SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5b25'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EI6_D_PPFD412_1
(PHOSPHONOACETATE
HYDROLASE)		 5b25 CALCIUM/CALMODULIN-D
EPENDENT
3',5'-CYCLIC
NUCLEOTIDE
PHOSPHODIESTERASE 1B
(Homo
sapiens) 		4 / 8 THR A 334
ASP A 264
HIS A 223
HIS A 227
 MG  A 602 ( 4.9A)
MG  A 602 ( 2.6A)
4QJ  A 603 ( 4.9A)
ZN  A 601 (-3.4A)
 1.02A 1ei6D-5b25A:
undetectable		 1ei6D-5b25A:
23.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GRM_A_DVAA6_0
(GRAMICIDIN A)		 5b25 CALCIUM/CALMODULIN-D
EPENDENT
3',5'-CYCLIC
NUCLEOTIDE
PHOSPHODIESTERASE 1B
(Homo
sapiens) 		3 / 3 ALA A 229
VAL A 231
TRP A 384
 None
 0.96A 1grmA-5b25A:
undetectable		 1grmA-5b25A:
3.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GRM_B_DVAB6_0
(GRAMICIDIN A)		 5b25 CALCIUM/CALMODULIN-D
EPENDENT
3',5'-CYCLIC
NUCLEOTIDE
PHOSPHODIESTERASE 1B
(Homo
sapiens) 		3 / 3 ALA A 229
VAL A 231
TRP A 384
 None
 0.95A 1grmB-5b25A:
undetectable		 1grmB-5b25A:
3.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SN0_B_T44B602_1
(TRANSTHYRETIN)		 5b25 CALCIUM/CALMODULIN-D
EPENDENT
3',5'-CYCLIC
NUCLEOTIDE
PHOSPHODIESTERASE 1B
(Homo
sapiens) 		4 / 7 LYS A 360
GLU A 329
ALA A 361
ALA A 349
 None
 1.11A 1sn0B-5b25A:
undetectable
1sn0D-5b25A:
undetectable		 1sn0B-5b25A:
19.26
1sn0D-5b25A:
19.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UDU_A_CIAA1003_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		 5b25 CALCIUM/CALMODULIN-D
EPENDENT
3',5'-CYCLIC
NUCLEOTIDE
PHOSPHODIESTERASE 1B
(Homo
sapiens) 		5 / 11 TYR A 222
PHE A 392
LEU A 409
GLN A 421
PHE A 424
 None
GOL  A 607 (-3.9A)
GOL  A 607 (-4.6A)
4QJ  A 603 (-3.0A)
4QJ  A 603 (-3.5A)
 1.05A 1uduA-5b25A:
33.8		 1uduA-5b25A:
28.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UDU_B_CIAB2003_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		 5b25 CALCIUM/CALMODULIN-D
EPENDENT
3',5'-CYCLIC
NUCLEOTIDE
PHOSPHODIESTERASE 1B
(Homo
sapiens) 		5 / 12 TYR A 222
PHE A 392
LEU A 409
GLN A 421
PHE A 424
 None
GOL  A 607 (-3.9A)
GOL  A 607 (-4.6A)
4QJ  A 603 (-3.0A)
4QJ  A 603 (-3.5A)
 1.01A 1uduB-5b25A:
33.9		 1uduB-5b25A:
28.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UHO_A_VDNA1000_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		 5b25 CALCIUM/CALMODULIN-D
EPENDENT
3',5'-CYCLIC
NUCLEOTIDE
PHOSPHODIESTERASE 1B
(Homo
sapiens) 		6 / 10 TYR A 222
HIS A 223
PHE A 392
GLN A 421
GLY A 423
PHE A 424
 None
4QJ  A 603 ( 4.9A)
GOL  A 607 (-3.9A)
4QJ  A 603 (-3.0A)
4QJ  A 603 (-4.2A)
4QJ  A 603 (-3.5A)
 0.65A 1uhoA-5b25A:
34.9		 1uhoA-5b25A:
28.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UHO_A_VDNA1000_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		 5b25 CALCIUM/CALMODULIN-D
EPENDENT
3',5'-CYCLIC
NUCLEOTIDE
