SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5b04'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID
Hit
Macromolecule
Res.
Matches
Interface HETATM RMSD Dali
Z-score
Seq.
Identity (%)
View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DZ4_B_CAMB502_0
(CYTOCHROME P450-CAM)
5b04 PROBABLE TRANSLATION
INITIATION FACTOR
EIF-2B SUBUNIT BETA
PROBABLE TRANSLATION
INITIATION FACTOR
EIF-2B SUBUNIT DELTA

(Schizosaccharomy
ces
pombe;
Schizosaccharomy
ces
pombe)
4 / 6 TYR G 331
LEU C 351
VAL G 324
VAL G 270
None
1.13A 1dz4B-5b04G:
undetectable
1dz4B-5b04G:
22.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E7C_A_HLTA4002_1
(SERUM ALBUMIN)
5b04 PROBABLE TRANSLATION
INITIATION FACTOR
EIF-2B SUBUNIT
EPSILON

(Schizosaccharomy
ces
pombe)
4 / 5 ARG I 215
ALA I 266
LYS I 267
GLU I 161
None
1.15A 1e7cA-5b04I:
undetectable
1e7cA-5b04I:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EII_A_RTLA135_0
(CELLULAR
RETINOL-BINDING
PROTEIN II)
5b04 PROBABLE TRANSLATION
INITIATION FACTOR
EIF-2B SUBUNIT BETA
PROBABLE TRANSLATION
INITIATION FACTOR
EIF-2B SUBUNIT DELTA

(Schizosaccharomy
ces
pombe;
Schizosaccharomy
ces
pombe)
5 / 12 ALA C 299
ARG G 438
LEU G 341
LEU G 439
LEU G 329
None
1.37A 1eiiA-5b04C:
undetectable
1eiiA-5b04C:
15.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EKJ_E_ACTE3005_0
(BETA-CARBONIC
ANHYDRASE)
5b04 PROBABLE TRANSLATION
INITIATION FACTOR
EIF-2B SUBUNIT BETA

(Schizosaccharomy
ces
pombe)
4 / 7 ASP C  52
GLY C 165
GLY C 166
TYR C  90
None
0.90A 1ekjE-5b04C:
undetectable
1ekjF-5b04C:
undetectable
1ekjE-5b04C:
20.71
1ekjF-5b04C:
20.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EKJ_F_ACTF3008_0
(BETA-CARBONIC
ANHYDRASE)
5b04 PROBABLE TRANSLATION
INITIATION FACTOR
EIF-2B SUBUNIT BETA

(Schizosaccharomy
ces
pombe)
4 / 8 TYR C  90
ASP C  52
GLY C 165
GLY C 166
None
0.91A 1ekjE-5b04C:
undetectable
1ekjF-5b04C:
undetectable
1ekjE-5b04C:
20.71
1ekjF-5b04C:
20.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1F9G_A_ASCA950_0
(HYALURONATE LYASE)
5b04 PROBABLE TRANSLATION
INITIATION FACTOR
EIF-2B SUBUNIT
EPSILON

(Schizosaccharomy
ces
pombe)
4 / 7 ASN I 216
ARG I 171
ARG I 194
ASN I 192
None
1.34A 1f9gA-5b04I:
undetectable
1f9gA-5b04I:
21.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FM4_A_DXCA1001_0
(MAJOR POLLEN
ALLERGEN BET V 1-L)
5b04 TRANSLATION
INITIATION FACTOR
EIF-2B SUBUNIT ALPHA
PROBABLE TRANSLATION
INITIATION FACTOR
EIF-2B SUBUNIT DELTA

(Schizosaccharomy
ces
pombe;
Schizosaccharomy
ces
pombe)
5 / 12 PRO A 254
PHE A 253
PRO G 451
THR G 453
ILE A 337
None
1.07A 1fm4A-5b04A:
undetectable
1fm4A-5b04A:
18.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KT4_A_RTLA184_0
(PLASMA
RETINOL-BINDING
PROTEIN)
5b04 PROBABLE TRANSLATION
INITIATION FACTOR
EIF-2B SUBUNIT GAMMA

(Schizosaccharomy
ces
pombe)
5 / 12 LEU E  80
LEU E  90
ALA E 102
VAL E  43
TYR E 108
None
1.04A 1kt4A-5b04E:
undetectable
1kt4A-5b04E:
18.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KT6_A_RTLA184_0
(PLASMA
RETINOL-BINDING
PROTEIN)
5b04 PROBABLE TRANSLATION
INITIATION FACTOR
EIF-2B SUBUNIT GAMMA

(Schizosaccharomy
ces
pombe)
5 / 11 LEU E  80
LEU E  90
ALA E 102
VAL E  43
TYR E 108
None
1.13A 1kt6A-5b04E:
undetectable
1kt6A-5b04E:
18.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KT7_A_RTLA184_0
(PLASMA
RETINOL-BINDING
PROTEIN)
5b04 PROBABLE TRANSLATION
INITIATION FACTOR
EIF-2B SUBUNIT GAMMA

(Schizosaccharomy
ces
pombe)
5 / 11 LEU E  80
LEU E  90
ALA E 102
VAL E  43
TYR E 108
None
1.08A 1kt7A-5b04E:
undetectable
1kt7A-5b04E:
18.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MEH_A_MOAA600_1
(INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE)
5b04 PROBABLE TRANSLATION
INITIATION FACTOR
EIF-2B SUBUNIT DELTA

(Schizosaccharomy
ces
pombe)
5 / 10 SER G 278
ASN G 281
GLY G 342
GLY G 254
GLU G 377
PO4  G 501 (-2.0A)
None
PO4  G 501 ( 4.6A)
None
None
1.31A 1mehA-5b04G:
undetectable
1mehA-5b04G:
23.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1S14_A_NOVA1300_1
(TOPOISOMERASE IV
SUBUNIT B)
5b04 TRANSLATION
INITIATION FACTOR
EIF-2B SUBUNIT ALPHA

(Schizosaccharomy
ces
pombe)
5 / 12 SER A 246
GLU A 245
ASP A 322
ARG A 122
ILE A  40
None
PO4  A 401 ( 4.3A)
None
None
None
1.33A 1s14A-5b04A:
undetectable
1s14A-5b04A:
19.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZZQ_B_ACTB861_0
(NITRIC-OXIDE
SYNTHASE, BRAIN)
5b04 PROBABLE TRANSLATION
INITIATION FACTOR
EIF-2B SUBUNIT BETA

(Schizosaccharomy
ces
pombe)
4 / 5 GLY C 234
GLN C 239
VAL C 258
SER C 242
None
1.33A 1zzqB-5b04C:
undetectable
1zzqB-5b04C:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZZU_A_ACTA860_0
(NITRIC-OXIDE
SYNTHASE, BRAIN)
5b04 PROBABLE TRANSLATION
INITIATION FACTOR
EIF-2B SUBUNIT BETA

