SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5b0n'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_B_115B1_1
(HMG-COA REDUCTASE)		 5b0n E3 UBIQUITIN-PROTEIN
LIGASE IPAH9.8
(Shigella
flexneri) 		5 / 9 ASN A  74
LEU A  50
ALA A  46
LEU A  63
LEU A  68
 None
 1.35A 1hwiA-5b0nA:
undetectable		 1hwiA-5b0nA:
19.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IG3_A_VIBA502_1
(THIAMIN
PYROPHOSPHOKINASE)		 5b0n E3 UBIQUITIN-PROTEIN
LIGASE IPAH9.8
(Shigella
flexneri) 		4 / 8 SER A 104
SER A 106
ASN A 107
ASP A  64
 None
 1.14A 1ig3A-5b0nA:
undetectable
1ig3B-5b0nA:
undetectable		 1ig3A-5b0nA:
21.32
1ig3B-5b0nA:
21.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IG3_B_VIBB501_1
(THIAMIN
PYROPHOSPHOKINASE)		 5b0n E3 UBIQUITIN-PROTEIN
LIGASE IPAH9.8
(Shigella
flexneri) 		4 / 7 ASP A  64
SER A 104
SER A 106
ASN A 107
 None
 1.17A 1ig3A-5b0nA:
undetectable
1ig3B-5b0nA:
undetectable		 1ig3A-5b0nA:
21.32
1ig3B-5b0nA:
21.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1T9U_A_CPFA5002_1
(ACRIFLAVINE
RESISTANCE PROTEIN B)		 5b0n E3 UBIQUITIN-PROTEIN
LIGASE IPAH9.8
(Shigella
flexneri) 		4 / 6 PHE A 187
PHE A 188
ASN A 191
ASN A 161
 None
 1.47A 1t9uA-5b0nA:
undetectable		 1t9uA-5b0nA:
11.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YAJ_A_BEZA11_0
(CES1 PROTEIN)		 5b0n E3 UBIQUITIN-PROTEIN
LIGASE IPAH9.8
(Shigella
flexneri) 		4 / 4 LEU A  71
SER A 104
LEU A  61
LEU A  75
 None
 1.18A 1yajA-5b0nA:
undetectable		 1yajA-5b0nA:
16.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIM_J_CHDJ60_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART)		 5b0n E3 UBIQUITIN-PROTEIN
LIGASE IPAH9.8
(Shigella
flexneri) 		4 / 5 ARG A 163
MET A 142
THR A 141
LEU A 122
 None
 1.32A 2eimJ-5b0nA:
undetectable		 2eimJ-5b0nA:
11.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q83_B_ADNB2_1
(YTAA PROTEIN)		 5b0n E3 UBIQUITIN-PROTEIN
LIGASE IPAH9.8
(Shigella
flexneri) 		4 / 6 ILE A 193
PRO A 236
LEU A 224
ILE A 238
 None
 0.99A 2q83B-5b0nA:
undetectable		 2q83B-5b0nA:
21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XN7_A_T44A1355_1
(THYROXINE-BINDING
GLOBULIN)		 5b0n E3 UBIQUITIN-PROTEIN
LIGASE IPAH9.8
(Shigella
flexneri) 		5 / 10 LEU A  82
LEU A  75
LEU A  50
LEU A  61
ARG A  49
 None
 1.14A 2xn7A-5b0nA:
undetectable
2xn7B-5b0nA:
undetectable		 2xn7A-5b0nA:
19.61
2xn7B-5b0nA:
7.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG1_J_CHDJ60_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1)		 5b0n E3 UBIQUITIN-PROTEIN
LIGASE IPAH9.8
(Shigella
flexneri) 		4 / 5 ARG A 163
MET A 142
THR A 141
LEU A 122
 None
 1.41A 3ag1J-5b0nA:
undetectable		 3ag1J-5b0nA:
11.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG2_J_CHDJ60_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1)		 5b0n E3 UBIQUITIN-PROTEIN
LIGASE IPAH9.8
(Shigella
flexneri) 		4 / 5 ARG A 163
MET A 142
THR A 141
LEU A 122
 None
 1.30A 3ag2J-5b0nA:
undetectable		 3ag2J-5b0nA:
11.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG4_J_CHDJ60_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1)		 5b0n E3 UBIQUITIN-PROTEIN
LIGASE IPAH9.8
(Shigella
flexneri) 		4 / 5 ARG A 163
MET A 142
THR A 141
LEU A 122
 None
 1.36A 3ag4J-5b0nA:
undetectable		 3ag4J-5b0nA:
11.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G1U_A_ADNA438_1
(ADENOSYLHOMOCYSTEINA
SE)		 5b0n E3 UBIQUITIN-PROTEIN
LIGASE IPAH9.8
(Shigella
flexneri) 		5 / 12 LEU A 152
ASN A 143
LEU A 139
LEU A 159
PHE A 188
 None
 1.18A 3g1uA-5b0nA:
undetectable		 3g1uA-5b0nA:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4U14_A_0HKA2000_2
(MUSCARINIC
ACETYLCHOLINE
RECEPTOR
M3,ENDOLYSIN,MUSCARI
NIC ACETYLCHOLINE
RECEPTOR M3)		 5b0n E3 UBIQUITIN-PROTEIN
LIGASE IPAH9.8
(Shigella
flexneri) 		4 / 4 ASN A 214
LEU A 152
PHE A 187
TYR A 186
 None
 1.30A 4u14A-5b0nA:
undetectable		 4u14A-5b0nA:
18.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B1B_W_CHDW101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 5b0n E3 UBIQUITIN-PROTEIN