PHOSPHODIESTERASE 1B
(Homo
sapiens) 		5 / 10 TYR A 222
LEU A 409
GLN A 421
GLY A 423
PHE A 424
 None
GOL  A 607 (-4.6A)
4QJ  A 603 (-3.0A)
4QJ  A 603 (-4.2A)
4QJ  A 603 (-3.5A)
 0.91A 1uhoA-5b25A:
34.9		 1uhoA-5b25A:
28.69
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1XLX_A_CIOA101_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4B)		 5b25 CALCIUM/CALMODULIN-D
EPENDENT
3',5'-CYCLIC
NUCLEOTIDE
PHOSPHODIESTERASE 1B
(Homo
sapiens) 		8 / 12 TYR A 222
HIS A 223
HIS A 267
MET A 336
THR A 385
SER A 420
GLN A 421
PHE A 424
 None
4QJ  A 603 ( 4.9A)
None
4QJ  A 603 ( 3.9A)
None
4QJ  A 603 (-4.7A)
4QJ  A 603 (-3.0A)
4QJ  A 603 (-3.5A)
 0.67A 1xlxA-5b25A:
44.0		 1xlxA-5b25A:
35.63
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1XLX_B_CIOB102_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4B)		 5b25 CALCIUM/CALMODULIN-D
EPENDENT
3',5'-CYCLIC
NUCLEOTIDE
PHOSPHODIESTERASE 1B
(Homo
sapiens) 		8 / 12 TYR A 222
HIS A 223
HIS A 267
MET A 336
THR A 385
PHE A 392
GLN A 421
PHE A 424
 None
4QJ  A 603 ( 4.9A)
None
4QJ  A 603 ( 3.9A)
None
GOL  A 607 (-3.9A)
4QJ  A 603 (-3.0A)
4QJ  A 603 (-3.5A)
 0.63A 1xlxB-5b25A:
44.0		 1xlxB-5b25A:
35.63
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1XMU_A_ROFA101_0
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4B)		 5b25 CALCIUM/CALMODULIN-D
EPENDENT
3',5'-CYCLIC
NUCLEOTIDE
PHOSPHODIESTERASE 1B
(Homo
sapiens) 		8 / 12 TYR A 222
HIS A 223
ASP A 370
PRO A 374
TRP A 384
PHE A 392
SER A 420
PHE A 424
 None
4QJ  A 603 ( 4.9A)
ZN  A 601 (-2.5A)
None
None
GOL  A 607 (-3.9A)
4QJ  A 603 (-4.7A)
4QJ  A 603 (-3.5A)
 0.59A 1xmuA-5b25A:
43.7		 1xmuA-5b25A:
35.63
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1XMU_B_ROFB102_0
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4B)		 5b25 CALCIUM/CALMODULIN-D
EPENDENT
3',5'-CYCLIC
NUCLEOTIDE
PHOSPHODIESTERASE 1B
(Homo
sapiens) 		8 / 12 TYR A 222
HIS A 223
MET A 336
ASP A 370
PRO A 374
TRP A 384
PHE A 392
SER A 420
 None
4QJ  A 603 ( 4.9A)
4QJ  A 603 ( 3.9A)
ZN  A 601 (-2.5A)
None
None
GOL  A 607 (-3.9A)
4QJ  A 603 (-4.7A)
 0.52A 1xmuB-5b25A:
43.9		 1xmuB-5b25A:
35.63
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1XOM_A_CIOA603_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)		 5b25 CALCIUM/CALMODULIN-D
EPENDENT
3',5'-CYCLIC
NUCLEOTIDE
PHOSPHODIESTERASE 1B
(Homo
sapiens) 		8 / 12 TYR A 222
HIS A 223
MET A 336
ASP A 370
PHE A 392
SER A 420
GLN A 421
PHE A 424
 None
4QJ  A 603 ( 4.9A)
4QJ  A 603 ( 3.9A)
ZN  A 601 (-2.5A)
GOL  A 607 (-3.9A)
4QJ  A 603 (-4.7A)
4QJ  A 603 (-3.0A)
4QJ  A 603 (-3.5A)
 0.56A 1xomA-5b25A:
44.0		 1xomA-5b25A:
38.27
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1XOM_B_CIOB601_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)		 5b25 CALCIUM/CALMODULIN-D
