SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5azb'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HO5_A_ADNA1604_1
(5'-NUCLEOTIDASE)		 5azb PROLIPOPROTEIN
DIACYLGLYCERYL
TRANSFERASE
(Escherichia
coli) 		5 / 11 ILE A 107
SER A 101
GLY A  72
GLY A 105
PHE A  79
 PGT  A 309 ( 4.8A)
None
None
BOG  A 303 ( 4.1A)
None
 0.91A 1ho5A-5azbA:
undetectable		 1ho5A-5azbA:
20.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AVD_B_SAMB601_1
(CATECHOL-O-METHYLTRA
NSFERASE)		 5azb PROLIPOPROTEIN
DIACYLGLYCERYL
TRANSFERASE
(Escherichia
coli) 		3 / 3 SER A 198
GLU A 243
ASP A 249
 None
 0.70A 2avdB-5azbA:
undetectable		 2avdB-5azbA:
22.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XAT_A_CLMA301_0
(XENOBIOTIC
ACETYLTRANSFERASE)		 5azb PROLIPOPROTEIN
DIACYLGLYCERYL
TRANSFERASE
(Escherichia
coli) 		3 / 3 GLY A 236
TYR A 235
SER A 267
 None
PLM  A 301 (-4.7A)
None
 0.73A 2xatA-5azbA:
0.8		 2xatA-5azbA:
19.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7W_C_SALC1300_1
(LYSR-TYPE REGULATORY
PROTEIN)		 5azb PROLIPOPROTEIN
DIACYLGLYCERYL
TRANSFERASE
(Escherichia
coli) 		4 / 7 ILE A  74
GLY A  75
PHE A  79
ILE A 107
 PGT  A 309 ( 4.2A)
None
None
PGT  A 309 ( 4.8A)
 0.82A 2y7wC-5azbA:
undetectable		 2y7wC-5azbA:
24.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7W_C_SALC1300_1
(LYSR-TYPE REGULATORY
PROTEIN)		 5azb PROLIPOPROTEIN
DIACYLGLYCERYL
TRANSFERASE
(Escherichia
coli) 		4 / 7 ILE A 233
GLY A 234
PHE A 238
ILE A 213
 PGT  A 307 (-4.2A)
None
None
None
 0.84A 2y7wC-5azbA:
undetectable		 2y7wC-5azbA:
24.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AXZ_A_ADNA401_1
(TRNA
(GUANINE-N(1)-)-METH
YLTRANSFERASE)		 5azb PROLIPOPROTEIN
DIACYLGLYCERYL
TRANSFERASE
(Escherichia
coli) 		5 / 12 GLY A  71
GLY A  75
LEU A 106
GLY A 105
GLY A 108
 PGT  A 309 ( 3.7A)
None
None
BOG  A 303 ( 4.1A)
PGT  A 309 (-3.6A)
 0.81A 3axzA-5azbA:
undetectable		 3axzA-5azbA:
23.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3L35_H_DHIH3_0
(GP41 N-PEPTIDE
HIV ENTRY INHIBITOR
PIE12)		 5azb PROLIPOPROTEIN
DIACYLGLYCERYL
TRANSFERASE
(Escherichia
coli) 		3 / 3 LEU A 152
TRP A 153
GLY A 168
 None
 0.69A 3l35A-5azbA:
undetectable
3l35H-5azbA:
undetectable		 3l35A-5azbA:
8.21
3l35H-5azbA:
4.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3L35_K_DHIK3_0
(GP41 N-PEPTIDE
HIV ENTRY INHIBITOR
PIE12)		 5azb PROLIPOPROTEIN
DIACYLGLYCERYL
TRANSFERASE
(Escherichia
coli) 		3 / 3 LEU A 152
TRP A 153
GLY A 168
 None
 0.72A 3l35B-5azbA:
undetectable
3l35K-5azbA:
undetectable		 3l35B-5azbA:
8.21
3l35K-5azbA:
4.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QOI_A_ML1A303_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 5azb PROLIPOPROTEIN
DIACYLGLYCERYL
TRANSFERASE