LIGASE IPAH9.8
(Shigella
flexneri) 		4 / 7 ILE A 149
ARG A 163
MET A 142
LEU A 122
 None
 0.91A 5b1bN-5b0nA:
undetectable
5b1bW-5b0nA:
undetectable		 5b1bN-5b0nA:
17.29
5b1bW-5b0nA:
11.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B3S_W_CHDW101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 5b0n E3 UBIQUITIN-PROTEIN
LIGASE IPAH9.8
(Shigella
flexneri) 		4 / 7 ILE A 149
ARG A 163
MET A 142
LEU A 122
 None
 0.94A 5b3sN-5b0nA:
undetectable
5b3sW-5b0nA:
undetectable		 5b3sN-5b0nA:
17.29
5b3sW-5b0nA:
11.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IY5_J_CHDJ101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 5b0n E3 UBIQUITIN-PROTEIN
LIGASE IPAH9.8
(Shigella
flexneri) 		4 / 7 ILE A 149
ARG A 163
MET A 142
LEU A 122
 None
 0.99A 5iy5A-5b0nA:
undetectable
5iy5J-5b0nA:
undetectable		 5iy5A-5b0nA:
17.29
5iy5J-5b0nA:
13.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5U63_A_ACTA406_0
(THIOREDOXIN
REDUCTASE)		 5b0n E3 UBIQUITIN-PROTEIN
LIGASE IPAH9.8
(Shigella
flexneri) 		3 / 3 HIS A 126
SER A 145
ARG A 166
 None
 0.91A 5u63A-5b0nA:
undetectable		 5u63A-5b0nA:
19.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5W97_J_CHDJ101_1
(CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 5b0n E3 UBIQUITIN-PROTEIN
LIGASE IPAH9.8
(Shigella
flexneri) 		4 / 5 ARG A 163
MET A 142
THR A 141
LEU A 122
 None
 1.28A 5w97J-5b0nA:
undetectable		 5w97J-5b0nA:
11.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WAU_J_CHDJ101_1
(CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 5b0n E3 UBIQUITIN-PROTEIN
LIGASE IPAH9.8
(Shigella
flexneri) 		4 / 5 ARG A 163
MET A 142
THR A 141
LEU A 122
 None
 1.29A 5wauJ-5b0nA:
undetectable		 5wauJ-5b0nA:
11.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X1F_W_CHDW101_0
(CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 5b0n E3 UBIQUITIN-PROTEIN
LIGASE IPAH9.8
(Shigella
flexneri) 		4 / 5 ARG A 163
MET A 142
THR A 141
LEU A 122
 None
 1.32A 5x1fW-5b0nA:
undetectable		 5x1fW-5b0nA:
11.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z86_J_CHDJ101_0
(CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 5b0n E3 UBIQUITIN-PROTEIN
LIGASE IPAH9.8
(Shigella
flexneri) 		4 / 5 ARG A 163
MET A 142
THR A 141
LEU A 122
 None
 1.13A 5z86J-5b0nA:
undetectable		 5z86J-5b0nA:
11.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z86_W_CHDW101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 5b0n E3 UBIQUITIN-PROTEIN
LIGASE IPAH9.8
(Shigella
flexneri) 		4 / 6 ILE A 149
ARG A 163
MET A 142
LEU A 122
 None
 0.95A 5z86N-5b0nA:
undetectable
5z86W-5b0nA:
undetectable		 5z86N-5b0nA:
17.29
5z86W-5b0nA:
11.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZCO_W_CHDW101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 5b0n E3 UBIQUITIN-PROTEIN
LIGASE IPAH9.8
(Shigella
flexneri) 		4 / 6 ILE A 149
ARG A 163
MET A 142
LEU A 122
 None
 0.98A 5zcoN-5b0nA:
undetectable
5zcoW-5b0nA:
undetectable		 5zcoN-5b0nA:
17.29
5zcoW-5b0nA:
11.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F5U_A_CQNA610_1
(ENVELOPE
GLYCOPROTEIN,ENVELOP
E GLYCOPROTEIN,GP1
ENVELOPE
GLYCOPROTEIN)		 5b0n E3 UBIQUITIN-PROTEIN
LIGASE IPAH9.8
(Shigella
flexneri) 		5 / 10 VAL A  84
LEU A  89
LEU A 109
LEU A  75
LEU A  71
 None
 1.00A 6f5uA-5b0nA:
undetectable
6f5uB-5b0nA:
undetectable		 6f5uA-5b0nA:
19.78
6f5uB-5b0nA:
18.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6G9B_A_IXXA609_1
(ENVELOPE
GLYCOPROTEIN,ENVELOP
E GLYCOPROTEIN
ENVELOPE
GLYCOPROTEIN)		 5b0n E3 UBIQUITIN-PROTEIN
LIGASE IPAH9.8
(Shigella
flexneri) 		4 / 7 LEU A 112
VAL A  84
LEU A 102
LEU A  99
 None
 0.73A 6g9bA-5b0nA:
undetectable
6g9bB-5b0nA:
undetectable		 6g9bA-5b0nA:
19.78
6g9bB-5b0nA:
18.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NKN_W_CHDW102_0
(CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 5b0n E3 UBIQUITIN-PROTEIN
LIGASE IPAH9.8
(Shigella
flexneri) 		4 / 5 ARG A 163
MET A 142
THR A 141
LEU A 122
 None
 1.28A 6nknW-5b0nA:
undetectable		 6nknW-5b0nA:
11.16