SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5b16'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CRB_A_RTLA200_0
(CELLULAR RETINOL
BINDING PROTEIN)		 5b16 RIBONUCLEASE
3,DROSHA,RIBONUCLEAS
E
3,DROSHA,RIBONUCLEAS
E 3
(Homo
sapiens) 		5 / 12 LEU A 652
LEU A 657
ALA A 860
ILE A 600
ILE A 852
 None
 1.15A 1crbA-5b16A:
undetectable		 1crbA-5b16A:
8.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HXB_A_ROCA100_2
(HIV-1 PROTEASE)		 5b16 RIBONUCLEASE
3,DROSHA,RIBONUCLEAS
E
3,DROSHA,RIBONUCLEAS
E 3
(Homo
sapiens) 		3 / 3 ARG A 684
THR A 416
VAL A 696
 None
 0.98A 1hxbA-5b16A:
undetectable		 1hxbA-5b16A:
6.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KLM_A_SPPA999_1
(HIV-1 REVERSE
TRANSCRIPTASE)		 5b16 RIBONUCLEASE
3,DROSHA,RIBONUCLEAS
E
3,DROSHA,RIBONUCLEAS
E 3
(Homo
sapiens) 		5 / 11 LEU A1162
PHE A1252
LEU A1249
PRO A1247
TYR A1161
 None
 1.32A 1klmA-5b16A:
undetectable		 1klmA-5b16A:
17.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LIN_A_TFPA155_1
(CALMODULIN)		 5b16 RIBONUCLEASE
3,DROSHA,RIBONUCLEAS
E
3,DROSHA,RIBONUCLEAS
E 3
(Homo
sapiens) 		4 / 7 GLU A1147
PHE A1240
MET A1196
ALA A1200
 None
 1.37A 1linA-5b16A:
undetectable		 1linA-5b16A:
9.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2O4P_A_TPVA300_2
(PROTEASE)		 5b16 RIBONUCLEASE
3,DROSHA,RIBONUCLEAS
E
3,DROSHA,RIBONUCLEAS
E 3
(Homo
sapiens) 		5 / 9 LEU A1047
ALA A1060
VAL A 976
GLY A1065
ILE A1048
 None
 1.03A 2o4pB-5b16A:
undetectable		 2o4pB-5b16A:
6.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0M_C_KLNC1498_1
(CYTOCHROME P450 3A4)		 5b16 RIBONUCLEASE
3,DROSHA,RIBONUCLEAS
E
3,DROSHA,RIBONUCLEAS
E 3
(Homo
sapiens) 		5 / 12 PHE A 988
LEU A1067
LEU A1068
ILE A1048
ALA A1060
 None
 1.11A 2v0mC-5b16A:
undetectable		 2v0mC-5b16A:
16.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XN6_A_T44A1370_1
(THYROXINE-BINDING
GLOBULIN)		 5b16 RIBONUCLEASE
3,DROSHA,RIBONUCLEAS
E
3,DROSHA,RIBONUCLEAS
E 3
(Homo
sapiens) 		5 / 10 ALA A1050
LEU A 876
LEU A 879
LEU A1047
LEU A 893
 None
 1.12A 2xn6A-5b16A:
undetectable
2xn6B-5b16A:
undetectable		 2xn6A-5b16A:
14.79
2xn6B-5b16A:
3.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XN7_A_T44A1355_1
(THYROXINE-BINDING
GLOBULIN)		 5b16 RIBONUCLEASE
3,DROSHA,RIBONUCLEAS
E
3,DROSHA,RIBONUCLEAS
E 3
(Homo
sapiens) 		5 / 10 ALA A1050
LEU A 876
LEU A 879
LEU A1047
LEU A 893
 None
 1.11A 2xn7A-5b16A:
undetectable
2xn7B-5b16A:
undetectable		 2xn7A-5b16A:
14.90
2xn7B-5b16A:
3.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A51_A_VDYA6178_1
(VITAMIN D
HYDROXYLASE)		 5b16 RIBONUCLEASE
3,DROSHA,RIBONUCLEAS
E
3,DROSHA,RIBONUCLEAS
E 3
(Homo