EPENDENT
3',5'-CYCLIC
NUCLEOTIDE
PHOSPHODIESTERASE 1B
(Homo
sapiens) 		8 / 12 TYR A 222
HIS A 223
MET A 336
THR A 385
PHE A 392
SER A 420
GLN A 421
PHE A 424
 None
4QJ  A 603 ( 4.9A)
4QJ  A 603 ( 3.9A)
None
GOL  A 607 (-3.9A)
4QJ  A 603 (-4.7A)
4QJ  A 603 (-3.0A)
4QJ  A 603 (-3.5A)
 0.62A 1xomB-5b25A:
44.0		 1xomB-5b25A:
38.27
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1XOQ_A_ROFA502_0
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)		 5b25 CALCIUM/CALMODULIN-D
EPENDENT
3',5'-CYCLIC
NUCLEOTIDE
PHOSPHODIESTERASE 1B
(Homo
sapiens) 		8 / 12 TYR A 222
HIS A 223
MET A 336
ASP A 370
PRO A 374
THR A 385
SER A 420
PHE A 424
 None
4QJ  A 603 ( 4.9A)
4QJ  A 603 ( 3.9A)
ZN  A 601 (-2.5A)
None
None
4QJ  A 603 (-4.7A)
4QJ  A 603 (-3.5A)
 0.44A 1xoqA-5b25A:
44.0		 1xoqA-5b25A:
38.27
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1XOQ_B_ROFB501_0
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)		 5b25 CALCIUM/CALMODULIN-D
EPENDENT
3',5'-CYCLIC
NUCLEOTIDE
PHOSPHODIESTERASE 1B
(Homo
sapiens) 		8 / 12 TYR A 222
HIS A 223
ASP A 370
PRO A 374
TRP A 384
THR A 385
SER A 420
PHE A 424
 None
4QJ  A 603 ( 4.9A)
ZN  A 601 (-2.5A)
None
None
None
4QJ  A 603 (-4.7A)
4QJ  A 603 (-3.5A)
 0.47A 1xoqB-5b25A:
44.0		 1xoqB-5b25A:
38.27
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1XOS_A_VIAA1_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4B)		 5b25 CALCIUM/CALMODULIN-D
EPENDENT
3',5'-CYCLIC
NUCLEOTIDE
PHOSPHODIESTERASE 1B
(Homo
sapiens) 		8 / 12 TYR A 222
HIS A 223
MET A 336
ASP A 370
PHE A 392
GLN A 421
PHE A 424
ILE A 428
 None
4QJ  A 603 ( 4.9A)
4QJ  A 603 ( 3.9A)
ZN  A 601 (-2.5A)
GOL  A 607 (-3.9A)
4QJ  A 603 (-3.0A)
4QJ  A 603 (-3.5A)
None
 0.66A 1xosA-5b25A:
43.9		 1xosA-5b25A:
35.63
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1XOS_A_VIAA1_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4B)		 5b25 CALCIUM/CALMODULIN-D
EPENDENT
3',5'-CYCLIC
NUCLEOTIDE
PHOSPHODIESTERASE 1B
(Homo
sapiens) 		6 / 12 TYR A 222
HIS A 223
MET A 336
ASP A 370
PHE A 392
SER A 407
 None
4QJ  A 603 ( 4.9A)
4QJ  A 603 ( 3.9A)
ZN  A 601 (-2.5A)
GOL  A 607 (-3.9A)
GOL  A 607 (-4.1A)
 1.12A 1xosA-5b25A:
43.9		 1xosA-5b25A:
35.63
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1XOT_A_VDNA101_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4B)		 5b25 CALCIUM/CALMODULIN-D
EPENDENT
3',5'-CYCLIC
NUCLEOTIDE
PHOSPHODIESTERASE 1B
(Homo
sapiens) 		7 / 12 TYR A 222
HIS A 223
MET A 336
SER A 407
GLN A 421
PHE A 424
ILE A 428
 None
4QJ  A 603 ( 4.9A)
4QJ  A 603 ( 3.9A)
GOL  A 607 (-4.1A)
4QJ  A 603 (-3.0A)
4QJ  A 603 (-3.5A)
None
 0.92A 1xotA-5b25A:
44.0		 1xotA-5b25A:
35.63
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1XOT_A_VDNA101_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4B)		 5b25 CALCIUM/CALMODULIN-D
