SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5azd'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JFA_B_RALB600_1
(ESTROGEN RECEPTOR)		 5azd BACTERIORHODOPSIN
(Thermus
thermophilus) 		5 / 12 LEU A 166
LEU A 187
LEU A 184
GLY A 112
LEU A 113
 None
 1.08A 2jfaB-5azdA:
undetectable		 2jfaB-5azdA:
25.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_A_TFPA202_1
(PROTEIN S100-A4)		 5azd BACTERIORHODOPSIN
(Thermus
thermophilus) 		5 / 12 LEU A  50
SER A  51
ILE A  46
GLU A 106
LEU A 109
 None
 1.05A 3ko0A-5azdA:
1.5
3ko0B-5azdA:
1.8
3ko0C-5azdA:
1.6
3ko0D-5azdA:
0.7		 3ko0A-5azdA:
15.53
3ko0B-5azdA:
15.53
3ko0C-5azdA:
15.53
3ko0D-5azdA:
15.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_K_TFPK202_1
(PROTEIN S100-A4)		 5azd BACTERIORHODOPSIN
(Thermus
thermophilus) 		5 / 12 LEU A  50
SER A  51
ILE A  46
GLU A 106
LEU A 109
 None
 1.03A 3ko0K-5azdA:
1.6
3ko0L-5azdA:
1.7
3ko0S-5azdA:
1.5
3ko0T-5azdA:
1.7		 3ko0K-5azdA:
15.53
3ko0L-5azdA:
15.53
3ko0S-5azdA:
15.53
3ko0T-5azdA:
15.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_L_TFPL202_1
(PROTEIN S100-A4)		 5azd BACTERIORHODOPSIN
(Thermus
thermophilus) 		5 / 12 GLU A 106
LEU A 109
LEU A  50
SER A  51
ILE A  46
 None
 1.06A 3ko0K-5azdA:
1.7
3ko0L-5azdA:
1.5
3ko0M-5azdA:
1.7
3ko0N-5azdA:
1.7		 3ko0K-5azdA:
15.53
3ko0L-5azdA:
15.53
3ko0M-5azdA:
15.53
3ko0N-5azdA:
15.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_M_TFPM202_1
(PROTEIN S100-A4)		 5azd BACTERIORHODOPSIN
(Thermus
thermophilus) 		5 / 12 LEU A  50
SER A  51
ILE A  46
GLU A 106
LEU A 109
 None
 1.04A 3ko0M-5azdA:
1.7
3ko0N-5azdA:
1.7
3ko0O-5azdA:
1.7
3ko0P-5azdA:
1.8		 3ko0M-5azdA:
15.53
3ko0N-5azdA:
15.53
3ko0O-5azdA:
15.53
3ko0P-5azdA:
15.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_P_TFPP202_1
(PROTEIN S100-A4)		 5azd BACTERIORHODOPSIN
(Thermus
thermophilus) 		5 / 12 GLU A 106
LEU A 109
LEU A  50
SER A  51
ILE A  46
 None
 1.00A 3ko0M-5azdA:
1.8
3ko0N-5azdA:
1.5
3ko0O-5azdA:
1.7
3ko0P-5azdA:
1.8		 3ko0M-5azdA:
15.53
3ko0N-5azdA:
15.53
3ko0O-5azdA:
15.53
3ko0P-5azdA:
15.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P65_G_IPHG101_0
(INSULIN)		 5azd BACTERIORHODOPSIN
(Thermus
thermophilus) 		5 / 11 LEU A 170
VAL A 183
LEU A 184
LEU A 113
ALA A 173
 None
 1.01A 4p65B-5azdA:
undetectable
4p65D-5azdA:
undetectable
4p65G-5azdA:
undetectable
4p65H-5azdA:
undetectable		 4p65B-5azdA:
13.04
4p65D-5azdA:
13.04
4p65G-5azdA:
16.18
4p65H-5azdA:
13.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BYJ_A_OQRA302_0
(SULFOTRANSFERASE)		 5azd BACTERIORHODOPSIN
(Thermus
thermophilus) 		5 / 12 PHE A 179
ILE A 174
LEU A 186
THR A 190
THR A 118
 None
 1.08A 5byjA-5azdA:
undetectable		 5byjA-5azdA:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I71_A_68PA701_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		 5azd BACTERIORHODOPSIN
(Thermus
thermophilus) 		5 / 12 ILE A 174
ALA A 173
LEU A 121
GLY A 180
VAL A 183
 None
 1.24A 5i71A-5azdA:
undetectable		 5i71A-5azdA:
19.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I73_A_68PA701_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		 5azd BACTERIORHODOPSIN
(Thermus
thermophilus) 		6 / 12 ILE A 174
ALA A 173
GLY A 188
LEU A 121
GLY A 180
VAL A 183
 None
 1.32A 5i73A-5azdA:
2.3		 5i73A-5azdA:
19.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I75_A_68PA701_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		 5azd BACTERIORHODOPSIN
(Thermus
thermophilus) 		5 / 12 ILE A 174
ALA A 173
LEU A 121
GLY A 180
VAL A 183
 None
 1.25A 5i75A-5azdA:
1.3		 5i75A-5azdA:
19.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X80_B_SALB203_1
(UNCHARACTERIZED
HTH-TYPE
TRANSCRIPTIONAL
REGULATOR RV2887)		 5azd BACTERIORHODOPSIN
(Thermus
thermophilus) 		4 / 6 PRO A 202
GLY A 199
TYR A 201
LEU A 163
 LYR  A 233 ( 4.1A)
None
LYR  A 233 ( 3.2A)
None
 0.89A 5x80A-5azdA:
1.0
5x80B-5azdA:
0.8		 5x80A-5azdA:
18.96
5x80B-5azdA:
18.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B52_A_OAQA302_0
(SULFOTRANSFERASE)		 5azd BACTERIORHODOPSIN
(Thermus
thermophilus) 		5 / 12 ILE A 108
LEU A 102
VAL A 240
LEU A 113
LEU A 187
 None
 1.20A 6b52A-5azdA:
undetectable		 6b52A-5azdA:
21.20