(Schizosaccharomy
ces
pombe)
4 / 5 GLY C 234
GLN C 239
VAL C 258
SER C 242
None
1.29A 1zzuA-5b04C:
undetectable
1zzuA-5b04C:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A7Q_A_CFBA328_2
(DEOXYCYTIDINE KINASE)
5b04 PROBABLE TRANSLATION
INITIATION FACTOR
EIF-2B SUBUNIT BETA
PROBABLE TRANSLATION
INITIATION FACTOR
EIF-2B SUBUNIT DELTA

(Schizosaccharomy
ces
pombe)
4 / 4 ILE C 336
ASP C 261
LEU G 329
ARG G 308
None
1.34A 2a7qA-5b04C:
undetectable
2a7qA-5b04C:
19.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXG_A_IBPA2001_1
(SERUM ALBUMIN)
5b04 PROBABLE TRANSLATION
INITIATION FACTOR
EIF-2B SUBUNIT
EPSILON

(Schizosaccharomy
ces
pombe)
5 / 11 LEU I  36
VAL I 406
GLY I 405
ALA I 403
SER I 425
None
1.16A 2bxgA-5b04I:
undetectable
2bxgA-5b04I:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2H77_A_T3A1_1
(THRA PROTEIN)
5b04 PROBABLE TRANSLATION
INITIATION FACTOR
EIF-2B SUBUNIT
EPSILON

(Schizosaccharomy
ces
pombe)
5 / 12 ILE I 414
ALA I 400
ALA I 365
LEU I 384
ILE I 362
None
1.09A 2h77A-5b04I:
undetectable
2h77A-5b04I:
17.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NNH_A_9CRA501_1
(CYTOCHROME P450 2C8)
5b04 PROBABLE TRANSLATION
INITIATION FACTOR
EIF-2B SUBUNIT
EPSILON

(Schizosaccharomy
ces
pombe)
5 / 11 GLY I 409
SER I 435
ILE I 396
ALA I 382
VAL I 388
None
0.89A 2nnhA-5b04I:
undetectable
2nnhA-5b04I:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OTF_A_2TNA201_1
(PHOSPHOLIPASE A2
VRV-PL-VIIIA)
5b04 PROBABLE TRANSLATION
INITIATION FACTOR
EIF-2B SUBUNIT BETA
PROBABLE TRANSLATION
INITIATION FACTOR
EIF-2B SUBUNIT DELTA

(Schizosaccharomy
ces
pombe)
4 / 5 LEU G 364
ILE G 326
SER G 327
GLY C 292
None
0.98A 2otfA-5b04G:
undetectable
2otfA-5b04G:
14.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PKK_A_2FAA501_2
(ADENOSINE KINASE)
5b04 PROBABLE TRANSLATION
INITIATION FACTOR
EIF-2B SUBUNIT
EPSILON

(Schizosaccharomy
ces
pombe)
4 / 4 ALA I  20
VAL I  68
PHE I  93
THR I  54
None
1.36A 2pkkA-5b04I:
undetectable
2pkkA-5b04I:
18.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W98_A_P1ZA1352_1
(PROSTAGLANDIN
REDUCTASE 2)
5b04 PROBABLE TRANSLATION
INITIATION FACTOR
EIF-2B SUBUNIT BETA
PROBABLE TRANSLATION
INITIATION FACTOR
EIF-2B SUBUNIT
EPSILON

(Schizosaccharomy
ces
pombe)
4 / 7 TYR I 293
TYR I 314
LEU C 330
ASN C 352
None
1.13A 2w98A-5b04I:
undetectable
2w98B-5b04I:
2.5
2w98A-5b04I:
19.91
2w98B-5b04I:
19.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W9S_D_TOPD1158_1
(DIHYDROFOLATE
REDUCTASE TYPE 1
FROM TN4003)
5b04 PROBABLE TRANSLATION
INITIATION FACTOR
EIF-2B SUBUNIT BETA
PROBABLE TRANSLATION
INITIATION FACTOR
EIF-2B SUBUNIT DELTA

(Schizosaccharomy
ces
pombe)
5 / 10 ILE C 264
ALA C 266
LEU G 390
LEU G 428
ILE C 259
None
0.93A 2w9sD-5b04C:
undetectable
2w9sD-5b04C:
18.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W9S_F_TOPF1159_1
(DIHYDROFOLATE
REDUCTASE TYPE 1
FROM TN4003)
5b04 PROBABLE TRANSLATION
INITIATION FACTOR
EIF-2B SUBUNIT BETA
PROBABLE TRANSLATION
INITIATION FACTOR
EIF-2B SUBUNIT DELTA

(Schizosaccharomy
ces
pombe)
5 / 10 ILE C 264
ALA C 266
LEU G 390
LEU G 428
ILE C 259
None
0.96A 2w9sF-5b04C:
undetectable
2w9sF-5b04C:
18.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YQZ_A_SAMA301_1
(HYPOTHETICAL PROTEIN
TTHA0223)
5b04 PROBABLE TRANSLATION
INITIATION FACTOR
EIF-2B SUBUNIT DELTA

(Schizosaccharomy
ces
pombe)
4 / 5 TYR G 323
GLU G 306
ARG G 308
ASP G 433
None
1.43A 2yqzA-5b04G:
undetectable
2yqzA-5b04G:
21.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YQZ_B_SAMB401_1
(HYPOTHETICAL PROTEIN
TTHA0223)
5b04 PROBABLE TRANSLATION
INITIATION FACTOR
EIF-2B SUBUNIT DELTA

(Schizosaccharomy
ces
pombe)
4 / 5 TYR G 323
GLU G 306
ARG G 308
ASP G 433
None
1.43A 2yqzB-5b04G:
5.0
2yqzB-5b04G:
21.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AVP_A_MV2A313_1
(PANTOTHENATE KINASE)
5b04 PROBABLE TRANSLATION
INITIATION FACTOR
EIF-2B SUBUNIT
EPSILON

(Schizosaccharomy
ces
pombe)
4 / 7 VAL I 230
ASP I 122
HIS I 143
ILE I 243
None
1.00A 3avpA-5b04I:
undetectable
3avpA-5b04I:
18.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BGD_A_PM6A302_1
(THIOPURINE
S-METHYLTRANSFERASE)
5b04 PROBABLE TRANSLATION
INITIATION FACTOR
EIF-2B SUBUNIT BETA
PROBABLE TRANSLATION
INITIATION FACTOR
EIF-2B SUBUNIT DELTA

(Schizosaccharomy
ces
pombe)
4 / 6 HIS G 366
GLN C 298
LEU G 439
LEU G 363
None
1.05A 3bgdA-5b04G:
undetectable
3bgdA-5b04G:
22.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_B_SVRB501_2
(PHOSPHOLIPASE A2)
5b04 PROBABLE TRANSLATION
INITIATION FACTOR
EIF-2B SUBUNIT GAMMA

