SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5b1h'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1G5Y_C_9CRC502_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 5b1h CYSTATHIONINE
BETA-SYNTHASE
(Lactobacillus
plantarum) 		5 / 10 ALA A  30
LEU A 252
LEU A 272
ALA A 269
ILE A  28
 None
 1.25A 1g5yC-5b1hA:
undetectable		 1g5yC-5b1hA:
22.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MEI_A_MOAA600_1
(INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE)		 5b1h CYSTATHIONINE
BETA-SYNTHASE
(Lactobacillus
plantarum) 		4 / 8 ASP A 290
SER A 291
SER A 292
GLY A 265
 LLP  A  42 ( 3.2A)
None
None
None
 0.83A 1meiA-5b1hA:
undetectable		 1meiA-5b1hA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA3_B_STRB2001_1
(MINERALOCORTICOID
RECEPTOR)		 5b1h CYSTATHIONINE
BETA-SYNTHASE
(Lactobacillus
plantarum) 		5 / 12 LEU A 268
MET A  34
LEU A 259
LEU A  32
THR A 286
 None
 1.18A 1ya3B-5b1hA:
undetectable		 1ya3B-5b1hA:
20.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FK8_A_SAMA302_0
(METHOXY MYCOLIC ACID
SYNTHASE 4)		 5b1h CYSTATHIONINE
BETA-SYNTHASE
(Lactobacillus
plantarum) 		5 / 12 ILE A  75
GLY A  76
GLY A  46
GLY A  71
ALA A  78
 None
LLP  A  42 ( 3.5A)
LLP  A  42 ( 3.8A)
SO4  A 404 (-3.3A)
None
 0.98A 2fk8A-5b1hA:
3.3		 2fk8A-5b1hA:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HY7_B_097B801_1
(A DISINTEGRIN AND
METALLOPROTEINASE
WITH THROMBOSPONDIN
MOTIFS 5)		 5b1h CYSTATHIONINE
BETA-SYNTHASE
(Lactobacillus
plantarum) 		5 / 9 LEU A 278
THR A 169
HIS A 283
HIS A  27
ILE A  28
 None
GOL  A 408 (-3.1A)
None
None
None
 1.24A 3hy7B-5b1hA:
undetectable		 3hy7B-5b1hA:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3I5U_B_SAMB401_0
(O-METHYLTRANSFERASE)		 5b1h CYSTATHIONINE
BETA-SYNTHASE
(Lactobacillus
plantarum) 		5 / 12 GLY A 176
GLY A 221
PRO A 202
SER A 264
ALA A  70
 LLP  A  42 ( 3.7A)
None
None
None
SO4  A 404 (-3.7A)
 1.05A 3i5uB-5b1hA:
2.3		 3i5uB-5b1hA:
23.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KWA_A_SPMA300_1
(CARBONIC ANHYDRASE 2)		 5b1h CYSTATHIONINE
BETA-SYNTHASE
(Lactobacillus
plantarum) 		5 / 11 GLN A 236
VAL A 198
VAL A 172
LEU A 278
PRO A 279
 None
None
None
None
GOL  A 408 ( 4.4A)
 1.08A 3kwaA-5b1hA:
undetectable		 3kwaA-5b1hA:
20.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NRR_A_D16A530_1
(DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 5b1h CYSTATHIONINE
BETA-SYNTHASE
(Lactobacillus
plantarum) 		5 / 12 ALA A  80
ILE A  65
ASN A 136
LEU A  54
GLY A  53
 None
None
SO4  A 403 ( 4.0A)
GOL  A 407 (-4.4A)
None
 1.14A 3nrrA-5b1hA:
undetectable		 3nrrA-5b1hA:
20.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NRR_B_D16B530_1
(DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 5b1h CYSTATHIONINE
BETA-SYNTHASE
(Lactobacillus
plantarum) 		5 / 12 ALA A  80
