SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5b1u'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FDU_A_ESTA351_1
(17-BETA-HYDROXYSTERO
ID DEHYDROGENASE)		 5b1u METALLO-BETA-LACTAMA
SE
(Serratia
marcescens) 		5 / 12 SER A  82
GLY A 122
GLY A  80
LEU A 117
SER A 118
 NA  A 305 (-3.2A)
None
None
None
None
 1.10A 1fduA-5b1uA:
undetectable		 1fduA-5b1uA:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GXS_A_BEZA601_0
(P-(S)-HYDROXYMANDELO
NITRILE LYASE CHAIN
A
P-(S)-HYDROXYMANDELO
NITRILE LYASE CHAIN
B)		 5b1u METALLO-BETA-LACTAMA
SE
(Serratia
marcescens) 		4 / 7 GLY A 122
PRO A 121
SER A 123
ALA A  48
 None
None
NA  A 305 (-4.6A)
None
 0.97A 1gxsA-5b1uA:
undetectable
1gxsB-5b1uA:
undetectable		 1gxsA-5b1uA:
19.93
1gxsB-5b1uA:
20.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OQ5_A_CELA701_1
(CARBONIC ANHYDRASE
II)		 5b1u METALLO-BETA-LACTAMA
SE
(Serratia
marcescens) 		5 / 12 ASN A  98
HIS A  72
VAL A 203
LEU A 176
THR A 177
 NA  A 303 (-3.6A)
ZN  A 301 (-3.2A)
None
None
HIW  A 321 ( 2.8A)
 1.17A 1oq5A-5b1uA:
undetectable		 1oq5A-5b1uA:
25.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IT4_A_PPFA500_1
(CARBONIC ANHYDRASE 1)		 5b1u METALLO-BETA-LACTAMA
SE
(Serratia
marcescens) 		4 / 8 ALA A 213
VAL A 218
LEU A 176
THR A 177
 None
HIW  A 321 (-4.6A)
None
HIW  A 321 ( 2.8A)
 0.80A 2it4A-5b1uA:
undetectable		 2it4A-5b1uA:
21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IT4_A_PPFA500_1
(CARBONIC ANHYDRASE 1)		 5b1u METALLO-BETA-LACTAMA
SE
(Serratia
marcescens) 		5 / 8 HIS A  72
HIS A 150
HIS A  74
ALA A  78
HIS A 215
 ZN  A 301 (-3.2A)
ZN  A 301 (-3.2A)
ZN  A 301 (-3.1A)
None
ZN  A 302 ( 3.3A)
 1.37A 2it4A-5b1uA:
undetectable		 2it4A-5b1uA:
21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZIF_B_SAMB298_0
(PUTATIVE
MODIFICATION
METHYLASE)		 5b1u METALLO-BETA-LACTAMA
SE
(Serratia
marcescens) 		5 / 12 ALA A  94
SER A  82
ALA A  48
GLY A  42
LEU A  69
 NA  A 304 (-3.6A)
NA  A 305 (-3.2A)
None
None
None
 1.08A 2zifB-5b1uA:
undetectable		 2zifB-5b1uA:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZIF_B_SAMB298_0
(PUTATIVE
MODIFICATION
METHYLASE)		 5b1u METALLO-BETA-LACTAMA
SE
(Serratia
marcescens) 		5 / 12 ALA A  94
SER A  82
GLY A  42
THR A  43
LEU A  69
 NA  A 304 (-3.6A)
NA  A 305 (-3.2A)
None
None
None
 1.07A 2zifB-5b1uA:
undetectable		 2zifB-5b1uA:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QXY_B_SAMB6735_0
(N-LYSINE
METHYLTRANSFERASE
SETD6
TRANSCRIPTION FACTOR
P65)		 5b1u METALLO-BETA-LACTAMA
SE
(Serratia
marcescens) 		5 / 11 ALA A 241
GLY A 240
ALA A 235
ASN A 219
TYR A 236
 None
 1.40A 3qxyB-5b1uA:
undetectable
3qxyQ-5b1uA:
undetectable		 3qxyB-5b1uA:
19.12
3qxyQ-5b1uA:
9.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3S_D_9PLD1_1
(CYTOCHROME P450 2A13)		 5b1u METALLO-BETA-LACTAMA
SE
(Serratia
marcescens) 		4 / 8 ALA A 241
ASN A 219
ALA A 173
THR A 156
 None
 0.71A 3t3sD-5b1uA:
undetectable		 3t3sD-5b1uA:
20.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TWP_A_SALA404_1
(ANTHRANILATE
PHOSPHORIBOSYLTRANSF
ERASE)		 5b1u METALLO-BETA-LACTAMA
SE
(Serratia
marcescens) 		4 / 7 ALA A 202
ARG A 243
ALA A 246
ARG A 250
 None
 0.93A 3twpA-5b1uA:
undetectable		 3twpA-5b1uA:
23.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C1D_B_X8ZB350_1
(BETA-LACTAMASE CLASS
B VIM-2)		 5b1u METALLO-BETA-LACTAMA
SE
(Serratia
marcescens) 		5 / 10 HIS A  72
HIS A  74
ASP A  76
HIS A 150
HIS A 215
 ZN  A 301 (-3.2A)
ZN  A 301 (-3.1A)
ZN  A 302 ( 2.5A)
ZN  A 301 (-3.2A)
ZN  A 302 ( 3.3A)
 0.79A 4c1dB-5b1uA:
18.4		 4c1dB-5b1uA:
23.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C1F_A_X8ZA300_1
(BETA-LACTAMASE IMP-1)		 5b1u METALLO-BETA-LACTAMA
SE
(Serratia
marcescens) 		5 / 11 HIS A  72
HIS A  74
ASP A  76
HIS A 150
HIS A 215
 ZN  A 301 (-3.2A)
ZN  A 301 (-3.1A)
ZN  A 302 ( 2.5A)
ZN  A 301 (-3.2A)
ZN  A 302 ( 3.3A)
 0.86A 4c1fA-5b1uA:
17.7
4c1fB-5b1uA:
17.0		 4c1fA-5b1uA:
22.03
4c1fB-5b1uA:
22.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C1H_A_X8ZA305_1
(BETA-LACTAMASE 2)		 5b1u METALLO-BETA-LACTAMA
SE
(Serratia
marcescens) 		5 / 9 HIS A  72
HIS A  74
ASP A  76
HIS A 150
HIS A 215
 ZN  A 301 (-3.2A)
ZN  A 301 (-3.1A)
ZN  A 302 ( 2.5A)
ZN  A 301 (-3.2A)
ZN  A 302 ( 3.3A)
 0.80A 4c1hA-5b1uA:
19.0		 4c1hA-5b1uA:
25.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C1H_A_X8ZA305_1
(BETA-LACTAMASE 2)		 5b1u METALLO-BETA-LACTAMA
SE
(Serratia
marcescens) 		5 / 9 TRP A   5
HIS A  72
HIS A  74
ASP A  76
HIS A 150
 None
ZN  A 301 (-3.2A)
ZN  A 301 (-3.1A)
ZN  A 302 ( 2.5A)
ZN  A 301 (-3.2A)
 0.89A 4c1hA-5b1uA:
19.0		 4c1hA-5b1uA:
25.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EXS_B_X8ZB301_1
(BETA-LACTAMASE NDM-1)		 5b1u METALLO-BETA-LACTAMA
SE
(Serratia
marcescens) 		4 / 8 HIS A  74
ASP A  76
HIS A  72
HIS A 215
 ZN  A 301 (-3.1A)
ZN  A 302 ( 2.5A)
ZN  A 301 (-3.2A)
ZN  A 302 ( 3.3A)
 0.90A 4exsB-5b1uA:
17.5		 4exsB-5b1uA:
24.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EXS_B_X8ZB301_1
(BETA-LACTAMASE NDM-1)		 5b1u METALLO-BETA-LACTAMA
SE
(Serratia
marcescens) 		4 / 8 HIS A  74
ASP A  76
HIS A 150
HIS A 215
 ZN  A 301 (-3.1A)
ZN  A 302 ( 2.5A)
ZN  A 301 (-3.2A)
ZN  A 302 ( 3.3A)
 0.72A 4exsB-5b1uA:
17.5		 4exsB-5b1uA:
24.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EXS_B_X8ZB301_1
(BETA-LACTAMASE NDM-1)		 5b1u METALLO-BETA-LACTAMA
SE
(Serratia
marcescens) 		4 / 8 TRP A   5
HIS A  74
ASP A  76
HIS A 150
 None
ZN  A 301 (-3.1A)
ZN  A 302 ( 2.5A)
ZN  A 301 (-3.2A)
 0.90A 4exsB-5b1uA:
17.5		 4exsB-5b1uA:
24.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FEU_B_KANB301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 5b1u METALLO-BETA-LACTAMA
SE
(Serratia
marcescens) 		4 / 7 ASP A  76
ASP A 174
GLU A 217
ASP A  41
 ZN  A 302 ( 2.5A)
None
HIW  A 321 ( 4.6A)
None
 1.16A 4feuB-5b1uA:
undetectable		 4feuB-5b1uA:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FEU_F_KANF301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 5b1u METALLO-BETA-LACTAMA
SE
(Serratia
marcescens) 		4 / 8 ASP A  76
ASP A 174
GLU A 217
ASP A  41
 ZN  A 302 ( 2.5A)
None
HIW  A 321 ( 4.6A)
None
 1.10A 4feuF-5b1uA:
undetectable		 4feuF-5b1uA:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FEV_B_KANB301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 5b1u METALLO-BETA-LACTAMA
SE
(Serratia
marcescens) 		4 / 7 ASP A  76
ASP A 174
GLU A 217
ASP A  41
 ZN  A 302 ( 2.5A)
None
HIW  A 321 ( 4.6A)
None
 1.17A 4fevB-5b1uA:
undetectable		 4fevB-5b1uA:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FEV_D_KAND301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 5b1u METALLO-BETA-LACTAMA
SE
(Serratia
marcescens) 		4 / 7 ASP A  76
ASP A 174
GLU A 217
ASP A  41
 ZN  A 302 ( 2.5A)
None
HIW  A 321 ( 4.6A)
None
 1.12A 4fevD-5b1uA:
undetectable		 4fevD-5b1uA:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FEV_F_KANF301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 5b1u METALLO-BETA-LACTAMA
SE
(Serratia
marcescens) 		4 / 7 ASP A  76
ASP A 174
GLU A 217
ASP A  41
 ZN  A 302 ( 2.5A)
None
HIW  A 321 ( 4.6A)
None
 1.11A 4fevF-5b1uA:
undetectable		 4fevF-5b1uA:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FEW_B_KANB301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 5b1u METALLO-BETA-LACTAMA
SE
(Serratia
marcescens) 		4 / 7 ASP A  76
ASP A 174
GLU A 217
ASP A  41
 ZN  A 302 ( 2.5A)
None
HIW  A 321 ( 4.6A)
None
 1.14A 4fewB-5b1uA:
undetectable		 4fewB-5b1uA:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FEW_D_KAND301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 5b1u METALLO-BETA-LACTAMA
SE
(Serratia
marcescens) 		4 / 8 ASP A  76
ASP A 174
GLU A 217
ASP A  41
 ZN  A 302 ( 2.5A)
None
HIW  A 321 ( 4.6A)
None
 1.12A 4fewD-5b1uA:
undetectable		 4fewD-5b1uA:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FEW_F_KANF301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 5b1u METALLO-BETA-LACTAMA
SE
(Serratia
marcescens) 		4 / 8 ASP A  76
ASP A 174
GLU A 217
ASP A  41
 ZN  A 302 ( 2.5A)
None
HIW  A 321 ( 4.6A)
None
 1.16A 4fewF-5b1uA:
undetectable		 4fewF-5b1uA:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FEX_B_KANB301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 5b1u METALLO-BETA-LACTAMA
SE
(Serratia
marcescens) 		4 / 7 ASP A  76
ASP A 174
GLU A 217
ASP A  41
 ZN  A 302 ( 2.5A)
None
HIW  A 321 ( 4.6A)
None
 1.14A 4fexB-5b1uA:
undetectable		 4fexB-5b1uA:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GKH_B_KANB301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 5b1u METALLO-BETA-LACTAMA
SE
(Serratia
marcescens) 		4 / 8 ASP A  76
ASP A 174
GLU A 217
ASP A  41
 ZN  A 302 ( 2.5A)
None
HIW  A 321 ( 4.6A)
None
 1.09A 4gkhB-5b1uA:
undetectable		 4gkhB-5b1uA:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GKH_D_KAND301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 5b1u METALLO-BETA-LACTAMA
SE
(Serratia
marcescens) 		4 / 8 ASP A  76
ASP A 174
GLU A 217
ASP A  41
 ZN  A 302 ( 2.5A)
None
HIW  A 321 ( 4.6A)
None
 1.15A 4gkhD-5b1uA:
undetectable		 4gkhD-5b1uA:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GKH_F_KANF301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 5b1u METALLO-BETA-LACTAMA
SE
(Serratia
marcescens) 		4 / 8 ASP A  76
ASP A 174
GLU A 217
ASP A  41
 ZN  A 302 ( 2.5A)
None
HIW  A 321 ( 4.6A)
None
 1.11A 4gkhF-5b1uA:
undetectable		 4gkhF-5b1uA:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GKH_G_KANG301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 5b1u METALLO-BETA-LACTAMA
SE
(Serratia
marcescens) 		4 / 7 ASP A  76
ASP A 174
GLU A 217
ASP A  41
 ZN  A 302 ( 2.5A)
None
HIW  A 321 ( 4.6A)
None
 1.12A 4gkhG-5b1uA:
undetectable		 4gkhG-5b1uA:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GKH_K_KANK301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 5b1u METALLO-BETA-LACTAMA
SE
(Serratia
marcescens) 		4 / 8 ASP A  76
ASP A 174
GLU A 217
ASP A  41
 ZN  A 302 ( 2.5A)
None
HIW  A 321 ( 4.6A)
None
 1.14A 4gkhC-5b1uA:
undetectable
4gkhK-5b1uA:
undetectable		 4gkhC-5b1uA:
21.36
4gkhK-5b1uA:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GKI_A_KANA301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 5b1u METALLO-BETA-LACTAMA
SE
(Serratia
marcescens) 		4 / 8 ASP A  76
ASP A 174
GLU A 217
ASP A  41
 ZN  A 302 ( 2.5A)
None
HIW  A 321 ( 4.6A)
None
 1.13A 4gkiA-5b1uA:
undetectable		 4gkiA-5b1uA:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GKI_C_KANC301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 5b1u METALLO-BETA-LACTAMA
SE
(Serratia
marcescens) 		4 / 8 ASP A  76
ASP A 174
GLU A 217
ASP A  41
 ZN  A 302 ( 2.5A)
None
HIW  A 321 ( 4.6A)
None
 1.09A 4gkiC-5b1uA:
undetectable		 4gkiC-5b1uA:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IOM_A_FOLA608_0
(FORMATE--TETRAHYDROF
OLATE LIGASE)		 5b1u METALLO-BETA-LACTAMA
SE
(Serratia
marcescens) 		4 / 7 PRO A 190
GLU A 260
LEU A 257
LEU A 253
 None
 0.83A 4iomA-5b1uA:
undetectable		 4iomA-5b1uA:
19.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RTB_A_SAMA501_0
(HYDG PROTEIN)		 5b1u METALLO-BETA-LACTAMA
SE
(Serratia
marcescens) 		5 / 12 VAL A  21
PHE A 172
LEU A  69
LEU A  93
ALA A  90
 None
 1.34A 4rtbA-5b1uA:
undetectable		 4rtbA-5b1uA:
21.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A5Z_A_WJZA304_0
(BETA-LACTAMASE NDM-1)		 5b1u METALLO-BETA-LACTAMA
SE
(Serratia
marcescens) 		4 / 8 HIS A  74
ASP A  76
HIS A 150
HIS A 215
 ZN  A 301 (-3.1A)
ZN  A 302 ( 2.5A)
ZN  A 301 (-3.2A)
ZN  A 302 ( 3.3A)
 0.73A 5a5zA-5b1uA:
17.5		 5a5zA-5b1uA:
25.26
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5AYA_A_X8ZA307_1
(METALLO-BETA-LACTAMA
SE)		 5b1u METALLO-BETA-LACTAMA
SE
(Serratia