EPENDENT
3',5'-CYCLIC
NUCLEOTIDE
PHOSPHODIESTERASE 1B
(Homo
sapiens) 		7 / 12 TYR A 222
HIS A 223
MET A 336
SER A 407
SER A 420
PHE A 424
ILE A 428
 None
4QJ  A 603 ( 4.9A)
4QJ  A 603 ( 3.9A)
GOL  A 607 (-4.1A)
4QJ  A 603 (-4.7A)
4QJ  A 603 (-3.5A)
None
 1.08A 1xotA-5b25A:
44.0		 1xotA-5b25A:
35.63
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1XOT_B_VDNB102_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4B)		 5b25 CALCIUM/CALMODULIN-D
EPENDENT
3',5'-CYCLIC
NUCLEOTIDE
PHOSPHODIESTERASE 1B
(Homo
sapiens) 		6 / 12 TYR A 222
HIS A 223
MET A 336
SER A 407
GLN A 421
PHE A 424
 None
4QJ  A 603 ( 4.9A)
4QJ  A 603 ( 3.9A)
GOL  A 607 (-4.1A)
4QJ  A 603 (-3.0A)
4QJ  A 603 (-3.5A)
 0.81A 1xotB-5b25A:
43.9		 1xotB-5b25A:
35.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2H42_A_VIAA901_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		 5b25 CALCIUM/CALMODULIN-D
EPENDENT
3',5'-CYCLIC
NUCLEOTIDE
PHOSPHODIESTERASE 1B
(Homo
sapiens) 		5 / 11 TYR A 222
HIS A 223
PHE A 392
GLN A 421
PHE A 424
 None
4QJ  A 603 ( 4.9A)
GOL  A 607 (-3.9A)
4QJ  A 603 (-3.0A)
4QJ  A 603 (-3.5A)
 0.63A 2h42A-5b25A:
34.6		 2h42A-5b25A:
28.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WEK_A_DIFA1375_1
(ZINC-BINDING ALCOHOL
DEHYDROGENASE
DOMAIN-CONTAINING
PROTEIN 2)		 5b25 CALCIUM/CALMODULIN-D
EPENDENT
3',5'-CYCLIC
NUCLEOTIDE
PHOSPHODIESTERASE 1B
(Homo
sapiens) 		3 / 3 LEU A 211
TYR A 215
GLN A 225
 None
 0.73A 2wekA-5b25A:
undetectable		 2wekA-5b25A:
21.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WEY_A_EV1A1771_1
(CAMP AND
CAMP-INHIBITED CGMP
3', 5'-CYCLIC
PHOSPHODIESTERASE)		 5b25 CALCIUM/CALMODULIN-D
EPENDENT
3',5'-CYCLIC
NUCLEOTIDE
PHOSPHODIESTERASE 1B
(Homo
sapiens) 		6 / 12 TYR A 222
HIS A 223
GLU A 391
PHE A 392
GLN A 421
PHE A 424
 None
4QJ  A 603 ( 4.9A)
None
GOL  A 607 (-3.9A)
4QJ  A 603 (-3.0A)
4QJ  A 603 (-3.5A)
 0.84A 2weyA-5b25A:
37.0		 2weyA-5b25A:
25.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B2R_A_VDNA1_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		 5b25 CALCIUM/CALMODULIN-D
EPENDENT
3',5'-CYCLIC
NUCLEOTIDE
PHOSPHODIESTERASE 1B
(Homo
sapiens) 		5 / 12 TYR A 222
HIS A 223
PHE A 392
GLN A 421
PHE A 424
 None
4QJ  A 603 ( 4.9A)
GOL  A 607 (-3.9A)
4QJ  A 603 (-3.0A)
4QJ  A 603 (-3.5A)
 0.57A 3b2rA-5b25A:
30.3		 3b2rA-5b25A:
28.49
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3G4L_A_ROFA901_0
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)		 5b25 CALCIUM/CALMODULIN-D
EPENDENT
3',5'-CYCLIC
NUCLEOTIDE
PHOSPHODIESTERASE 1B
(Homo
sapiens) 		8 / 12 TYR A 222
HIS A 223
MET A 336
PRO A 374
TRP A 384
THR A 385
SER A 420
PHE A 424
 None
4QJ  A 603 ( 4.9A)
4QJ  A 603 ( 3.9A)
None
None
None