(Schizosaccharomy
ces
pombe)
5 / 11 LEU E 205
GLY E 317
ILE E 318
PRO E 176
SER E 175
None
1.21A 3bjwB-5b04E:
undetectable
3bjwB-5b04E:
14.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_F_SVRF502_3
(PHOSPHOLIPASE A2)
5b04 PROBABLE TRANSLATION
INITIATION FACTOR
EIF-2B SUBUNIT GAMMA

(Schizosaccharomy
ces
pombe)
5 / 12 LEU E 205
GLY E 317
ILE E 318
PRO E 176
SER E 175
None
1.25A 3bjwF-5b04E:
undetectable
3bjwF-5b04E:
14.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CE6_D_ADND500_2
(ADENOSYLHOMOCYSTEINA
SE)
5b04 PROBABLE TRANSLATION
INITIATION FACTOR
EIF-2B SUBUNIT
EPSILON

(Schizosaccharomy
ces
pombe)
4 / 5 LEU I 252
GLN I 190
HIS I 209
LEU I 212
None
1.19A 3ce6D-5b04I:
undetectable
3ce6D-5b04I:
21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CFQ_A_DIFA1_1
(TRANSTHYRETIN)
5b04 PROBABLE TRANSLATION
INITIATION FACTOR
EIF-2B SUBUNIT GAMMA

(Schizosaccharomy
ces
pombe)
4 / 6 LEU E  64
ALA E  96
LEU E  60
SER E  57
None
0.94A 3cfqA-5b04E:
undetectable
3cfqA-5b04E:
13.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CR5_X_PNTX95_0
(PROTEIN S100-B)
5b04 PROBABLE TRANSLATION
INITIATION FACTOR
EIF-2B SUBUNIT GAMMA

(Schizosaccharomy
ces
pombe)
3 / 3 CYH E 145
PHE E 243
PHE E 245
None
0.89A 3cr5X-5b04E:
undetectable
3cr5X-5b04E:
11.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D91_B_REMB350_1
(RENIN)
5b04 PROBABLE TRANSLATION
INITIATION FACTOR
EIF-2B SUBUNIT BETA

(Schizosaccharomy
ces
pombe)
5 / 12 GLN C  41
GLY C  62
THR C  46
VAL C  13
LEU C  83
None
1.25A 3d91B-5b04C:
undetectable
3d91B-5b04C:
20.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3F8W_A_ADNA300_1
(PURINE-NUCLEOSIDE
PHOSPHORYLASE)
5b04 TRANSLATION
INITIATION FACTOR
EIF-2B SUBUNIT ALPHA

(Schizosaccharomy
ces
pombe)
5 / 12 ALA A 244
GLY A 210
VAL A 148
GLY A 147
ASN A 222
None
PO4  A 401 ( 4.0A)
None
PO4  A 401 (-3.7A)
None
1.16A 3f8wA-5b04A:
undetectable
3f8wA-5b04A:
22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3F8W_C_ADNC302_1
(PURINE-NUCLEOSIDE
PHOSPHORYLASE)
5b04 TRANSLATION
INITIATION FACTOR
EIF-2B SUBUNIT ALPHA

(Schizosaccharomy
ces
pombe)
5 / 12 ALA A 244
GLY A 210
VAL A 148
GLY A 147
ASN A 222
None
PO4  A 401 ( 4.0A)
None
PO4  A 401 (-3.7A)
None
1.15A 3f8wC-5b04A:
undetectable
3f8wC-5b04A:
22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FL9_C_TOPC200_1
(DIHYDROFOLATE
REDUCTASE (DHFR))
5b04 PROBABLE TRANSLATION
INITIATION FACTOR
EIF-2B SUBUNIT
EPSILON

(Schizosaccharomy
ces
pombe)
5 / 11 ALA I 365
LEU I 384
ILE I 401
LEU I  34
THR I 348
None
1.00A 3fl9C-5b04I:
undetectable
3fl9C-5b04I:
11.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FL9_G_TOPG200_1
(DIHYDROFOLATE
REDUCTASE (DHFR))
5b04 PROBABLE TRANSLATION
INITIATION FACTOR
EIF-2B SUBUNIT
EPSILON

(Schizosaccharomy
ces
pombe)
5 / 12 ALA I 365
LEU I 384
ILE I 401
LEU I  34
THR I 348
None
1.02A 3fl9G-5b04I:
undetectable
3fl9G-5b04I:
11.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FL9_H_TOPH200_1
(DIHYDROFOLATE
REDUCTASE (DHFR))
5b04 PROBABLE TRANSLATION
INITIATION FACTOR
EIF-2B SUBUNIT
EPSILON

(Schizosaccharomy
ces
pombe)
5 / 9 ALA I 365
LEU I 384
ILE I 401
LEU I  34
THR I 348
None
0.99A 3fl9H-5b04I:
undetectable
3fl9H-5b04I:
11.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GV1_B_BEZB303_0
(DISULFIDE
INTERCHANGE PROTEIN)
5b04 PROBABLE TRANSLATION
INITIATION FACTOR
EIF-2B SUBUNIT GAMMA

(Schizosaccharomy
ces
pombe)
4 / 4 LEU E  65
ALA E 414
VAL E 432
PRO E  53
None
1.04A 3gv1B-5b04E:
undetectable
3gv1B-5b04E:
14.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ILT_H_TRUH800_1
(GLUTAMATE RECEPTOR 2)
5b04 PROBABLE TRANSLATION
INITIATION FACTOR
EIF-2B SUBUNIT
EPSILON

(Schizosaccharomy
ces
pombe)
3 / 3 ILE I 327
SER I 343
SER I 324
None
0.64A 3iltH-5b04I:
undetectable
3iltH-5b04I:
15.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K37_A_BCZA468_0
(NEURAMINIDASE)
5b04 PROBABLE TRANSLATION
INITIATION FACTOR
EIF-2B SUBUNIT
EPSILON

(Schizosaccharomy
ces
pombe)
5 / 12 LEU I  45
ARG I 275
ALA I 170
GLU I 173
TYR I 270
None
PO4  I 701 (-2.7A)
PO4  I 701 ( 4.5A)
None
None
1.43A 3k37A-5b04I:
undetectable
3k37A-5b04I:
20.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K39_A_BCZA1001_0
(NEURAMINIDASE)
5b04 PROBABLE TRANSLATION
INITIATION FACTOR
EIF-2B SUBUNIT
EPSILON

(Schizosaccharomy
ces
pombe)
5 / 12 LEU I  45
ARG I 275
ALA I 170
GLU I 173
TYR I 270
None
PO4  I 701 (-2.7A)
PO4  I 701 ( 4.5A)
None
None
1.48A 3k39A-5b04I:
undetectable
3k39A-5b04I:
19.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K39_E_BCZE1001_0
(NEURAMINIDASE)
5b04 PROBABLE TRANSLATION
INITIATION FACTOR
EIF-2B SUBUNIT
EPSILON

