SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5b2g'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FE2_A_LAXA700_2
(PROSTAGLANDIN
ENDOPEROXIDE H
SYNTHASE-1)		 5b2g ENDOLYSIN,CLAUDIN-4
(Escherichia
virus
T4;
Homo
sapiens) 		5 / 12 GLY A1330
ALA A1332
SER A1334
GLY A1292
LEU A1338
 None
 1.12A 1fe2A-5b2gA:
undetectable		 1fe2A-5b2gA:
21.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HK3_A_T44A3002_1
(SERUM ALBUMIN)		 5b2g ENDOLYSIN,CLAUDIN-4
(Escherichia
virus
T4;
Homo
sapiens) 		4 / 8 LEU A1099
ARG A1096
LEU A1118
SER A1090
 None
 1.11A 1hk3A-5b2gA:
undetectable		 1hk3A-5b2gA:
19.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NBH_A_SAMA293_0
(GLYCINE
N-METHYLTRANSFERASE)		 5b2g ENDOLYSIN,CLAUDIN-4
(Homo
sapiens;
Escherichia
virus
T4) 		5 / 12 TRP A1181
ILE A1251
GLY A1180
VAL A1184
ALA A1175
 None
 1.24A 1nbhA-5b2gA:
undetectable		 1nbhA-5b2gA:
20.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NBH_D_SAMD3293_0
(GLYCINE
N-METHYLTRANSFERASE)		 5b2g ENDOLYSIN,CLAUDIN-4
(Homo
sapiens;
Escherichia
virus
T4) 		5 / 12 TRP A1181
ILE A1251
GLY A1180
VAL A1184
ALA A1175
 None
 1.24A 1nbhD-5b2gA:
undetectable		 1nbhD-5b2gA:
20.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZZQ_A_ACTA860_0
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 5b2g ENDOLYSIN,CLAUDIN-4
(Homo
sapiens;
Escherichia
virus
T4) 		4 / 4 GLY A1257
TRP A1181
VAL A1178
SER A1261
 None
 1.47A 1zzqA-5b2gA:
0.0		 1zzqA-5b2gA:
20.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZZQ_B_ACTB861_0
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 5b2g ENDOLYSIN,CLAUDIN-4
(Homo
sapiens;
Escherichia
virus
T4) 		4 / 5 GLY A1257
TRP A1181
VAL A1178
SER A1261
 None
 1.49A 1zzqB-5b2gA:
undetectable		 1zzqB-5b2gA:
20.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZZU_A_ACTA860_0
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 5b2g ENDOLYSIN,CLAUDIN-4
(Homo
sapiens;
Escherichia
virus
T4) 		4 / 5 GLY A1257
TRP A1181
VAL A1178
SER A1261
 None
 1.48A 1zzuA-5b2gA:
undetectable		 1zzuA-5b2gA:
20.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A3A_A_TEPA1436_1
(CHITINASE)		 5b2g HEAT-LABILE
ENTEROTOXIN B CHAIN
(Clostridium
perfringens) 		3 / 3 ASP B 288
PHE B 319
ARG B 252
 None
 0.85A 2a3aA-5b2gB:
undetectable		 2a3aA-5b2gB:
17.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NDV_A_AICA375_1
(BETA-PEPTIDYL
AMINOPEPTIDASE)		 5b2g HEAT-LABILE
ENTEROTOXIN B CHAIN
(Clostridium
perfringens) 		5 / 11 LEU B 215
ASN B 218
SER B 217
LEU B 211
LEU B 209
 None
 1.38A 3ndvA-5b2gB:
undetectable
3ndvB-5b2gB:
undetectable		 3ndvA-5b2gB:
16.62
3ndvB-5b2gB:
16.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NDV_D_AICD374_1
(BETA-PEPTIDYL
AMINOPEPTIDASE)		 5b2g HEAT-LABILE
ENTEROTOXIN B CHAIN
(Clostridium
perfringens) 		5 / 11 LEU B 211
LEU B 209
LEU B 215
ASN B 218
SER B 217
 None
 1.39A 3ndvC-5b2gB:
undetectable
3ndvD-5b2gB:
undetectable		 3ndvC-5b2gB:
16.62
3ndvD-5b2gB:
16.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E1G_B_LNLB701_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 5b2g ENDOLYSIN,CLAUDIN-4
(Escherichia
virus
T4;
Homo
sapiens) 		5 / 12 GLY A1330
ALA A1332
SER A1334
GLY A1292
LEU A1338
 None
 1.10A 4e1gB-5b2gA:
undetectable		 4e1gB-5b2gA:
20.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4W5N_A_IPHA903_0
(PROTEIN ARGONAUTE-2)		 5b2g ENDOLYSIN,CLAUDIN-4
(Homo
sapiens;
Escherichia
virus
T4) 		4 / 4 TYR A1018
THR A1026
GLY A1028
LEU A1013
 None
 1.30A 4w5nA-5b2gA:
undetectable		 4w5nA-5b2gA:
18.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WYQ_B_SAMB301_0
(TRNA
(GUANINE-N(1)-)-METH
YLTRANSFERASE)		 5b2g ENDOLYSIN,CLAUDIN-4
(Homo
sapiens;
Escherichia
virus
T4) 		5 / 12 LEU A1289
GLY A1342
LEU A1337
GLY A1340
GLY A1341
 None
 1.00A 5wyqB-5b2gA:
undetectable		 5wyqB-5b2gA:
20.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BXL_B_SAMB401_0
(2-(3-AMINO-3-CARBOXY
PROPYL)HISTIDINE
SYNTHASE)		 5b2g ENDOLYSIN,CLAUDIN-4
(Homo
sapiens;
Escherichia
virus
T4) 		5 / 12 LEU A1176
GLY A1340
SER A1250
VAL A1253
VAL A1287
 None
 1.38A 6bxlB-5b2gA:
undetectable		 6bxlB-5b2gA:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HUO_D_08HD501_0
(GAMMA-AMINOBUTYRIC
ACID RECEPTOR
SUBUNIT
ALPHA-1,GAMMA-AMINOB
UTYRIC ACID RECEPTOR
SUBUNIT ALPHA-1
GAMMA-AMINOBUTYRIC
ACID RECEPTOR
SUBUNIT GAMMA-2)		 5b2g HEAT-LABILE
ENTEROTOXIN B CHAIN
(Clostridium
perfringens) 		4 / 8 ASN B 269
VAL B 297
SER B 265
TYR B 296
 None
 1.15A 6huoC-5b2gB:
undetectable
6huoD-5b2gB:
undetectable		 6huoC-5b2gB:
26.13
6huoD-5b2gB:
25.21