4QJ  A 603 (-4.7A)
4QJ  A 603 (-3.5A)
 0.43A 3g4lA-5b25A:
43.8		 3g4lA-5b25A:
37.96
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3G4L_B_ROFB902_0
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)		 5b25 CALCIUM/CALMODULIN-D
EPENDENT
3',5'-CYCLIC
NUCLEOTIDE
PHOSPHODIESTERASE 1B
(Homo
sapiens) 		8 / 12 TYR A 222
HIS A 223
MET A 336
ASP A 370
PRO A 374
TRP A 384
THR A 385
PHE A 424
 None
4QJ  A 603 ( 4.9A)
4QJ  A 603 ( 3.9A)
ZN  A 601 (-2.5A)
None
None
None
4QJ  A 603 (-3.5A)
 0.48A 3g4lB-5b25A:
43.6		 3g4lB-5b25A:
37.96
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3G4L_C_ROFC903_0
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)		 5b25 CALCIUM/CALMODULIN-D
EPENDENT
3',5'-CYCLIC
NUCLEOTIDE
PHOSPHODIESTERASE 1B
(Homo
sapiens) 		7 / 12 TYR A 222
HIS A 223
MET A 336
ASP A 370
PRO A 374
TRP A 384
THR A 385
 None
4QJ  A 603 ( 4.9A)
4QJ  A 603 ( 3.9A)
ZN  A 601 (-2.5A)
None
None
None
 0.50A 3g4lC-5b25A:
43.5		 3g4lC-5b25A:
37.96
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3G4L_C_ROFC903_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)		 5b25 CALCIUM/CALMODULIN-D
EPENDENT
3',5'-CYCLIC
NUCLEOTIDE
PHOSPHODIESTERASE 1B
(Homo
sapiens) 		3 / 3 SER A 420
GLN A 421
PHE A 424
 4QJ  A 603 (-4.7A)
4QJ  A 603 (-3.0A)
4QJ  A 603 (-3.5A)
 0.54A 3g4lC-5b25A:
43.5		 3g4lC-5b25A:
37.96
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3G4L_D_ROFD904_0
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)		 5b25 CALCIUM/CALMODULIN-D
EPENDENT
3',5'-CYCLIC
NUCLEOTIDE
PHOSPHODIESTERASE 1B
(Homo
sapiens) 		9 / 12 TYR A 222
HIS A 223
MET A 336
ASP A 370
PRO A 374
TRP A 384
THR A 385
SER A 420
GLN A 421
 None
4QJ  A 603 ( 4.9A)
4QJ  A 603 ( 3.9A)
ZN  A 601 (-2.5A)
None
None
None
4QJ  A 603 (-4.7A)
4QJ  A 603 (-3.0A)
 0.58A 3g4lD-5b25A:
43.5		 3g4lD-5b25A:
37.96
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3IAK_A_EV1A415_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)		 5b25 CALCIUM/CALMODULIN-D
EPENDENT
3',5'-CYCLIC
NUCLEOTIDE
PHOSPHODIESTERASE 1B
(Homo
sapiens) 		6 / 9 TYR A 222
MET A 336
PHE A 392
GLN A 421
PHE A 424
ILE A 428
 None
4QJ  A 603 ( 3.9A)
GOL  A 607 (-3.9A)
4QJ  A 603 (-3.0A)
4QJ  A 603 (-3.5A)
None
 0.75A 3iakA-5b25A:
43.5		 3iakA-5b25A:
38.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JWQ_C_VIAC901_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE
CATALYTIC DOMAIN,
CONE CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE
SUBUNIT ALPHA
CHIMERA)		 5b25 CALCIUM/CALMODULIN-D
EPENDENT
3',5'-CYCLIC
NUCLEOTIDE
PHOSPHODIESTERASE 1B
(Homo
sapiens) 		4 / 7 TYR A 222
HIS A 223
GLN A 421
PHE A 424
 None
4QJ  A 603 ( 4.9A)
4QJ  A 603 (-3.0A)
4QJ  A 603 (-3.5A)
 0.57A 3jwqC-5b25A:
37.7		 3jwqC-5b25A:
27.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JWQ_D_VIAD901_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE
CATALYTIC DOMAIN,
CONE CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE
SUBUNIT ALPHA
CHIMERA)		 5b25 CALCIUM/CALMODULIN-D
EPENDENT
3',5'-CYCLIC
NUCLEOTIDE
PHOSPHODIESTERASE 1B
(Homo
sapiens) 		5 / 11 TYR A 222
HIS A 223
PHE A 392
GLN A 421
PHE A 424
 None
4QJ  A 603 ( 4.9A)
GOL  A 607 (-3.9A)
4QJ  A 603 (-3.0A)
4QJ  A 603 (-3.5A)
 0.66A 3jwqA-5b25A:
37.8
3jwqD-5b25A:
37.5		 3jwqA-5b25A:
27.93
3jwqD-5b25A:
27.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QEO_B_LLTB261_1
(DEOXYCYTIDINE KINASE)		 5b25 CALCIUM/CALMODULIN-D
EPENDENT
3',5'-CYCLIC
NUCLEOTIDE
PHOSPHODIESTERASE 1B
(Homo
sapiens) 		4 / 7 VAL A 184
LEU A 180
TYR A 215
LEU A 303
 None
 0.98A 3qeoB-5b25A:
undetectable		 3qeoB-5b25A:
20.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SP9_A_IL2A901_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR DELTA)		 5b25 CALCIUM/CALMODULIN-D
EPENDENT
3',5'-CYCLIC
NUCLEOTIDE
PHOSPHODIESTERASE 1B
(Homo
sapiens) 		5 / 12 THR A 189
ILE A 194
LEU A 253
VAL A 245
TYR A 150
 None
 1.15A 3sp9A-5b25A:
undetectable		 3sp9A-5b25A:
21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SP9_B_IL2B901_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR DELTA)		 5b25 CALCIUM/CALMODULIN-D
EPENDENT
3',5'-CYCLIC
NUCLEOTIDE
PHOSPHODIESTERASE 1B
(Homo
sapiens) 		5 / 12 THR A 189
ILE A 194
LEU A 253
VAL A 245
TYR A 150
 None
 1.17A 3sp9B-5b25A:
undetectable		 3sp9B-5b25A:
21.79
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3TVX_A_PNXA902_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4A)		 5b25 CALCIUM/CALMODULIN-D
EPENDENT
3',5'-CYCLIC
NUCLEOTIDE
PHOSPHODIESTERASE 1B
(Homo
sapiens) 		5 / 9 TYR A 222
PRO A 374
THR A 385
GLN A 421
PHE A 424
 None
None
None
4QJ  A 603 (-3.0A)
4QJ  A 603 (-3.5A)
 0.47A 3tvxA-5b25A:
43.5		 3tvxA-5b25A:
37.67
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3TVX_B_PNXB902_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4A)		 5b25 CALCIUM/CALMODULIN-D
EPENDENT
3',5'-CYCLIC
NUCLEOTIDE
PHOSPHODIESTERASE 1B
(Homo
sapiens) 		4 / 7 TYR A 222
PHE A 392
GLN A 421
PHE A 424
 None
GOL  A 607 (-3.9A)
4QJ  A 603 (-3.0A)
4QJ  A 603 (-3.5A)
 0.44A 3tvxB-5b25A:
43.4		 3tvxB-5b25A:
37.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E0F_A_RBFA301_1
(RIBOFLAVIN SYNTHASE
SUBUNIT ALPHA)		 5b25 CALCIUM/CALMODULIN-D
EPENDENT
3',5'-CYCLIC
NUCLEOTIDE
PHOSPHODIESTERASE 1B
(Homo
sapiens) 		5 / 11 VAL A 291
THR A 270
GLU A 281
ALA A 283
HIS A 295
 None
 1.16A 4e0fA-5b25A:
undetectable		 4e0fA-5b25A:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E1G_B_LNLB701_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		 5b25 CALCIUM/CALMODULIN-D
EPENDENT
3',5'-CYCLIC