(Schizosaccharomy
ces
pombe)
5 / 12 LEU I  45
ARG I 275
ALA I 170
GLU I 173
TYR I 270
None
PO4  I 701 (-2.7A)
PO4  I 701 ( 4.5A)
None
None
1.46A 3k39E-5b04I:
undetectable
3k39E-5b04I:
19.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K39_F_BCZF1001_0
(NEURAMINIDASE)
5b04 PROBABLE TRANSLATION
INITIATION FACTOR
EIF-2B SUBUNIT
EPSILON

(Schizosaccharomy
ces
pombe)
5 / 12 LEU I  45
ARG I 275
ALA I 170
GLU I 173
TYR I 270
None
PO4  I 701 (-2.7A)
PO4  I 701 ( 4.5A)
None
None
1.45A 3k39F-5b04I:
undetectable
3k39F-5b04I:
19.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K39_G_BCZG1001_0
(NEURAMINIDASE)
5b04 PROBABLE TRANSLATION
INITIATION FACTOR
EIF-2B SUBUNIT
EPSILON

(Schizosaccharomy
ces
pombe)
5 / 12 LEU I  45
ARG I 275
ALA I 170
GLU I 173
TYR I 270
None
PO4  I 701 (-2.7A)
PO4  I 701 ( 4.5A)
None
None
1.47A 3k39G-5b04I:
undetectable
3k39G-5b04I:
19.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K39_H_BCZH1001_0
(NEURAMINIDASE)
5b04 PROBABLE TRANSLATION
INITIATION FACTOR
EIF-2B SUBUNIT
EPSILON

(Schizosaccharomy
ces
pombe)
5 / 12 LEU I  45
ARG I 275
ALA I 170
GLU I 173
TYR I 270
None
PO4  I 701 (-2.7A)
PO4  I 701 ( 4.5A)
None
None
1.45A 3k39H-5b04I:
undetectable
3k39H-5b04I:
19.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K39_M_BCZM1001_0
(NEURAMINIDASE)
5b04 PROBABLE TRANSLATION
INITIATION FACTOR
EIF-2B SUBUNIT
EPSILON

(Schizosaccharomy
ces
pombe)
5 / 12 LEU I  45
ARG I 275
ALA I 170
GLU I 173
TYR I 270
None
PO4  I 701 (-2.7A)
PO4  I 701 ( 4.5A)
None
None
1.47A 3k39M-5b04I:
undetectable
3k39M-5b04I:
19.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K39_N_BCZN1001_0
(NEURAMINIDASE)
5b04 PROBABLE TRANSLATION
INITIATION FACTOR
EIF-2B SUBUNIT
EPSILON

(Schizosaccharomy
ces
pombe)
5 / 12 LEU I  45
ARG I 275
ALA I 170
GLU I 173
TYR I 270
None
PO4  I 701 (-2.7A)
PO4  I 701 ( 4.5A)
None
None
1.47A 3k39N-5b04I:
undetectable
3k39N-5b04I:
19.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K39_O_BCZO1001_0
(NEURAMINIDASE)
5b04 PROBABLE TRANSLATION
INITIATION FACTOR
EIF-2B SUBUNIT
EPSILON

(Schizosaccharomy
ces
pombe)
5 / 12 LEU I  45
ARG I 275
ALA I 170
GLU I 173
TYR I 270
None
PO4  I 701 (-2.7A)
PO4  I 701 ( 4.5A)
None
None
1.46A 3k39O-5b04I:
undetectable
3k39O-5b04I:
19.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K39_P_BCZP1001_0
(NEURAMINIDASE)
5b04 PROBABLE TRANSLATION
INITIATION FACTOR
EIF-2B SUBUNIT
EPSILON

(Schizosaccharomy
ces
pombe)
5 / 12 LEU I  45
ARG I 275
ALA I 170
GLU I 173
TYR I 270
None
PO4  I 701 (-2.7A)
PO4  I 701 ( 4.5A)
None
None
1.48A 3k39P-5b04I:
undetectable
3k39P-5b04I:
19.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KPB_D_SAMD1000_0
(UNCHARACTERIZED
PROTEIN MJ0100)
5b04 PROBABLE TRANSLATION
INITIATION FACTOR
EIF-2B SUBUNIT BETA
PROBABLE TRANSLATION
INITIATION FACTOR
EIF-2B SUBUNIT DELTA

(Schizosaccharomy
ces
pombe;
Schizosaccharomy
ces
pombe)
5 / 10 ILE C 230
THR C 257
VAL C 271
ILE G 122
SER G 121
None
1.31A 3kpbD-5b04C:
undetectable
3kpbD-5b04C:
17.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LPS_A_NOVA901_1
(TOPOISOMERASE IV
SUBUNIT B)
5b04 TRANSLATION
INITIATION FACTOR
EIF-2B SUBUNIT ALPHA

(Schizosaccharomy
ces
pombe)
5 / 12 SER A 246
GLU A 245
ASP A 322
ARG A 122
ILE A  40
None
PO4  A 401 ( 4.3A)
None
None
None
1.25A 3lpsA-5b04A:
undetectable
3lpsA-5b04A:
23.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LXI_A_CAMA423_0
(CYTOCHROME P450)
5b04 TRANSLATION
INITIATION FACTOR
EIF-2B SUBUNIT ALPHA

(Schizosaccharomy
ces
pombe)
5 / 10 THR A 141
LEU A 153
LEU A 152
THR A 189
VAL A 166
None
1.14A 3lxiA-5b04A:
undetectable
3lxiA-5b04A:
22.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LXI_B_CAMB423_0
(CYTOCHROME P450)
5b04 TRANSLATION
INITIATION FACTOR
EIF-2B SUBUNIT ALPHA

(Schizosaccharomy
ces
pombe)
5 / 11 THR A 141
LEU A 153
LEU A 152
THR A 189
VAL A 166
None
1.12A 3lxiB-5b04A:
undetectable
3lxiB-5b04A:
22.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MS9_A_STIA1_2
(TYROSINE-PROTEIN
KINASE ABL1)
5b04 PROBABLE TRANSLATION
INITIATION FACTOR
EIF-2B SUBUNIT
EPSILON

(Schizosaccharomy
ces
pombe)
4 / 6 LYS I 315
VAL I 345
ILE I 313
ARG I 323
None
0.94A 3ms9A-5b04I:
undetectable
3ms9A-5b04I:
17.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MSS_A_STIA1_2
(TYROSINE-PROTEIN
KINASE ABL1)
5b04 PROBABLE TRANSLATION
INITIATION FACTOR
EIF-2B SUBUNIT
EPSILON

(Schizosaccharomy
ces
pombe)
4 / 6 LYS I 315
VAL I 345
ILE I 313
ARG I 323
None
0.94A 3mssA-5b04I:
undetectable
3mssA-5b04I:
17.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MSS_C_STIC1_2
(TYROSINE-PROTEIN
KINASE ABL1)
5b04 PROBABLE TRANSLATION
INITIATION FACTOR
EIF-2B SUBUNIT
EPSILON