sapiens) 		6 / 11 THR A 416
ILE A 702
LYS A 694
THR A 590
VAL A 856
PRO A 683
 None
 1.14A 3a51A-5b16A:
undetectable		 3a51A-5b16A:
15.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A51_C_VDYC6178_1
(VITAMIN D
HYDROXYLASE)		 5b16 RIBONUCLEASE
3,DROSHA,RIBONUCLEAS
E
3,DROSHA,RIBONUCLEAS
E 3
(Homo
sapiens) 		5 / 12 THR A 416
ILE A 702
THR A 590
VAL A 856
PRO A 683
 None
 1.06A 3a51C-5b16A:
undetectable		 3a51C-5b16A:
15.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A51_E_VDYE6178_1
(VITAMIN D
HYDROXYLASE)		 5b16 RIBONUCLEASE
3,DROSHA,RIBONUCLEAS
E
3,DROSHA,RIBONUCLEAS
E 3
(Homo
sapiens) 		6 / 12 THR A 416
ILE A 702
LYS A 694
THR A 590
VAL A 856
PRO A 683
 None
 1.18A 3a51E-5b16A:
undetectable		 3a51E-5b16A:
15.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ELZ_B_CHDB153_0
(ILEAL BILE
ACID-BINDING PROTEIN)		 5b16 RIBONUCLEASE
3,DROSHA,RIBONUCLEAS
E
3,DROSHA,RIBONUCLEAS
E 3
(Homo
sapiens) 		4 / 6 ILE A 656
THR A 590
PHE A 601
PHE A 604
 None
 1.23A 3elzB-5b16A:
undetectable		 3elzB-5b16A:
7.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KP6_B_SALB3001_1
(TRANSCRIPTIONAL
REGULATOR TCAR)		 5b16 RIBONUCLEASE
3,DROSHA,RIBONUCLEAS
E
3,DROSHA,RIBONUCLEAS
E 3
(Homo
sapiens) 		4 / 8 LYS A 958
HIS A 964
ASN A 963
ILE A 621
 None
 1.05A 3kp6A-5b16A:
undetectable
3kp6B-5b16A:
undetectable		 3kp6A-5b16A:
8.87
3kp6B-5b16A:
8.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MEC_A_65BA561_0
(P66 REVERSE
TRANSCRIPTASE)		 5b16 RIBONUCLEASE
3,DROSHA,RIBONUCLEAS
E
3,DROSHA,RIBONUCLEAS
E 3
(Homo
sapiens) 		5 / 12 LEU A1162
PHE A1252
LEU A1249
PRO A1247
TYR A1161
 None
 1.25A 3mecA-5b16A:
undetectable		 3mecA-5b16A:
17.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NU5_B_478B401_2
(PROTEASE)		 5b16 RIBONUCLEASE
3,DROSHA,RIBONUCLEAS
E
3,DROSHA,RIBONUCLEAS
E 3
(Homo
sapiens) 		5 / 12 LEU A1047
ALA A1060
VAL A 976
GLY A1065
ILE A1048
 None
 0.98A 3nu5B-5b16A:
undetectable		 3nu5B-5b16A:
6.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NU6_B_478B401_2
(PROTEASE)		 5b16 RIBONUCLEASE
3,DROSHA,RIBONUCLEAS
E
3,DROSHA,RIBONUCLEAS
E 3
(Homo
sapiens) 		5 / 10 LEU A1047
ALA A1060
VAL A 976
GLY A1065
ILE A1048
 None
 1.06A 3nu6B-5b16A:
undetectable		 3nu6B-5b16A:
7.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VKX_A_T3A301_1
(PROLIFERATING CELL
NUCLEAR ANTIGEN)		 5b16 MICROPROCESSOR
COMPLEX SUBUNIT
DGCR8
RIBONUCLEASE
3,DROSHA,RIBONUCLEAS
E
3,DROSHA,RIBONUCLEAS
E 3
(Homo
sapiens) 		4 / 6 MET B 739
LEU B 742
PRO A 989
PRO A1082
 None
 1.17A 3vkxA-5b16B:
undetectable		 3vkxA-5b16B:
12.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WG7_P_CHDP306_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 5b16 RIBONUCLEASE