NUCLEOTIDE
PHOSPHODIESTERASE 1B
(Homo
sapiens) 		4 / 7 VAL A 184
LEU A 187
ASN A 224
VAL A 235
 None
 1.04A 4e1gB-5b25A:
undetectable		 4e1gB-5b25A:
20.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVY_B_BO2B201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 5b25 CALCIUM/CALMODULIN-D
EPENDENT
3',5'-CYCLIC
NUCLEOTIDE
PHOSPHODIESTERASE 1B
(Homo
sapiens) 		5 / 11 SER A 280
THR A 271
THR A 270
SER A 290
ALA A 283
 None
GOL  A 607 (-3.9A)
None
None
None
 1.47A 4qvyV-5b25A:
undetectable
4qvyb-5b25A:
undetectable		 4qvyV-5b25A:
22.48
4qvyb-5b25A:
20.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVY_N_BO2N201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 5b25 CALCIUM/CALMODULIN-D
EPENDENT
3',5'-CYCLIC
NUCLEOTIDE
PHOSPHODIESTERASE 1B
(Homo
sapiens) 		5 / 11 SER A 280
THR A 271
THR A 270
SER A 290
ALA A 283
 None
GOL  A 607 (-3.9A)
None
None
None
 1.47A 4qvyH-5b25A:
undetectable
4qvyN-5b25A:
undetectable		 4qvyH-5b25A:
22.48
4qvyN-5b25A:
20.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HV1_A_RFPA902_1
(PHOSPHOENOLPYRUVATE
SYNTHASE)		 5b25 CALCIUM/CALMODULIN-D
EPENDENT
3',5'-CYCLIC
NUCLEOTIDE
PHOSPHODIESTERASE 1B
(Homo
sapiens) 		5 / 12 ALA A 260
VAL A 235
LEU A 248
LEU A 208
ILE A 199
 None
 0.83A 5hv1A-5b25A:
1.7		 5hv1A-5b25A:
17.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L5F_B_BO2B201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 5b25 CALCIUM/CALMODULIN-D
EPENDENT
3',5'-CYCLIC
NUCLEOTIDE
PHOSPHODIESTERASE 1B
(Homo
sapiens) 		5 / 11 SER A 280
THR A 271
THR A 270
SER A 290
ALA A 283
 None
GOL  A 607 (-3.9A)
None
None
None
 1.43A 5l5fV-5b25A:
undetectable
5l5fb-5b25A:
undetectable		 5l5fV-5b25A:
22.48
5l5fb-5b25A:
20.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L5F_N_BO2N201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 5b25 CALCIUM/CALMODULIN-D
EPENDENT
3',5'-CYCLIC
NUCLEOTIDE
PHOSPHODIESTERASE 1B
(Homo
sapiens) 		5 / 11 SER A 280
THR A 271
THR A 270
SER A 290
ALA A 283
 None
GOL  A 607 (-3.9A)
None
None
None
 1.43A 5l5fH-5b25A:
undetectable
5l5fN-5b25A:
undetectable		 5l5fH-5b25A:
22.48
5l5fN-5b25A:
20.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VCG_A_08YA602_1
(CYTOCHROME P450 3A4)		 5b25 CALCIUM/CALMODULIN-D
EPENDENT
3',5'-CYCLIC
NUCLEOTIDE
PHOSPHODIESTERASE 1B
(Homo
sapiens) 		5 / 12 PHE A 301
ILE A 297
PHE A 258
ALA A 261
ALA A 210
 None
 1.26A 5vcgA-5b25A:
undetectable		 5vcgA-5b25A:
19.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A4I_A_TRPA403_0
(TRYPTOPHAN
2,3-DIOXYGENASE)		 5b25 CALCIUM/CALMODULIN-D
EPENDENT
3',5'-CYCLIC
NUCLEOTIDE
PHOSPHODIESTERASE 1B
(Homo
sapiens) 		4 / 8 ARG A 482
THR A 432
PRO A 431
ILE A 371
 None
None
None
4QJ  A 603 (-4.4A)
 1.11A 6a4iA-5b25A:
undetectable		 6a4iA-5b25A:
20.53