(Schizosaccharomy
ces
pombe)
4 / 6 LYS I 315
VAL I 345
ILE I 313
ARG I 323
None
0.91A 3mssC-5b04I:
undetectable
3mssC-5b04I:
17.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PYY_A_STIA3_2
(V-ABL ABELSON MURINE
LEUKEMIA VIRAL
ONCOGENE HOMOLOG 1
ISOFORM B VARIANT)
5b04 PROBABLE TRANSLATION
INITIATION FACTOR
EIF-2B SUBUNIT
EPSILON

(Schizosaccharomy
ces
pombe)
4 / 6 LYS I 315
VAL I 345
ILE I 313
ARG I 323
None
0.97A 3pyyA-5b04I:
undetectable
3pyyA-5b04I:
17.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R55_A_PZAA598_0
(LACTOPEROXIDASE)
5b04 TRANSLATION
INITIATION FACTOR
EIF-2B SUBUNIT ALPHA

(Schizosaccharomy
ces
pombe)
3 / 3 GLU A 314
PHE A 315
GLN A 257
None
0.92A 3r55A-5b04A:
undetectable
3r55A-5b04A:
19.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SM2_A_478A126_2
(GAG-PRO-POL
POLYPROTEIN)
5b04 PROBABLE TRANSLATION
INITIATION FACTOR
EIF-2B SUBUNIT GAMMA

(Schizosaccharomy
ces
pombe)
5 / 11 ALA E 417
VAL E 413
VAL E 402
GLY E 420
LEU E 396
None
1.05A 3sm2B-5b04E:
undetectable
3sm2B-5b04E:
13.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SO9_A_017A100_2
(HIV-1 PROTEASE)
5b04 PROBABLE TRANSLATION
INITIATION FACTOR
EIF-2B SUBUNIT BETA
PROBABLE TRANSLATION
INITIATION FACTOR
EIF-2B SUBUNIT DELTA

(Schizosaccharomy
ces
pombe)
5 / 12 LEU C 351
VAL G 299
ILE G 361
THR G 322
VAL G 324
None
0.87A 3so9B-5b04C:
undetectable
3so9B-5b04C:
11.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3S_B_9PLB1_1
(CYTOCHROME P450 2A13)
5b04 PROBABLE TRANSLATION
INITIATION FACTOR
EIF-2B SUBUNIT
EPSILON

(Schizosaccharomy
ces
pombe)
4 / 6 PHE I 123
ASN I 228
ALA I 232
THR I 235
None
1.05A 3t3sB-5b04I:
undetectable
3t3sB-5b04I:
20.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3S_E_9PLE1_1
(CYTOCHROME P450 2A13)
5b04 PROBABLE TRANSLATION
INITIATION FACTOR
EIF-2B SUBUNIT
EPSILON

(Schizosaccharomy
ces
pombe)
4 / 8 PHE I 123
ASN I 228
ALA I 232
THR I 235
None
1.06A 3t3sE-5b04I:
undetectable
3t3sE-5b04I:
20.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TEG_A_DAHA416_1
(PHENYLALANYL-TRNA
SYNTHETASE,
MITOCHONDRIAL)
5b04 PROBABLE TRANSLATION
INITIATION FACTOR
EIF-2B SUBUNIT GAMMA

(Schizosaccharomy
ces
pombe)
5 / 12 SER E 147
ARG E 263
GLY E  48
ALA E  63
GLY E  46
None
0.99A 3tegA-5b04E:
undetectable
3tegA-5b04E:
22.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U9F_I_CLMI221_0
(CHLORAMPHENICOL
ACETYLTRANSFERASE)
5b04 PROBABLE TRANSLATION
INITIATION FACTOR
EIF-2B SUBUNIT GAMMA

(Schizosaccharomy
ces
pombe)
3 / 3 PHE E 243
CYH E 145
HIS E 241
None
1.22A 3u9fG-5b04E:
undetectable
3u9fG-5b04E:
18.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U9F_R_CLMR221_1
(CHLORAMPHENICOL
ACETYLTRANSFERASE)
5b04 PROBABLE TRANSLATION
INITIATION FACTOR
EIF-2B SUBUNIT GAMMA

(Schizosaccharomy
ces
pombe)
3 / 3 PHE E 243
CYH E 145
HIS E 241
None
1.18A 3u9fS-5b04E:
undetectable
3u9fS-5b04E:
18.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UJ7_A_SAMA301_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE)
5b04 PROBABLE TRANSLATION
INITIATION FACTOR
EIF-2B SUBUNIT GAMMA

(Schizosaccharomy
ces
pombe)
5 / 12 ILE E 374
ILE E 400
ILE E 379
ILE E 430
ARG E 407
None
1.12A 3uj7A-5b04E:
undetectable
3uj7A-5b04E:
22.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UQ6_B_ADNB401_2
(ADENOSINE KINASE,
PUTATIVE)
5b04 PROBABLE TRANSLATION
INITIATION FACTOR
EIF-2B SUBUNIT
EPSILON

(Schizosaccharomy
ces
pombe)
4 / 5 LEU I 256
GLY I 250
MET I 155
PHE I 234
None
1.23A 3uq6B-5b04I:
2.3
3uq6B-5b04I:
19.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V4T_E_ACTE502_0
(UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE)
5b04 PROBABLE TRANSLATION
INITIATION FACTOR
EIF-2B SUBUNIT GAMMA

(Schizosaccharomy
ces
pombe)
3 / 3 LYS E  62
ARG E 263
LEU E 326
None
1.11A 3v4tE-5b04E:
undetectable
3v4tE-5b04E:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WDM_A_ADNA901_1
(4-PHOSPHOPANTOATE--B
ETA-ALANINE LIGASE)
5b04 PROBABLE TRANSLATION
INITIATION FACTOR
EIF-2B SUBUNIT GAMMA

(Schizosaccharomy
ces
pombe)
5 / 9 ALA E 442
ARG E 443
GLY E 444
LEU E 425
ILE E 430
None
1.47A 3wdmA-5b04E:
undetectable
3wdmA-5b04E:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ASD_A_BAXA1500_2
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)
5b04 PROBABLE TRANSLATION
INITIATION FACTOR
EIF-2B SUBUNIT DELTA

(Schizosaccharomy
ces
pombe)
5 / 6 ILE G 332
VAL G 298
CYH G 310
LEU G 314
CYH G 321
None
1.49A 4asdA-5b04G:
3.1
4asdA-5b04G:
21.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C9K_B_CAMB424_0
(CYTOCHROME P450)
5b04 TRANSLATION
INITIATION FACTOR
EIF-2B SUBUNIT ALPHA

(Schizosaccharomy
ces
pombe)
5 / 9 THR A 141
LEU A 153
LEU A 152
THR A 189
VAL A 166
None
1.20A 4c9kB-5b04A:
undetectable
4c9kB-5b04A:
22.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D33_A_ACTA860_0
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)
5b04 PROBABLE TRANSLATION
INITIATION FACTOR
EIF-2B SUBUNIT
EPSILON

