SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5b0v'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

Filter list by:

	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)	View	Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1G60_B_SAMB501_0 (ADENINE-SPECIFIC METHYLTRANSFERASE MBOIIA)	5b0v	MATRIX PROTEIN VP40 (Marburg marburgvirus)	5 / 12	ASN A 142 ILE A 151 PRO A 152 PHE A 145 TYR A 162	None	1.47A	1g60B-5b0vA: undetectable	1g60B-5b0vA: 22.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2ACL_C_REAC503_1 (RETINOIC ACID RECEPTOR RXR-ALPHA)	5b0v	MATRIX PROTEIN VP40 (Marburg marburgvirus)	5 / 10	ILE A 228 ALA A 227 PHE A 256 ALA A 213 ILE A 204	None	1.11A	2aclC-5b0vA: undetectable	2aclC-5b0vA: 22.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3BJW_E_SVRE510_2 (PHOSPHOLIPASE A2)	5b0v	MATRIX PROTEIN VP40 (Marburg marburgvirus)	4 / 6	VAL A 303 GLN A 143 ARG A 125 LEU A 126	None	1.00A	3bjwE-5b0vA: undetectable	3bjwE-5b0vA: 14.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3G1U_C_ADNC438_2 (ADENOSYLHOMOCYSTEINA SE)	5b0v	MATRIX PROTEIN VP40 (Marburg marburgvirus)	4 / 5	GLN A 172 THR A 62 THR A 99 HIS A 59	None	1.35A	3g1uC-5b0vA: undetectable	3g1uC-5b0vA: 20.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4HWK_B_SFYB806_0 (SEPIAPTERIN REDUCTASE)	5b0v	MATRIX PROTEIN VP40 (Marburg marburgvirus)	5 / 11	LEU A 174 PHE A 247 TYR A 274 GLN A 172 ALA A 60	None	1.16A	4hwkB-5b0vA: undetectable	4hwkB-5b0vA: 23.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4HWK_C_SFYC804_0 (SEPIAPTERIN REDUCTASE)	5b0v	MATRIX PROTEIN VP40 (Marburg marburgvirus)	5 / 12	LEU A 174 PHE A 247 TYR A 274 GLN A 172 ALA A 60	None	1.15A	4hwkC-5b0vA: undetectable	4hwkC-5b0vA: 23.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4K50_A_ACTA505_0 (RNA POLYMERASE 3D-POL)	5b0v	MATRIX PROTEIN VP40 (Marburg marburgvirus)	3 / 3	CYH A 58 ASN A 56 LYS A 173	None	1.47A	4k50A-5b0vA: undetectable	4k50A-5b0vA: 21.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5HPU_C_IPHC101_0 (INSULIN, CHAIN A INSULIN, CHAIN B)	5b0v	MATRIX PROTEIN VP40 (Marburg marburgvirus)	4 / 6	LEU A 246 CYH A 58 HIS A 59 LEU A 174	None	1.13A	5hpuC-5b0vA: undetectable 5hpuD-5b0vA: undetectable	5hpuC-5b0vA: 5.38 5hpuD-5b0vA: 7.75

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["1G60_B_SAMB501_0","ADENINE-SPECIFIC METHYLTRANSFERASE MBOIIA","5b0v","MATRIX PROTEIN VP40","Marburg marburgvirus",5,"ASN A 142;ILE A 151;PRO A 152;PHE A 145;TYR A 162","None","1.47A","1g60B-5b0vA:undetectable","1g60B-5b0vA:22.59"],["2ACL_C_REAC503_1","RETINOIC ACID RECEPTOR RXR-ALPHA","5b0v","MATRIX PROTEIN VP40","Marburg marburgvirus",5,"ILE A 228;ALA A 227;PHE A 256;ALA A 213;ILE A 204","None","1.11A","2aclC-5b0vA:undetectable","2aclC-5b0vA:22.74"],["3BJW_E_SVRE510_2","PHOSPHOLIPASE A2","5b0v","MATRIX PROTEIN VP40","Marburg marburgvirus",4,"VAL A 303;GLN A 143;ARG A 125;LEU A 126","None","1.00A","3bjwE-5b0vA:undetectable","3bjwE-5b0vA:14.20"],["3G1U_C_ADNC438_2","ADENOSYLHOMOCYSTEINASE","5b0v","MATRIX PROTEIN VP40","Marburg marburgvirus",4,"GLN A 172;THR A  62;THR A  99;HIS A  59","None","1.35A","3g1uC-5b0vA:undetectable","3g1uC-5b0vA:20.35"],["4HWK_B_SFYB806_0","SEPIAPTERIN REDUCTASE","5b0v","MATRIX PROTEIN VP40","Marburg marburgvirus",5,"LEU A 174;PHE A 247;TYR A 274;GLN A 172;ALA A  60","None","1.16A","4hwkB-5b0vA:undetectable","4hwkB-5b0vA:23.93"],["4HWK_C_SFYC804_0","SEPIAPTERIN REDUCTASE","5b0v","MATRIX PROTEIN VP40","Marburg marburgvirus",5,"LEU A 174;PHE A 247;TYR A 274;GLN A 172;ALA A  60","None","1.15A","4hwkC-5b0vA:undetectable","4hwkC-5b0vA:23.93"],["4K50_A_ACTA505_0","RNA POLYMERASE 3D-POL","5b0v","MATRIX PROTEIN VP40","Marburg marburgvirus",3,"CYH A  58;ASN A  56;LYS A 173","None","1.47A","4k50A-5b0vA:undetectable","4k50A-5b0vA:21.46"],["5HPU_C_IPHC101_0","INSULIN, CHAIN A;INSULIN, CHAIN B","5b0v","MATRIX PROTEIN VP40","Marburg marburgvirus",4,"LEU A 246;CYH A  58;HIS A  59;LEU A 174","None","1.13A","5hpuC-5b0vA:undetectable;5hpuD-5b0vA:undetectable","5hpuC-5b0vA:5.38;5hpuD-5b0vA:7.75"]]