SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5b1y'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FO4_A_SALA3005_1
(XANTHINE
DEHYDROGENASE)		 5b1y 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
REDUCTASE
(Aeropyrum
pernix) 		5 / 9 GLU A  47
LEU A  51
SER A  53
ARG A  49
VAL A  30
 None
 1.37A 1fo4A-5b1yA:
0.8		 1fo4A-5b1yA:
11.79
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1UAY_A_ADNA1001_1
(TYPE II
3-HYDROXYACYL-COA
DEHYDROGENASE)		 5b1y 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
REDUCTASE
(Aeropyrum
pernix) 		7 / 11 GLY A  10
SER A  12
ASP A  62
VAL A  63
ALA A  90
VAL A  92
VAL A 112
 NDP  A 300 (-3.5A)
NDP  A 300 (-3.6A)
NDP  A 300 (-4.3A)
NDP  A 300 (-3.1A)
NDP  A 300 (-3.4A)
None
None
 1.25A 1uayA-5b1yA:
27.3		 1uayA-5b1yA:
32.99
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1UAY_B_ADNB1002_1
(TYPE II
3-HYDROXYACYL-COA
DEHYDROGENASE)		 5b1y 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
REDUCTASE
(Aeropyrum
pernix) 		6 / 10 GLY A  10
ASP A  62
VAL A  63
ALA A  90
VAL A  92
VAL A 112
 NDP  A 300 (-3.5A)
NDP  A 300 (-4.3A)
NDP  A 300 (-3.1A)
NDP  A 300 (-3.4A)
None
None
 0.38A 1uayB-5b1yA:
28.3		 1uayB-5b1yA:
32.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZGW_A_ADNA1301_1
(BIOTIN--[ACETYL-COA-
CARBOXYLASE] LIGASE)		 5b1y 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
REDUCTASE
(Aeropyrum
pernix) 		4 / 7 ARG A  25
GLU A  26
ALA A  18
ALA A 222
 None
 1.11A 2zgwA-5b1yA:
undetectable		 2zgwA-5b1yA:
23.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LJ0_A_ACTA505_0
(NAB2)		 5b1y 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
REDUCTASE
(Aeropyrum
pernix) 		3 / 3 LEU A 125
LYS A 122
THR A 121
 None
 0.50A 4lj0A-5b1yA:
undetectable		 4lj0A-5b1yA:
11.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R7I_A_STIA1001_2
(MACROPHAGE
COLONY-STIMULATING
FACTOR 1 RECEPTOR)		 5b1y 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
REDUCTASE
(Aeropyrum
pernix) 		4 / 5 LEU A 125
VAL A 180
VAL A  85
TYR A 176
 None
 1.12A 4r7iA-5b1yA:
undetectable		 4r7iA-5b1yA:
25.41