(Schizosaccharomy
ces
pombe)
4 / 5 GLY I 429
ILE I 439
VAL I 406
SER I 435
None
1.11A 4d33A-5b04I:
undetectable
4d33A-5b04I:
20.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D33_B_ACTB860_0
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)
5b04 PROBABLE TRANSLATION
INITIATION FACTOR
EIF-2B SUBUNIT
EPSILON

(Schizosaccharomy
ces
pombe)
4 / 5 GLY I 429
ILE I 439
VAL I 406
SER I 435
None
1.10A 4d33B-5b04I:
undetectable
4d33B-5b04I:
20.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D39_B_ACTB860_0
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)
5b04 PROBABLE TRANSLATION
INITIATION FACTOR
EIF-2B SUBUNIT
EPSILON

(Schizosaccharomy
ces
pombe)
4 / 6 GLY I 429
ILE I 439
VAL I 406
SER I 435
None
1.12A 4d39B-5b04I:
undetectable
4d39B-5b04I:
20.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4I89_A_1FLA201_1
(TRANSTHYRETIN)
5b04 PROBABLE TRANSLATION
INITIATION FACTOR
EIF-2B SUBUNIT GAMMA

(Schizosaccharomy
ces
pombe)
4 / 6 LEU E  64
ALA E  96
LEU E  60
SER E  57
None
1.02A 4i89A-5b04E:
undetectable
4i89A-5b04E:
14.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IKI_B_IMNB201_1
(TRANSTHYRETIN)
5b04 PROBABLE TRANSLATION
INITIATION FACTOR
EIF-2B SUBUNIT GAMMA

(Schizosaccharomy
ces
pombe)
4 / 6 LEU E  64
ALA E  96
LEU E  60
SER E  57
None
0.96A 4ikiB-5b04E:
undetectable
4ikiB-5b04E:
14.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J7U_D_YTZD802_1
(SEPIAPTERIN
REDUCTASE)
5b04 PROBABLE TRANSLATION
INITIATION FACTOR
EIF-2B SUBUNIT GAMMA

(Schizosaccharomy
ces
pombe)
4 / 8 LEU E  90
TRP E 103
TYR E 108
PRO E  76
None
1.13A 4j7uD-5b04E:
2.4
4j7uD-5b04E:
23.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K0B_B_SAMB504_0
(S-ADENOSYLMETHIONINE
SYNTHASE)
5b04 PROBABLE TRANSLATION
INITIATION FACTOR
EIF-2B SUBUNIT DELTA

(Schizosaccharomy
ces
pombe)
5 / 8 HIS G 276
LEU G 313
ASN G 281
ASP G 282
ILE G 285
None
1.30A 4k0bA-5b04G:
undetectable
4k0bA-5b04G:
22.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K7G_B_ACTB902_0
(3-HYDROXYPROLINE
DEHYDRATSE)
5b04 PROBABLE TRANSLATION
INITIATION FACTOR
EIF-2B SUBUNIT GAMMA

(Schizosaccharomy
ces
pombe)
4 / 7 ASP E 149
SER E 150
HIS E 241
SER E 147
None
0.82A 4k7gB-5b04E:
undetectable
4k7gB-5b04E:
21.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KKY_X_CAMX503_0
(CAMPHOR
5-MONOOXYGENASE)
5b04 PROBABLE TRANSLATION
INITIATION FACTOR
EIF-2B SUBUNIT BETA
PROBABLE TRANSLATION
INITIATION FACTOR
EIF-2B SUBUNIT DELTA

(Schizosaccharomy
ces
pombe;
Schizosaccharomy
ces
pombe)
4 / 6 TYR G 331
LEU C 351
VAL G 324
VAL G 270
None
1.14A 4kkyX-5b04G:
undetectable
4kkyX-5b04G:
22.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L49_A_CAMA502_0
(CAMPHOR
5-MONOOXYGENASE)
5b04 PROBABLE TRANSLATION
INITIATION FACTOR
EIF-2B SUBUNIT BETA
PROBABLE TRANSLATION
INITIATION FACTOR
EIF-2B SUBUNIT DELTA

(Schizosaccharomy
ces
pombe;
Schizosaccharomy
ces
pombe)
4 / 5 TYR G 331
LEU C 351
VAL G 324
VAL G 270
None
1.12A 4l49A-5b04G:
undetectable
4l49A-5b04G:
22.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L7I_B_SAMB501_0
(S-ADENOSYLMETHIONINE
SYNTHASE)
5b04 PROBABLE TRANSLATION
INITIATION FACTOR
EIF-2B SUBUNIT DELTA

(Schizosaccharomy
ces
pombe)
5 / 8 HIS G 276
LEU G 313
ASN G 281
ASP G 282
ILE G 285
None
1.30A 4l7iA-5b04G:
undetectable
4l7iA-5b04G:
22.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M11_C_MXMC606_2
(PROSTAGLANDIN G/H
SYNTHASE 2)
5b04 TRANSLATION
INITIATION FACTOR
EIF-2B SUBUNIT ALPHA

(Schizosaccharomy
ces
pombe)
3 / 3 LEU A 153
ARG A 122
MET A  35
None
0.86A 4m11C-5b04A:
2.4
4m11C-5b04A:
19.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MX0_A_BCZA513_0
(NEURAMINIDASE)
5b04 PROBABLE TRANSLATION
INITIATION FACTOR
EIF-2B SUBUNIT
EPSILON

(Schizosaccharomy
ces
pombe)
5 / 12 LEU I  45
ARG I 275
ALA I 170
GLU I 173
TYR I 270
None
PO4  I 701 (-2.7A)
PO4  I 701 ( 4.5A)
None
None
1.46A 4mx0A-5b04I:
undetectable
4mx0A-5b04I:
19.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4N09_A_ADNA401_1
(ADENOSINE KINASE)
5b04 PROBABLE TRANSLATION
INITIATION FACTOR
EIF-2B SUBUNIT GAMMA

(Schizosaccharomy
ces
pombe)
5 / 12 LEU E  64
CYH E 148
ALA E  63
ASN E  49
ASP E 124
None
1.06A 4n09A-5b04E:
undetectable
4n09A-5b04E:
20.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OBW_A_SAMA602_0
(2-METHOXY-6-POLYPREN
YL-1,4-BENZOQUINOL
METHYLASE,
MITOCHONDRIAL)
5b04 TRANSLATION
INITIATION FACTOR
EIF-2B SUBUNIT ALPHA

(Schizosaccharomy
ces
pombe)
5 / 12 ALA A  81
GLY A  82
ILE A  77
ASN A  76
GLY A 213
None
1.09A 4obwA-5b04A:
2.6
4obwA-5b04A:
20.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OBW_B_SAMB601_0
(2-METHOXY-6-POLYPREN
YL-1,4-BENZOQUINOL
METHYLASE,
MITOCHONDRIAL)
5b04 TRANSLATION
INITIATION FACTOR
EIF-2B SUBUNIT ALPHA

