR
YL TRANSFERASE STT3
SUBUNIT RELATED
PROTEIN
(Escherichia
coli;
Pyrococcus
furiosus) 		4 / 5 PHE A 463
PHE A 608
LEU A 604
PHE A 600
 None
 1.27A 5xdqP-5azaA:
undetectable
5xdqW-5azaA:
undetectable		 5xdqP-5azaA:
13.40
5xdqW-5azaA:
5.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B58_A_ACTA603_0
(FUMARATE REDUCTASE
FLAVOPROTEIN SUBUNIT)		 5aza MALTOSE-BINDING
PERIPLASMIC
PROTEIN,OLIGOSACCHAR
YL TRANSFERASE STT3
SUBUNIT RELATED
PROTEIN
(Escherichia
coli;
Pyrococcus
furiosus) 		3 / 3 TYR A 155
ASN A 227
LEU A 113
 MAL  A 901 (-3.8A)
None
None
 0.82A 6b58A-5azaA:
undetectable		 6b58A-5azaA:
20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6C2M_B_SUEB1202_1
(NS3 PROTEASE)		 5aza MALTOSE-BINDING
PERIPLASMIC
PROTEIN,OLIGOSACCHAR
YL TRANSFERASE STT3
SUBUNIT RELATED
PROTEIN
(Escherichia
coli;
Pyrococcus
furiosus) 		5 / 9 LEU A 692
ARG A 660
VAL A 453
SER A 451
ASP A 454
 None
 1.14A 6c2mB-5azaA:
undetectable		 6c2mB-5azaA:
6.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6D8F_A_ACTA803_0
(UNCHARACTERIZED
PROTEIN)		 5aza MALTOSE-BINDING
PERIPLASMIC
PROTEIN,OLIGOSACCHAR
YL TRANSFERASE STT3
SUBUNIT RELATED
PROTEIN
(Escherichia
coli;
Pyrococcus
furiosus) 		3 / 3 GLU A 815
LEU A 739
ARG A 740
 None
 0.75A 6d8fA-5azaA:
undetectable		 6d8fA-5azaA:
23.04