ILE A  65
ASN A 136
LEU A  54
GLY A  53
 None
None
SO4  A 403 ( 4.0A)
GOL  A 407 (-4.4A)
None
 1.15A 3nrrB-5b1hA:
undetectable		 3nrrB-5b1hA:
20.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUD_A_SUEA1201_1
(NS3 PROTEASE, NS4A
PROTEIN)		 5b1h CYSTATHIONINE
BETA-SYNTHASE
(Lactobacillus
plantarum) 		5 / 12 ASP A 235
GLY A 183
ALA A 185
PHE A 171
ALA A 173
 None
 1.10A 3sudA-5b1hA:
undetectable		 3sudA-5b1hA:
20.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUG_A_SUEA1201_1
(NS3 PROTEASE, NS4A
PROTEIN)		 5b1h CYSTATHIONINE
BETA-SYNTHASE
(Lactobacillus
plantarum) 		5 / 12 ASP A 235
GLY A 183
ALA A 185
PHE A 171
ALA A 173
 None
 1.06A 3sugA-5b1hA:
undetectable		 3sugA-5b1hA:
20.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TZF_B_08DB280_1
(7,8-DIHYDROPTEROATE
SYNTHASE)		 5b1h CYSTATHIONINE
BETA-SYNTHASE
(Lactobacillus
plantarum) 		4 / 8 PHE A 143
PRO A 226
GLY A 179
PHE A 228
 None
None
LLP  A  42 ( 3.8A)
None
 1.10A 3tzfB-5b1hA:
undetectable		 3tzfB-5b1hA:
22.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AF0_A_MOAA1526_1
(INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE)		 5b1h CYSTATHIONINE
BETA-SYNTHASE
(Lactobacillus
plantarum) 		4 / 8 ASP A 290
SER A 291
SER A 292
GLY A 265
 LLP  A  42 ( 3.2A)
None
None
None
 0.83A 4af0A-5b1hA:
undetectable		 4af0A-5b1hA:
21.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KM2_B_TOPB202_1
(DIHYDROFOLATE
REDUCTASE)		 5b1h CYSTATHIONINE
BETA-SYNTHASE
(Lactobacillus
plantarum) 		5 / 12 ALA A 275
ILE A 284
LEU A 252
ILE A  20
THR A 276
 None
 0.99A 4km2B-5b1hA:
undetectable		 4km2B-5b1hA:
22.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M2R_A_BZ1A302_1
(CARBONIC ANHYDRASE 2)		 5b1h CYSTATHIONINE
BETA-SYNTHASE
(Lactobacillus
plantarum) 		5 / 12 GLN A 236
VAL A 198
VAL A 172
LEU A 278
PRO A 279
 None
None
None
None
GOL  A 408 ( 4.4A)
 1.03A 4m2rA-5b1hA:
undetectable		 4m2rA-5b1hA:
19.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CR1_A_T44A201_1
(TRANSTHYRETIN)		 5b1h CYSTATHIONINE
BETA-SYNTHASE
(Lactobacillus
plantarum) 		4 / 5 LEU A 272
ALA A 270
LEU A 268
VAL A 198
 None
 1.21A 5cr1A-5b1hA:
undetectable		 5cr1A-5b1hA:
21.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VW5_A_NCAA403_0
(FERREDOXIN--NADP
REDUCTASE)		 5b1h CYSTATHIONINE
BETA-SYNTHASE
(Lactobacillus
plantarum) 		4 / 8 THR A  73
GLY A  76
GLY A  46
LEU A  49
 SO4  A 404 (-3.7A)
LLP  A  42 ( 3.5A)
LLP  A  42 ( 3.8A)
None
 0.68A 5vw5A-5b1hA:
undetectable		 5vw5A-5b1hA:
18.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BCC_A_EZLA302_1
(CARBONIC ANHYDRASE 2)		 5b1h CYSTATHIONINE
BETA-SYNTHASE
(Lactobacillus
plantarum) 		5 / 12 GLN A 236
VAL A 198
VAL A 172
LEU A 278
PRO A 279
 None
None
None
None
GOL  A 408 ( 4.4A)
 1.03A 6bccA-5b1hA:
undetectable		 6bccA-5b1hA:
13.71