(Schizosaccharomy
ces
pombe)
5 / 12 ALA A  81
GLY A  82
ILE A  77
ASN A  76
GLY A 213
None
0.91A 4obwB-5b04A:
4.5
4obwB-5b04A:
20.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OBW_D_SAMD601_0
(2-METHOXY-6-POLYPREN
YL-1,4-BENZOQUINOL
METHYLASE,
MITOCHONDRIAL)
5b04 TRANSLATION
INITIATION FACTOR
EIF-2B SUBUNIT ALPHA

(Schizosaccharomy
ces
pombe)
5 / 12 ALA A  81
GLY A  82
ILE A  77
ASN A  76
GLY A 213
None
1.07A 4obwD-5b04A:
4.8
4obwD-5b04A:
20.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PD5_A_GEOA501_1
(NUPC FAMILY PROTEIN)
5b04 TRANSLATION
INITIATION FACTOR
EIF-2B SUBUNIT ALPHA

(Schizosaccharomy
ces
pombe)
5 / 12 GLY A 210
ALA A 211
VAL A 214
LEU A 319
ILE A 125
PO4  A 401 ( 4.0A)
None
None
None
None
0.98A 4pd5A-5b04A:
undetectable
4pd5A-5b04A:
21.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PD9_A_ADNA501_1
(NUPC FAMILY PROTEIN)
5b04 TRANSLATION
INITIATION FACTOR
EIF-2B SUBUNIT ALPHA

(Schizosaccharomy
ces
pombe)
5 / 12 GLY A 210
ALA A 211
VAL A 214
LEU A 319
ILE A 125
PO4  A 401 ( 4.0A)
None
None
None
None
0.94A 4pd9A-5b04A:
undetectable
4pd9A-5b04A:
21.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PSY_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)
5b04 PROBABLE TRANSLATION
INITIATION FACTOR
EIF-2B SUBUNIT BETA

(Schizosaccharomy
ces
pombe)
5 / 12 ILE C 367
ALA C 216
PHE C 217
ILE C 205
LEU C 199
None
1.02A 4psyA-5b04C:
undetectable
4psyA-5b04C:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QYQ_A_3CJA607_1
(LACTOPEROXIDASE)
5b04 PROBABLE TRANSLATION
INITIATION FACTOR
EIF-2B SUBUNIT
EPSILON

(Schizosaccharomy
ces
pombe)
3 / 3 GLN I 185
HIS I 262
ARG I 146
None
0.56A 4qyqA-5b04I:
undetectable
4qyqA-5b04I:
21.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QYQ_B_3CJB607_1
(LACTOPEROXIDASE)
5b04 PROBABLE TRANSLATION
INITIATION FACTOR
EIF-2B SUBUNIT
EPSILON

(Schizosaccharomy
ces
pombe)
3 / 3 GLN I 185
HIS I 262
ARG I 146
None
0.61A 4qyqB-5b04I:
undetectable
4qyqB-5b04I:
21.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R20_B_AERB602_1
(CYTOCHROME P450
FAMILY 17
POLYPEPTIDE 2)
5b04 TRANSLATION
INITIATION FACTOR
EIF-2B SUBUNIT ALPHA

(Schizosaccharomy
ces
pombe)
5 / 9 ALA A 244
ASN A 217
GLY A 219
SER A  78
VAL A 250
None
1.28A 4r20B-5b04A:
undetectable
4r20B-5b04A:
20.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4URN_A_NOVA2000_1
(DNA TOPOISOMERASE
IV, B SUBUNIT)
5b04 TRANSLATION
INITIATION FACTOR
EIF-2B SUBUNIT ALPHA

(Schizosaccharomy
ces
pombe)
5 / 11 SER A 246
GLU A 245
ASP A 322
ARG A 122
ILE A  40
None
PO4  A 401 ( 4.3A)
None
None
None
1.13A 4urnA-5b04A:
undetectable
4urnA-5b04A:
18.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4URN_B_NOVB2000_1
(DNA TOPOISOMERASE
IV, B SUBUNIT)
5b04 TRANSLATION
INITIATION FACTOR
EIF-2B SUBUNIT ALPHA

(Schizosaccharomy
ces
pombe)
5 / 11 SER A 246
GLU A 245
ASP A 322
ARG A 122
ILE A  40
None
PO4  A 401 ( 4.3A)
None
None
None
1.21A 4urnB-5b04A:
undetectable
4urnB-5b04A:
18.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4URN_C_NOVC2000_1
(DNA TOPOISOMERASE
IV, B SUBUNIT)
5b04 TRANSLATION
INITIATION FACTOR
EIF-2B SUBUNIT ALPHA

(Schizosaccharomy
ces
pombe)
5 / 11 SER A 246
GLU A 245
ASP A 322
ARG A 122
ILE A  40
None
PO4  A 401 ( 4.3A)
None
None
None
1.20A 4urnC-5b04A:
undetectable
4urnC-5b04A:
18.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4URO_C_NOVC2000_1
(DNA GYRASE SUBUNIT B)
5b04 PROBABLE TRANSLATION
INITIATION FACTOR
EIF-2B SUBUNIT DELTA

(Schizosaccharomy
ces
pombe)
5 / 12 ILE G 137
PRO G 138
ASP G 140
GLN G 197
ILE G 146
None
1.33A 4uroC-5b04G:
undetectable
4uroC-5b04G:
19.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4C_A_IPHA906_0
(PROTEIN ARGONAUTE-2)
5b04 PROBABLE TRANSLATION
INITIATION FACTOR
EIF-2B SUBUNIT
EPSILON

(Schizosaccharomy
ces
pombe)
4 / 6 ASP I 363
LYS I 328
THR I 348
THR I 331
None
1.20A 4z4cA-5b04I:
2.0
4z4cA-5b04I:
22.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZPH_A_PRLA501_0
(ARYL HYDROCARBON
RECEPTOR NUCLEAR
TRANSLOCATOR
ENDOTHELIAL PAS
DOMAIN-CONTAINING
PROTEIN 1)
5b04 TRANSLATION
INITIATION FACTOR
EIF-2B SUBUNIT ALPHA

(Schizosaccharomy
ces
pombe)
4 / 7 VAL A  73
LEU A  79
SER A  78
GLU A 212
None
1.01A 4zphA-5b04A:
undetectable
4zphB-5b04A:
undetectable
4zphA-5b04A:
21.86
4zphB-5b04A:
21.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5GTR_A_ESTA601_1
(ESTROGEN RECEPTOR)
5b04 PROBABLE TRANSLATION
INITIATION FACTOR
EIF-2B SUBUNIT BETA
PROBABLE TRANSLATION
INITIATION FACTOR
EIF-2B SUBUNIT DELTA