marcescens) 		10 / 11 HIS A  72
HIS A  74
ASP A  76
HIS A  77
HIS A 150
SER A 175
THR A 177
VAL A 179
HIS A 215
GLU A 217
 ZN  A 301 (-3.2A)
ZN  A 301 (-3.1A)
ZN  A 302 ( 2.5A)
ZN  A 302 ( 3.3A)
ZN  A 301 (-3.2A)
HIW  A 321 ( 2.6A)
HIW  A 321 ( 2.8A)
NA  A 312 (-4.0A)
ZN  A 302 ( 3.3A)
HIW  A 321 ( 4.6A)
 0.41A 5ayaA-5b1uA:
47.5		 5ayaA-5b1uA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5AYA_A_X8ZA307_1
(METALLO-BETA-LACTAMA
SE)		 5b1u METALLO-BETA-LACTAMA
SE
(Serratia
marcescens) 		10 / 11 HIS A  72
HIS A  74
ASP A  76
HIS A 150
SER A 175
THR A 177
VAL A 179
HIS A 215
GLU A 217
ARG A 252
 ZN  A 301 (-3.2A)
ZN  A 301 (-3.1A)
ZN  A 302 ( 2.5A)
ZN  A 301 (-3.2A)
HIW  A 321 ( 2.6A)
HIW  A 321 ( 2.8A)
NA  A 312 (-4.0A)
ZN  A 302 ( 3.3A)
HIW  A 321 ( 4.6A)
HIW  A 321 (-3.8A)
 0.62A 5ayaA-5b1uA:
47.5		 5ayaA-5b1uA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DBY_A_ACTA610_0
(SERUM ALBUMIN)		 5b1u METALLO-BETA-LACTAMA
SE
(Serratia
marcescens) 		3 / 3 TYR A  15
LYS A 166
LYS A 168
 None
 1.25A 5dbyA-5b1uA:
undetectable		 5dbyA-5b1uA:
18.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5SYE_B_TA1B502_1
(TUBULIN BETA CHAIN)		 5b1u METALLO-BETA-LACTAMA
SE
(Serratia
marcescens) 		5 / 12 GLU A 204
VAL A 203
ALA A 173
GLN A 113
GLY A 149
 None
None
None
HIW  A 321 (-3.0A)
None
 1.14A 5syeB-5b1uA:
undetectable		 5syeB-5b1uA:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VCV_A_1N1A404_2
(MEMBRANE-ASSOCIATED
TYROSINE- AND
THREONINE-SPECIFIC
CDC2-INHIBITORY
KINASE)		 5b1u METALLO-BETA-LACTAMA
SE
(Serratia
marcescens) 		4 / 5 VAL A 192
HIS A  72
LEU A 253
ASP A 111
 None
ZN  A 301 (-3.2A)
None
NA  A 311 (-4.1A)
 1.47A 5vcvA-5b1uA:
undetectable		 5vcvA-5b1uA:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZJ8_A_9DCA303_0
(METALLO-BETA-LACTAMA
SE TYPE 2)		 5b1u METALLO-BETA-LACTAMA
SE
(Serratia
marcescens) 		4 / 8 HIS A  74
ASP A  76
HIS A  72
HIS A 215
 ZN  A 301 (-3.1A)
ZN  A 302 ( 2.5A)
ZN  A 301 (-3.2A)
ZN  A 302 ( 3.3A)
 0.86A 5zj8A-5b1uA:
17.6		 5zj8A-5b1uA:
25.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZJ8_A_9DCA303_0
(METALLO-BETA-LACTAMA
SE TYPE 2)		 5b1u METALLO-BETA-LACTAMA
SE
(Serratia
marcescens) 		4 / 8 HIS A  74
ASP A  76
HIS A 150
HIS A 215
 ZN  A 301 (-3.1A)
ZN  A 302 ( 2.5A)
ZN  A 301 (-3.2A)
ZN  A 302 ( 3.3A)
 0.79A 5zj8A-5b1uA:
17.6		 5zj8A-5b1uA:
25.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZJ8_A_9DCA303_0
(METALLO-BETA-LACTAMA
SE TYPE 2)		 5b1u METALLO-BETA-LACTAMA
SE
(Serratia
marcescens) 		4 / 8 TRP A   5
HIS A  74
ASP A  76
HIS A 150
 None
ZN  A 301 (-3.1A)
ZN  A 302 ( 2.5A)
ZN  A 301 (-3.2A)
 0.92A 5zj8A-5b1uA:
17.6		 5zj8A-5b1uA:
25.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EKZ_A_SNPA414_0
(AROMATIC
PEROXYGENASE)		 5b1u METALLO-BETA-LACTAMA
SE
(Serratia
marcescens) 		4 / 5 PHE A  12
VAL A  40
PRO A 216
MET A 221
 None
 1.16A 6ekzA-5b1uA:
undetectable		 6ekzA-5b1uA:
16.28