SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5b22'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_C_FUAC701_1
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 5b22 NECTIN-3
(Mus
musculus) 		4 / 4 ALA A 138
VAL A 136
ALA A 137
HIS A 192
 None
 1.16A 1q23A-5b22A:
undetectable		 1q23A-5b22A:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TDN_A_LEUA487_0
(L-AMINO ACID OXIDASE)		 5b22 NECTIN-3
(Mus
musculus) 		4 / 7 ASN A  67
HIS A  47
PHE A  65
ILE A  22
 None
 1.36A 1tdnA-5b22A:
undetectable		 1tdnA-5b22A:
19.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IZQ_D_DVAD6_0
(GRAMICIDIN D)		 5b22 NECTIN-3
(Mus
musculus) 		3 / 3 TRP A  12
ALA A  10
VAL A 110
 NAG  A 301 (-3.4A)
None
None
 0.96A 2izqC-5b22A:
undetectable
2izqD-5b22A:
undetectable		 2izqC-5b22A:
5.50
2izqD-5b22A:
5.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3L8L_B_DVAB6_0
(GRAMICIDIN D)		 5b22 NECTIN-3
(Mus
musculus) 		3 / 3 TRP A  12
ALA A  10
VAL A 110
 NAG  A 301 (-3.4A)
None
None
 1.02A 3l8lA-5b22A:
undetectable
3l8lB-5b22A:
undetectable		 3l8lA-5b22A:
5.50
3l8lB-5b22A:
5.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3L8L_D_DVAD6_0
(GRAMICIDIN D)		 5b22 NECTIN-3
(Mus
musculus) 		3 / 3 TRP A  12
ALA A  10
VAL A 110
 NAG  A 301 (-3.4A)
None
None
 0.96A 3l8lC-5b22A:
undetectable
3l8lD-5b22A:
undetectable		 3l8lC-5b22A:
5.50
3l8lD-5b22A:
5.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E7C_A_ACTA504_0
(UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE)		 5b22 NECTIN-3
(Mus
musculus) 		3 / 3 ARG A  62
TRP A  12
GLY A  13
 None
NAG  A 301 (-3.4A)
None
 0.88A 4e7cA-5b22A:
undetectable		 4e7cA-5b22A:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DQY_A_BEZA401_0
(THIOREDOXIN)		 5b22 NECTIN-3
(Mus
musculus) 		4 / 8 ILE A  22
LYS A  91
VAL A  24
GLN A 101
 None
 0.74A 5dqyA-5b22A:
undetectable		 5dqyA-5b22A:
19.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QGK_A_ACTA301_0
(PEROXISOMAL COENZYME
A DIPHOSPHATASE
NUDT7)		 5b22 NECTIN-3
(Mus
musculus) 		3 / 3 VAL A  63
TYR A  59
GLN A  60
 None
 0.70A 5qgkA-5b22A:
undetectable		 5qgkA-5b22A:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QGR_A_ACTA301_0
(PEROXISOMAL COENZYME
A DIPHOSPHATASE
NUDT7)		 5b22 NECTIN-3
(Mus
musculus) 		3 / 3 VAL A  63
TYR A  59
GLN A  60
 None
 0.72A 5qgrA-5b22A:
undetectable		 5qgrA-5b22A:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QGT_A_ACTA301_0
(PEROXISOMAL COENZYME
A DIPHOSPHATASE
NUDT7)		 5b22 NECTIN-3
(Mus
musculus) 		3 / 3 VAL A  63
TYR A  59
GLN A  60
 None
 0.73A 5qgtA-5b22A:
undetectable		 5qgtA-5b22A:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WGG_A_SAMA504_0
(RADICAL SAM DOMAIN
PROTEIN)		 5b22 NECTIN-3
(Mus
musculus) 		5 / 12 PHE A 162
PRO A 163
THR A 113
VAL A 114
VAL A 136
 NAG  A 302 (-4.2A)
None
None
None
None
 1.43A 5wggA-5b22A:
undetectable		 5wggA-5b22A:
18.60