3,DROSHA,RIBONUCLEAS
E
3,DROSHA,RIBONUCLEAS
E 3
(Homo
sapiens) 		4 / 6 LEU A1012
PHE A1064
LEU A1068
PHE A1069
 None
 0.99A 3wg7P-5b16A:
3.2
3wg7W-5b16A:
undetectable		 3wg7P-5b16A:
12.26
3wg7W-5b16A:
4.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FR0_A_SAMA401_0
(ARSENIC
METHYLTRANSFERASE)		 5b16 RIBONUCLEASE
3,DROSHA,RIBONUCLEAS
E
3,DROSHA,RIBONUCLEAS
E 3
(Homo
sapiens) 		5 / 12 GLY A 921
GLN A 858
ILE A 656
ASN A 919
LEU A 659
 None
 1.10A 4fr0A-5b16A:
undetectable		 4fr0A-5b16A:
15.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NJU_A_TPVA500_2
(PROTEASE)		 5b16 RIBONUCLEASE
3,DROSHA,RIBONUCLEAS
E
3,DROSHA,RIBONUCLEAS
E 3
(Homo
sapiens) 		5 / 10 LEU A1047
ALA A1060
VAL A 976
GLY A1065
ILE A1048
 None
 1.04A 4njuB-5b16A:
undetectable		 4njuB-5b16A:
6.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NJU_C_TPVC500_2
(PROTEASE)		 5b16 RIBONUCLEASE
3,DROSHA,RIBONUCLEAS
E
3,DROSHA,RIBONUCLEAS
E 3
(Homo
sapiens) 		5 / 10 LEU A1047
ALA A1060
VAL A 976
GLY A1065
ILE A1048
 None
 1.04A 4njuD-5b16A:
undetectable		 4njuD-5b16A:
6.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QWP_A_GCSA303_1
(CHITOSANASE)		 5b16 RIBONUCLEASE
3,DROSHA,RIBONUCLEAS
E
3,DROSHA,RIBONUCLEAS
E 3
(Homo
sapiens) 		4 / 6 ILE A 922
THR A 586
HIS A 859
TYR A 627
 None
 1.34A 4qwpA-5b16A:
undetectable		 4qwpA-5b16A:
12.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TWD_C_377C401_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 5b16 RIBONUCLEASE
3,DROSHA,RIBONUCLEAS
E
3,DROSHA,RIBONUCLEAS
E 3
(Homo
sapiens) 		4 / 6 ASN A 639
GLU A 419
TYR A 594
LEU A 697
 None
 1.31A 4twdB-5b16A:
3.0
4twdC-5b16A:
3.2		 4twdB-5b16A:
14.23
4twdC-5b16A:
14.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TWD_J_377J401_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 5b16 RIBONUCLEASE
3,DROSHA,RIBONUCLEAS
E
3,DROSHA,RIBONUCLEAS
E 3
(Homo
sapiens) 		4 / 6 ASN A 639
GLU A 419
TYR A 594
LEU A 697
 None
 1.31A 4twdI-5b16A:
undetectable
4twdJ-5b16A:
undetectable		 4twdI-5b16A:
14.23
4twdJ-5b16A:
14.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4G_A_IPHA903_0
(PROTEIN ARGONAUTE-2)		 5b16 RIBONUCLEASE
3,DROSHA,RIBONUCLEAS
E
3,DROSHA,RIBONUCLEAS
E 3
(Homo
sapiens) 		4 / 6 LEU A1265
PRO A1282
GLU A1321
TYR A1284
 None
 1.22A 4z4gA-5b16A:
undetectable		 4z4gA-5b16A:
18.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HRQ_G_IPHG101_0
(INSULIN A-CHAIN
INSULIN B-CHAIN)		 5b16 RIBONUCLEASE
3,DROSHA,RIBONUCLEAS
E
3,DROSHA,RIBONUCLEAS
E 3
(Homo
sapiens) 		4 / 6 HIS A1120
LEU A1123
HIS A1084
LEU A1083
 None
 1.14A 5hrqD-5b16A:
undetectable
5hrqG-5b16A:
undetectable
5hrqH-5b16A:
undetectable		 5hrqD-5b16A:
3.92
5hrqG-5b16A:
2.54
5hrqH-5b16A:
3.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IAO_C_URFC301_1
(BIFUNCTIONAL PROTEIN
PYRR)		 5b16 RIBONUCLEASE
3,DROSHA,RIBONUCLEAS
E
3,DROSHA,RIBONUCLEAS
E 3
(Homo
sapiens) 		3 / 3 ARG A 622
HIS A 903
ARG A 914
 None
 0.99A 5iaoC-5b16A:
undetectable		 5iaoC-5b16A:
10.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IAO_F_URFF301_1
(BIFUNCTIONAL PROTEIN
PYRR)		 5b16 RIBONUCLEASE
3,DROSHA,RIBONUCLEAS
E
3,DROSHA,RIBONUCLEAS
E 3
(Homo
sapiens) 		3 / 3 ARG A 622
HIS A 903
ARG A 914
 None
 0.96A 5iaoF-5b16A:
undetectable		 5iaoF-5b16A:
10.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JMN_B_FUAB1101_1
(MULTIDRUG EFFLUX
PUMP SUBUNIT ACRB)		 5b16 RIBONUCLEASE
3,DROSHA,RIBONUCLEAS
E
3,DROSHA,RIBONUCLEAS
E 3
(Homo
sapiens) 		4 / 5 ILE A 625
LEU A 917
HIS A 859
VAL A 578
 None
 0.95A 5jmnB-5b16A:
2.1		 5jmnB-5b16A:
17.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KC4_A_RBFA201_1
(RIBOFLAVIN
TRANSPORTER RIBU)		 5b16 RIBONUCLEASE
3,DROSHA,RIBONUCLEAS
E
3,DROSHA,RIBONUCLEAS
E 3
(Homo
sapiens) 		5 / 12 GLU A 977
GLY A 972
ALA A1041
ASN A1042
ASN A1006
 None
 1.32A 5kc4A-5b16A:
undetectable		 5kc4A-5b16A:
10.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KKZ_E_ASCE1004_0
(CYTOCHROME B
UBIQUINOL-CYTOCHROME
C REDUCTASE
IRON-SULFUR SUBUNIT)		 5b16 RIBONUCLEASE
3,DROSHA,RIBONUCLEAS
E
3,DROSHA,RIBONUCLEAS
E 3
(Homo
sapiens) 		4 / 7 HIS A 868
HIS A 549
ILE A 547
ARG A 871
 None
ZN  A1402 (-3.4A)
None
None
 1.12A 5kkzC-5b16A:
undetectable
5kkzE-5b16A:
undetectable		 5kkzC-5b16A:
10.79
5kkzE-5b16A:
15.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KKZ_K_ASCK1004_0
(CYTOCHROME B
UBIQUINOL-CYTOCHROME
C REDUCTASE
IRON-SULFUR SUBUNIT)		 5b16 RIBONUCLEASE
3,DROSHA,RIBONUCLEAS
E
3,DROSHA,RIBONUCLEAS
E 3
(Homo
sapiens) 		4 / 7 HIS A 549
ILE A 547
ARG A 871
HIS A 868
 ZN  A1402 (-3.4A)
None
None
None
 1.08A 5kkzK-5b16A:
2.4
5kkzQ-5b16A:
undetectable		 5kkzK-5b16A:
15.56
5kkzQ-5b16A:
10.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AYC_A_1YNA502_1
(PROTEIN CYP51)		 5b16 RIBONUCLEASE
3,DROSHA,RIBONUCLEAS
E
3,DROSHA,RIBONUCLEAS
E 3
(Homo
sapiens) 		5 / 12 PHE A 906
ALA A 913
PHE A 604
PHE A 685
THR A 850
 None
 1.09A 6aycA-5b16A:
undetectable		 6aycA-5b16A:
5.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HU9_N_PCFN606_0
(CYTOCHROME B)		 5b16 RIBONUCLEASE
3,DROSHA,RIBONUCLEAS
E
3,DROSHA,RIBONUCLEAS
E 3
(Homo
sapiens) 		5 / 12 MET A1326
ALA A1328
THR A1271
VAL A1302
VAL A1300
 None
 0.93A 6hu9N-5b16A:
undetectable		 6hu9N-5b16A:
14.26