(Schizosaccharomy
ces
pombe)
5 / 12 ALA C 299
LEU G 363
LEU G 364
ILE G 326
GLY G 357
None
0.90A 5gtrA-5b04C:
undetectable
5gtrA-5b04C:
20.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HV1_A_RFPA902_1
(PHOSPHOENOLPYRUVATE
SYNTHASE)
5b04 PROBABLE TRANSLATION
INITIATION FACTOR
EIF-2B SUBUNIT DELTA

(Schizosaccharomy
ces
pombe)
5 / 12 VAL G 442
ALA G 261
VAL G 444
SER G 362
MET G 333
None
1.05A 5hv1A-5b04G:
3.0
5hv1A-5b04G:
20.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IFU_B_GBMB801_1
(PROLINE--TRNA LIGASE)
5b04 PROBABLE TRANSLATION
INITIATION FACTOR
EIF-2B SUBUNIT GAMMA

(Schizosaccharomy
ces
pombe)
5 / 9 ILE E 267
TYR E 269
LEU E 266
ILE E 196
GLY E 197
None
1.26A 5ifuB-5b04E:
undetectable
5ifuB-5b04E:
22.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKQ_A_JMSA602_2
(PROSTAGLANDIN G/H
SYNTHASE 2)
5b04 PROBABLE TRANSLATION
INITIATION FACTOR
EIF-2B SUBUNIT GAMMA

(Schizosaccharomy
ces
pombe)
3 / 3 VAL E 402
SER E 394
MET E 361
None
0.55A 5ikqA-5b04E:
undetectable
5ikqA-5b04E:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KM9_B_ADNB201_1
(HISTIDINE TRIAD
NUCLEOTIDE-BINDING
PROTEIN 2,
MITOCHONDRIAL)
5b04 TRANSLATION
INITIATION FACTOR
EIF-2B SUBUNIT ALPHA

(Schizosaccharomy
ces
pombe)
5 / 12 PHE A 162
ILE A 139
LEU A 206
VAL A 151
ALA A 126
None
1.13A 5km9B-5b04A:
undetectable
5km9B-5b04A:
16.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LG3_I_Z80I401_1
(GAMMA-AMINOBUTYRIC-A
CID RECEPTOR SUBUNIT
BETA-1)
5b04 PROBABLE TRANSLATION
INITIATION FACTOR
EIF-2B SUBUNIT
EPSILON

(Schizosaccharomy
ces
pombe)
4 / 9 ILE I 373
VAL I 345
THR I 348
ILE I 350
None
1.01A 5lg3I-5b04I:
undetectable
5lg3I-5b04I:
18.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NU7_A_RTLA201_0
(RETINOL-BINDING
PROTEIN 4)
5b04 PROBABLE TRANSLATION
INITIATION FACTOR
EIF-2B SUBUNIT GAMMA

(Schizosaccharomy
ces
pombe)
4 / 8 LEU E  90
ALA E 102
VAL E  43
TYR E 108
None
0.99A 5nu7A-5b04E:
undetectable
5nu7A-5b04E:
18.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5U63_A_ACTA405_0
(THIOREDOXIN
REDUCTASE)
5b04 PROBABLE TRANSLATION
INITIATION FACTOR
EIF-2B SUBUNIT BETA
PROBABLE TRANSLATION
INITIATION FACTOR
EIF-2B SUBUNIT DELTA

(Schizosaccharomy
ces
pombe;
Schizosaccharomy
ces
pombe)
3 / 3 GLY G 414
LEU G 416
HIS C 243
None
0.71A 5u63A-5b04G:
undetectable
5u63A-5b04G:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_B_PCFB1802_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)
5b04 PROBABLE TRANSLATION
INITIATION FACTOR
EIF-2B SUBUNIT
EPSILON

(Schizosaccharomy
ces
pombe)
4 / 7 SER I 427
THR I 421
VAL I 406
ILE I 383
None
1.24A 5vkqA-5b04I:
undetectable
5vkqB-5b04I:
undetectable
5vkqA-5b04I:
18.16
5vkqB-5b04I:
18.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_D_PCFD1803_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)
5b04 PROBABLE TRANSLATION
INITIATION FACTOR
EIF-2B SUBUNIT
EPSILON

(Schizosaccharomy
ces
pombe)
4 / 7 SER I 427
THR I 421
VAL I 406
ILE I 383
None
1.21A 5vkqC-5b04I:
undetectable
5vkqD-5b04I:
undetectable
5vkqC-5b04I:
18.16
5vkqD-5b04I:
18.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y80_A_IREA402_0
(CYCLIN-G-ASSOCIATED
KINASE)
5b04 PROBABLE TRANSLATION
INITIATION FACTOR
EIF-2B SUBUNIT BETA
PROBABLE TRANSLATION
INITIATION FACTOR
EIF-2B SUBUNIT DELTA

(Schizosaccharomy
ces
pombe;
Schizosaccharomy
ces
pombe)
5 / 11 SER G 301
HIS C 243
VAL C 231
ILE C 259
THR C 263
None
1.23A 5y80A-5b04G:
2.7
5y80A-5b04G:
10.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B3A_A_SAMA701_0
(APRA
METHYLTRANSFERASE 1)
5b04 PROBABLE TRANSLATION
INITIATION FACTOR
EIF-2B SUBUNIT
EPSILON

(Schizosaccharomy
ces
pombe)
5 / 12 GLY I 334
GLY I 351
TYR I 336
ASN I 353
ASP I 318
None
1.09A 6b3aA-5b04I:
2.0
6b3aA-5b04I:
23.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B3B_A_SAMA701_0
(APRA
METHYLTRANSFERASE 1)
5b04 PROBABLE TRANSLATION
INITIATION FACTOR
EIF-2B SUBUNIT
EPSILON

(Schizosaccharomy
ces
pombe)
5 / 12 GLY I 334
GLY I 351
TYR I 336
ASN I 353
ASP I 318
None
1.06A 6b3bA-5b04I:
2.6
6b3bA-5b04I:
23.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6C2M_B_SUEB1202_1
(NS3 PROTEASE)
5b04 PROBABLE TRANSLATION
INITIATION FACTOR
EIF-2B SUBUNIT GAMMA

(Schizosaccharomy
ces
pombe)
5 / 9 VAL E 249
HIS E 247
LEU E 205
ALA E 172
VAL E 173
None
1.31A 6c2mB-5b04E:
undetectable
6c2mB-5b04E:
10.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MA6_A_MYTA603_0
(CYTOCHROME P450 3A4)
5b04 TRANSLATION
INITIATION FACTOR
EIF-2B SUBUNIT ALPHA

(Schizosaccharomy
ces
pombe)
4 / 6 ARG A 146
SER A 145
ALA A 244
ALA A 118
PO4  A 401 (-3.7A)
PO4  A 401 (-2.6A)
None
None
1.02A 6ma6A-5b04A:
undetectable
6ma6A-5b04A:
13.08