(Escherichia
coli) 		4 / 8 PHE A 244
TYR A 201
PHE A 245
PHE A 160
 None
 0.73A 4qoiA-5azbA:
undetectable
4qoiB-5azbA:
undetectable		 4qoiA-5azbA:
22.78
4qoiB-5azbA:
22.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YV5_A_SVRA205_2
(BASIC PHOSPHOLIPASE
A2 HOMOLOG 2)		 5azb PROLIPOPROTEIN
DIACYLGLYCERYL
TRANSFERASE
(Escherichia
coli) 		4 / 6 LEU A 134
ASN A 215
PRO A 133
ARG A 122
 PGT  A 305 ( 4.7A)
None
None
None
 1.40A 4yv5B-5azbA:
undetectable		 4yv5B-5azbA:
14.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YV5_B_SVRB207_1
(BASIC PHOSPHOLIPASE
A2 HOMOLOG 2)		 5azb PROLIPOPROTEIN
DIACYLGLYCERYL
TRANSFERASE
(Escherichia
coli) 		4 / 6 LEU A 134
ASN A 215
PRO A 133
ARG A 122
 PGT  A 305 ( 4.7A)
None
None
None
 1.42A 4yv5A-5azbA:
undetectable		 4yv5A-5azbA:
14.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YVG_A_SAMA301_0
(TRNA
(GUANINE-N(1)-)-METH
YLTRANSFERASE)		 5azb PROLIPOPROTEIN
DIACYLGLYCERYL
TRANSFERASE
(Escherichia
coli) 		5 / 12 GLY A  71
GLY A  75
LEU A 106
GLY A 105
GLY A 108
 PGT  A 309 ( 3.7A)
None
None
BOG  A 303 ( 4.1A)
PGT  A 309 (-3.6A)
 0.86A 4yvgA-5azbA:
undetectable		 4yvgA-5azbA:
23.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_O_BEZO801_0
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 2
BEZ-LEU-LEU)		 5azb PROLIPOPROTEIN
DIACYLGLYCERYL
TRANSFERASE
(Escherichia
coli) 		4 / 6 PHE A   8
SER A 169
PRO A 167
LEU A 165
 None
 1.29A 5dzka-5azbA:
undetectable
5dzko-5azbA:
undetectable		 5dzka-5azbA:
22.58
5dzko-5azbA:
1.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IEO_A_VDYA206_2
(CDL2.3A)		 5azb PROLIPOPROTEIN
DIACYLGLYCERYL
TRANSFERASE
(Escherichia
coli) 		4 / 8 ILE A 271
MET A 278
ILE A 213
TYR A 235
 PGT  A 311 ( 4.1A)
PGT  A 307 (-4.0A)
None
PLM  A 301 (-4.7A)
 0.87A 5ieoA-5azbA:
undetectable		 5ieoA-5azbA:
20.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5O4Y_A_CCSA14_0
(PHE-MAA-ASN-PRO-HIS-
LEU-SER-TRP-SER-TRP-
9KK-9KK-ARG-CCS-GLY-
NH2)		 5azb PROLIPOPROTEIN
DIACYLGLYCERYL
TRANSFERASE
(Escherichia
coli) 		4 / 6 PHE A 147
ASN A 146
LEU A 152
GLY A 154
 None
 1.12A 5o4yA-5azbA:
undetectable		 5o4yA-5azbA:
3.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X80_B_SALB203_1
(UNCHARACTERIZED
HTH-TYPE
TRANSCRIPTIONAL
REGULATOR RV2887)		 5azb PROLIPOPROTEIN
DIACYLGLYCERYL
TRANSFERASE
(Escherichia
coli) 		4 / 6 PRO A 194
TYR A 190
LEU A 177
VAL A 156
 None
 0.99A 5x80A-5azbA:
undetectable
5x80B-5azbA:
1.2		 5x80A-5azbA:
20.07
5x80B-5azbA:
20.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BEO_A_DHIA4_0
((DPR)PY(DHI)PKDL(DGN
))		 5azb PROLIPOPROTEIN
DIACYLGLYCERYL
TRANSFERASE
(Escherichia
coli) 		3 / 3 TYR A 190
PRO A 194
LEU A 193
 None
 0.80A 6beoA-5azbA:
undetectable		 6beoA-5azbA:
2.88