SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5azs'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FC6_C_REAC501_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 5azs OUTER MEMBRANE
PROTEIN OPRJ
(Pseudomonas
aeruginosa) 		5 / 12 VAL A 127
ALA A 133
ALA A 134
ARG A 281
ALA A 280
 None
 0.79A 3fc6C-5azsA:
undetectable		 3fc6C-5azsA:
18.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S3V_A_TOPA193_1
(DIHYDROFOLATE
REDUCTASE)		 5azs OUTER MEMBRANE
PROTEIN OPRJ
(Pseudomonas
aeruginosa) 		4 / 5 ASP A 164
LEU A 167
ILE A 242
PRO A 243
 None
 1.23A 3s3vA-5azsA:
undetectable		 3s3vA-5azsA:
18.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RTB_A_SAMA501_1
(HYDG PROTEIN)		 5azs OUTER MEMBRANE
PROTEIN OPRJ
(Pseudomonas
aeruginosa) 		3 / 3 GLU A 120
ARG A 295
GLN A  75
 None
 0.81A 4rtbA-5azsA:
undetectable		 4rtbA-5azsA:
21.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KIR_A_RCXA601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 5azs OUTER MEMBRANE
PROTEIN OPRJ
(Pseudomonas
aeruginosa) 		5 / 12 ALA A 345
GLY A 286
ALA A 287
SER A 129
LEU A 130
 None
 1.02A 5kirA-5azsA:
undetectable		 5kirA-5azsA:
20.34